Cryptococcosis associated with low-dose methotrexate for arthritis

Academic Article


  • One patient with psoriatic arthritis and a second with rheumatoid arthritis were each treated with low-dose methotrexate (10 to 15 mg per week, orally) for more than a year before pulmonary cryptococcosis developed. These are the first case reports of opportunistic fungal disease during this treatment. Low-dose methotrexate may be more immunosuppressive than has been appreciated. Patients demonstrating pneumonitis while receiving this therapy should be carefully evaluated to rule out an infectious cause. © 1987.
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    Digital Object Identifier (doi)

    Author List

  • Altz-Smith M; Kendall LG; Stamm AM
  • Start Page

  • 179
  • End Page

  • 181
  • Volume

  • 83
  • Issue

  • 1