Mapping the bovine homolog of the human cystic fibrosis gene

Academic Article

Abstract

  • Human cDNA probe H1 6 (clone 10-1) encoding cystic fibrosis transmembrane conductance regulator (CFTR) was used to map the bovine homolog of CFTR Using a panel of bovine × rodent hybrid somatic cells, the homolog was mapped to bovine syntenic group U13 which corresponds to chromosome 4 CFTR is 97 7% concordant with syntenic markers T-cell receptor beta (TCRB) and P-glycoprotein 3 (PGY3) The comparative gene maps of CFTR, TCRB, and PGY3 on human chromosome 7, bovine chromosome 4, and mouse chromosomes 5 and 6 indicate conservation of synteny, although internal rearrangements relative to HSA 7 are present in both cattle and mice. © 1994 The American Genetic Association.
  • Authors

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    Digital Object Identifier (doi)

    Author List

  • Wallis D; Womack JE
  • Start Page

  • 490
  • End Page

  • 492
  • Volume

  • 85
  • Issue

  • 6