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Selvarangan Ponnazhagan Ph.D.
Professor
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E-mail
pons@uab.edu
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Co-investigator Network
Selvarangan Ponnazhagan Ph.D.
Professor
Positions
Senior Scientist
,
Experimental Therapeutics
,
O'Neal Comprehensive Cancer Center
Professor (P)
,
Molecular & Cellular Pathology
,
Joint Pathology
2005 -
Senior Scientist (C)
,
Cystic Fibrosis Research Center
,
School of Medicine
2006 -
Scientist (C)
,
Biomatrix Eng Regen Med (BERM) Center
,
Biomedical Engineering
2006 -
Senior Scientist (C)
,
Center for Biophysical Sciences and Engineering (CBSE)
,
School of Optometry
2008 -
Senior Scientist (C)
,
Comprehensive Diabetes Center
,
School of Medicine
2013 -
Senior Scientist (C)
,
Nephrology Research & Training Center
,
General Clinical Research Center
2014 -
Senior Scientist (C)
,
Comprehensive Arthritis, Musculoskeletal, Bone and Autoimmunity Center (CAMBAC)
,
School of Medicine
2015 -
Senior Scientist (C)
,
Global Center for Craniofacial, Oral and Dental Disorders (GC-CODED)
,
School of Dentistry
2017 -
Senior Scientist (C)
,
O'Neal Comprehensive Cancer Center
,
School of Medicine
2019 -
Publications
Research
Teaching
Background
Contact
Publications
Selected Publications
Academic Article
Filter
Year
Title
Altmetric
2020
Adeno-Associated Virus D-Sequence-Mediated Suppression of Expression of a Human Major Histocompatibility Class II Gene: Implications in the Development of Adeno-Associated Virus Vectors for Modulating Humoral Immune Response
.
Human Gene Therapy
. 31:565-574.
2020
2018
Pathology, chemoprevention, and preclinical models for target validation in Barrett esophagus
.
Cancer Research
. 78:3747-3754.
2018
2018
Myeloid-derived suppressor cells impair B cell responses in lung cancer through IL-7 and STAT5
.
Journal of Immunology
. 201:278-295.
2018
2017
Mesenchymal stem cells expressing osteoprotegerin variants inhibit osteolysis in a murine model of multiple myeloma
.
Blood Advances
. 1:2375-2385.
2017
2017
Effects of cellular methylation on transgene expression and site-specific integration of adeno-associated virus
.
Genes
. 8.
2017
2017
Location of tumor affects local and distant immune cell type and number:
.
Immunity, Inflammation and Disease
. 5:85-94.
2017
2016
Immature myeloid cells are critical for enhancing bone fracture healing through angiogenic cascade
.
BONE
. 93:113-124.
2016
2015
SOCS3 deficiency in myeloid cells promotes tumor development: Involvement of STAT3 activation and myeloid-derived suppressor cells
.
Cancer Immunology Research
. 3:727-740.
2015
2013
Enhancement of antitumor immunity in lung cancer by targeting myeloid-derived suppressor cell pathways
.
Cancer Research
. 73:6609-6620.
2013
2013
Myeloid-derived suppressor cells as osteoclast progenitors: A novel target for controlling osteolytic bone metastasis
.
Cancer Research
. 73:4606-4610.
2013
2013
Polyglutamate directed coupling of bioactive peptides for the delivery of osteoinductive signals on allograft bone
.
Biomaterials
. 34:1506-1513.
2013
2013
Myeloid-derived suppressor cells function as novel osteoclast progenitors enhancing bone loss in breast cancer
.
Cancer Research
. 73:672-682.
2013
2012
Depletion of plasmacytoid dendritic cells inhibits tumor growth and prevents bone metastasis of breast cancer cells
.
Journal of Immunology
. 189:4258-4265.
2012
2012
Bone healing by endogenous stem cell mobilization
.
BONE
. 51:635.
2012
2012
DiVerential eVects of low-dose decitabine on immune eVector and suppressor responses in melanoma-bearing mice
2012
2012
Noggin is novel inducer of mesenchymal stem cell adipogenesis: Implications for bone health and obesity
.
Journal of Biological Chemistry
. 287:12241-12249.
2012
2012
Mobilization of bone marrow mesenchymal stem cells in vivo augments bone healing in a mouse model of segmental bone defect
.
BONE
. 50:1012-1018.
2012
2011
Inhibition and promotion of tumor growth with adeno-associated virus carcinoembryonic antigen vaccine and Toll-like receptor agonists
.
Cancer Gene Therapy
. 18:850-858.
2011
2011
Conditionally replicating adenovirus expressing TIMP2 for ovarian cancer therapy
.
