Positions

Selected Publications

Academic Article

Year Title Altmetric
2021 Adverse childhood events and cardiovascular diseases: The potential role of Sirt1 2021
2021 HDAC1: an environmental sensor regulating endothelial function..  Cardiovascular Research.  2021
2021 Time-restricted feeding rescues high-fat-diet-induced hippocampal impairment.  iScience.  24. 2021
2021 Liver circadian clock disruption alters perivascular adipose tissue gene expression and aortic function in mice 2021
2021 Early life stress induces dysregulation of the heme pathway in adult mice.  Physiological Reports.  9. 2021
2021 Early life stress in mice alters gut microbiota independent of maternal microbiota inheritance 2021
2021 Hydroxyurea improves nitric oxide bioavailability in humanized sickle cell mice 2021
2021 Activation of G protein-coupled estrogen receptor 1 ameliorates proximal tubular injury and proteinuria in Dahl salt-sensitive female rats 2021
2021 High salt intake induces collecting duct HDAC1-dependent NO signaling 2021
2021 Team Science: American Heart Association's Hypertension Strategically Focused Research Network Experience.  Hypertension.  1857-1866. 2021
2020 A year of challenge and change 2020
2020 Fluid-electrolyte homeostasis requires histone deacetylase function.  JCI insight.  5. 2020
2020 Serum 25-hydroxyvitamin D concentrations are associated with mental health and psychosocial stress in young adults.  Nutrients.  12:1-12. 2020
2020 Diurnal Control of Blood Pressure Is Uncoupled from Sodium Excretion.  Hypertension.  75:1624-1634. 2020
2020 Sirt1 during childhood is associated with microvascular function later in life 2020
2020 Evidence for g-protein–coupled estrogen receptor as a pronatriuretic factor 2020
2020 Loss of circadian gene Bmal1 in the collecting duct lowers blood pressure in male, but not female, mice 2020
2019 A pilot study of the effect of atorvastatin on endothelial function and albuminuria in sickle cell disease.  American Journal of Hematology.  94:E299-E301. 2019
2019 Ethnic differences in nighttime melatonin and nighttime blood pressure: A study in European Americans and African Americans.  American Journal of Hypertension.  32:968-974. 2019
2019 SONAR propels endothelin A receptor antagonists to success.  Nature Reviews Nephrology.  15:461-462. 2019
2019 Childhood adversity and mechanistic links to hypertension risk in adulthood.  British Journal of Pharmacology.  176:1932-1950. 2019
2019 Tauroursodeoxycholic acid (TUDCA) abolishes chronic high salt-induced renal injury and inflammation 2019
2019 Combined hydroxyurea and ETA receptor blockade reduces renal injury in the humanized sickle cell mouse 2019
2019 Angiotensin II receptor blocker attenuates stress pressor response in young adult African Americans.  Journal of Clinical Hypertension.  21:1191-1199. 2019
2019 Hyperfiltration predicts long-term renal outcomes in humanized sickle cell mice.  Blood Advances.  3:1460-1475. 2019
2018 Maternal separation enhances anticontractile perivascular adipose tissue function in male rats on a high-fat diet 2018
2018 Superoxide dismutase activity in small mesenteric arteries is downregulated by angiotensin II but not by hypertension.  Toxicological Research.  34:363-370. 2018
2018 Acute Tetrahydrobiopterin Improves Endothelial Function in Patients With COPD.  Chest.  154:597-606. 2018
2018 Angiotensin II and the natriuretic and blood pressure response to mental stress in African Americans.  Ethnicity and Disease.  28:511-516. 2018
2018 Reactive species balance via GTP cyclohydrolase i regulates glioblastoma growth and tumor initiating cell maintenance.  Neuro-Oncology.  20:1055-1067. 2018
2018 Early life stress induces immune priming in kidneys of adult male rats 2018
2018 Influence of the selective COX-2 inhibitor celecoxib on sex differences in blood pressure and albuminuria in spontaneously hypertensive rats.  Prostaglandins and Other Lipid Mediators.  135:16-20. 2018
2018 Acute pressor response to psychosocial stress is dependent on endothelium-derived endothelin-1 2018
2018 High dietary sodium causes dyssynchrony of the renal molecular clock in rats 2018
2018 Natriuretic response to renal medullary endothelin B receptor activation is impaired in Dahl-salt sensitive rats on a high-fat diet.  Physiological Research.  67:S149-S154. 2018
2018 Relation of urinary endothelin-1 to stress-induced pressure natriuresis in healthy adolescents.  Journal of the American Society of Hypertension.  12:34-41. 2018
2017 Renal denervation attenuates hypertension but not salt sensitivity in ETB receptor-deficient rats 2017
