Synthesis of symmetrical C- and pseudo-symmetrical O-linked disaccharide analogs for arabinosyltransferase inhibitory activity in Mycobacterium tuberculosis

Academic Article

Abstract

  • Herein we report the synthesis of symmetrical C-linked and pseudo-symmetrical O-linked disaccharides structurally related to Araf motifs present in the cell wall of MTB. Their activity in a competition-based arabinosyltransferase assay using [14C]-DPA as the glycosyl donor is also presented. In addition, in vitro inhibitory activity for the disaccharides was determined in a colorimetric broth microdilution assay system against MTB H37Ra and Mycobacterium avium. © 2007 Elsevier Ltd. All rights reserved.
  • Digital Object Identifier (doi)

    Author List

  • Pathak AK; Pathak V; Riordan JR; Suling WJ; Gurcha SS; Besra GS; Reynolds RC
  • Start Page

  • 4527
  • End Page

  • 4530
  • Volume

  • 17
  • Issue

  • 16