Steven Pittler

Steven Pittler
Professor of Vision Sciences

Senior Scientist (C), Comprehensive Arthritis, Musculoskeletal, Bone and Autoimmunity Center (CAMBAC) , School of Medicine
Professor (S), Ophthalmology , School of Medicine
Senior Scientist (C), Center for Clinical and Translational Science (CCTS) , General Clinical Research Center
Scientist (C), Comprehensive Neuroscience Center , General Clinical Research Center
Senior Scientist (C), Center for Biophysical Sciences and Engineering (CBSE) , School of Optometry
Professor (P), Dept of Optometry & Vision Science , School of Optometry
Senior Scientist (C), Vision Science Research Center , Dept of Optometry & Vision Science

Selected Publications

Academic Article

Year	Title	Altmetric
2022	Vertebrate Animal Models of RP59: Current Status and Future Prospects. International Journal of Molecular Sciences. 23. 2022
2020	Retinal Degeneration Caused by Rod-Specific Dhdds Ablation Occurs without Concomitant Inhibition of Protein N-Glycosylation. iScience. 23. 2020
2020	Lack of Overt Retinal Degeneration in a K42E Dhdds Knock-In Mouse Model of RP59. Cells. 9. 2020
2020	Selective Ablation of Dehydrodolichyl Diphosphate Synthase in Murine Retinal Pigment Epithelium (RPE) Causes RPE Atrophy and Retinal Degeneration. Cells. 9. 2020
2017	GARP2 accelerates retinal degeneration in rod cGMP-gated cation channel β-subunit knockout mice. Scientific Reports. 7. 2017
2016	The B3 subunit of the cone cyclic nucleotide-gated channel regulates the light responses of cones and contributes to the channel structural flexibility. Journal of Biological Chemistry. 291:8721-8734. 2016
2016	Role of RDS and rhodopsin in Cngb1-related retinal degeneration 2016
2015	Varying the GARP2-to-RDS ratio leads to defects in rim formation and rod and cone function 2015
2014	Overexpression of rod photoreceptor glutamic acid rich protein 2 (GARP2) increases gain and slows recovery in mouse retina. Cell Communication and Signaling. 12. 2014
2014	Overexpression of rod photoreceptor glutamic acid rich protein 2 (GARP2) increases gain and slows recovery in mouse retina. Cell Communication and Signaling. 12. 2014
2013	Dynamic near-infrared imaging reveals transient phototropic change in retinal rod photoreceptors. Journal of Biomedical Optics. 18. 2013
2012	Three-dimensional architecture of the rod sensory cilium and its disruption in retinal neurodegeneration. Cell. 151:1029-1041. 2012
2012	Age-related changes in Cngb1-X1 knockout mice: Prolonged cone survival. Documenta Ophthalmologica. 124:163-175. 2012
2012	Investigation of the hyper-reflective inner/outer segment band in optical coherence tomography of living frog retina. Journal of Biomedical Optics. 17. 2012
2012	Comparative intrinsic optical signal imaging of wild-type and mutant mouse retinas. Optics Express. 20:7646-7654. 2012
2010	Activation of retinal guanylyl cyclase RetGC1 by GCAP1: Stoichiometry of binding and effect of new LCA-related mutations. Biochemistry. 49:709-717. 2010
2009	Knockout of GARPs and the β-subunit of the rod cGMP-gated channel disrupts disk morphogenesis and rod outer segment structural integrity. Journal of Cell Science. 122:1192-1200. 2009
2009	Characterization of a canine model of autosomal recessive retinitis pigmentosa due to a PDE6A mutation 2009
2007	Focus on Molecules: Rod photoreceptor cGMP-gated cation channel. Experimental Eye Research. 85:173-174. 2007
2007	Focus on Molecules: Rod cGMP Phosphodiesterase Type 6. Experimental Eye Research. 84:1-2. 2007
2005	Identifying photoreceptors in blind eyes caused by RPE65 mutations: Prerequisite for human gene therapy success 2005
2004	Characterization of 3′,5′ cyclic nucleotide phosphodiesterase activity in Y79 retinoblastoma cells: Absence of functional PDE6. Molecular Vision. 10:738-749. 2004
2004	Functional analysis of the rod photoreceptor cGMP phosphodiesterase α-subunit gene promoter: Nrl and Crx are required for full transcriptional activity. Journal of Biological Chemistry. 279:19800-19807. 2004
2002	Electroretinographic abnormalities in parents of patients with leber congenital amaurosis who have heterozygous GUCY2D mutations. JAMA Ophthalmology. 120:1325-1330. 2002
2001	Reproducible high efficiency gene transfer into Y79 retinoblastoma cells using adenofection. Journal of Neuroscience Methods. 106:1-7. 2001
2001	A PDE6A promoter fragment directs transcription predominantly in the photoreceptor. Biochemical and Biophysical Research Communications. 282:543-547. 2001
2001	Four novel mutations in the RPE65 gene in patients with Leber congenital amaurosis.. Human Mutation. 18:164. 2001
2000	Rapid restoration of visual pigment and function with oral retinoid in a mouse model of childhood blindness 2000
2000	Genomic organization of the human rod photoreceptor cGMP-gated cation channel β-subunit gene. Gene. 245:311-318. 2000
1998	Structure and upstream region characterization of the human gene encoding rod photoreceptor cGMP phosphodiesterase α-subunit. Journal of Molecular Neuroscience. 10:235-250. 1998
