• Dr. Li's major research interest includes design, management, conduct, analysis and interpretation of clinical trials, epidemiologic studies and evaluation research, with particular expertise in cluster-randomized trials. He has broad collaborative experience with researchers from multidiscipline including clinicians and biologists, involving in study design, power and sample size calculation, data management and analysis.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2020 Identification of an Anti-diabetic, Orally Available Small Molecule that Regulates TXNIP Expression and Glucagon ActionCell Metabolism.  32:353-365.e8. 2020
    2020 Nuclear receptor binding factor 2 (NRBF2) is required for learning and memoryLaboratory Investigation.  100:1238-1251. 2020
    2020 The Clinical Benefit of Adjuvant Therapy in Long-Term Survival of Early-Stage Ampullary Carcinoma: A Single Institutional Experience.Journal of Clinical Medicine Research.  12:560-567. 2020
    2020 A randomized trial on the effects of root resorption after orthodontic treatment using pulsating forceBMC Oral Health.  20:238. 2020
    2020 Authors' Comments—Long-Term Postoperative Cone-Beam Computed Tomography Analysis of Secondary Bone Grafting in 79 Patients With Unrepaired Alveolar CleftsJournal of Oral and Maxillofacial Surgery.  78:e1-e3. 2020
    2020 Commentary – “Long-Term Postoperative Cone-Beam Computed Tomography Analysis of Secondary Bone Grafting in 79 Patients With Unrepaired Alveolar Clefts”Journal of Oral and Maxillofacial Surgery.  78:e4-e5. 2020
    2020 Long-Term Postoperative Cone-Beam Computed Tomography Analysis of Secondary Bone Grafting in 79 Patients With Unrepaired Alveolar CleftsJournal of Oral and Maxillofacial Surgery.  78:1164-1170. 2020
    2020 Implications of Atrial Fibrillation Among Patients With Atherosclerotic Cardiovascular Disease Undergoing Noncardiac SurgeryAmerican Journal of Cardiology.  125:1836-1844. 2020
    2020 Obesity induces limited changes to systemic and local immune profiles in treatment-naive human clear cell renal cell carcinomaPLoS ONE.  15. 2020
    2020 Spinal Mobilization Prevents NGF-Induced Trunk Mechanical Hyperalgesia and Attenuates Expression of CGRPFrontiers in Neuroscience.  14. 2020
    2020 Effectiveness of Combined Behavioral and Drug Therapy for Overactive Bladder Symptoms in Men: A Randomized Clinical TrialJAMA Internal Medicine.  180:411-419. 2020
    2020 How does workplace bullying influence nurses’ abilities to provide patient care? A nurse perspectiveJournal of Clinical Nursing2020
    2019 Serum miR-204 is an early biomarker of type 1 diabetes-associated pancreatic beta-cell loss 2019
    2019 Ethnic differences in the root to crown ratios of the permanent dentition 2019
    2019 Phase 1b trial of nintedanib in combination with bevacizumab in patients with advanced solid tumorsCancer Chemotherapy and Pharmacology.  83:551-559. 2019
    2019 Best (but oft-forgotten) practices: Missing data methods in randomized controlled nutrition trialsAmerican Journal of Clinical Nutrition.  109:504-508. 2019
    2019 Illustration of Measurement Error Models for Reducing Bias in Nutrition and Obesity Research Using 2-D Body Composition Data 2019
    2019 Kilocalorie expenditure and all-cause mortality in older male veterans and nonveteransJournal of Aging and Physical Activity.  27:67-72. 2019
    2019 Preoperative hematocrit on early prosthetic joint infection and deep venous thrombosis rates in primary total hip arthroplasty: A database studyJournal of Clinical Orthopaedics and Trauma.  10:124-127. 2019
    2018 Effects of Indoor Thermal Environment on Human Food Intake, Productivity, and Comfort: Pilot, Randomized, Crossover Trial 2018
    2018 Impact of time to surgery from injury on postoperative infection and deep vein thrombosis in periprosthetic knee fracturesChinese Journal of Traumatology (English Edition).  21:329-332. 2018
    2018 Late-life targeting of the IGF-1 receptor improves healthspan and lifespan in female miceNature Communications.  9. 2018