2017 Collecting duct nitric oxide synthase 1ß activation maintains sodium homeostasis during high sodium intake through suppression of aldosterone and renal angiotensin II pathways 2017
2017 Long-term endothelin-a receptor antagonism provides robust renal protection in humanized sickle cell disease mice.  Journal of the American Society of Nephrology.  28:2443-2458. 2017
2017 Endothelin receptor-specific control of endoplasmic reticulum stress and apoptosis in the kidney.  Scientific Reports.  7. 2017
2017 BH4 improves postprandial endothelial function after a high-fat meal in men and postmenopausal women 2017
2016 Free radical scavenging decreases endothelin-1 excretion and glomerular albumin permeability during type 1 diabetes.  Physiological Reports.  4. 2016
2016 High salt induces autocrine actions of ET-1 on inner medullary collecting duct NO production via upregulated ETB receptor expression 2016
2016 Early life stress in male mice induces superoxide production and endothelial dysfunction in adulthood 2016
2016 Dynamin-2 is a novel NOS1β interacting protein and negative regulator in the collecting duct 2016
2016 Endothelin.  Pharmacological Reviews.  68:357-418. 2016
2016 Introduction to the American Heart Association's hypertension strategically focused research network.  Hypertension.  67:674-680. 2016
2016 Pentosan polysulfate preserves renal microvascular P2X1 receptor reactivity and autoregulatory behavior in DOCA-salt hypertensive rats 2016
2016 Dahl SS rats demonstrate enhanced aortic perivascular adipose tissuemediated buffering of vasoconstriction through activation of NOS in the endothelium 2016
2016 Collecting duct-specific knockout of nitric oxide synthase 3 impairs water excretion in a sex-dependent manner 2016
2016 Endothelin-1 contributes to the progression of renal injury in sickle cell disease via reactive oxygen species.  British Journal of Pharmacology.  173:386-395. 2016
2016 Macula densa nitric oxide synthase 1b protects against salt-sensitive hypertension.  Journal of the American Society of Nephrology.  27:2346-2356. 2016
2015 Endothelin-1 as a master regulator of whole-body Na+ homeostasis.  The FASEB Journal.  29:4937-4944. 2015
2015 Mentoring for Collaborations and Team Science.  Physiologist.  58. 2015
2015 Adverse childhood experiences and blood pressure trajectories from childhood to young adulthood the georgia stress and heart study.  Circulation.  131:1674-1681. 2015
2015 Angiotensin II is required to induce exaggerated salt sensitivity in Dahl rats exposed to maternal separation.  Physiological Reports.  3. 2015
2015 ET-1 increases reactive oxygen species following hypoxia and high-salt diet in the mouse glomerulus 2015
2015 Endothelium-derived ET-1 and the development of renal injury 2015
2015 Five years of data diuresis: What have WEH learned? 2015
2015 High salt diet increases the pressor response to stress in female, but not male ETB-receptor-deficient rats.  Physiological Reports.  3. 2015
2015 Jennifer Pollock receives Schmidt-Nielsen distinguished mentor and scientist award at EB 2015.  Physiologist.  58:244. 2015
2015 NOS1-dependent negative feedback regulation of the epithelial sodium channel in the collecting duct 2015
2015 Obesity is associated with more activated neutrophils in African American male youth.  International Journal of Obesity.  39:26-32. 2015
2014 Combined endothelin a blockade and chlorthalidone treatment in a rat model of metabolic syndrome.  Journal of Pharmacology and Experimental Therapeutics.  351:467-473. 2014
2014 Histone deacetylase 1 reduces NO production in endothelial cells via lysine deacetylation of NO synthase 3 2014
2014 Water and electrolyte homeostasis brings balance to physiology 2014
2014 Clopidogrel preserves whole kidney autoregulatory behavior in ANG II-induced hypertension 2014
2014 A mechanistic look at the effects of adversity early in life on cardiovascular disease risk during adulthood 2014
2014 Adverse childhood experiences are associated with detrimental hemodynamics and elevated circulating endothelin-1 in adolescents and young adults.  Hypertension.  64:201-207. 2014
2014 Antihypertensive and anti-inflammatory actions of combined azilsartan and chlorthalidone in Dahl salt-sensitive rats on a high-fat, high-salt diet.  Clinical and Experimental Pharmacology and Physiology.  41:579-588. 2014
2014 Sphingosine-1-phosphate evokes unique segment-specific vasoconstriction of the renal microvasculature.  Journal of the American Society of Nephrology.  25:1774-1785. 2014
2013 Differential regulation of nitric oxide synthase function in aorta and tail artery from 5/6 nephrectomized rats.  Physiological Reports.  1:1-10. 2013
