Neurochemical mechanisms in brain injury and treatment: A review

Academic Article


  • This article reviews cellular energy transformation processes and neurochemical events that take place at the time of brain injury and shortly thereafter, emphasizing hypoxia-ischemia, cerebrovascular accident, and traumatic brain injury. New interpretations of established concepts, such as diffuse axonal injury, are discussed; specific events, such as free radical production, excess production of excitatory amino acids, and disruption of calcium homeostasis, are reviewed. Neurochemically-based interventions are also presented: calcium channel blockers, excitatory amino acid antagonists, free radical scavengers, and hypothermia treatment. Concluding remarks focus on the role of clinical neuropsychologists in validation of treatment interventions.
  • Authors

    Digital Object Identifier (doi)

    Author List

  • Novack TA; Dillon MC; Jackson WT
  • Start Page

  • 685
  • End Page

  • 706
  • Volume

  • 18
  • Issue

  • 5