Positions

Selected Publications

Academic Article

Year Title Altmetric
2018 Pathology, chemoprevention, and preclinical models for target validation in Barrett esophagus 2018
2018 Myeloid-derived suppressor cells impair B cell responses in lung cancer through IL-7 and STAT5 2018
2017 Silencing of TGF-β1 in tumor cells impacts MMP-9 in tumor microenvironment 2017
2017 Mesenchymal stem cells expressing osteoprotegerin variants inhibit osteolysis in a murine model of multiple myeloma. 2017
2017 Effects of cellular methylation on transgene expression and site-specific integration of adeno-associated virus 2017
2017 Endostatin inhibits androgen-independent prostate cancer growth by suppressing nuclear receptor-mediated oxidative stress 2017
2017 Location of tumor affects local and distant immune cell type and number: 2017
2017 Osteoclast proton pump regulator Atp6v1c1 enhances breast cancer growth by activating the mTORC1 pathway and bone metastasis by increasing V-ATPase activity 2017
2017 Resveratrol induces mitochondria-mediated, caspaseindependent apoptosis in murine prostate cancer cells 2017
2016 Immature myeloid cells are critical for enhancing bone fracture healing through angiogenic cascade 2016
2016 Prostate cancer-derived cathelicidin-related antimicrobial peptide facilitates macrophage differentiation and polarization of immature myeloid progenitors to protumorigenic macrophages 2016
2016 Indoleamine 2,3-dioxygenase regulates anti-tumor immunity in lung cancer by metabolic reprogramming of immune cells in the tumor microenvironment 2016
2015 SOCS3 deficiency in myeloid cells promotes tumor development: Involvement of STAT3 activation and myeloid-derived suppressor cells 2015
2015 Endostatin: A novel inhibitor of androgen receptor function in prostate cancer 2015
2015 Variants of osteoprotegerin lacking trail binding for therapeutic bone remodeling in osteolytic malignancies 2015
2014 Anterior gradient protein-2 is a regulator of cellular adhesion in prostate cancer 2014
2014 Detection of Merkel cell polyomavirus in formalin-fixed, paraffin-embedded tissue of merkel cell carcinoma and correlation with prognosis 2014
2014 The dual targeting of immunosuppressive cells and oxidants promotes effector and memory T-cell functions against lung cancer 2014
2013 Enhancement of antitumor immunity in lung cancer by targeting myeloid-derived suppressor cell pathways 2013
2013 Myeloid-derived suppressor cells as osteoclast progenitors: A novel target for controlling osteolytic bone metastasis 2013
2013 Myeloid-derived suppressor cells as a novel target for the control of osteolytic bone disease 2013
2013 Muscle-directed anti-Aβ Single-Chain Antibody Delivery Via AAV1 reduces cerebral Aβ load in an Alzheimer's disease mouse model 2013
2013 Polyglutamate directed coupling of bioactive peptides for the delivery of osteoinductive signals on allograft bone 2013
2013 Role of plasmacytoid dendritic cells in breast cancer bone dissemination 2013
2013 Myeloid-derived suppressor cells function as novel osteoclast progenitors enhancing bone loss in breast cancer 2013
2012 Depletion of plasmacytoid dendritic cells inhibits tumor growth and prevents bone metastasis of breast cancer cells 2012
2012 Bone healing by endogenous stem cell mobilization 2012
2012 DiVerential eVects of low-dose decitabine on immune eVector and suppressor responses in melanoma-bearing mice 2012
2012 Noggin is novel inducer of mesenchymal stem cell adipogenesis: Implications for bone health and obesity 2012
2012 Mobilization of bone marrow mesenchymal stem cells in vivo augments bone healing in a mouse model of segmental bone defect 2012
2011 Inhibition and promotion of tumor growth with adeno-associated virus carcinoembryonic antigen vaccine and Toll-like receptor agonists 2011
2011 Conditionally replicating adenovirus expressing TIMP2 increases survival in a mouse model of disseminated ovarian cancer 2011
2011 LL-37 as a therapeutic target for late stage prostate cancer 2011
2011 Conditionally replicating adenovirus expressing TIMP2 for ovarian cancer therapy 2011
2011 Anti-amyloid-β single-chain antibody brain delivery via aav reduces amyloid load but may increase cerebral hemorrhages in an alzheimer's disease mouse model 2011
2010 Bacteriophage hyaluronidase effectively inhibits growth, migration and invasion by disrupting hyaluronan-mediated Erk1/2 activation and RhoA expression in human breast carcinoma cells 2010
2010 Regulation of the activity of an adeno-associated virus vector cancer vaccine administered with synthetic Toll-like receptor agonists 2010
