Selective association of murine T lymphoblastoid cell surface alloantigens with Mycoplasma hyorhinis

Academic Article

Abstract

  • M. hyorhinis, isolated by isopycnic centrifugation from supernatants of a persistently infected murine T lymphoblastoid cell line, demonstrated the presence of the Thy-1.1 differentiation alloantigen and H-2Kk histocompatibility antigens. The murine leukemic virus-related gp70 antigen also present on the surface of these lymphoblastoid cells was absent from mycoplasma preparations. Quantitative assessment of Thy-1.1 present in preparations of M. hyorhinis revealed a specific activity greater or equal to that of membrane preparations from lymphoblastoid cells, suggesting a marked accumulation of the Thy-1.1 antigen in association with purified mycoplasmas. The accumulation of the Thy-1.1 antigen in association with purified mycoplasmas was also demonstrated in lymphoblastoid cells experimentally infected with a defined culture of M. hyorhinis.
  • Authors

    Digital Object Identifier (doi)

    Pubmed Id

  • 19762692
  • Author List

  • Wise KS; Cassell GH; Acton RT
  • Start Page

  • 4479
  • End Page

  • 4483
  • Volume

  • 75
  • Issue

  • 9