2013 Mycophenolate mofetil prevents high-fat diet–induced hypertension and renal glomerular injury in dahl SS rats.  Physiological Reports.  1:1-11. 2013
2013 Interaction between NO synthase and NADPH oxidase in control of sodium transport by the renal thick ascending limb during diabetes 2013
2013 Immunosuppression preserves renal autoregulatory function and microvascular P2X1 receptor reactivity in ANG II-hypertensive rats 2013
2013 Early life stress sensitizes the renal and systemic sympathetic system in rats 2013
2013 Data diuresis: Research "to go" from the water and electrolyte homeostasis section 2013
2013 Does endoplasmic reticulum stress mediate endothelin-1-induced renal inflammation? 2013
2013 Renal collecting duct nos1 maintains fluid-electrolyte homeostasis and blood pressure.  Hypertension.  62:91-98. 2013
2013 Distinct regulation of inner medullary collecting duct nitric oxide production from mice and rats.  Clinical and Experimental Pharmacology and Physiology.  40:233-239. 2013
2013 Short-term hypercaloric diet induces blunted aortic vasoconstriction and enhanced vasorelaxation via increased nitric oxide synthase 3 activity and expression in Dahl salt-sensitive rats 2013
2013 Early life stress induces renal dysfunction in adult male rats but not female rats 2013
2013 A genome-wide methylation study on obesity: Differential variability and differential methylation.  Epigenetics.  8:522-533. 2013
2013 Nitric oxide and the A and B of endothelin of sodium homeostasis.  Current Opinion in Nephrology and Hypertension.  22:26-31. 2013
2012 Loss of renal medullary endothelin B receptor function during salt deprivation is regulated by angiotensin II 2012
2012 Changing standard chow diet promotes vascular NOS dysfunction in Dahl S rats 2012
2011 ETA activation mediates angiotensin II-induced infiltration of renal cortical T cells.  Journal of the American Society of Nephrology.  22:2187-2192. 2011
2011 Endothelin, nitric oxide, and reactive oxygen species in diabetic kidney disease..  Contributions to Nephrology.  172:149-159. 2011
2011 Early life stress enhances angiotensin II-mediated vasoconstriction by reduced endothelial nitric oxide buffering capacity.  Hypertension.  58:619-626. 2011
2011 Erratum: Endothelin-1 increases glomerular permeability and inflammation independent of blood pressure in the rat (Hypertension (2010) 56 (942-949)).  Hypertension.  58. 2011
2011 Sex differences in renal medullary endothelin receptor function in angiotensin ii hypertensive rats.  Hypertension.  58:212-218. 2011
2011 Distinct actions of endothelin A-selective versus combined endothelin A/B receptor antagonists in early diabetic kidney disease.  Journal of Pharmacology and Experimental Therapeutics.  338:263-270. 2011
2011 Dynamin activates NO production in rat renal inner medullary collecting ducts via protein-protein interaction with NOS1 2011
2011 Blood pressure and not uraemia is the major determinant of arterial stiffness and endothelial dysfunction in patients with chronic kidney disease and minimal co-morbidity.  Atherosclerosis.  216:217-225. 2011
2011 Endothelin receptor A-specific stimulation of glomerular inflammation and injury in a streptozotocin-induced rat model of diabetes.  Diabetologia.  54:979-988. 2011
2011 Antihypertensive therapy increases tetrahydrobiopterin levels and NO/cGMP signaling in small arteries of angiotensin II-infused hypertensive rats 2011
2011 Flow regulation of collecting duct endothelin-1 production 2011
2010 Endothelin-1 increases glomerular permeability and inflammation independent of blood pressure in the rat.  Hypertension.  56:942-949. 2010
2010 Immunosuppression with mycophenolate mofetil attenuates the development of hypertension and albuminuria in deoxycorticosterone acetate-salt hypertensive rats.  Clinical and Experimental Pharmacology and Physiology.  37:1016-1022. 2010
2010 Sex differences in acute ANG II-mediated hemodynamic responses in mice 2010
2010 Contrasting effects of intervention with ETa and ETb receptor antagonists in hypertension induced by angiotensin II and high-salt diet.  Canadian Journal of Physiology and Pharmacology.  88:802-807. 2010
2010 Endothelin activation of reactive oxygen species mediates stress-induced pressor response in dahl salt-sensitive prehypertensive rats.  Hypertension.  56:282-289. 2010
2010 Early life stress downregulates endothelin receptor expression and enhances acute stress-mediated blood pressure responses in adult rats 2010
2010 Pentosan polysulfate treatment preserves renal autoregulation in ANG II-infused hypertensive rats via normalization of P2X 1 receptor activation 2010
