A combined method for the determination of myocardial perfusion in experimental animals using microspheres and CMR

Academic Article


  • A convenient method is introduced for myocardial perfusion research by combining multislice short-axis cine cardiovascular magnetic resonance (MSA-CMR) and colored microspheres (CM). In canine control-ischemia-reperfusion (n = 11), Cardiac output (CO) was measured using MSA-CMR (COMSA), Phase Contrast CMR (PC-CMR, COPC) and CM (from reference blood samples, COμ) in 3 experimental periods per animal. COμ significantly and systematically overestimated COMSA (median deviation: 291 mL/min, p < 0.01), while there was excellent agreement between PC-CMR and MSA-CMR without significant over-or underestimation (median deviation: -14 ml/min, p = NS). In quantitative myocardial perfusion assay by CM, CMR should be used instead of reference blood sampling. This should improve the accuracy of absolute regional perfusion measurement. Copyright © 2007 Informa Healthcare.
  • Authors

    Digital Object Identifier (doi)

    Author List

  • Surányi P; Kiss P; Simor T; Elgavish A; Elgavish GA
  • Start Page

  • 549
  • End Page

  • 556
  • Volume

  • 9
  • Issue

  • 3