Expression of Sulfated Glycoprotein 2 Is Associated with Carcinogenesis Induced by A^Nitroso-AT-methylurea in Rat Prostate and Seminal Vesicle

Academic Article

Abstract

  • To understand the molecular mechanism of carcinogenesis in androgen-dependent tumors, we have searched for new markers which are associated with this process. In normal rat prostate and seminal vesicle, sulfated glycoprotein 2 (SGP-2) messenger RNA is barely detectable. However, we have found high levels of SGP-2 expression in the epithelial component of carcinomas of the prostate and seminal vesicle after initiation with iV-nitroso-./V-methylurea and promotion with testosterone propionate. We have also observed induction of SGP-2 expression in epithelial cells at early stages in carcinogenesis when cytologically malignant cells first begin to appear. SGP-2 has been reported previously to be associated with a variety of models of programmed cell death (apoptosis), including the prostate following castration. Our present findings provide a novel marker for carcinogenesis in the rat prostate and seminal vesicle. © 1993, American Association for Cancer Research. All rights reserved.
  • Authors

    Published In

  • Cancer Research  Journal
  • Author List

  • Kadomatsu K; Anzano MA; Winokur TS; Smith JM; Sporn MB; Slayter MV
  • Start Page

  • 1480
  • End Page

  • 1483
  • Volume

  • 53
  • Issue

  • 7