2010 Response to role of epithelial sodium channels in the renal myogenic response?.  Hypertension.  55. 2010
2010 Protective role of extracellular superoxide dismutase in renal ischemia/reperfusion injury.  Kidney International.  78:374-381. 2010
2010 Renal NOS activity, expression, and localization in male and female spontaneously hypertensive rats 2010
2009 Effect of epithelial sodium channel blockade on the myogenic response of rat juxtamedullary afferent arterioles.  Hypertension.  54:1062-1069. 2009
2009 PKC-dependent superoxide production by the renal medullary thick ascending limb from diabetic rats 2009
2009 PP2B-dependent NO production in the medullary thick ascending limb during diabetes 2009
2009 Novel use of ultrasound to examine regional blood flow in the mouse kidney 2009
2009 Greater fractalkine expression in mesenteric arteries of female spontaneously hypertensive rats compared with males 2009
2009 Complications impair the usefulness and validity of the rat tail arteriovenous fistula model.  Kidney International.  76:916. 2009
2008 Interleukin-1β, but not interleukin-6, enhances renal and systemic endothelin production in vivo 2008
2008 Collecting duct-derived endothelin regulates arterial pressure and Na excretion via nitric oxide.  Hypertension.  51:1605-1610. 2008
2008 Renal medullary ETB receptors produce diuresis and natriuresis via NOS1 2008
2008 Influence of salt on subcellular localization of nitric oxide synthase activity and expression in the renal inner medulla.  Clinical and Experimental Pharmacology and Physiology.  35:120-125. 2008
2008 Racial differences in microalbumin excretion in healthy adolescents.  Hypertension.  51:334-338. 2008
2008 Diabetic nephropathy: Nitric oxide and renal medullary hypoxia 2008
2008 Endothelin and NOS1/nitric oxide signaling and regulation of sodium homeostasis.  Current Opinion in Nephrology and Hypertension.  17:70-75. 2008
2008 TNF-α inhibition reduces renal injury in DOCA-salt hypertensive rats 2008
2007 EndothelinA (ETA) and ETB receptor-mediated regulation of nitric oxide synthase 1 (NOS1) and NOS3 isoforms in the renal inner medulla 2007
2007 Sex and sex hormones influence the development of albuminuria and renal macrophage infiltration in spontaneously hypertensive rats 2007
2007 Novel nitric oxide synthase-dependent mechanism of vasorelaxation in small arteries from hypertensive rats.  Hypertension.  49:893-901. 2007
2007 Sexual dimorphism in oxidant status in spontaneously hypertensive rats 2007
2007 Synergistic actions of enalapril and tempol during chronic angiotensin II-induced hypertension.  Vascular Pharmacology.  46:144-151. 2007
2007 Endothelin A receptor blockade reduces diabetic renal injury via an anti-inflammatory mechanism.  Journal of the American Society of Nephrology.  18:143-154. 2007
2006 Increased reactive oxygen species contributes to kidney injury in mineralocorticoid hypertensive rats.  Journal of Physiology and Pharmacology.  57:343-357. 2006
2006 Angiotensin II hypertension is attenuated in interleukin-6 knockout mice 2006
2006 Coupled and uncoupled NOS: Separate but equal? Uncoupled NOS in endothelial cells is a critical pathway for intracellular signaling.  Circulation Research.  98:717-719. 2006
2006 In vivo evidence for endothelin-1-mediated attenuation of α1-adrenergic stimulation 2006
2006 NOS3 regulation: Renal tubular epithelial cells are not simply large endothelial cells.  Hypertension.  47:19-21. 2006
2005 Endothelin mediates superoxide production and vasoconstriction through activation of NADPH oxidase and uncoupled nitric-oxide synthase in the rat aorta.  Journal of Pharmacology and Experimental Therapeutics.  315:1058-1064. 2005
2005 Endothelin and oxidative stress in the vascular system 2005
2005 Impaired Ca2+ signaling attenuates P2X receptor-mediated vasoconstriction of afferent arterioles in angiotensin II hypertension.  Hypertension.  46:562-568. 2005
2005 Endogenous endothelin attenuates the pressor response to acute environmental stress via the ETA receptor 2005
2005 Sexual dimorphism in renal production of prostanoids in spontaneously hypertensive rats.  Hypertension.  45:406-411. 2005
2005 NADPH oxidase inhibition attenuates oxidative stress but not hypertension produced by chronic ET-1.  Hypertension.  45:283-287. 2005
2005 Decreased epoxygenase and increased epoxide hydrolase expression in the mesenteric artery of obese Zucker rats 2005
2005 Posttranslational regulation of NO synthase activity in the renal medulla of diabetic rats 2005
2004 Effects of NOS3 Glu298Asp polymorphism on hemodynamic reactivity to stress: Influences of ethnicity and obesity.  Hypertension.  44:866-871. 2004
