Synthesis of mannopyranose disaccharides as photoaffinity probes for mannosyltransferases in Mycobacterium tuberculosis

Academic Article

Abstract

  • Mannosyltransferases play a crucial role in mycobacterial cell-wall biosynthesis and are potential new drug targets for the treatment of tuberculosis. Herein, we describe the synthesis of α-(1→2)- and α-(1→6)-linked mannopyranosyl disaccharides possessing a 5-azidonaphthlene-1-sulfonamidoethyl group as photoaffinity probes for active-site labeling studies of mannosyltransferases in Mycobacetrium tuberculosis. © 2003 Elsevier Ltd. All rights reserved.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Pathak AK; Pathak V; Riordan JM; Gurcha SS; Besra GS; Reynolds RC
  • Start Page

  • 683
  • End Page

  • 691
  • Volume

  • 339
  • Issue

  • 3