Positions

Selected Publications

Academic Article

Year Title Altmetric
2020 Adeno-Associated Virus D-Sequence-Mediated Suppression of Expression of a Human Major Histocompatibility Class II Gene: Implications in the Development of Adeno-Associated Virus Vectors for Modulating Humoral Immune ResponseHuman Gene Therapy.  31:565-574. 2020
2018 Pathology, chemoprevention, and preclinical models for target validation in Barrett esophagusCancer Research.  78:3747-3754. 2018
2018 Myeloid-derived suppressor cells impair B cell responses in lung cancer through IL-7 and STAT5Journal of Immunology.  201:278-295. 2018
2017 Mesenchymal stem cells expressing osteoprotegerin variants inhibit osteolysis in a murine model of multiple myelomaBlood Advances.  1:2375-2385. 2017
2017 Effects of cellular methylation on transgene expression and site-specific integration of adeno-associated virusGenes.  8. 2017
2017 Location of tumor affects local and distant immune cell type and number:Immunity, Inflammation and Disease.  5:85-94. 2017
2016 Immature myeloid cells are critical for enhancing bone fracture healing through angiogenic cascadeBONE.  93:113-124. 2016
2015 SOCS3 deficiency in myeloid cells promotes tumor development: Involvement of STAT3 activation and myeloid-derived suppressor cellsCancer Immunology Research.  3:727-740. 2015
2013 Enhancement of antitumor immunity in lung cancer by targeting myeloid-derived suppressor cell pathwaysCancer Research.  73:6609-6620. 2013
2013 Myeloid-derived suppressor cells as osteoclast progenitors: A novel target for controlling osteolytic bone metastasisCancer Research.  73:4606-4610. 2013
2013 Polyglutamate directed coupling of bioactive peptides for the delivery of osteoinductive signals on allograft boneBiomaterials.  34:1506-1513. 2013
2013 Myeloid-derived suppressor cells function as novel osteoclast progenitors enhancing bone loss in breast cancerCancer Research.  73:672-682. 2013
2012 Depletion of plasmacytoid dendritic cells inhibits tumor growth and prevents bone metastasis of breast cancer cellsJournal of Immunology.  189:4258-4265. 2012
2012 Bone healing by endogenous stem cell mobilizationBONE.  51:635. 2012
2012 DiVerential eVects of low-dose decitabine on immune eVector and suppressor responses in melanoma-bearing mice 2012
2012 Noggin is novel inducer of mesenchymal stem cell adipogenesis: Implications for bone health and obesityJournal of Biological Chemistry.  287:12241-12249. 2012
2012 Mobilization of bone marrow mesenchymal stem cells in vivo augments bone healing in a mouse model of segmental bone defectBONE.  50:1012-1018. 2012
2011 Inhibition and promotion of tumor growth with adeno-associated virus carcinoembryonic antigen vaccine and Toll-like receptor agonistsCancer Gene Therapy.  18:850-858. 2011
2011 Conditionally replicating adenovirus expressing TIMP2 for ovarian cancer therapyClinical Cancer Research.  17:538-549. 2011
2011 Anti-amyloid-β single-chain antibody brain delivery via aav reduces amyloid load but may increase cerebral hemorrhages in an alzheimer's disease mouse modelJournal of Alzheimer's Disease.  27:23-28. 2011
2010 Bacteriophage hyaluronidase effectively inhibits growth, migration and invasion by disrupting hyaluronan-mediated Erk1/2 activation and RhoA expression in human breast carcinoma cellsCancer Letters.  298:238-249. 2010
2010 Merkel cell carcinoma: Correlation of KIT expression with survival and evaluation of KIT gene mutational statusHuman Pathology.  41:1405-1412. 2010
2010 Therapeutic potential of adult bone marrow-derived mesenchymal stem cells in diseases of the skeletonJournal of Cellular Biochemistry.  111:249-257. 2010
2010 Therapeutic potential of genetically modified adult stem cells for osteopenia 2010
2009 Therapeutic potential of adult bone marrow-derived mesenchymal stem cells in prostate cancer bone metastasisClinical Cancer Research.  15:7175-7185. 2009
2009 High Cks1 expression in transgenic and carcinogeninitiated mammary tumors is not always accompanied by reduction in p27Kip1International Journal of Oncology.  34:1425-1431. 2009
2009 Detection of Merkel cell polyomavirus in formalin-fixed, paraffin-embedded tissue of Merkel cell carcinoma and its correlation with prognosis.Journal of Clinical Oncology.  27:6027. 2009
2009 Pulmonary Angiogenesis in a Rat Model of Hepatopulmonary SyndromeGastroenterology.  136:1070-1080. 2009
2008 Genetic modification of adeno-associated viral vector type 2 capsid enhances gene transfer efficiency in polarized human airway epithelial cellsHuman Gene Therapy.  19:1407-1414. 2008
2008 Silencing of transforming growth factor-β1 in situ by RNA interference for breast cancer: Implications for proliferation and migration in vitro and metastasis in vivoClinical Cancer Research.  14:4961. 2008
2008 Telomere maintenance in laser capture microdissection - Purified Barrett's adenocarcinoma cells and effect of telomerase inhibition in vivoClinical Cancer Research.  14:4971. 2008
2008 Cancer gene therapy using mesenchymal stem cells expressing interferon-β in a mouse prostate cancer lung metastasis model 2008