2004 Rofecoxib decreases renal injury in obese Zucker rats.  Clinical Science.  107:561-570. 2004
2004 Arterial pressure response to the antioxidant tempol and ETB receptor blockade in rats on a high-salt diet.  Hypertension.  44:770-775. 2004
2004 ETA receptor blockade attenuates hypertension and decreases reactive oxygen species in ETB receptor-deficient rats.  Journal of Cardiovascular Pharmacology.  44. 2004
2004 Age-related alterations in NOS and oxidative stress in mesenteric arteries from male and female rats 2004
2004 Hypertensive response to acute stress is attenuated in interleukin-6 knockout mice.  Hypertension.  44:259-263. 2004
2004 Reduced NOS3 Phosphorylation Mediates Reduced NO/cGMP Signaling in Mesenteric Arteries of Deoxycorticosterone Acetate-Salt Hypertensive Rats.  Hypertension.  43:1080-1085. 2004
2004 Soluble Epoxide Hydrolase Inhibition Protects the Kidney from Hypertension-Induced Damage.  Journal of the American Society of Nephrology.  15:1244-1253. 2004
2003 Omapatrilat increases renal endothelin in deoxycorticosterone acetate-salt hypertensive rats.  Vascular Pharmacology.  40:253-259. 2003
2003 Endothelin-1 gene LYS198ASN polymorphism and blood pressure reactivity.  Hypertension.  42:494-499. 2003
2003 Unique endothelin receptor binding in kidneys of ETB receptor deficient rats 2003
2003 Down-regulation of soluble guanylyl cyclase in the inner medulla of DOCA-salt hypertensive rats.  Vascular Pharmacology.  40:155-160. 2003
2002 Plasma endothelin-1 release during acute stress: Role of ethnicity and sex.  Psychosomatic Medicine.  64:707-713. 2002
2002 Transforming growth factor β mimetics: Discovery of 7-[4-(4-cyanophenyl) phenoxy]-heptanohydroxamic acid, a biaryl hydroxamate inhibitor of histone deacetylase.  Molecular Cancer Therapeutics.  1:759-768. 2002
2002 cGMP-dependent protein kinase expression restores contractile function in cultured vascular smooth muscle cells.  Journal of Vascular Research.  39:95-103. 2002
2002 Birth upregulates nitric oxide synthase activity in the porcine lung.  Life Sciences.  70:1609-1620. 2002
2002 Decreased endothelin binding and [Ca2+]i signaling in microvessels of DOCA-salt hypertensive rats.  Journal of Hypertension.  20:1799-1805. 2002
2002 Dissecting the genetic architecture of the cardiovascular and renal stress response.  Biological Psychology.  61:73-95. 2002
2002 Functional NOS 1 in the rat mesenteric arterial bed 2002
2002 Renal endothelin in chronic angiotensin II hypertension 2002
2002 Role of ET-1 receptor binding and [Ca2+]i in contraction of coronary arteries from DOCA-salt hypertensive rats 2002
2001 Urinary excretion of vasoactive factors are correlated to sodium excretion.  American Journal of Hypertension.  14:1003-1006. 2001
2001 Nitric oxide synthesis and oxidative stress in the renal cortex of rats with diabetes mellitus.  Journal of the American Society of Nephrology.  12:1630-1639. 2001
2001 Antibody neutralization of vascular endothelial growth factor inhibits wound granulation tissue formation.  Journal of Surgical Research.  96:173-182. 2001
2001 Enhanced endothelin-1 response and receptor expression in small mesenteric arteries of insulin-resistant rats 2001
2001 EtB receptor-deficient rats exhibit reduced contraction to ET-1 despite an increase in ETA receptors 2001
2001 Evidence for endothelin involvement in the response to high salt 2001
2001 Exercise in sickle cell anemia: Effect on inflammatory and vasoactive mediators.  Endothelium.  8:147-155. 2001
2001 Nitric oxide synthase isoform expression in a porcine model of granulation tissue formation.  Surgery.  129:341-350. 2001
2001 Training induces nonuniform increases in eNOS content along the coronary arterial tree 2001
2000 Combined effects of AT1 and ETA receptor antagonists, candesartan, and A-127722 in DOCA-salt hypertensive rats.  General Pharmacology.  34:337-342. 2000
2000 Functional expression of NOS 1 in vascular smooth muscle 2000
2000 Racial differences in endothelin-1 at rest and in response to acute stress in adolescent males.  Hypertension.  35:722-725. 2000
2000 Shear stress-mediated NO production in inner medullary collecting duct cells 2000
2000 Upregulation of endothelin B receptors in kidneys of DOCA-salt hypertensive rats 2000
1999 Increased nitric oxide synthase-3 expression in kidneys of deoxycorticosterone acetate-salt hypertensive rats.  Journal of the American Society of Nephrology.  10:2283-2289. 1999
1998 Changes in nitric oxide synthase activity in the porcine lung after birth.  Thorax.  53. 1998
