Outcome measures in spinal cord injury: Recent assessments and recommendations for future directions

Academic Article


  • Study design: Review by the spinal cord outcomes partnership endeavor (SCOPE), which is a broad-based international consortium of scientists and clinical researchers representing academic institutions, industry, government agencies, not-for-profit organizations and foundations. Objectives: Assessment of current and evolving tools for evaluating human spinal cord injury (SCI) outcomes for both clinical diagnosis and clinical research studies. Methods: a framework for the appraisal of evidence of metric properties was used to examine outcome tools or tests for accuracy, sensitivity, reliability and validity for human SCI. Results: Imaging, neurological, functional, autonomic, sexual health, bladder/bowel, pain and psychosocial tools were evaluated. Several specific tools for human SCI studies have or are being developed to allow the more accurate determination for a clinically meaningful benefit (improvement in functional outcome or quality of life) being achieved as a result of a therapeutic intervention. Conclusion: Significant progress has been made, but further validation studies are required to identify the most appropriate tools for specific targets in a human SCI study or clinical trial. © 2009 International Spinal Cord Society All rights reserved.
  • Authors

    Published In

  • Spinal Cord  Journal
  • Digital Object Identifier (doi)

    Author List

  • Alexander MS; Anderson KD; Biering-Sorensen F; Blight AR; Brannon R; Bryce TN; Creasey G; Catz A; Curt A; Donovan W
  • Start Page

  • 582
  • End Page

  • 591
  • Volume

  • 47
  • Issue

  • 8