Positions

Selected Publications

Academic Article

Year Title Altmetric
2020 Retinal Degeneration Caused by Rod-Specific Dhdds Ablation Occurs without Concomitant Inhibition of Protein N-GlycosylationiScience.  23. 2020
2020 Lack of Overt Retinal Degeneration in a K42E Dhdds Knock-In Mouse Model of RP59Cells.  9. 2020
2020 Selective Ablation of Dehydrodolichyl Diphosphate Synthase in Murine Retinal Pigment Epithelium (RPE) Causes RPE Atrophy and Retinal Degeneration.Cells.  9. 2020
2017 GARP2 accelerates retinal degeneration in rod cGMP-gated cation channel β-subunit knockout miceScientific Reports.  7. 2017
2016 The B3 subunit of the cone cyclic nucleotide-gated channel regulates the light responses of cones and contributes to the channel structural flexibilityJournal of Biological Chemistry.  291:8721-8734. 2016
2016 Role of RDS and rhodopsin in Cngb1-related retinal degenerationInvestigative Ophthalmology and Visual Science.  57:787-797. 2016
2015 Varying the GARP2-to-RDS ratio leads to defects in rim formation and rod and cone functionInvestigative Ophthalmology and Visual Science.  56:8187-8198. 2015
2014 Overexpression of rod photoreceptor glutamic acid rich protein 2 (GARP2) increases gain and slows recovery in mouse retinaCell Communication and Signaling.  12. 2014
2014 Overexpression of rod photoreceptor glutamic acid rich protein 2 (GARP2) increases gain and slows recovery in mouse retinaCell Communication and Signaling.  12. 2014
2013 Dynamic near-infrared imaging reveals transient phototropic change in retinal rod photoreceptorsJournal of Biomedical Optics.  18. 2013
2012 Three-dimensional architecture of the rod sensory cilium and its disruption in retinal neurodegenerationCell.  151:1029-1041. 2012
2012 Investigation of the hyper-reflective inner/outer segment band in optical coherence tomography of living frog retinaJournal of Biomedical Optics.  17. 2012
2012 Comparative intrinsic optical signal imaging of wild-type and mutant mouse retinasOptics Express.  20:7646-7654. 2012
2012 Age-related changes in Cngb1-X1 knockout mice: Prolonged cone survivalDocumenta Ophthalmologica.  124:163-175. 2012
2010 Activation of retinal guanylyl cyclase RetGC1 by GCAP1: Stoichiometry of binding and effect of new LCA-related mutationsBiochemistry.  49:709-717. 2010
2009 Knockout of GARPs and the β-subunit of the rod cGMP-gated channel disrupts disk morphogenesis and rod outer segment structural integrityJournal of Cell Science.  122:1192-1200. 2009
2009 Characterization of a canine model of autosomal recessive retinitis pigmentosa due to a PDE6A mutationInvestigative Ophthalmology and Visual Science.  50:801-813. 2009
2007 Focus on Molecules: Rod photoreceptor cGMP-gated cation channelExperimental Eye Research.  85:173-174. 2007
2007 Focus on Molecules: Rod cGMP Phosphodiesterase Type 6Experimental Eye Research.  84:1-2. 2007
2005 Identifying photoreceptors in blind eyes caused by RPE65 mutations: Prerequisite for human gene therapy success 2005
2004 Characterization of 3′,5′ cyclic nucleotide phosphodiesterase activity in Y79 retinoblastoma cells: Absence of functional PDE6Molecular Vision.  10:738-749. 2004
2004 Functional analysis of the rod photoreceptor cGMP phosphodiesterase α-subunit gene promoter: Nrl and Crx are required for full transcriptional activityJournal of Biological Chemistry.  279:19800-19807. 2004
2002 Electroretinographic abnormalities in parents of patients with leber congenital amaurosis who have heterozygous GUCY2D mutationsJAMA Ophthalmology.  120:1325-1330. 2002
2001 Reproducible high efficiency gene transfer into Y79 retinoblastoma cells using adenofectionJournal of Neuroscience Methods.  106:1-7. 2001
2001 A PDE6A promoter fragment directs transcription predominantly in the photoreceptorBiochemical and Biophysical Research Communications.  282:543-547. 2001
2001 Four novel mutations in the RPE65 gene in patients with Leber congenital amaurosis.Human Mutation.  18:164. 2001
2000 Rapid restoration of visual pigment and function with oral retinoid in a mouse model of childhood blindness 2000
2000 Genomic organization of the human rod photoreceptor cGMP-gated cation channel β-subunit geneGene.  245:311-318. 2000
1998 Structure and upstream region characterization of the human gene encoding rod photoreceptor cGMP phosphodiesterase α-subunitJournal of Molecular Neuroscience.  10:235-250. 1998
1997 Cloning and expression of the glucocorticoid receptor from the squirrel monkey (Saimiri boliviensis boliviensis), a glucocorticoid-resistant primateJournal of Clinical Endocrinology and Metabolism.  82:465-472. 1997