1998 High expression of endothelial nitric oxide synthase in plexiform lesions of pulmonary hypertension.  Journal of Pathology.  185:313-318. 1998
1998 Role of endothelin ET(A) receptors in the hypertension produced by 4- day L-nitroarginine methyl ester and cyclosporine treatment 1998
1997 Expression of nitric oxide synthase isoforms in bone and bone cell cultures.  Journal of Bone and Mineral Research.  12:1108-1115. 1997
1997 Characterization of nitric oxide synthase isoforms expressed in different structures of the guinea pig cochlea.  Brain Research.  747:26-33. 1997
1997 Endothelial nitric oxide synthase in hypoxic newborn porcine pulmonary vessels 1997
1997 Expression of multiple isoforms of nitric oxide synthase in normal and atherosclerotic vessels 1997
1997 Identification of the NO synthase isoforms expressed in human neutrophil granulocytes, megakaryocytes and platelets.  Thrombosis and Haemostasis.  77:163-167. 1997
1996 Restenosis is associated with decreased coronary artery nitric oxide synthase.  International Journal of Cardiology.  55:183-191. 1996
1996 Expression of nitric oxide synthase in mucosal cells of the canine colon.  Histochemistry and Cell Biology.  105:33-41. 1996
1996 Leukotrienes do not regulate nitric oxide production in RAW 264.7 macrophages 1996
1996 [10] Purification of endothelial nitric oxide synthase.  Methods in Neurosciences.  31:125-129. 1996
1996 [13] Generation of monoclonal antibodies to endothelial nitric oxide synthase.  Methods in Neurosciences.  31:152-155. 1996
1995 Abundance of endothelial nitric oxide synthase in newborn intrapulmonary arteries.  Archives of Disease in Childhood.  73. 1995
1995 Functional Expression of Three Isoforms of Human Nitric Oxide Synthase in Baculovirus-Infected Insect Cells.  Biochemical and Biophysical Research Communications.  206:511-517. 1995
1995 Hypoxia activates nitric oxide synthase and stimulates nitric oxide production in porcine coronary resistance arteriolar endothelial cells.  Cardiovascular Research.  30:841-847. 1995
1995 Immunohistochemical characterization of placental nitric oxide synthase expression in preeclampsia.  American Journal of Obstetrics and Gynecology.  173:687-694. 1995
1995 Immunohistochemical localization of endothelial nitric oxide synthase in human villous and extravillous trophoblast populations and expression during syncytiotrophoblast formation in vitro.  Placenta.  16:113-126. 1995
1995 Nitric oxide synthase and guanylate cyclase levels in canine basilar artery after subarachnoid hemorrhage.  Journal of Neurosurgery.  82:250-255. 1995
1995 Nitric oxide synthase isozymes antibodies 1995
1995 Novel potent and selective inhibitors of inducible nitric oxide synthase.  Molecular Pharmacology.  47:831-834. 1995
1995 The Golgi association of endothelial nitric oxide synthase is necessary for the efficient synthesis of nitric oxide.  Journal of Biological Chemistry.  270:17641-17644. 1995
1994 Nitric oxide synthase activity is elevated in brain microvessels in alzheimer′s disease.  Biochemical and Biophysical Research Communications.  205:659-665. 1994
1994 Upregulation of neuronal nitric oxide synthase and mRNA, and selective sparing of nitric oxide synthase-containing neurons after local cerebral ischemia in rat.  Brain Research.  654:85-95. 1994
1994 Endothelioma Cells Express and Secrete Endothelin-1 and Inhibit Platelet Aggregation through Nitric Oxide Formation.  Endothelium.  2:125-137. 1994
1994 Expression of nitric oxide synthase immunoreactivity by interstitial cells of the canine proximal colon 1994
1994 Identification of an endothelial-like type III NO synthase in LLC-PK1 kidney epithelial cells.  American Journal of Physiology.  266. 1994
1994 Identification of an endothelial-like type III NO synthase in LLC-PK1 kidney epithelial cells.  American Journal of Physiology.  266. 1994
1994 Immunochemical detection of inducible NO synthase in human lung 1994
1994 Immunochemical detection of inducible NO synthase in human lung 1994
1994 Isoforms of nitric-oxide synthase: Purification and regulation.  Methods in Enzymology.  233:258-264. 1994
1994 Maturation-related changes in endothelial nitric oxide synthase immunolocalization in developing ovine lung 1994
1994 Maturation-related changes in endothelial nitric oxide synthase immunolocalization in developing ovine lung.  American Journal of Physiology.  267. 1994
1994 Nitric oxide synthase isozymes characterization, purification, molecular cloning, and functions.  Hypertension.  23:1121-1131. 1994
1993 Characterization and localization of endothelial nitric oxide synthase using specific monoclonal antibodies.  American Journal of Physiology.  265. 1993