Clinical Cancer Research
. 17:538-549.
2011
2011
Anti-amyloid-β single-chain antibody brain delivery via aav reduces amyloid load but may increase cerebral hemorrhages in an alzheimer's disease mouse model
.
Journal of Alzheimer's Disease
. 27:23-28.
2011
2010
Bacteriophage hyaluronidase effectively inhibits growth, migration and invasion by disrupting hyaluronan-mediated Erk1/2 activation and RhoA expression in human breast carcinoma cells
.
Cancer Letters
. 298:238-249.
2010
2010
Merkel cell carcinoma: Correlation of KIT expression with survival and evaluation of KIT gene mutational status
.
Human Pathology
. 41:1405-1412.
2010
2010
Therapeutic potential of adult bone marrow-derived mesenchymal stem cells in diseases of the skeleton
.
Journal of Cellular Biochemistry
. 111:249-257.
2010
2010
Therapeutic potential of genetically modified adult stem cells for osteopenia
2010
2009
Therapeutic potential of adult bone marrow-derived mesenchymal stem cells in prostate cancer bone metastasis
.
Clinical Cancer Research
. 15:7175-7185.
2009
2009
High Cks1 expression in transgenic and carcinogeninitiated mammary tumors is not always accompanied by reduction in p27
Kip1
.
International Journal of Oncology
. 34:1425-1431.
2009
2009
Detection of Merkel cell polyomavirus in formalin-fixed, paraffin-embedded tissue of Merkel cell carcinoma and its correlation with prognosis.
.
Journal of Clinical Oncology
. 27:6027.
2009
2009
Pulmonary Angiogenesis in a Rat Model of Hepatopulmonary Syndrome
.
Gastroenterology
. 136:1070-1080.
2009
2008
Genetic modification of adeno-associated viral vector type 2 capsid enhances gene transfer efficiency in polarized human airway epithelial cells
.
Human Gene Therapy
. 19:1407-1414.
2008
2008
Silencing of transforming growth factor-β1 in situ by RNA interference for breast cancer: Implications for proliferation and migration in vitro and metastasis in vivo
.
Clinical Cancer Research
. 14:4961.
2008
2008
Telomere maintenance in laser capture microdissection - Purified Barrett's adenocarcinoma cells and effect of telomerase inhibition in vivo
.
Clinical Cancer Research
. 14:4971.
2008
2008
Cancer gene therapy using mesenchymal stem cells expressing interferon-β in a mouse prostate cancer lung metastasis model
2008
2008
Clinical significance of a novel single nucleotide polymorphism in the 5′ untranslated region of the Rabphillin-3A-Like gene in colorectal adenocarcinoma
.
Frontiers in Bioscience
. 13:1050-1061.
2008
2008
Therapeutic potential of genetically modified mesenchymal stem cells
2008
2007
Effects of sustained antiangiogenic therapy in multistage prostate cancer in TRAMP ,model
.
Cancer Research
. 67:5789-5797.
2007
2007
Targeting EGFR with metabolically biotinylated fiber-mosaic adenovirus
2007
2007
Intraperitoneal gene therapy by rAAV provides long-term survival against epithelial ovarian cancer independently of survivin pathway
2007
2006
Activators of viral gene expression in polarized epithelial monolayers identified by rapid-throughput drug screening
2006
2006
Enhanced transduction of mouse bone marrow-derived dendritic cells by repetitive infection with self-complementary adeno-associated virus 6 combined with immunostimulatory ligands
2006
2005
Determination of osteoprogenitor-specific promoter activity in mouse mesenchymal stem cells by recombinant adeno-associated virus transduction
2005
2005
Protein transduction of dendritic cells for NY-ESO-1-based immunotherapy of myeloma
.
Cancer Research
. 65:10041-10049.
2005
2005
Genomic stability of self-complementary adeno-associated virus 2 during early stages of transduction in mouse muscle in vivo
.
Human Gene Therapy
. 16:1047-1057.
2005
2005
Recombinant adeno-associated virus 2-mediated antiangiogenic prevention in a mouse model of intraperitoneal ovarian cancer
.
Clinical Cancer Research
. 11:1342-1347.
2005
2005
Antiangiogenic cancer gene therapy by adeno-associated virus 2-mediated stable expression of the soluble FMS-like tyrosine kinase-1 receptor
.
Cancer Gene Therapy
. 12:26-34.
2005
2004
Augmentation of antitumor activity of a recombinant adeno-associated virus carcinoembryonic antigen vaccine with plasmid adjuvant
.
Human Gene Therapy
. 15:856-864.
2004
2004
Detection of disseminated breast cancer growth and treatment response using non-invasive bioluminescence imaging.
.
