Evaluation of nickel complexes of bioligands - Effect on distribution profile

Academic Article

Abstract

  • Distribution of various nickel-63 bioligand complexes in tissues of rats and their binding to subcellular fractions have been studied. Nickel-binding with glutathione and histidine significantly decreased nickel-63 accumulation while nickel-serum binding increased nickel body burden and its accumulation in subcellular fractions. Nickel-renal cytosol binding exhibited distribution pattern similar to serum complex only in lung tissue.
  • Author List

  • Srivastava RC; Srivastava SK; Gupta S; Athar M; Hasan SK
  • Start Page

  • 253
  • End Page

  • 256
  • Volume

  • 65
  • Issue

  • 2