Palmitate stimulates glucose transport in rat adipocytes by a mechanism involving translocation of the insulin sensitive glucose transporter (GLUT4)

Academic Article


  • In rat adipocytes, palmitate: a) increases basal 2-deoxyglucose transport 129±27% (p<0.02), b) decreases the insulin sensitive glucose transporter (GLUT4) in low density microsomes and increases GLUT4 in plasma membranes and c) increases the activity of the insulin receptor tyrosine kinase. Palmitate-stimulated glucose transport is not additive with the effect of insulin and is not inhibited by the protein kinase C inhibitors staurosporine and sphingosine. In rat muscle, palmitate: a) does not affect basal glucose transport in either the soleus or epitrochlearis and b) inhibits insulin-stimulated glucose transport by 28% (p<0.005) in soleus but not in epitrochlearis muscle. These studies demonstrate a potentially important differential role for fatty acids in the regulation of glucose transport in different insulin target tissues. © 1991.
  • Digital Object Identifier (doi)

    Author List

  • Hardy RW; Ladenson JH; Henriksen EJ; Holloszy JO; McDonald JM
  • Start Page

  • 343
  • End Page

  • 349
  • Volume

  • 177
  • Issue

  • 1