Effect of myocardial contractility on hemodynamic end points under concomitant microvascular disease in a porcine model

Academic Article


  • In this study, coronary diagnostic parameters, pressure drop coefficient (CDP: ratio of trans-stenotic pressure drop to distal dynamic pressure), and lesion flow coefficient (LFC: ratio of % area stenosis (%AS) to the CDP at throat region), were evaluated to distinguish levels of %AS under varying contractility conditions, in the presence of microvascular disease (MVD). In 10 pigs, %AS and MVD were created using angioplasty balloons and 90-l m microspheres, respectively. Simultaneous measurements of pressure drop, left ventricular pressure ( p), and velocity were obtained. Contractility was calculated as (dp/dt)max, categorized into low contractility <900 mmHg/s and high contractility >900 mmHg/s, and in each group, compared between %AS <50 and >50 using analysis of variance. In the presence of MVD, between the %AS <50 and >50 groups, values of CDP (71 ± 1.4 and 121 ± 1.3) and LFC (0.10 ± 0.04 and 0.19 ± 0.04) were significantly different (P < 0.05), under low-contractility conditions. A similar %AS trend was observed under high-contractility conditions (CDP: 18 ± 1.4 and 91 ± 1.4; LFC: 0.08 ± 0.04 and 0.25 ± 0.04). Under MVD conditions, similar to fractional flow reserve, CDP and LFC were not influenced by contractility. © Springer 2013.
  • Authors

    Digital Object Identifier (doi)

    Author List

  • Peelukhana SV; Kolli KK; Leesar MA; Effat MA; Helmy TA; Arif I; Schneeberger EW; Succop P; Banerjee RK
  • Start Page

  • 97
  • End Page

  • 109
  • Volume

  • 29
  • Issue

  • 1