Tracking RNA polymerase, one step at a time

Academic Article


  • Although the structural analysis of transcription has attained atomic resolution, techniques to manipulate single molecules involved in transcription have lagged behind. A recent paper in Nature by Abbondanzieri et al. (2005) closes this gap. This study finds that individual molecules of bacterial RNA polymerase move in single base-pair steps and concludes that RNA polymerase acts as a Brownian ratchet that is driven forward by the binding of incoming nucleoside triphosphates. ©2005 Elsevier Inc.
  • Published In

  • Cell  Journal
  • Digital Object Identifier (doi)

    Author List

  • Vassylyev DG; Artsimovitch I
  • Start Page

  • 977
  • End Page

  • 979
  • Volume

  • 123
  • Issue

  • 6