1993 Nitric Oxide Synthases in Neuronal Cells, Macrophages and Endothelium Are NADPH Diaphorases, but Represent Only a Fraction of Total Cellular NADPH Diaphorase Activity.  Biochemical and Biophysical Research Communications.  195:1035-1040. 1993
1993 Developmental changes of cytosolic and particulate nitric oxide synthase in rat brain 1993
1993 A correlation between soluble brain nitric oxide synthase and NADPH-diaphorase activity is only seen after exposure of the tissue to fixative.  Neuroscience Letters.  155:61-64. 1993
1993 Cloned human brain nitric oxide synthase is highly expressed in skeletal muscle.  FEBS Letters.  316:175-180. 1993
1993 Cerebral endothelial nitric oxide synthase expression after focal cerebral ischemia in rats.  Stroke.  24:2016-2021. 1993
1993 Characterization and localization of endothelial nitric oxide synthase using specific monoclonal antibodies.  American Journal of Physiology.  265. 1993
1993 Constitutive calcium-dependent isoform of nitric oxide synthase in the human placental villous vascular tree.  Placenta.  14:373-383. 1993
1993 Genomic analysis and expression patterns reveal distinct genes for endothelial and brain nitric oxide synthase.  Hypertension.  21:934-938. 1993
1993 Immunohistochemical localization of nitric oxide synthase in the human placenta.  Placenta.  14:487-495. 1993
1993 Nitric oxide synthases in the cardiovascular system.  Trends in Cardiovascular Medicine.  3:104-110. 1993
1993 Particulate Endothelial Nitric Oxide Synthase: Requirement and Content of Tetrahydrobiopterin, FAD, and FMN.  Endothelium.  1:147-152. 1993
1993 The nitric oxide-cyclic GMP signal transduction system for intracellular and intercellular communication..  Advances in Second Messenger and Phosphoprotein Research.  28:101-109. 1993
1992 Induction of NADPH-dependent diaphorase and nitric oxide synthase activity in aortic smooth muscle and cultured macrophages.  Molecular Pharmacology.  41:1163-1168. 1992
1992 Endothelial nitric oxide synthase is myristylated.  FEBS Letters.  309:402-404. 1992
1992 Bioassay for EDRF/NO by accumulation of cyclic GMP in RFL-6 fetal rat lung fibroblasts.  Methods.  1:117-123. 1992
1992 Ca2+ calmodulin-regulated nitric oxide synthases.  Cell Calcium.  13:427-434. 1992
1992 Characterization and localization of nitric oxide synthase in non‐adrenergic non‐cholinergic nerves from bovine retractor penis muscles.  British Journal of Pharmacology.  106:768-773. 1992
1992 Mapping of neural nitric oxide synthase in the rat suggests frequent co- localization with NADPH diaphorase but not with soluble guanylyl cyclase, and novel paraneural functions for nitrinergic signal transduction 1992
1991 Isoforms of nitric oxide synthase Characterization and purification from different cell types.  Biochemical Pharmacology.  42:1849-1857. 1991
1991 Endothelial cells have a particulate enzyme system responsible for EDRF formation: Measurement by vascular relaxation.  Biochemical and Biophysical Research Communications.  176:1417-1423. 1991
1991 Calmodulin-dependent endothelium-derived relaxing factor/nitric oxide synthase activity is present in the particulate and cytosolic fractions of bovine aortic endothelial cells 1991
1991 Purification and characterization of particulate endothelium-derived relaxing factor synthase from cultured and native bovine aortic endothelial cells 1991
1991 Purification of a soluble isoform of guanylyl cyclase-activating-factor synthase 1991
1990 Regional distribution of EDRF NO-synthesizing enzyme(s) in rat brain.  Biochemical and Biophysical Research Communications.  168:727-732. 1990
1990 EDRF is an intracellular second messenger and autacoid to regulate cyclic GMP synthesis in many cells..  Advances in Second Messenger and Phosphoprotein Research.  24:441-448. 1990
1990 Hormone-induced biosynthesis of endothelium-derived relaxing factor/nitric oxide-like material in N1E-115 neuroblastoma cells requires calcium and calmodulin.  Molecular Pharmacology.  38:7-13. 1990
1988 The determination of a calcium-dependent binding constant of the bovine prothrombin GLA domain (residues 1-45) to phospholipid vesicles.  Biochemical and Biophysical Research Communications.  155:230-235. 1988
1988 Chemical modification of bovine prothrombin fragment 1 in the presence of Tb3+ ions. Sequence studies on 3-γ-MGlu-fragment 1.  Journal of Biological Chemistry.  263:8150-8156. 1988
1988 Phospholipid bindng properties of bovine prothrombin peptide residues 1-45.  Journal of Biological Chemistry.  263:14216-14223. 1988
1978 Pitfalls of the alcohol dehydrogenase procedure for the emergency assay of alcohol: A case study of isopropanol overdose 1978

