The predicted amino acid sequence of the Salmonella typhimurium virulence gene mviA+ strongly indicates that MviA is a regulator protein of a previously unknown S. typhimurium response regulator family

Academic Article


  • The Salmonella typhimurium virulence gene mviA+ has a predicted amino acid sequence with homology to the N-terminal 112-amino-acid sequence of response regulator proteins. A previously described mutant allele (mviA), which restores virulence to avirulent LT2 strains, was shown to contain a point mutation which would be predicted to cause a single amino acid change, V-102→G (W. H. Benjamin, Jr., J. Yother, P. Hall, and D. E. Briles, J. Exp. Med. 174:1073-1083, 1991). A comparison of the nucleotide sequence of mviA+ with that of the Escherichia colt and Salmonella typhi genes revealed a high degree of conservation.
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    Digital Object Identifier (doi)

    Author List

  • Benjamin WH; Wu X; Swords WE
  • Start Page

  • 2365
  • End Page

  • 2367
  • Volume

  • 64
  • Issue

  • 6