Design of benzoic acid inhibitors of influenza neuraminidase containing a cyclic substitution for the N-acetyl grouping

Academic Article


  • A 2-pyrrolidinone ring containing a single hydroxymethyl side chain effectively replaces the N-acetylamino group of 4-(N-acetylamino)-3- guanidinobenzoic acid, a low micromolar inhibitor of influenza neuraminidase. This novel structural template affords new opportunities to evolve more potent benzoic acid inhibitors.
  • Digital Object Identifier (doi)

    Author List

  • Brouillette WJ; Atigadda VR; Ming L; Air GM; Babu YS; Bantia S
  • Start Page

  • 1901
  • End Page

  • 1906
  • Volume

  • 9
  • Issue

  • 14