Metastasis suppressors and the tumor microenvironment

Academic Article

Abstract

  • The most lethal and debilitating attribute of cancer cells is their ability to metastasize. Throughout the process of metastasis, tumor cells interact with other tumor cells, host cells and a variety of molecules. Tumor cells are also faced with a number of insults, such as hemodynamic sheer pressure and immune selection. This brief review explores how metastasis suppressor proteins regulate interactions between tumor cells and the microenvironments in which tumor cells find themselves. © 2010 Elsevier Ltd.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Cook LM; Hurst DR; Welch DR
  • Start Page

  • 113
  • End Page

  • 122
  • Volume

  • 21
  • Issue

  • 2