Biochemistry of Cytosolic Sulfotransferases Involved in Bioactivation

Academic Article

Abstract

  • This chapter discusses the biochemistry of the cytosolic sulfotranferases (STs) that appear to be involved in the conjugation and activation of small xenobiotic substrates to reactive electrophiles. Numerous studies have indicated that two classes of cytosolic STs are involved in the bioactivation of procarcinogens and drugs to reactive electrophiles, especially in rodent tissues. These two classes of STs are the hydroxysteroid STs, which are involved in the conjugation of hydroxymethyl PAHs, and the phenol STs involved in the sulfation of alkenylbenzenes and N-hydroxyarylamines. In human tissues, only two phenol STs (P-PST and M-PST) have been identified. The role of these enzymes or unidentified STs in the sulfation of N-hydroxyarylamine procarcinogens has not yet been established. Further, initial reports of the molecular cloning and expression of the rat and human phenol ST genes will provide a valuable mechanism for the characterization of roles of the individual enzymes in bioactivation. © 1994, Academic Press Inc.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Falany CN; Wilborn TW
  • Start Page

  • 301
  • End Page

  • 329
  • Volume

  • 27
  • Issue

  • C