Antimycobacterial Agents. 1. Thio Analogues of Purine

Academic Article

Abstract

  • Thio analogues of purine, pyridine, and pyrimidine were prepared based on the initial activity screening of several analogues of these heterocycles against Mycobacterium tuberculosis (Mtb). Certain 6-thio-substituted purine analogues described herein showed moderate to good inhibitory activity. In particular, two purine analogues 9-(ethylcarboxymethyl)-6-(decylthio)-9H-purine (20) and 9-(ethylcarboxymethyl)-6-(dodecylthio)-9H-purine (21) exhibited MIC values of 1.56 and 0.78 μg/mL respectively against the Mtb H37Rv strain. N9-Substitution apparently enhances the antimycobacterial activity in the purine series described herein.
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    Digital Object Identifier (doi)

    Author List

  • Pathak AK; Pathak V; Seitz LE; Suling WJ; Reynolds RC
  • Start Page

  • 273
  • End Page

  • 276
  • Volume

  • 47
  • Issue

  • 1