Positions

Overview

  • I am a Biomedical Engineer by training with a PhD from the University of Michigan where I worked with Dr. Carlos, H. Mastrangelo developing new polymer based lab-on-a-chip technologies for genomic and proteomic assays. I completed my postdoctoral training in the laboratory of Dr. Mehmet Toner at the Center for Engineering in Medicine at Massachusetts General Hospital, Harvard Medical School and Shriners Burns Hospital working on label-free approaches to isolate leukocyte sub-populations from whole blood. After spending the 1st 7 years of my career at the University of Louisville, I am currently an Associate Professor of Medicine and Biomedical Engineering within the Division of Cardiovascular Disease at the University of Alabama-Birmingham.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 Evaluation of flow-modulation approaches in ventricular assist devices using an in-vitro endothelial cell culture model 2019
    2019 Mitoquinone ameliorates pressure overload-induced cardiac fibrosis and left ventricular dysfunction in mice 2019
    2016 A biphasic effect of TNF-α in regulation of the Keap1/Nrf2 pathway in cardiomyocytes 2016
    2016 Evaluation of the effect of diminished pulsatility as seen in continuous flow ventricular assist devices on arterial endothelial cell phenotype and function 2016
    2014 Thermally induced substrate release via intramolecular cyclizations of Amino esters and Amino carbonates 2014
    2009 Microfluidic cardiac circulation model (μCCM) for functional cardiomyocyte studies 2009
    2008 Three-dimensional hydrodynamic focusing in a microfluidic Coulter counter 2008
    2007 Osmotic selection of human mesenchymal stem/progenitor cells from umbilical cord blood 2007
    2004 Cast epoxy-based microfluidic systems and their application in biotechnology 2004
    2003 Polyethylene glycol (PEG)-based actuator for nozzle-diffuser pumps in plastic microfluidic systems 2003

    Chapter

    Year Title Altmetric
    2016 Validation of a new image-based approach for the accurate estimating of the growth rate of detected lung nodules using real computed tomography images and elastic phantoms generated by state-of-the-art microfluidics technology.  405-420. 2016
    2013 Connecting microbial population genetics with microbial pathogenesis: Engineering microfluidic cell arrays for high-throughput interrogation of host-pathogen interaction.  745-760. 2013
    2011 Connecting microbial population genetics with microbial pathogenesis: Engineering microfluidic cell arrays for high-throughput interrogation of host-pathogen interaction.  533-548. 2011

    Research Overview

  • My laboratory pioneered Cardiac and Vascular Tissue Chip Models (BCTM and VPPM) which represent the state-of-the art for culture of cardiac and vascular cells in-vitro. As a Biomedical Engineer, I have extensive experience in the areas of tissue engineering and fluid mechanics, which has enabled me to design and construct systems for culture of cells in environments that mimic the complex hemodynamic stresses in cardiac and vascular tissues. Recently, we have expanded our work to build tissue chip models of the Kidney focusing on drug induced nephrotoxicity. My laboratory has been funded by major federal funding agencies including NIH, NSF, DoD and NASA and private foundations like the Alabama Institute of Medicine, Kentucky Science and Technology Foundation and the Wallace H. Coulter Foundation. I have successfully administered projects, collaborated with other researchers, and produced several peer-reviewed publications from each project.
  • Teaching Overview

  • I have extensive teaching experience that includes courses within the core Biomedical Engineering Curriculum (i.e) Biomechanics Principles and Biotransport Phenomena and elective courses such as Biomechanics of Organs and Tissue, Cardiovascular Dynamics, Advanced Biotransport, Molecular and Tissue Engineering Laboratory, and Biomedical Microfluidics.
  • Teaching Activities

  • BME798 - Non-Dissertation Research (Summer Term 2019) 2019
  • BME350 - Biological Transport Phenomena (Spring Term 2019) 2019
  • BME798 - Non-Dissertation Research (Spring Term 2019) 2019
  • BME699 - Masters Thesis Research (Summer Term 2018) 2018
  • BME799 - Dissertation Research (Summer Term 2018) 2018
  • BME350 - Biological Transport Phenomena (Spring Term 2018) 2018
  • BME699 - Masters Thesis Research (Spring Term 2018) 2018
  • BME699 - Masters Thesis Research (Spring Term 2018) 2018
  • BME799 - Dissertation Research (Spring Term 2018) 2018
  • BME698 - Non-Thesis Research (Fall Term 2017) 2017
  • BME798 - Non-Dissertation Research (Fall Term 2017) 2017
  • BME799 - Dissertation Research (Fall Term 2017) 2017
  • BME698 - Non-Thesis Research (Summer Term 2017) 2017
  • BME798 - Non-Dissertation Research (Summer Term 2017) 2017
  • BME799 - Dissertation Research (Summer Term 2017) 2017
  • BME350 - Biological Transport Phenomena (Spring Term 2017) 2017
  • BME691 - Individual Study in (Area) (Spring Term 2017) 2017
  • BME698 - Non-Thesis Research (Spring Term 2017) 2017
  • BME798 - Non-Dissertation Research (Spring Term 2017) 2017
  • BME698 - Non-Thesis Research (Fall Term 2016) 2016
  • BME798 - Non-Dissertation Research (Fall Term 2016) 2016
  • BME698 - Non-Thesis Research (Summer Term 2016) 2016
  • BME798 - Non-Dissertation Research (Summer Term 2016) 2016
  • BME350 - Biological Transport Phenomena (Spring Term 2016) 2016
  • BME798 - Non-Dissertation Research (Spring Term 2016) 2016
  • BME698 - Non-Thesis Research (Fall Term 2015) 2015
  • BME798 - Non-Dissertation Research (Fall Term 2015) 2015
  • BME698 - Non-Thesis Research (Summer Term 2015) 2015
  • BME699 - Masters Thesis Research (Summer Term 2015) 2015
  • BME798 - Non-Dissertation Research (Summer Term 2015) 2015
  • BME350 - Biological Transport Phenomena (Spring Term 2015) 2015
  • BME698 - Non-Thesis Research (Spring Term 2015) 2015
  • BME699 - Masters Thesis Research (Spring Term 2015) 2015
  • BME798 - Non-Dissertation Research (Spring Term 2015) 2015
  • BME408 - Biofluids (Fall Term 2014) 2014
  • BME491 - Individual Study in BME (Fall Term 2014) 2014
  • BME508 - Biofluids (Fall Term 2014) 2014
  • BME698 - Non-Thesis Research (Fall Term 2014) 2014
  • BME798 - Non-Dissertation Research (Fall Term 2014) 2014
  • BME798 - Non-Dissertation Research (Summer Term 2014) 2014
  • Education And Training

  • Doctor of Philosophy in Biomedical / Medical Engineering, University of Michigan System : Ann Arbor 2002
  • Master of Sciences or Mathematics in Biomedical / Medical Engineering, University of Michigan System : Ann Arbor 1998
  • Full Name

  • Palaniappan Sethu