1997 Cloning and expression of the glucocorticoid receptor from the squirrel monkey (Saimiri boliviensis boliviensis), a glucocorticoid-resistant primate.Journal of Clinical Endocrinology and Metabolism.  82:465-472. 1997
1996 Retinal-specific guanylate cyclase gene mutations in Leber's congenital amaurosisNature Genetics.  14:461-464. 1996
1996 Cell-specific expression of the rat secretogranin II promoter.Endocrinology.  137:3815-3822. 1996
1996 Gene structure and chromosome localization to 7q21.3 of the human rod photoreceptor transducin γ-subunit gene (GNGT1)Genomics.  35:241-243. 1996
1996 The β subunit of human rod photoreceptor cGMP-gated cation channel is generated from a complex transcription unitFEBS Letters.  389:213-218. 1996
1996 Cell-specific expression of the rat secretogranin II promoterEndocrinology.  137:3815-3822. 1996
1995 In vivo requirement of protein prenylation for maintenance of retinal cytoarchitecture and photoreceptor structure 1995
1995 cDNA, gene structure, and chromosomal localization of human GAR1 (CNCG3L), a homolog of the third subunit of bovine photoreceptor cGMP-gated channelGenomics.  28:32-38. 1995
1995 Autosomal recessive retinitis pigmentosa caused by mutations in the α subunit of rod cGMP phosphodiesteraseNature Genetics.  11:468-471. 1995
1995 Clyde Edgar Keeler (1900–1994)Experimental Eye Research.  60:3-4. 1995
1995 Lysosomal chitobiase (CTB) and the G-protein γ5 subunit (GNG5) genes co-localize to human chromosome 1p22 1995
1994 Sequence of rho Small GTP-Binding Protein cDNAs From Human Retina and Identification of Novel 5′ End Cloning ArtifactsExperimental Eye Research.  59:235-237. 1994
1994 A yac contig of approximately 3 mb from human chromosome 5q31 → q33Genomics.  19:470-477. 1994
1994 Human retinal guanylate cyclase (GUC2D) maps to chromosome 17p13.1Genomics.  22:478-481. 1994
1993 In vivo biosynthesis of cholesterol in the rat retinaFEBS Letters.  335:234-238. 1993
1993 PCR analysis of DNA from 70-year-old sections of rodless retina demonstrates identity with the mouse rd defect 1993
1993 Irish setter dogs affected with rod/cone dysplasia contain a nonsense mutation in the rod cGMP phosphodiesterase β-subunit gene 1993
1992 Primary structure of frog rhodopsinFEBS Letters.  313:103-108. 1992
1992 INVITRO ISOPRENYLATION AND MEMBRANE ASSOCIATION OF MOUSE ROD PHOTORECEPTOR CGMP PHOSPHODIESTERASE ALPHA-SUBUNIT AND BETA-SUBUNIT EXPRESSED IN BACTERIAJournal of Biological Chemistry.  267:8458-8463. 1992
1992 Primary structure and chromosomal localization of human and mouse rod photoreceptor cGMP-gated cation channelJournal of Biological Chemistry.  267:6257-6262. 1992
1992 Chromosome mapping of the rod photoreceptor cGMP phosphodiesterase β-subunit gene in mouse and human: Tight linkage to the Huntington disease region (4p16.3)Genomics.  12:750-754. 1992
1992 In vitro isoprenylation and membrane association of mouse rod photoreceptor cGMP phosphodiesterase α and β subunits expressed in bacteriaJournal of Biological Chemistry.  267:8458-8463. 1992
1992 Novel morphological changes in rat retina induced by intravitreal injection of lovastatinExperimental Eye Research.  54:149-152. 1992
1992 Syntenic assignments of visual transduction genes in cattleGenomics.  14:699-706. 1992
1991 Identification of a nonsense mutation in the rod photoreceptor cGMP phosphodiesterase β-subunit gene of the rd mouse 1991
1991 Complete cDNA sequences of mouse rod photoreceptor cGMP phosphodiesterase α- and β-subunits, and identification of β′-, a putative β-subunit isozyme produced by alternative splicing of the β-subunit geneFEBS Letters.  278:107-114. 1991
1991 HSV antigens and HSV DNA in avascular and vascularized lesions of human herpes simplex keratitisCurrent Eye Research.  10:63-68. 1991
1991 The molecular genetics of retinal photoreceptor proteins involved in cGMP metabolism.Progress in clinical and biological research.  362:33-66. 1991
1990 Mouse opsin. Gene structure and molecular basis of multiple transcriptsJournal of Biological Chemistry.  265:20563-20569. 1990
1990 Molecular characterization of human and bovine rod photoreceptor cGMP phosphodiesterase α-subunit and chromosomal localization of the human geneGenomics.  6:272-283. 1990
1987 A new family of the poly-deoxyadenylated class of Drosophila transposable elements identified by a representative member at the dunce locus 1987
1987 An interchromosomal gene conversion of the Drosophila dunce locus identified with restriction site polymorphisms: A potential involvement of transposable elements in gene conversion 1987
1985 In vitro synthesis of rat brain hexokinase 1985

