© The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. Among 6789 HIV-infected Zambian adults screened for hepatitis B virus (HBV) coinfection, estimated glomerular filtration rate (eGFR) was 50-90 mL/minute/1.73 m 2 in 17.6% and <50 mL/minute/1.73 m 2 in 2.5%. Human immunodeficiency virus/HBV coinfection was associated with eGFR <50 mL/minute/1.73 m 2 (adjusted odds ratio, 1.96 [95% confidence interval, 1.34-2.86]), adjusted for age, sex, CD4 + count, and World Health Organization disease stage.