2008 Clinical significance of a novel single nucleotide polymorphism in the 5′ untranslated region of the Rabphillin-3A-Like gene in colorectal adenocarcinomaFrontiers in Bioscience.  13:1050-1061. 2008
2008 Therapeutic potential of genetically modified mesenchymal stem cells 2008
2007 Effects of sustained antiangiogenic therapy in multistage prostate cancer in TRAMP ,modelCancer Research.  67:5789-5797. 2007
2007 Targeting EGFR with metabolically biotinylated fiber-mosaic adenovirus 2007
2007 Intraperitoneal gene therapy by rAAV provides long-term survival against epithelial ovarian cancer independently of survivin pathway 2007
2006 Activators of viral gene expression in polarized epithelial monolayers identified by rapid-throughput drug screening 2006
2006 Enhanced transduction of mouse bone marrow-derived dendritic cells by repetitive infection with self-complementary adeno-associated virus 6 combined with immunostimulatory ligands 2006
2005 Determination of osteoprogenitor-specific promoter activity in mouse mesenchymal stem cells by recombinant adeno-associated virus transduction 2005
2005 Protein transduction of dendritic cells for NY-ESO-1-based immunotherapy of myelomaCancer Research.  65:10041-10049. 2005
2005 Genomic stability of self-complementary adeno-associated virus 2 during early stages of transduction in mouse muscle in vivoHuman Gene Therapy.  16:1047-1057. 2005
2005 Recombinant adeno-associated virus 2-mediated antiangiogenic prevention in a mouse model of intraperitoneal ovarian cancerClinical Cancer Research.  11:1342-1347. 2005
2005 Antiangiogenic cancer gene therapy by adeno-associated virus 2-mediated stable expression of the soluble FMS-like tyrosine kinase-1 receptorCancer Gene Therapy.  12:26-34. 2005
2004 Augmentation of antitumor activity of a recombinant adeno-associated virus carcinoembryonic antigen vaccine with plasmid adjuvantHuman Gene Therapy.  15:856-864. 2004
2004 Detection of disseminated breast cancer growth and treatment response using non-invasive bioluminescence imaging.Journal of Clinical Oncology.  22:742. 2004
2004 Adeno-Associated Virus 2-Mediated Antiangiogenic Cancer Gene Therapy: Long-Term Efficacy of a Vector Encoding Angiostatin and Endostatin over Vectors Encoding a Single FactorCancer Research.  64:1781-1787. 2004
2004 Anti-angiogenic gene therapy for cancer (review).International Journal of Oncology.  25:335-343. 2004
2004 Gene therapy for osteoinduction 2004
2004 Osteogenic differentiation of recombinant adeno-associated virus 2-transduced murine mesenchymal stem cells and development of an immunocompetent mouse model for ex vivo osteoporosis gene therapyHuman Gene Therapy.  15:1197-1206. 2004
2004 Parvovirus vectors for cancer gene therapyExpert Opinion on Biological Therapy.  4:53-64. 2004
2002 Adenoassociated virus vectors for genetic immunizationImmunologic Research.  26:247-253. 2002
2001 Adeno-associated virus for cancer gene therapyCancer Research.  61:6313-6321. 2001
1997 Evaluation of recombinant adeno-associated virus as a gene transfer vector for the retinaCurrent Eye Research.  16:949-956. 1997
1997 Adeno-associated virus 2-mediated gene transfer in vivo: Organ-tropism and expression of transduced sequences in miceGene.  190:203-210. 1997
1997 Lack of site-specific integration of the recombinant adeno-associated virus 2 genomes in human cellsHuman Gene Therapy.  8:275-284. 1997
1996 Adeno-associated virus 2-mediated transduction and erythroid lineage-specific expression in human hematopoietic progenitor cellsCurrent Topics in Microbiology and Immunology.  218:93-117. 1996
1996 Differential expression in human cells from the p6 promoter of human parvovirus B19 following plasmid transfection and recombinant adeno-associated virus 2 (AAV) infection: Human megakaryocytic leukaemia cells are non-permissive for AAV infectionJournal of General Virology.  77:1111-1122. 1996
1995 Cord Blood Transplantation and the Potential for Gene Therapy: Gene Transduction Using a Recombinant Adeno‐Associated Viral VectorAnnals of the New York Academy of Sciences.  770:105-115. 1995
1994 Suppression of human α-globin gene expression mediated by the recombinant adeno-associated virus 2-based antisense vectorsJournal of Experimental Medicine.  179:733-738. 1994
1992 Amelioration of clinical severity through raised fetal hemoglobin in sickle cell anaemiaIndian Journal of Pediatrics.  59:85-90. 1992
1992 Enzymes of the Pentose Phosphate Pathway in Glutathione-Regulated Membrane Protection in β-ThalassaemiaClinical Chemistry and Laboratory Medicine.  30:481-484. 1992
1992 Enzymes of the pentose phosphate pathway in glutathione-regulated membrane protection in β-thalassaemiaEuropean journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies.  30:481-484. 1992
1990 Elevated G gamma:A gamma globin chain ratio in homozygous beta thalassemia.Clinical Biochemistry.  23:529-531. 1990
1990 Elevated Gγ:Aγ globin chain ratio in homozygous beta thalassemiaClinical Biochemistry.  23:529-531. 1990

