Purpose: To report the clinical findings for patients with binocular vision difficulties attributed to retinally induced aniseikonia. Methods. Clinical records of patients referred to the author and diagnosed with retinally induced aniseikonia from 2006 to 2012 were retrospectively reviewed. Results. Twelve patients with retinally induced aniseikonia attributed to epiretinal membrane, retinal detachment surgical repair, or age-related macular degeneration are reported. Eleven patients were male. The age range was 44 to 76 years. Diplopia occurred in 10 patients, and prism lenses were prescribed for seven patients by their referring practitioner. The amount of aniseikonia measured using either the computerized Aniseikonia Inspector (visual field angle, È 14.5 degrees) or the New Aniseikonia Test (visual field angle, È 5.7 degrees) ranged from 1.7 to 11.3% and from 1.5 to 13.3% in the vertical and horizontal meridians, respectively. At other visual field angles, the amount of aniseikonia might have been different. Five patients perceived macropsia and seven patients perceived micropsia in the affected eye. Seven patients had measurable stereopsis. Use of Bangerter filters was the most frequent treatment modality. Detailed case reports on three patients are included. Conclusions: Retinally induced aniseikonia is an increasingly important cause of binocular vision symptoms in the aging population. Long-term studies on its incidence, clinical course, and effect of treatment are needed. Copyright © 2012 American Academy of Optometry.