In vitro activity of LY127935, a new 1-oxa cephalosporin, against aerobic gram-negative bacilli

Academic Article

Abstract

  • A total of 434 clinical aerobic gram-negative bacillary isolates were tested against LY127935, a new 1-oxa cephalosporin, and compared with other cephalosporins, penicillins, and aminoglycosides by a broth microdilution technique. Cefotaxime (HR756), a new semisynthetic cephalosporin, and LY127935 were more active, and showed lower minimum inhibitory concentrations (ranges ≤0.12 to 2.0 μg/ml), than cefamandole, cefoxitin, and cefazolin against Escherichia coli, Klebsiella spp., Enterobacter spp., Proteus mirabilis, indole-positive Proteus spp., Serratia marcescens, Providencia spp., and Citrobacter spp. Against P. aeruginosa, piperacillin, azlocillin, and mezlocillin were the most active beta-lactam agents; 64 μg/ml inhibited 99, 93, and 87% of the isolates, respectively. LY127935 and cefotaxime at 16 μg/ml inhibited 71% of Pseudomonas isolates whereas the aminoglycosides gentamicin, tobramycin, and amikacin at a concentration of 4 μg/ml inhibited 84, 88, and 93% respectively. Minimum bactericidal concentrations were determined for all isolates and were generally the same as the minimum inhibitory concentrations.
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    Digital Object Identifier (doi)

    Author List

  • Delgado DG; Brau CJ; Cobbs CG; Dismukes WE
  • Start Page

  • 864
  • End Page

  • 868
  • Volume

  • 16
  • Issue

  • 6