    2018 Verapamil and beta cell function in adults with recent-onset type 1 diabetesNature Medicine.  24:1108-1112. 2018
    2018 Featured article: Evaluating smartphone-based virtual reality to improve Chinese schoolchildren's pedestrian safety: A nonrandomized trialJournal of Pediatric Psychology.  43:573-584. 2018
    2018 Impact of operative time on early joint infection and deep vein thrombosis in primary total hip arthroplastyOrthopaedics and Traumatology: Surgery and Research.  104:445-448. 2018
    2018 Impact of operative time on early joint infection and deep vein thrombosis in primary total hip arthroplastyRevue de Chirurgie Orthopédique et Traumatologique.  104:311. 2018
    2018 Randomization to randomization probability: Estimating treatment effects under actual conditions of usePsychological Methods.  23:337-350. 2018
    2018 Evaluation of a Multimodal, Direct-to-Patient Educational Intervention Targeting Barriers to Osteoporosis Care: A Randomized Clinical TrialJournal of Bone and Mineral Research.  33:763-772. 2018
    2018 Generalized lambda distribution for flexibly testing differences beyond the mean in the distribution of a dependent variable such as body mass indexInternational Journal of Obesity.  42:930-933. 2018
    2018 A Comment on Scherr et al “A Multicomponent, School-Based Intervention, the Shaping Healthy Choices Program, Improves Nutrition-Related Outcomes” 2018
    2018 Early progressive feeding in extremely preterm infants: A randomized trialAmerican Journal of Clinical Nutrition.  107:365-370. 2018
    2018 MicroRNA-145 antagonism reverses TGF-b inhibition of F508del CFTR correction in airway EpitheliaAmerican Journal of Respiratory and Critical Care Medicine.  197:632-643. 2018
    2018 Cutaneous neurofibromas in Neurofibromatosis type I: A quantitative natural history studyOrphanet Journal of Rare Diseases.  13. 2018
    2018 Case series on multimodal endoscopic therapy for gastric antral vascular ectasia, a tertiary center experience.World Journal of Gastrointestinal Endoscopy.  10:30-36. 2018
    2017 Obesity as defined by waist circumference but not body mass index is associated with higher renal mass complexityUrologic Oncology: Seminars and Original Investigations.  35:661.e1-661.e6. 2017
    2017 Evaluating Otto the Auto: Does engagement in an interactivewebsite improve young children’s transportation safety?International Journal of Environmental Research and Public Health.  14. 2017
    2017 Current guidelines for chemoembolization for hepatocellular carcinoma: Room for improvement?Hepatology Communications.  1:338-346. 2017
    2017 A SEER Database Analysis of the Survival Advantage of Transarterial Chemoembolization for Hepatocellular Carcinoma: An Underutilized Therapy 2017
    2016 Evaluating a website to teach children safety with dogs: A randomized controlled trialInternational Journal of Environmental Research and Public Health.  13. 2016
    2016 Observational research rigour alone does not justify causal inferenceEuropean Journal of Clinical Investigation.  46:985-993. 2016
    2016 Improved Postoperative Survival for Intraductal-Growth Subtype of Intrahepatic Cholangiocarcinoma.American Surgeon.  82:1133-1139. 2016
    2016 Improved postoperative survival for intraductal- growth subtype of intrahepatic cholangiocarcinomaAmerican Surgeon.  82:1133-1139. 2016
    2016 Body Mass Index Predicts 24-Hour Urinary Aldosterone Levels in Patients with Resistant HypertensionHypertension.  68:995-1003. 2016
    2016 The effects of urate lowering therapy on inflammation, endothelial function, and blood pressure (SURPHER) study design and rationaleContemporary Clinical Trials.  50:238-244. 2016
    2016 The importance of prediction model validation and assessment in obesity and nutrition researchInternational Journal of Obesity.  40:887-894. 2016
    2016 Common scientific and statistical errors in obesity research 2016