2010 Merkel cell carcinoma: Correlation of KIT expression with survival and evaluation of KIT gene mutational status 2010
2010 Therapeutic potential of adult bone marrow-derived mesenchymal stem cells in diseases of the skeleton 2010
2010 Mesenchymal stem cells expressing osteogenic and angiogenic factors synergistically enhance bone formation in a mouse model of segmental bone defect 2010
2010 Therapeutic potential of genetically modified adult stem cells for osteopenia 2010
2009 Therapeutic potential of adult bone marrow-derived mesenchymal stem cells in prostate cancer bone metastasis 2009
2009 Free fatty acids enhance breast cancer cell migration through plasminogen activator inhibitor-1 and SMAD4 2009
2009 High Cks1 expression in transgenic and carcinogeninitiated mammary tumors is not always accompanied by reduction in p27Kip1 2009
2009 Tumoristatic effects of endostatin in prostate cancer is dependent on androgen receptor status 2009
2009 Detection of Merkel cell polyomavirus in formalin-fixed, paraffin-embedded tissue of Merkel cell carcinoma and its correlation with prognosis. 2009
2009 Pulmonary Angiogenesis in a Rat Model of Hepatopulmonary Syndrome 2009
2008 Genetic modification of adeno-associated viral vector type 2 capsid enhances gene transfer efficiency in polarized human airway epithelial cells 2008
2008 Therapeutic potential of mesenchymal stem cells producing interferon-α in a mouse melanoma lung metastasis model 2008
2008 Silencing of transforming growth factor-β1 in situ by RNA interference for breast cancer: Implications for proliferation and migration in vitro and metastasis in vivo 2008
2008 Telomere maintenance in laser capture microdissection - Purified Barrett's adenocarcinoma cells and effect of telomerase inhibition in vivo 2008
2008 Cancer gene therapy using mesenchymal stem cells expressing interferon-β in a mouse prostate cancer lung metastasis model 2008
2008 Clinical significance of a novel single nucleotide polymorphism in the 5′ untranslated region of the Rabphillin-3A-Like gene in colorectal adenocarcinoma 2008
2008 Therapeutic potential of genetically modified mesenchymal stem cells 2008
2008 Systemic osteoprotegerin gene therapy restores tumor-induced bone loss in a therapeutic model of beast cancer bone metastasis 2008
2007 Bone homing of mesenchymal stem cells by ectopic α4 integrin expression 2007
2007 Effects of sustained antiangiogenic therapy in multistage prostate cancer in TRAMP ,model 2007
2007 Targeting EGFR with metabolically biotinylated fiber-mosaic adenovirus 2007
2007 Notch1 augments intracellular trafficking of adeno-associated virus type 2 2007
2007 Intraperitoneal gene therapy by rAAV provides long-term survival against epithelial ovarian cancer independently of survivin pathway 2007
2006 Airway epithelium directed gene therapy for cystic fibrosis 2006
2006 Anti-Aβ single-chain antibody delivery via adeno-associated virus for treatment of Alzheimer's disease 2006
2006 Activators of viral gene expression in polarized epithelial monolayers identified by rapid-throughput drug screening 2006
2006 Enhanced transduction of mouse bone marrow-derived dendritic cells by repetitive infection with self-complementary adeno-associated virus 6 combined with immunostimulatory ligands 2006
2005 Determination of osteoprogenitor-specific promoter activity in mouse mesenchymal stem cells by recombinant adeno-associated virus transduction 2005
2005 Protein transduction of dendritic cells for NY-ESO-1-based immunotherapy of myeloma 2005
2005 Genomic stability of self-complementary adeno-associated virus 2 during early stages of transduction in mouse muscle in vivo 2005
2005 Recombinant adeno-associated virus 2-mediated antiangiogenic prevention in a mouse model of intraperitoneal ovarian cancer 2005
2005 Antiangiogenic cancer gene therapy by adeno-associated virus 2-mediated stable expression of the soluble FMS-like tyrosine kinase-1 receptor 2005
2004 Augmentation of antitumor activity of a recombinant adeno-associated virus carcinoembryonic antigen vaccine with plasmid adjuvant 2004
2004 Detection of disseminated breast cancer growth and treatment response using non-invasive bioluminescence imaging. 2004
2004 Adeno-Associated Virus 2-Mediated Antiangiogenic Cancer Gene Therapy: Long-Term Efficacy of a Vector Encoding Angiostatin and Endostatin over Vectors Encoding a Single Factor 2004
2004 Anti-angiogenic gene therapy for cancer (review). 2004
2004 Delivery of DNA to tumor cells in vivo using adeno-associated virus. 2004
2004 Gene therapy for osteoinduction 2004
2004 Osteogenic differentiation of recombinant adeno-associated virus 2-transduced murine mesenchymal stem cells and development of an immunocompetent mouse model for ex vivo osteoporosis gene therapy 2004