Journal of Clinical Oncology
. 22:742.
2004
2004
Adeno-Associated Virus 2-Mediated Antiangiogenic Cancer Gene Therapy: Long-Term Efficacy of a Vector Encoding Angiostatin and Endostatin over Vectors Encoding a Single Factor
.
Cancer Research
. 64:1781-1787.
2004
2004
Anti-angiogenic gene therapy for cancer (review).
.
International Journal of Oncology
. 25:335-343.
2004
2004
Gene therapy for osteoinduction
2004
2004
Osteogenic differentiation of recombinant adeno-associated virus 2-transduced murine mesenchymal stem cells and development of an immunocompetent mouse model for ex vivo osteoporosis gene therapy
.
Human Gene Therapy
. 15:1197-1206.
2004
2004
Parvovirus vectors for cancer gene therapy
.
Expert Opinion on Biological Therapy
. 4:53-64.
2004
2002
Adenoassociated virus vectors for genetic immunization
.
Immunologic Research
. 26:247-253.
2002
2001
Adeno-associated virus for cancer gene therapy
.
Cancer Research
. 61:6313-6321.
2001
1997
Evaluation of recombinant adeno-associated virus as a gene transfer vector for the retina
.
Current Eye Research
. 16:949-956.
1997
1997
Adeno-associated virus 2-mediated gene transfer in vivo: Organ-tropism and expression of transduced sequences in mice
.
Gene
. 190:203-210.
1997
1997
Lack of site-specific integration of the recombinant adeno-associated virus 2 genomes in human cells
.
Human Gene Therapy
. 8:275-284.
1997
1996
Adeno-associated virus 2-mediated transduction and erythroid lineage-specific expression in human hematopoietic progenitor cells
.
Current Topics in Microbiology and Immunology
. 218:93-117.
1996
1996
Differential expression in human cells from the p6 promoter of human parvovirus B19 following plasmid transfection and recombinant adeno-associated virus 2 (AAV) infection: Human megakaryocytic leukaemia cells are non-permissive for AAV infection
.
Journal of General Virology
. 77:1111-1122.
1996
1995
Cord Blood Transplantation and the Potential for Gene Therapy: Gene Transduction Using a Recombinant Adeno‐Associated Viral Vector
.
Annals of the New York Academy of Sciences
. 770:105-115.
1995
1994
Suppression of human α-globin gene expression mediated by the recombinant adeno-associated virus 2-based antisense vectors
.
Journal of Experimental Medicine
. 179:733-738.
1994
1992
Amelioration of clinical severity through raised fetal hemoglobin in sickle cell anaemia
.
Indian Journal of Pediatrics
. 59:85-90.
1992
1992
Enzymes of the Pentose Phosphate Pathway in Glutathione-Regulated Membrane Protection in β-Thalassaemia
.
Clinical Chemistry and Laboratory Medicine
. 30:481-484.
1992
1992
Enzymes of the pentose phosphate pathway in glutathione-regulated membrane protection in β-thalassaemia
.
European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies
. 30:481-484.
1992
1990
Elevated G gamma:A gamma globin chain ratio in homozygous beta thalassemia.
.
Clinical Biochemistry
. 23:529-531.
1990
1990
Elevated
G
γ:
A
γ globin chain ratio in homozygous beta thalassemia
.
Clinical Biochemistry
. 23:529-531.