    2016 Unsubstantiated conclusions from improper statistical design and analysis of a randomized controlled trial.International Journal of Yoga.  9:87-88. 2016
    2015 Multiple imputation: A flexible tool for handling missing data 2015
    2015 Corrigendum: Warm Ambient Temperature Decreases Food Intake in a Simulated Office Setting: A Pilot Randomized Controlled Trial (Frontiers in Nutrition, (2015), 2, (20), 10.3389/fnut.2015.00020)Frontiers in Nutrition.  2. 2015
    2015 Warm Ambient Temperature Decreases Food Intake in a Simulated Office Setting: A Pilot Randomized Controlled TrialFrontiers in Nutrition.  2. 2015
    2015 Comparing denominator degrees of freedom approximations for the generalized linear mixed model in analyzing binary outcome in small sample cluster-randomized trialsBMC Medical Research Methodology.  15. 2015
    2015 Letter to the Editor: Exceptional Data in Paper on "The effect of meridian massage on BM, BMI, WC and HC in simple obesity patients: a randomized controlled trial".World Journal of Acupuncture - Moxibustion.  25:66-67. 2015
    2015 Best (but oft-forgotten) practices: Designing, analyzing, and reporting cluster randomized controlled trialsAmerican Journal of Clinical Nutrition.  102:241-248. 2015
    2015 Comment on "intervention Effects of a School-Based Health Promotion Programme on Obesity Related Behavioural Outcomes"Journal of Obesity.  2015. 2015
    2015 Comment on "school-based obesity prevention intervention in chilean children: Effective in controlling, but not reducing obesity"Journal of Obesity.  2015. 2015
    2015 Concerning Sichieri R, Cunha DB: Obes Facts 2014;7:221-232. the assertion that controlling for baseline (pre-randomization) covariates in randomized controlled trials leads to bias is false 2015
    2015 Correction of data errors and reanalysis of "The effect of glucomannan on body weight in overweight or obese children and adults: A systematic review of randomized controlled trials"Nutrition.  31:1056-1057. 2015
    2015 Refractory hypertension: Evidence of heightened sympathetic activity as a cause of antihypertensive treatment failureHypertension.  66:126-133. 2015
    2015 Small sample performance of bias-corrected sandwich estimators for cluster-randomized trials with binary outcomesStatistics in Medicine.  34:281-296. 2015
    2014 Genetic association analysis of 30 genes related to obesity in a European American populationInternational Journal of Obesity.  38:724-729. 2014
    2013 Endothelial cells overexpressing IL-8 receptor reduce cardiac remodeling and dysfunction following myocardial infarction 2013
    2012 Endothelial cells overexpressing interleukin-8 receptors reduce inflammatory and neointimal responses to arterial injuryCirculation.  125:1533-1541. 2012
    2011 Hypoxia induces downregulation of PPAR-γ in isolated pulmonary arterial smooth muscle cells and in rat lung via transforming growth factor-β signaling 2011
    2011 cGMP inhibits TGF-β signaling by sequestering Smad3 with cytosolic β2-tubulin in pulmonary artery smooth muscle cells 2011
    2011 Transforming growth factor-β inhibits myocardial PPARγ expression in pressure overload-induced cardiac fibrosis and remodeling in miceJournal of Hypertension.  29:1810-1819. 2011
    2010 Inhibition of transforming growth factor-β signaling induces left ventricular dilation and dysfunction in the pressure-overloaded heart 2010
    2008 Atrial natriuretic peptide inhibits transforming growth factor β-induced Smad signaling and myofibroblast transformation in mouse cardiac fibroblastsCirculation Research.  102:185-192. 2008
    2008 Role of matrix metalloproteinase-2 in newborn mouse lungs under hypoxic conditionsPediatric Research.  63:26-32. 2008
    2007 ANP signaling inhibits TGF-β-induced Smad2 and Smad3 nuclear translocation and extracellular matrix expression in rat pulmonary arterial smooth muscle cells 2007
    2007 Endothelin-1 Mediates Hypoxia-Induced Increases in Vascular Collagen in the Newborn Mouse LungPediatric Research.  61:559-564. 2007
