The long elusive IgM Fc receptor, FcμR

Academic Article

Abstract

  • IgM exists as both a monomer on the surface of B cells and a pentamer secreted by plasma cells. Both preimmune "natural" and antigen-induced "immune" IgM antibodies are important for protective immunity and for immune regulation of autoimmune processes by recognizing pathogens and self-antigens. Effector proteins interacting with the Fc portion of IgM, such as complement and complement receptors, have thus far been proposed but fail to fully account for the IgM-mediated protection and regulation. A major reason for this deficit in our understanding of IgM function seems to be lack of data on a long elusive Fc receptor for IgM (FcμR). We have recently identified a bona fide FcμR in both humans and mice. In this article we briefly review what we have learned so far about FcμR. © Springer Science+Business Media 2014.
  • Authors

    Published In

    Digital Object Identifier (doi)

    Author List

  • Kubagawa H; Oka S; Kubagawa Y; Torii I; Takayama E; Kang DW; Jones D; Nishida N; Miyawaki T; Bertoli LF
  • Volume

  • 34
  • Issue

  • SUPPL. 1