New Mycobactenum avium antifolate shows synergistic effect when used in combination with dihydropteroate synthase inhibitors

Academic Article


  • Mycobacterium avium complex (MAC) is resistant to trimethoprim, an inhibitor of bacterial dihydrofolate reductase (DHFR). A previously identified selective inhibitor of MAC DHFR, SRI-8858, was shown to have synergistic activity in combination with dapsone and sulfamethoxazole, two drugs that inhibit bacterial dihydropteroate synthase. Copyright © 2005, American Society for Microbiology. All Rights Reserved.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Suling WJ; Seitz LE; Reynolds RC; Barrow WW
  • Start Page

  • 4801
  • End Page

  • 4803
  • Volume

  • 49
  • Issue

  • 11