In vitro comparison of cilofungin alone and in combination with other antifungal agents against clinical isolates of Candida species

Academic Article

Abstract

  • Cilofungin, a lipopeptide antifungal agent, was tested for in vitro activity alone and in combination with ketoconazole, itraconazole, flucytosine and amphotericin B against 102 clinical isolates of Candida species. At 48 hours all isolates of Candida albicans, Candida tropicalis, Candida paratropicalis and Candida glabrata were inhibited by ≤5 mcg/ml of cilofungin. In contrast, the MIC90 for Candida krusei was 10 mcg/ml and for Candida parapsilosis >40 mcg/ml. The interaction of combinations of cilofungin with amphotericin B, itraconazole, ketoconazole and flucytosine was additive or indifferent at 48 hours for 100 %, 88 %, 78 % and 70 % of all Candida species isolates, respectively. Overall, cilofungin demonstrated good activity in vitro against most Candida species isolates. © 1991 Friedr. Vieweg & Sohn Verlagsgesellschaft mbH.
  • Digital Object Identifier (doi)

    Author List

  • Smith KR; Lank KM; Dismukes WE; Cobbs CG
  • Start Page

  • 588
  • End Page

  • 592
  • Volume

  • 10
  • Issue

  • 7