    2006 Eplerenone prevents adverse cardiac remodelling induced by pressure overload in atrial natriuretic peptide-null miceClinical and Experimental Pharmacology and Physiology.  33:773-779. 2006
    2006 Atrial natriuretic peptide-dependent modulation of hypoxia-induced pulmonary vascular remodelingLife Sciences.  79:1357-1365. 2006
    2006 Dominant negative mutation of the TGF-β eceptor blocks hypoxia-induced pulmonary vascular remodeling 2006
    2004 Hypoxia-responsive growth factors upregulate periostin and osteopontin expression via distinct signaling pathways in rat pulmonary arterial smooth muscle cells 2004
    2003 Fibroblast growth factor mediates hypoxia-induced endothelin-A receptor expression in lung artery smooth muscle cells 2003
    2003 Effects of pressure overload on extracellular matrix expression in the heart of the atrial natriuretic peptide-null mouseHypertension.  42:88-95. 2003
    2002 Transgenic study of the function of chymase in heart remodelingJournal of Hypertension.  20:2047-2055. 2002
    2002 Time-dependent expression of chymase and angiotensin converting enzyme in the hamser heart under pressure overloadHypertension Research.  25:757-762. 2002
    2001 Function of chymase in the heart angiotensin II formation in transgenic miceChinese Science Bulletin.  46:922-925. 2001
    1997 A new method of screening transgenic animal: PCR and its products sequencing 1997
    1997 Function of the Hydroxyl Radical in Bleomycin A(5)-induced DNA Degradation. 1997
    1996 Preparation and Characterization of Superoxide Dismutase Soluble in Organic Solvents. 1996


    Year Title Altmetric
    2019 Multiple Imputation: A Flexible Tool for Handling Missing Data 2019
    2004 Pulmonary vascular remodeling in pulmonary hypertension: evidence from animal models to man 2004

    Investigator On

  • Race, Natriuretic Peptides and Physiological Perturbations  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2019 - 2024
  • Development of An Early Diagnostic Biomarker and Novel Treatment Strategy for T1D  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2018 - 2022
  • Private Grant  awarded by VARIAN MEDICAL SYSTEMS, INC. 2019 - 2022
  • Private Grant  awarded by NOVOCURE, INC. 2019 - 2022
  • Boosting the Systemic and in Situ CD4+ T-Cell Responses to Malignant Glioma by Oncolytic HSV Virotherapy  awarded by DOD - Department of Defense 2018 - 2021
  • Proprioceptive Mechanisms Underlying Post-Spinal Manipulation Response In An NGF-Induced Low Back Pain Model  awarded by NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH/NIH/DHHS 2019 - 2021
  • O-GlcNAc Regulation of Protein Clearance in the Context of AD and DLB  awarded by National Institute on Aging/NIH/DHHS 2019 - 2021
  • Surveillance Of Military Nurse Outcomes During Corporate Restructuring  awarded by GENEVA FOUNDATION 2019 - 2021
  • A Multidomain Approach to Preventing Dementia in African Americans: Cognitive Prescriptions  awarded by National Institute on Aging/NIH/DHHS 2019 - 2021
  • Fertility Preservation in Women with Cystic Fibrosis Pre-Lung Transplantation  awarded by National Institute of Child Health and Human Development/NIH/DHHS 2019 - 2021
  • Brushing Away Infections  awarded by ALABAMA MEDICAID AGENCY 2020 - 2021
  • Identifying Outcome Mediators of Calorie Restriction Mimetic use in Renal Cancer  awarded by National Cancer Institute/NIH/DHHS 2018 - 2020
  • Brushing Away Infections  awarded by ALABAMA MEDICAID AGENCY 2019 - 2020
  • Early Progressive Feeding in Human Milk-Fed Extremely Preterm Infants: A Randomized Trial  awarded by Gerber Foundation 2016 - 2017
  • Education And Training

  • Doctor of Philosophy in Biostatistics, University of Alabama at Birmingham 2014
  • Master of Science in Biostatistics, University of Alabama at Birmingham 2011
  • Master of Science in Computer Science, University of Alabama at Birmingham 2004
  • Master of Life Sciences in Biochemistry, 1996
  • Full Name

  • Peng Li