1990
Research
Principal Investigator On
Targeted Therapy for Breast Cancer with Osteolytic Bone Damage
awarded by
National Cancer Institute/NIH/DHHS
2015 - 2022
Targeting the Androgen Receptor Axis Affects Macrophage Polarization in Castration Resistant Prostate Cancer
awarded by
MIKE SLIVE FOUNDATION
2021
1/2 The Alabama State University/UAB Comprehensive Cancer Center Partnership - Pilot Project #2
awarded by
National Cancer Institute/NIH/DHHS
2014 - 2019
Targeted Stem Cell Therapy Coupling Angiogenesis and Osteogenesis for Bone Defect
awarded by
National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
2011 - 2019
Osteoimmune Mechanisms of Segmental Bone Fracture Healing and Therapy
awarded by
DOD - ARMY MEDICAL RESEARCH ACQUISITION ACTIVITY
2015 - 2018
Gene-Engineered and Targeted Stem Cell Therapy for Myeloma
awarded by
National Cancer Institute/NIH/DHHS
2009 - 2016
Regenerative Stem Cell Therapy for Breast Cancer Bone Metastasis
awarded by
DOD - ARMY MEDICAL RESEARCH ACQUISITION ACTIVITY
2011 - 2015
rAAV Vaccine Vector
awarded by
National Cancer Institute/NIH/DHHS
2008 - 2014
AAV-Mediated Gene Therapy for Metabolic Bone Disease
awarded by
National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
2005 - 2012
UAB Core Center for Basic Skeletal Research
awarded by
National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
2010 - 2012
UAB Core Center for Basic Skeletal Research - Core A
awarded by
National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
2010 - 2012
AAV-Based Plasmacytoid Dentritic Cell Cancer Vaccine
awarded by
CLEVELAND CLINIC FOUNDATION
2006 - 2011
Investigator On
Characterizing the Negative Signaling in Dendritic Cells and Macrophages to Attenuate Inflammation and Bone Destruction in Rheumatoid Arthritis
awarded by
National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
2020 - 2024
Inhibiting Inflammation and Bone Erosion in Periodontal Disease by Targeting Cell Endogenous Negative Signaling
awarded by
National Institute of Dental and Craniofacial Research/NIH/DHHS
2019 - 2024
Ga13 Signaling Attenuates Periodontal Inflammation and Alveolar Bone Loss in the Mouse Model of Age-Associated Periodontitis
awarded by
National Institute of Dental and Craniofacial Research/NIH/DHHS
2018 - 2023
Investigating the Expression, Role and Targeting of Collagen Modifying Prolyl 4-hydroxylase P4HA1 in Prostate Cancer Progression and Metastasis
awarded by
DOD - Department of Defense
2019 - 2022
3/3 Morehouse School of Medicine/Tuskegee University/University of Alabama Cancer Center Partnership
awarded by
National Cancer Institute/NIH/DHHS
2016 - 2021
COMPLETED - Morehouse School of Medicine/Tuskegee University/University of Alabama Cancer Center Partnership: Project 1: CD24-Dependent Inactivation of Mutant p53 in Metastatic Castration-Resistant Prostate Cancer
awarded by
National Cancer Institute/NIH/DHHS
2016 - 2021
Morehouse School of Medicine/Tuskegee University/University of Alabama Cancer Center Partnership: (Admin Supplement) to Support Development of PDX at UAB CCC
awarded by
National Cancer Institute/NIH/DHHS
2016 - 2021
Heparanase Regulation of Myeloma Metastasis: Mechanism and Therapy
awarded by
National Cancer Institute/NIH/DHHS
2014 - 2020
1/2 The Alabama State University/UAB Comprehensive Cancer Center Partnership
awarded by
National Cancer Institute/NIH/DHHS
2014 - 2019
Lumina III System for UAB Optical Imaging
awarded by
NIH - OFFICE OF THE DIRECTOR
2016 - 2017
Morehouse School of Medicine/Tuskegee University/University of Alabama Cancer Center Partnership
awarded by
National Cancer Institute/NIH/DHHS
2011 - 2016
A Specific Screening Strategy to Reduce Prostate Cancer Mortality
awarded by
DOD - ARMY MEDICAL RESEARCH ACQUISITION ACTIVITY
2012 - 2015
Teaching
Teaching Activities
PAT791 - Adv Molecular/Cell Pathology (Fall Term 2015)
2015
PAT791 - Adv Molecular/Cell Pathology (Spring Term 2015)
2015
PAT791 - Adv Molecular/Cell Pathology (Fall Term 2014)
2014
PAT791 - Adv Molecular/Cell Pathology (Spring Term 2014)
2014
PAT791 - Adv Molecular/Cell Pathology (Fall Term 2013)
2013
PAT791 - Adv Molecular/Cell Pathology (Spring Term 2013)
2013
PAT791 - Adv Molecular/Cell Pathology (Fall Term 2012)
2012
PAT791 - Adv Molecular/Cell Pathology (Spring Term 2012)
2012
PAT791 - Adv Molecular/Cell Pathology (Fall Term 2011)
2011
PAT791 - Adv Molecular/Cell Pathology (Spring Term 2011)
2011
PAT791 - Adv Molecular/Cell Pathology (Fall Term 2010)
2010
PAT791 - Adv Molecular/Cell Pathology (Spring Term 2010)
2010
PAT791 - Adv Molecular/Cell Pathology (Fall Term 2009)
2009
PAT791 - Adv Molecular/Cell Pathology (Spring Term 2009)
2009
PAT791 - Adv Molecular/Cell Pathology (Fall Term 2008)
2008
PAT791 - Adv Molecular/Cell Pathology (Spring Term 2008)
2008
PAT791 - Adv Molecular/Cell Pathology (Fall Term 2007)
2007
Background
Education And Training
Doctor of Philosophy in Genetics,
University of Madras
1989
Master's Level Degree in Genetics,
University of Madras
1984
Contact
Full Name
Selvarangan
Ponnazhagan