2004 Parvovirus vectors for cancer gene therapy 2004
2002 Conjugate-based targeting of recombinant adeno-associated virus type 2 vectors by using avidin-linked ligands 2002
2002 Adenoassociated virus vectors for genetic immunization 2002
2001 Adeno-associated virus type 2-mediated transduction of human monocyte-derived dendritic cells: Implications for ex vivo immunotherapy 2001
2001 Adeno-associated virus for cancer gene therapy 2001
1999 Adeno-associated virus 2-mediated transduction and erythroid lineage- restricted expression from parvovirus B19p6 promoter in primary human hematopoietic progenitor cells 1999
1998 Adeno-associated virus type 2-mediated gene transfer: Role of epidermal growth factor receptor protein tyrosine kinase in transgene expression 1998
1998 Characterization of wild-type adeno-associated virus type 2-like particles generated during recombinant viral vector production and strategies for their elimination 1998
1998 Recombinant human parvovirus B19 vectors: Erythroid cell-specific delivery and expression of transduced genes 1998
1998 Adeno-associated virus type 2-mediated gene transfer: Correlation of tyrosine phosphorylation of the cellular single-stranded D sequence-binding protein transgene expression in human cells in vitro and murine tissues in vivo 1998
1997 Adeno-associated virus type 2-mediated transduction in primary human bone marrow-derived CD34+hematopoietic progenitor cells: Donor variation and correlation of transgene expression with cellular differentiation 1997
1997 Evaluation of recombinant adeno-associated virus as a gene transfer vector for the retina 1997
1997 Role of tyrosine phosphorylation of a cellular protein in adeno-associated virus 2-mediated transgene expression 1997
1997 Encapsidation of adeno-associated virus type 2 rep proteins in wild- type and recombinant progeny virions: Rep-mediated growth inhibition of primary human cells 1997
1997 Adeno-associated virus 2-mediated gene transfer in vivo: Organ-tropism and expression of transduced sequences in mice 1997
1997 Adeno-associated virus type 2 DNA replication in vivo: Mutation analyses of the D sequence in viral inverted terminal repeats 1997
1997 Adeno-associated virus type 2-mediated transduction of murine hematopoietic cells with long-term repopulating ability and sustained expression of a human globin gene in vivo 1997
1997 Lack of site-specific integration of the recombinant adeno-associated virus 2 genomes in human cells 1997
1996 Rescue and replication of adeno-associated virus type 2 as well as vector DNA sequences from recombinant plasmids containing deletions in the viral inverted terminal repeats: Selective encapsidation of viral genomes in progeny virions 1996
1996 Adeno-associated virus 2-mediated transduction and erythroid lineage-specific expression in human hematopoietic progenitor cells 1996
1996 Differential expression in human cells from the p6 promoter of human parvovirus B19 following plasmid transfection and recombinant adeno-associated virus 2 (AAV) infection: Human megakaryocytic leukaemia cells are non-permissive for AAV infection 1996
1995 Rescue and replication signals of the adeno-associated virus 2 genome 1995
1995 Mouse silver. Mutation is caused by a single base insertion in the putative cytoplasmic domain of Pmel 17 1995
1995 Cord Blood Transplantation and the Potential for Gene Therapy: Gene Transduction Using a Recombinant Adeno‐Associated Viral Vector 1995
1995 Transcriptional transactivation of parvovirus B19 promoters in nonpermissive human cells by adenovirus type 2 1995
1994 Suppression of human α-globin gene expression mediated by the recombinant adeno-associated virus 2-based antisense vectors 1994
1994 Structural organization of the human tyrosinase gene and sequence analysis and characterization of its promoter region 1994
1992 A cis‐Acting Element Involved in Mouse Tyrosinase Gene Expression and Partial Purification of its Binding Protein 1992
1992 Amelioration of clinical severity through raised fetal hemoglobin in sickle cell anaemia 1992
1992 Enzymes of the Pentose Phosphate Pathway in Glutathione-Regulated Membrane Protection in β-Thalassaemia 1992
1992 Enzymes of the pentose phosphate pathway in glutathione-regulated membrane protection in β-thalassaemia 1992
1990 Elevated G gamma:A gamma globin chain ratio in homozygous beta thalassemia. 1990
1990 Elevated Gγ:Aγ globin chain ratio in homozygous beta thalassemia 1990
1989 Influence of gamma chains in in vitro globin synthesis in β° and β+ homozygous thalassaemia 1989