Chapter

Year Title Altmetric
2011 Endothelin, nitric oxide, and reactive oxygen species in diabetic kidney disease.  149-159. 2011

Research Overview

  • Our laboratory is generally focused on the role of nitric oxide in vascular and renal function. Specifically, we have sought to determine the mechanisms of endothelial dysfunction in hypertension and diabetes as well as determining the role of nitric oxide synthase isoforms in control of renal sodium excretion and blood pressure. We have a strong effort in determining mechanisms of early life stress in adult vascular and renal dysfunction.

    • Principal Investigator On

  • (Environmental Triggers) Molecular Mechanisms of Early Life Stress and Risk of Inflammatory Bowel Disease  awarded by Crohn's & Colitis Foundation of America
  • Chronic Circadian Disruption in Cardiovascular Disease  awarded by American Heart Association
  • Circadian Control of Endothelial Function in Mice On a High Fat Diet  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Early Life Stress Induced Regulation of ET-1 and Vascular Disease  awarded by PHRMA FOUNDATION
  • Early Life Stress Induced Sensitivity to Hypertension and Renal Inflammation in Adult Life  awarded by American Physiological Society
  • Early Life Stress Induced Sensitivity to Hypertension and Renal Inflammation in Adult Life  awarded by American Physical Society
  • HDAC1 Regulation of Endothelial NO  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Integrating Novel Mechanisms Controlling Sodium Excretion and Blood Pressure - Core B = Animal and Analytical Core  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Integrating Novel Mechanisms Controlling Sodium Excretion and Blood Pressure - Project 3 = HDAC-Mediated Regulation of Endothelin and Nitric Oxide  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Kidney Undergraduate Research Experience (KURE)  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Mechanisms of Early Life Stress-Induced Endothelial Dysfunction  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Mechanisms of Salt-Dependent Shifts in Blood Pressure Rhythms  awarded by American Heart Association
  • Mentor/AHA Mentee Award  awarded by American Heart Association
  • Molecular Mechanisms of Early Life Stress and Risk of Inflammatory Bowel Disease  awarded by Crohn's & Colitis Foundation of America
  • Novel Endothelial and Immunologic Mechanisms of Pathophysiology in Sickle Cell Disease  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Novel Mechanisms of Decreased NO Bioavailability in Sickle Cell Nephropathy  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Novel Mechanisms of Nitric Oxide Activation in the Kidney  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • PRedoctoral Interdisciplinary Training in Renal Physiology and MEdIcIne (PRIME)  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Preparation for Graduate and Medical Education (PARAdiGM) Program  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Preparation for Graduate and Medical Education (PreGAME) Program  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Role of Circadian Rhythms in Chronic High Fat Diet-Induced Endothelial Dysfunction  awarded by American Heart Association
  • Stress Related Mechanisms of Hypertension Risk  awarded by GEORGIA REGENTS UNIVERSITY (AUGUSTA)
  • Stress Related Mechanisms of Hypertension Risk - Core B  awarded by GEORGIA REGENTS UNIVERSITY (AUGUSTA)
  • Stress Related Mechanisms of Hypertension Risk - Project 1  awarded by GEORGIA REGENTS UNIVERSITY (AUGUSTA)
  • Stress Related Mechanisms of Hypertension Risk - Project 2  awarded by GEORGIA REGENTS UNIVERSITY (AUGUSTA)
  • University of Alabama at Birmingham Strategically Focused Hypertension Research Center - Novel Mechanisms of Salt-Sensitivity and Diurnal Blood Pressure Rhythm - Project 3  awarded by American Heart Association

    • Investigator On

  • 3D Renal Tissue Chip Models to Evaluate Nephrotoxic Effects of Drugs  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Center for Clinical and Translational Science (3 Linked Awards UL1, KL2, TL1)  awarded by National Center for Advancing Translational Sciences/NIH/DHHS
  • ESTaBLISH: Impact of Early Life STressors on the BLood Pressure and Vascular Function In AdoleScents and cHildren  awarded by KAUL PEDIATRIC RESEARCH INSTITUTE
  • Glycolate Metabolism and Kidney Oxalate  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Hemodynamic Adaptation and Vascular Remodeling in Fistula Development  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Integrating Novel Mechanisms Controlling Sodium Excretion and Blood Pressure  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Integrating Novel Mechanisms Controlling Sodium Excretion and Blood Pressure - AD Supplement: Salt-Dependent Hypertension and the Central Clock  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Integrating Novel Mechanisms Controlling Sodium Excretion and Blood Pressure - Project 1 = Circadian Control of Sodium Excretion  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Integrating Novel Mechanisms Controlling Sodium Excretion and Blood Pressure - Research Supplement to Promote Diversity  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Interdisciplinary Training In Kidney-Related Research  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Mechanisms in Hypertension and Cardiovascular Diseases  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Molecular Mechanisms of Early Life Stress and Risk of Inflammatory Bowel Disease  awarded by Crohn's & Colitis Foundation of America
  • PRedOctoral Phd and MD Research Training In TEams (PROmoTE)  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Private Grant  awarded by ENDOMIMETICS, LLC ^
  • Private Grant  awarded by ENDOMIMETICS, LLC ^
  • Role of Endothelin in Hypertension-Mediated Inflammation and End-Organ Damage  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Stress Related Mechanisms of Hypertension Risk  awarded by GEORGIA REGENTS UNIVERSITY (AUGUSTA)
  • The Cytokines, MCP-1 and TGF-Beta, Mediate Renal Autoregulatory Impairment  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • The Role of ET-1 in Tubular Injury in Sickle Cell Disease  awarded by American Heart Association
  • The Role of Endothelin-1 in Sickle Cell Disease  awarded by AUGUSTA UNIVERSITY - NEW
  • Timing of Sodium Intake and Nocturnal Sodium Excretion and Blood Pressure in Obese African Americans  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • UAB Center for Clinical and Translational Science (CCTS) (3 Linked Awards UL1, KL2, TL1)  awarded by National Center for Advancing Translational Sciences/NIH/DHHS
  • University of Alabama at Birmingham Strategically Focused Hypertension Research Center  awarded by American Heart Association

    • Education And Training

  • Doctor of Philosophy in Biochemistry, University of North Carolina System : Chapel Hill 1987

    • Full Name

  • Jennifer Pollock