Cerebellar ataxia associated with high levels of anti-glutamic acid decarboxylase antibodies

Academic Article


  • We present, with a review of the relevant literature, the case of a 27-year-old woman with type 1 diabetes mellitus free of long-term complications who presented with vertigo and imbalance. Clinical exam showed evidence of cerebellar dysfunction, and magnetic resonance imaging demonstrated cerebellar atrophy. Anti-glutamic acid decarboxylase antibodies were detected in very high titers, and with all other causes of cerebellar atrophy being ruled out, the diagnosis of cerebellar atrophy associated with glutamic acid decarboxylase autoantibodies as previously described in the literature was made. After a review of the literature, we believe that this is the first report of this unusual condition in a young patient with type 1 diabetes mellitus.
  • Authors

    Published In

  • Endocrinologist  Journal
  • Digital Object Identifier (doi)

    Author List

  • Bell DSH; Ovalle F; Shadmany S
  • Start Page

  • 233
  • End Page

  • 235
  • Volume

  • 11
  • Issue

  • 3