Principal Investigator On

  • Targeted Therapy for Breast Cancer with Osteolytic Bone Damage  awarded by National Cancer Institute/NIH/DHHS 2015 - 2020
  • 1/2 The Alabama State University/UAB Comprehensive Cancer Center Partnership - Pilot Project #2  awarded by National Cancer Institute/NIH/DHHS 2014 - 2019
  • Targeted Stem Cell Therapy Coupling Angiogenesis and Osteogenesis for Bone Defect  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2011 - 2019
  • Osteoimmune Mechanisms of Segmental Bone Fracture Healing and Therapy  awarded by DOD - ARMY MEDICAL RESEARCH ACQUISITION ACTIVITY 2015 - 2018
  • Gene-Engineered and Targeted Stem Cell Therapy for Myeloma  awarded by National Cancer Institute/NIH/DHHS 2009 - 2016
  • Regenerative Stem Cell Therapy for Breast Cancer Bone Metastasis  awarded by DOD - ARMY MEDICAL RESEARCH ACQUISITION ACTIVITY 2011 - 2015
  • rAAV Vaccine Vector  awarded by National Cancer Institute/NIH/DHHS 2008 - 2014
  • AAV-Mediated Gene Therapy for Metabolic Bone Disease  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2005 - 2012
  • UAB Core Center for Basic Skeletal Research  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2010 - 2012
  • UAB Core Center for Basic Skeletal Research - Core A  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2010 - 2012
  • AAV-Based Plasmacytoid Dentritic Cell Cancer Vaccine  awarded by CLEVELAND CLINIC FOUNDATION 2006 - 2011

    • Investigator On

  • Inhibiting Inflammation and Bone Erosion in Periodontal Disease by Targeting Cell Endogenous Negative Signaling  awarded by National Institute of Dental and Craniofacial Research/NIH/DHHS 2019 - 2024
  • Ga13 Signaling Attenuates Periodontal Inflammation and Alveolar Bone Loss in the Mouse Model of Age-Associated Periodontitis  awarded by National Institute of Dental and Craniofacial Research/NIH/DHHS 2018 - 2023
  • 3/3 Morehouse School of Medicine/Tuskegee University/University of Alabama Cancer Center Partnership  awarded by National Cancer Institute/NIH/DHHS 2016 - 2021
  • Morehouse School of Medicine/Tuskegee University/University of Alabama Cancer Center Partnership: (Admin Supplement) to Support Development of PDX at UAB CCC  awarded by National Cancer Institute/NIH/DHHS 2016 - 2021
  • Morehouse School of Medicine/Tuskegee University/University of Alabama Cancer Center Partnership: Project 1: CD24-Dependent Inactivation of Mutant p53 in Metastatic Castration-Resistant Prostate Cancer  awarded by National Cancer Institute/NIH/DHHS 2016 - 2021
  • Heparanase Regulation of Myeloma Metastasis: Mechanism and Therapy  awarded by National Cancer Institute/NIH/DHHS 2014 - 2020
  • 1/2 The Alabama State University/UAB Comprehensive Cancer Center Partnership  awarded by National Cancer Institute/NIH/DHHS 2014 - 2019
  • Lumina III System for UAB Optical Imaging  awarded by NIH - OFFICE OF THE DIRECTOR 2016 - 2017
  • Morehouse School of Medicine/Tuskegee University/University of Alabama Cancer Center Partnership  awarded by National Cancer Institute/NIH/DHHS 2011 - 2016
  • A Specific Screening Strategy to Reduce Prostate Cancer Mortality  awarded by DOD - ARMY MEDICAL RESEARCH ACQUISITION ACTIVITY 2012 - 2015

    • Education And Training

  • Doctor of Philosophy in Genetics, University of Madras 1989
  • Master's Level Degree in Genetics, University of Madras 1984

    • Full Name

  • Selvarangan Ponnazhagan