Sources of variability in the measurement of perfusion defect size using commercially available software programs: Are there gender differences?

Academic Article


  • We recently showed that Quantitative Perfusion SPECT (QPS), Emory Cardiac Toolbox (ECTb) and 4-Dimension-Myocardial SPECT (4DM) yielded discordant results in the assessment of perfusion defect size (PDS) in patients with known or suspected coronary artery disease. In this report, we examined the sources of variability in the measurement of PDS using ECTb (Var ), 4DM (Var ) and QPS (Var ) and found that gender is a source of variability in the assessment of PDS. In 120 patients, Var was lower in men, compared with women, whereas Var and Var were similar between both genders. Among men, Var was lowest, compared with Var and Var , whereas, Var , Var , and Var were not different among women. Future studies should account for gender differences when comparing the 3 software programs. ECTb 4DM QPS ECTb 4DM QPS ECTb QPS 4DM ECTb QPS 4DM
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Ather S; Iskandrian AE; Hage FG
  • Start Page

  • 1089
  • End Page

  • 1093
  • Volume

  • 24
  • Issue

  • 3