Synthesis and antimycobacterial activity of pyrazine and quinoxaline derivatives

Academic Article

Abstract

  • A series of pyrazine and quinoxaline derivatives have been synthesized, and their activity against M. tuberculosis (Mtb) and Mycobacterium avium (MAC) are reported. The 4-acetoxy-benzyl ester of pyrazinoic acid and 4′-acetoxybenzyl 2-quinoxalinecarboxylate showed excellent activity against Mtb (MIC ranges of less than 1-6.25 μg/mL) but only modest activity against MAC (MICs of 4-32 μg/mL).
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Seitz LE; Suling WJ; Reynolds RC
  • Start Page

  • 5604
  • End Page

  • 5606
  • Volume

  • 45
  • Issue

  • 25