Principal Investigator On

  • Development and Characterization of Mouse Models of RP59 DHDDS Deficiency  awarded by National Eye Institute/NIH/DHHS 2018 - 2022
  • UAB Vision Science Research Center - Mole/Cell Core  awarded by National Eye Institute/NIH/DHHS 2018 - 2021
  • Analysis of Retina Rod Photoreceptor GARP and cGMP-Gated Channel  awarded by NIH - National Institutes of Health/DHHS 2019 - 2020
  • Private Grant  awarded by PTC THERAPEUTICS, INC. 2015 - 2019
  • Analysis of Retina Rod Photoreceptor GARP and cGMP-Gated Channel  awarded by National Eye Institute/NIH/DHHS 2013 - 2018
  • UAB Vision Science Research Center  awarded by National Eye Institute/NIH/DHHS 2016 - 2018
  • UAB Vision Science Research Center - Admin-Core  awarded by National Eye Institute/NIH/DHHS 2016 - 2018
  • UAB Vision Science Research Center - Biostatistical Analysis Core  awarded by National Eye Institute/NIH/DHHS 2016 - 2018
  • UAB Vision Science Research Center - Mole/Cell Core  awarded by National Eye Institute/NIH/DHHS 2016 - 2018
  • Vision Science Research Center  awarded by National Eye Institute/NIH/DHHS 2010 - 2016
  • Vision Science Research Center P30 Core Grant - Administrative Core  awarded by National Eye Institute/NIH/DHHS 2010 - 2016
  • Vision Science Research Center P30 Core Grant - Molecular & Cellular Analysis  awarded by National Eye Institute/NIH/DHHS 2010 - 2016
  • Analysis of Retina Rod Photoreceptor GARP and cGMP-Gated Cation Channel  awarded by National Eye Institute/NIH/DHHS 2008 - 2012
  • Development of a Novel Drug-Based Molecular Therapy for A Class of Hereditary Retinal Degeneration  awarded by EyeSight Foundation of Alabama 2007 - 2011
  • Noninvasive Visualization and Analysis of Organ Systems Using OCT and Digital Fundus Photography  awarded by National Center for Research Resources/NIH/DHHS 2009 - 2010
  • Teaching Activities

  • VIS702 - Techniques in Vision Science (Fall Term 2019) 2019
  • VS113 - Biochemistry of the Eye (Fall Term 2019) 2019
  • VIS745 - Biology/Patholgy Posterior Seg (Spring Term 2019) 2019
  • VS113 - Biochemistry of the Eye (Fall Term 2018) 2018
  • VIS745 - Biology/Patholgy Posterior Seg (Spring Term 2018) 2018
  • VIS745 - Biology/Patholgy Posterior Seg (Spring Term 2017) 2017
  • VIS745 - Biology/Patholgy Posterior Seg (Spring Term 2016) 2016
  • VS113 - Biochemistry of the Eye (Fall Term 2015) 2015
  • VIS745 - Biology/Patholgy Posterior Seg (Spring Term 2015) 2015
  • VS113 - Biochemistry of the Eye (Fall Term 2014) 2014
  • VIS745 - Biology/Patholgy Posterior Seg (Spring Term 2014) 2014
  • VS113 - Biochemistry of the Eye (Fall Term 2013) 2013
  • VIS745 - Biology/Patholgy Posterior Seg (Spring Term 2013) 2013
  • VS113 - Biochemistry of the Eye (Fall Term 2012) 2012
  • VIS745 - Ocular Anat: Physio/Biochem II (Spring Term 2012) 2012
  • VS121 - Biochemistry of the Eye (Fall Term 2011) 2011
  • OBHS111 - Fundamentals of Dent and Opt I (Fall Term 2011) 2011
  • VIS745 - Ocular Anat: Physio/Biochem II (Fall Term 2010) 2010
  • OBHS111 - Fundamentals of Dent and Opt I (Fall Term 2010) 2010
  • VIS745 - Ocular Anat: Physio/Biochem II (Fall Term 2009) 2009
  • OBHS111 - Fundamentals of Dent and Opt I (Fall Term 2009) 2009
  • OPVS111 - Basic Science/Clinical Opt I (Fall Term 2009) 2009
  • VIS745 - Ocular Anat: Physio/Biochem II (Fall Term 2008) 2008
  • OBHS111 - Fundamentals of Dent and Opt I (Fall Term 2008) 2008
  • VIS745 - Ocular Anat: Physio/Biochem II (Fall Term 2007) 2007
  • Education And Training

  • Doctor of Philosophy in Biochemistry, Michigan State University 1989
  • Full Name

  • Steven Pittler