Positions

Overview

  • Dr. O'Reilly completed his medical degree at the Royal College of Surgeons in Ireland (1986-1992). His internship and residency were accomplished in Dublin teaching hospitals (1992-1995) and at Boston University (1996-1998), followed by a fellowship in pulmonary and critical care medicine at the University of Alabama at Birmingham (1998-2001). Dr. O'Reilly has a longstanding interest in basic and translational research in the lung. During his fellowship, he worked in the laboratory of Professor Sadis Matalon in the UAB Dept. of Anesthesiology Research, studying innate immunity and acute lung injury.

    • Selected Publications

    Academic Article

    Year Title Altmetric
    2017 Angiotensin-converting enzyme defines matrikine-regulated inflammation and fibrosis.  JCI insight.  2. 2017
    2016 Matrix remodeling in pulmonary fibrosis and emphysema.  American Journal of Respiratory Cell and Molecular Biology.  54:751-760. 2016
    2014 Therapeutic targeting of Src kinase in myofibroblast differentiation and pulmonary fibrosis.  Journal of Pharmacology and Experimental Therapeutics.  351:87-95. 2014
    2014 An aberrant leukotriene A4 hydrolase-proline-glycine-proline pathway in the pathogenesis of chronic obstructive pulmonary disease.  American Journal of Respiratory and Critical Care Medicine.  190:51-61. 2014
    2013 Sputum PGP is reduced by azithromycin treatment in patients with COPD and correlates with exacerbations.  BMJ Open.  3. 2013
    2010 The role of biomarkers in clinical assessment of anti-inflammatory drugs in asthma and COPD.  Minerva Pneumologica.  49:119-132. 2010
    2009 Neutrophils contain prolyl endopeptidase and generate the chemotactic peptide, PGP, from collagen.  Journal of Neuroimmunology.  217:51-54. 2009
    2009 N-α-PGP and PGP, potential biomarkers and therapeutic targets for COPD.  Respiratory Research.  10. 2009
    2008 Interfering with extracellular matrix degradation to blunt inflammation.  Current Opinion in Pharmacology.  8:242-248. 2008
    2008 A novel proteolytic cascade generates an extracellular matrix-derived chemoattractant in Chronic neutrophilic inflammation.  Journal of Immunology.  180:5662-5669. 2008
    2007 Clinical use of exhaled biomarkers in COPD.  International Journal of COPD.  2:403-408. 2007
    2007 Long-term continuous oxygen treatment in chronic obstructive pulmonary disease: Proper use, benefits and unresolved issues.  Current Opinion in Pulmonary Medicine.  120-124. 2007
    2005 Renal replacement therapy III: IHD, CRRT, SLED.  Critical Care Clinics.  21:367-378. 2005
    2003 Hyperoxia impairs antibacterial function of macrophages through effects on actin.  American Journal of Respiratory Cell and Molecular Biology.  28:443-450. 2003
    2002 Killing of Klebsiella pneumoniae by human alveolar macrophages.  AJP - Lung Cellular and Molecular Physiology.  282. 2002
    2002 The role of nitric oxide in lung innate immunity: Modulation by surfactant protein-A.  Enzymologia.  234-235:39-48. 2002
    2000 The pregnancy that never was - Beta human chorionic gonadotropin secreting primary lung cancer.  Chest.  118. 2000
    2000 Cardiac rhythm disturbances in the obstructive sleep apnea syndrome: Effects of nasal continuous positive airway pressure therapy.  Chest.  118:591-595. 2000

    Research Overview

  • He has been a co-investigator in the NIH COPD clinical research network since 2002. In 2005, Dr. O'Reilly began work in the laboratory of Professor J Edwin Blalock, studying the role of matrix fragments in neutrophilic airway inflammation, with a particular emphasis on COPD. Dr. O'Reilly is a co-investigator on several NIH grants and was recently awarded a career development award (K08) by the National Institutes of Health.

    • Principal Investigator On

    Investigator On

    Education And Training

  • Doctorate in Medicine, Royal College of Surgeons in Ireland - Medical University of Bahrain 1992
  • Beaumont Hospital, Internship 1993
  • Boston University Medical Center, Residency 1998
  • St. Vincent's Hospital - Ireland, Residency 1996
  • St. Vincent's Hospital - Ireland, Residency 1995
  • UAB Hospital, Postdoctoral Fellowship 2001

    • Full Name

  • Philip O'Reilly