Olanzapine for the prevention of chemotherapy-induced nausea and vomiting



  • © Springer International Publishing Switzerland 2016. Chemotherapy-induced nausea and vomiting (CINV) is associated with a significant deterioration in quality of life and is perceived by patients as a major adverse effect of the treatment [1]. The use of 5-hydroxytryptamine-3 (5-HT3) receptor antagonists plus dexamethasone has significantly improved the control of CINV [2]. Recent studies have demonstrated additional improvement in the control of CINV with the use of new agents: palonosetron, a second generation 5-HT3 receptor antagonist [3]; NK-1 receptor antagonists aprepitant, netupitant, and rolapitant [4–6]; and olanzapine, an antipsychotic which blocks multiple neurotransmitters in the central nervous system [7–9].
  • Digital Object Identifier (doi)

    International Standard Book Number (isbn) 13

  • 9783319270142
  • Start Page

  • 107
  • End Page

  • 120