Stopping the control arm in response to the DSMB: Mother's choice of HIV prophylaxis during breastfeeding in the BAN Study

Academic Article

Abstract

  • The Data and Safety Monitoring Board (DSMB) for the Breastfeeding, Antiretrovirals, and Nutrition study, a clinical trial aimed to prevent postnatal HIV transmission, recommended halting randomization to the enhanced standard-of-care (control) arm. The 67 mother-infant pairs on the control arm and less than 21. weeks postpartum at the time of the DSMB recommendation were read a script informing them of the DSMB decision and offering them the maternal or infant antiretroviral interventions for the remainder of the 28-week breastfeeding period. This paper describes the BAN study response to the DSMB decision and what the women on the control arm chose, when given a choice to start the maternal or infant antiretroviral interventions. © 2011.
  • Authors

    Published In

    Digital Object Identifier (doi)

    Author List

  • Chavula C; Long D; Mzembe E; Kayira D; Chasela C; Hudgens MG; Hosseinipour M; King CC; Ellington S; Chigwenembe M
  • Start Page

  • 55
  • End Page

  • 59
  • Volume

  • 33
  • Issue

  • 1