Effect of plasma proteins on oxygen diffusion in the pulmonary capillaries

Academic Article


  • In the consideration of the gaseous diffusion capacities of the pulmonary membrane, the blood plasma, and the red blood cell, it has been calculated that the pulmonary membrane, and, in particular, the blood plasma may be major resistances to the gas transfer from the alveoli of the lungs to the hemoglobin molecules of the red cells. In vitro measurements of the effect of plasma protein concentrations on the diffusivity of oxygen show that the diffusivity can undergo a fivefold change as the plasma protein concentration is varied between the extremes of the normal physiological range. As a result, it appears that the overall gas transfer may be affected and possibly limited by altering the gaseous diffusion coefficient in plasma through changes in the concentration of the plasma proteins. © 1974.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Bryant SC; Navari RM
  • Start Page

  • 120
  • End Page

  • 130
  • Volume

  • 7
  • Issue

  • 1