Positions

Overview

  • The primary focus of Dr. Vayalil's research is to investigate changes in cellular metabolism or mitochondrial bioenergetics during different stages of development and its implications in the process of breast and prostate carcinogenesis. Major emphasis is on how cellular metabolic or bioenergetic changes during development alter the risk or increase the susceptibility to cancer and within tumor allows cancer cells to adapt to ever-changing micro-environment as tumor grows, invade and metastasize. A variety of tools are used including transgenic and knockout mouse models of breast and prostate carcinogenesis, cutting edge technology in bioenergetic analysis and metabolomics. The long-term goal is to develop novel therapeutic approaches to modulate cellular metabolism for the prevention and treatment of cancer; utilize characteristic metabolic or bioenergetic changes within the tumor to identify the aggressive nature of cancer from indolent tumor.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 Mitochondrial oncobioenergetics of prostate tumorigenesis (Review)Oncology Letters.  18:4367-4376. 2019
    2018 Deficiency of tumor suppressor Merlin facilitates metabolic adaptation by co-operative engagement of SMAD-Hippo signaling in breast cancerJournal of Autoimmunity.  39:1165-1175. 2018
    2016 Mitochondrial thiol modification by a targeted electrophile inhibits metabolism in breast adenocarcinoma cells by inhibiting enzyme activity and protein levelsRedox Biology.  8:136-148. 2016
    2015 A novel class of mitochondria-targeted soft electrophiles modifies mitochondrial proteins and inhibits mitochondrial metabolism in breast cancer cells through redox mechanismsPLoS ONE.  10. 2015
    2015 Mitochondrial oncobioenergetic index: A potential biomarker to predict progression from indolent to aggressive prostate cancerOncotarget.  6:43065-43080. 2015
    2014 Detection of electrophile-sensitive proteinsCirculation Research.  1840:913-922. 2014
    2013 Mitochondrial Bioenergetics of Metastatic Breast Cancer Cells in Response to Dynamic Changes in Oxygen Tension: Effects of HIF-1αPLoS ONE.  8. 2013
    2012 Transforming growth factor β suppresses glutamate-cysteine ligase gene expression and induces oxidative stress in a lung fibrosis modelFree Radical Biology and Medicine.  53:554-563. 2012
    2012 Date fruits (phoenix dactylifera Linn): An emerging medicinal foodMolecular BioSystems.  52:249-271. 2012
    2012 Therapeutic value of small molecule inhibitor to plasminogen activator inhibitor-1 for lung fibrosisInternational Journal for Numerical Methods in Engineering.  46:87-95. 2012
    2011 A review of the chemistry and pharmacology of the date fruits (Phoenix dactylifera L.)Food Research International.  44:1812-1822. 2011
    2007 Glutathione suppresses TGF-β-induced PAI-1 expression by inhibiting p38 and JNK MAPK and the binding of AP-1, SP-1, and Smad to the PAI-1 promoterPeritoneal Dialysis International.  293. 2007
    2005 Glutathione restores collagen degradation in TGF-β-treated fibroblasts by blocking plasminogen activator inhibitor-1 expression and activating plasminogenPeritoneal Dialysis International.  289. 2005
    2002 Rasayanas: Evidence for the concept of prevention of diseasesTransactions of the American Neurological Association.  30:155-171. 2002
    2002 Antioxidant and antimutagenic properties of aqueous extract of date fruit (Phoenix dactylifera L. Arecaceae)Journal of Agricultural and Food Chemistry.  50:610-617. 2002
    2002 Protective effects of Rasayanas on cyclophosphamide- and radiation-induced damageJournal of Alternative and Complementary Medicine.  8:787-796. 2002

    Chapter

    Year Title Altmetric
    2013 Bioactive compounds, nutritional and functional properties of date fruit.  285-303. 2013

    Education And Training

  • Doctor of Philosophy in Biochemistry, University of Alabama at Birmingham 2001
  • Full Name

  • Praveen Vayalil