Principal Investigator On

  • Targeted Therapy for Breast Cancer with Osteolytic Bone Damage  awarded by National Cancer Institute/NIH/DHHS 2015 - 2022
  • Targeting the Androgen Receptor Axis Affects Macrophage Polarization in Castration Resistant Prostate Cancer  awarded by MIKE SLIVE FOUNDATION 2021
  • 1/2 The Alabama State University/UAB Comprehensive Cancer Center Partnership - Pilot Project #2  awarded by National Cancer Institute/NIH/DHHS 2014 - 2019
  • Targeted Stem Cell Therapy Coupling Angiogenesis and Osteogenesis for Bone Defect  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2011 - 2019
  • Osteoimmune Mechanisms of Segmental Bone Fracture Healing and Therapy  awarded by DOD - ARMY MEDICAL RESEARCH ACQUISITION ACTIVITY 2015 - 2018
  • Gene-Engineered and Targeted Stem Cell Therapy for Myeloma  awarded by National Cancer Institute/NIH/DHHS 2009 - 2016
  • Regenerative Stem Cell Therapy for Breast Cancer Bone Metastasis  awarded by DOD - ARMY MEDICAL RESEARCH ACQUISITION ACTIVITY 2011 - 2015
  • rAAV Vaccine Vector  awarded by National Cancer Institute/NIH/DHHS 2008 - 2014
  • AAV-Mediated Gene Therapy for Metabolic Bone Disease  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2005 - 2012
  • UAB Core Center for Basic Skeletal Research  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2010 - 2012
  • UAB Core Center for Basic Skeletal Research - Core A  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2010 - 2012
  • AAV-Based Plasmacytoid Dentritic Cell Cancer Vaccine  awarded by CLEVELAND CLINIC FOUNDATION 2006 - 2011
  • Investigator On

  • Characterizing the Negative Signaling in Dendritic Cells and Macrophages to Attenuate Inflammation and Bone Destruction in Rheumatoid Arthritis  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2020 - 2024
  • Inhibiting Inflammation and Bone Erosion in Periodontal Disease by Targeting Cell Endogenous Negative Signaling  awarded by National Institute of Dental and Craniofacial Research/NIH/DHHS 2019 - 2024
  • Ga13 Signaling Attenuates Periodontal Inflammation and Alveolar Bone Loss in the Mouse Model of Age-Associated Periodontitis  awarded by National Institute of Dental and Craniofacial Research/NIH/DHHS 2018 - 2023
  • Investigating the Expression, Role and Targeting of Collagen Modifying Prolyl 4-hydroxylase P4HA1 in Prostate Cancer Progression and Metastasis  awarded by DOD - Department of Defense 2019 - 2022
  • 3/3 Morehouse School of Medicine/Tuskegee University/University of Alabama Cancer Center Partnership  awarded by National Cancer Institute/NIH/DHHS 2016 - 2021
  • COMPLETED - Morehouse School of Medicine/Tuskegee University/University of Alabama Cancer Center Partnership: Project 1: CD24-Dependent Inactivation of Mutant p53 in Metastatic Castration-Resistant Prostate Cancer  awarded by National Cancer Institute/NIH/DHHS 2016 - 2021
  • Morehouse School of Medicine/Tuskegee University/University of Alabama Cancer Center Partnership: (Admin Supplement) to Support Development of PDX at UAB CCC  awarded by National Cancer Institute/NIH/DHHS 2016 - 2021
  • Heparanase Regulation of Myeloma Metastasis: Mechanism and Therapy  awarded by National Cancer Institute/NIH/DHHS 2014 - 2020
  • 1/2 The Alabama State University/UAB Comprehensive Cancer Center Partnership  awarded by National Cancer Institute/NIH/DHHS 2014 - 2019
  • Lumina III System for UAB Optical Imaging  awarded by NIH - OFFICE OF THE DIRECTOR 2016 - 2017
  • Morehouse School of Medicine/Tuskegee University/University of Alabama Cancer Center Partnership  awarded by National Cancer Institute/NIH/DHHS 2011 - 2016
  • A Specific Screening Strategy to Reduce Prostate Cancer Mortality  awarded by DOD - ARMY MEDICAL RESEARCH ACQUISITION ACTIVITY 2012 - 2015
  • Education And Training

  • Doctor of Philosophy in Genetics, University of Madras 1989
  • Master's Level Degree in Genetics, University of Madras 1984
  • Full Name

  • Selvarangan Ponnazhagan