1997	Cloning and expression of the glucocorticoid receptor from the squirrel monkey (Saimiri boliviensis boliviensis), a glucocorticoid-resistant primate. Journal of Clinical Endocrinology and Metabolism. 82:465-472. 1997
1997	Cloning and expression of the glucocorticoid receptor from the squirrel monkey (Saimiri boliviensis boliviensis), a glucocorticoid-resistant primate.. Journal of Clinical Endocrinology and Metabolism. 82:465-472. 1997
1996	Retinal-specific guanylate cyclase gene mutations in Leber's congenital amaurosis. Nature Genetics. 14:461-464. 1996
1996	Cell-specific expression of the rat secretogranin II promoter.. Endocrinology. 137:3815-3822. 1996
1996	Gene structure and chromosome localization to 7q21.3 of the human rod photoreceptor transducin γ-subunit gene (GNGT1). Genomics. 35:241-243. 1996
1996	The β subunit of human rod photoreceptor cGMP-gated cation channel is generated from a complex transcription unit. FEBS Letters. 389:213-218. 1996
1996	Cell-specific expression of the rat secretogranin II promoter 1996
1995	In vivo requirement of protein prenylation for maintenance of retinal cytoarchitecture and photoreceptor structure 1995
1995	cDNA, gene structure, and chromosomal localization of human GAR1 (CNCG3L), a homolog of the third subunit of bovine photoreceptor cGMP-gated channel. Genomics. 28:32-38. 1995
1995	Autosomal recessive retinitis pigmentosa caused by mutations in the α subunit of rod cGMP phosphodiesterase. Nature Genetics. 11:468-471. 1995
1995	Clyde Edgar Keeler (1900–1994). Experimental Eye Research. 60:3-4. 1995
1995	Lysosomal chitobiase (CTB) and the G-protein γ5 subunit (GNG5) genes co-localize to human chromosome 1p22. Cytogenetic and Genome Research. 71:44-46. 1995
1994	Sequence of rho Small GTP-Binding Protein cDNAs From Human Retina and Identification of Novel 5′ End Cloning Artifacts. Experimental Eye Research. 59:235-237. 1994
1994	A yac contig of approximately 3 mb from human chromosome 5q31 → q33. Genomics. 19:470-477. 1994
1994	Human retinal guanylate cyclase (GUC2D) maps to chromosome 17p13.1. Genomics. 22:478-481. 1994
1993	In vivo biosynthesis of cholesterol in the rat retina. FEBS Letters. 335:234-238. 1993
1993	PCR analysis of DNA from 70-year-old sections of rodless retina demonstrates identity with the mouse rd defect 1993
1993	Irish setter dogs affected with rod/cone dysplasia contain a nonsense mutation in the rod cGMP phosphodiesterase β-subunit gene 1993
1992	Primary structure of frog rhodopsin. FEBS Letters. 313:103-108. 1992
1992	INVITRO ISOPRENYLATION AND MEMBRANE ASSOCIATION OF MOUSE ROD PHOTORECEPTOR CGMP PHOSPHODIESTERASE ALPHA-SUBUNIT AND BETA-SUBUNIT EXPRESSED IN BACTERIA. Journal of Biological Chemistry. 267:8458-8463. 1992
1992	Primary structure and chromosomal localization of human and mouse rod photoreceptor cGMP-gated cation channel. Journal of Biological Chemistry. 267:6257-6262. 1992
1992	Chromosome mapping of the rod photoreceptor cGMP phosphodiesterase β-subunit gene in mouse and human: Tight linkage to the Huntington disease region (4p16.3). Genomics. 12:750-754. 1992
1992	In vitro isoprenylation and membrane association of mouse rod photoreceptor cGMP phosphodiesterase α and β subunits expressed in bacteria. Journal of Biological Chemistry. 267:8458-8463. 1992
1992	Novel morphological changes in rat retina induced by intravitreal injection of lovastatin. Experimental Eye Research. 54:149-152. 1992
1992	Syntenic assignments of visual transduction genes in cattle. Genomics. 14:699-706. 1992
1991	Identification of a nonsense mutation in the rod photoreceptor cGMP phosphodiesterase β-subunit gene of the rd mouse 1991
1991	Complete cDNA sequences of mouse rod photoreceptor cGMP phosphodiesterase α- and β-subunits, and identification of β′-, a putative β-subunit isozyme produced by alternative splicing of the β-subunit gene. FEBS Letters. 278:107-114. 1991
1991	HSV antigens and HSV DNA in avascular and vascularized lesions of human herpes simplex keratitis. Current Eye Research. 10:63-68. 1991
1991	The molecular genetics of retinal photoreceptor proteins involved in cGMP metabolism.. Progress in clinical and biological research. 362:33-66. 1991
1990	Mouse opsin. Gene structure and molecular basis of multiple transcripts. Journal of Biological Chemistry. 265:20563-20569. 1990
1990	Molecular characterization of human and bovine rod photoreceptor cGMP phosphodiesterase α-subunit and chromosomal localization of the human gene. Genomics. 6:272-283. 1990
1987	A new family of the poly-deoxyadenylated class of Drosophila transposable elements identified by a representative member at the dunce locus 1987
1987	An interchromosomal gene conversion of the Drosophila dunce locus identified with restriction site polymorphisms: A potential involvement of transposable elements in gene conversion 1987
1985	In vitro synthesis of rat brain hexokinase 1985