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Steven Pittler
Professor of Vision Sciences
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E-mail
pittler@uab.edu
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Co-investigator Network
Steven Pittler
Professor of Vision Sciences
Positions
Senior Scientist (C)
,
Comprehensive Arthritis, Musculoskeletal, Bone and Autoimmunity Center (CAMBAC)
,
School of Medicine
Professor (S)
,
Ophthalmology
,
School of Medicine
Senior Scientist (C)
,
Center for Clinical and Translational Science (CCTS)
,
General Clinical Research Center
Scientist (C)
,
Comprehensive Neuroscience Center
,
General Clinical Research Center
Senior Scientist (C)
,
Center for Biophysical Sciences and Engineering (CBSE)
,
School of Optometry
Professor (P)
,
Dept of Optometry & Vision Science
,
School of Optometry
Senior Scientist (C)
,
Vision Science Research Center
,
Dept of Optometry & Vision Science
Publications
Research
Teaching
Background
Contact
Publications
Selected Publications
Academic Article
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Year
Title
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2022
Vertebrate Animal Models of RP59: Current Status and Future Prospects
.
International Journal of Molecular Sciences
. 23.
2022
2020
Retinal Degeneration Caused by Rod-Specific Dhdds Ablation Occurs without Concomitant Inhibition of Protein N-Glycosylation
.
iScience
. 23.
2020
2020
Lack of Overt Retinal Degeneration in a K42E Dhdds Knock-In Mouse Model of RP59
.
Cells
. 9.
2020
2020
Selective Ablation of Dehydrodolichyl Diphosphate Synthase in Murine Retinal Pigment Epithelium (RPE) Causes RPE Atrophy and Retinal Degeneration
.
Cells
. 9.
2020
2017
GARP2 accelerates retinal degeneration in rod cGMP-gated cation channel β-subunit knockout mice
.
Scientific Reports
. 7.
2017
2016
The B3 subunit of the cone cyclic nucleotide-gated channel regulates the light responses of cones and contributes to the channel structural flexibility
.
Journal of Biological Chemistry
. 291:8721-8734.
2016
2016
Role of RDS and rhodopsin in Cngb1-related retinal degeneration
2016
2015
Varying the GARP2-to-RDS ratio leads to defects in rim formation and rod and cone function
2015
2014
Overexpression of rod photoreceptor glutamic acid rich protein 2 (GARP2) increases gain and slows recovery in mouse retina
.
Cell Communication and Signaling
. 12.
2014
2014
Overexpression of rod photoreceptor glutamic acid rich protein 2 (GARP2) increases gain and slows recovery in mouse retina
.
Cell Communication and Signaling
. 12.
2014
2013
Dynamic near-infrared imaging reveals transient phototropic change in retinal rod photoreceptors
.
Journal of Biomedical Optics
. 18.
2013
2012
Three-dimensional architecture of the rod sensory cilium and its disruption in retinal neurodegeneration
.
Cell
. 151:1029-1041.
2012
2012
Age-related changes in Cngb1-X1 knockout mice: Prolonged cone survival
.
Documenta Ophthalmologica
. 124:163-175.
2012
2012
Investigation of the hyper-reflective inner/outer segment band in optical coherence tomography of living frog retina
.
Journal of Biomedical Optics
. 17.
2012
2012
Comparative intrinsic optical signal imaging of wild-type and mutant mouse retinas
.
Optics Express
. 20:7646-7654.
2012
2010
Activation of retinal guanylyl cyclase RetGC1 by GCAP1: Stoichiometry of binding and effect of new LCA-related mutations
.
Biochemistry
. 49:709-717.
2010
2009
Knockout of GARPs and the β-subunit of the rod cGMP-gated channel disrupts disk morphogenesis and rod outer segment structural integrity
.
Journal of Cell Science
. 122:1192-1200.
2009
2009
Characterization of a canine model of autosomal recessive retinitis pigmentosa due to a PDE6A mutation
2009
2007
Focus on Molecules: Rod photoreceptor cGMP-gated cation channel
.
Experimental Eye Research
. 85:173-174.
2007
2007
Focus on Molecules: Rod cGMP Phosphodiesterase Type 6
.
Experimental Eye Research
. 84:1-2.
2007
2005
Identifying photoreceptors in blind eyes caused by RPE65 mutations: Prerequisite for human gene therapy success
2005
2004
Characterization of 3′,5′ cyclic nucleotide phosphodiesterase activity in Y79 retinoblastoma cells: Absence of functional PDE6
.
Molecular Vision
. 10:738-749.
2004
2004
Functional analysis of the rod photoreceptor cGMP phosphodiesterase α-subunit gene promoter: Nrl and Crx are required for full transcriptional activity
.
Journal of Biological Chemistry
. 279:19800-19807.
2004
2002
Electroretinographic abnormalities in parents of patients with leber congenital amaurosis who have heterozygous GUCY2D mutations
.
JAMA Ophthalmology
. 120:1325-1330.
2002
2001
Reproducible high efficiency gene transfer into Y79 retinoblastoma cells using adenofection
.
Journal of Neuroscience Methods
. 106:1-7.
2001
2001
A PDE6A promoter fragment directs transcription predominantly in the photoreceptor
.
Biochemical and Biophysical Research Communications
. 282:543-547.
2001
2001
Four novel mutations in the RPE65 gene in patients with Leber congenital amaurosis.
.
Human Mutation
. 18:164.
2001
2000
Rapid restoration of visual pigment and function with oral retinoid in a mouse model of childhood blindness
2000
2000
Genomic organization of the human rod photoreceptor cGMP-gated cation channel β-subunit gene
.
Gene
. 245:311-318.
2000
1998
Structure and upstream region characterization of the human gene encoding rod photoreceptor cGMP phosphodiesterase α-subunit
.
Journal of Molecular Neuroscience
. 10:235-250.
1998
1997
Cloning and expression of the glucocorticoid receptor from the squirrel monkey (Saimiri boliviensis boliviensis), a glucocorticoid-resistant primate
.
Journal of Clinical Endocrinology and Metabolism
. 82:465-472.
1997
1997
Cloning and expression of the glucocorticoid receptor from the squirrel monkey (Saimiri boliviensis boliviensis), a glucocorticoid-resistant primate.
.
Journal of Clinical Endocrinology and Metabolism
. 82:465-472.
1997
1996
Retinal-specific guanylate cyclase gene mutations in Leber's congenital amaurosis
.
Nature Genetics
. 14:461-464.
1996
1996
Cell-specific expression of the rat secretogranin II promoter.
.
Endocrinology
. 137:3815-3822.
1996
1996
Gene structure and chromosome localization to 7q21.3 of the human rod photoreceptor transducin γ-subunit gene (GNGT1)
.
Genomics
. 35:241-243.
1996
1996
The β subunit of human rod photoreceptor cGMP-gated cation channel is generated from a complex transcription unit
.
FEBS Letters
. 389:213-218.
1996
1996
Cell-specific expression of the rat secretogranin II promoter
1996
1995
In vivo requirement of protein prenylation for maintenance of retinal cytoarchitecture and photoreceptor structure
1995
1995
cDNA, gene structure, and chromosomal localization of human GAR1 (CNCG3L), a homolog of the third subunit of bovine photoreceptor cGMP-gated channel
.
Genomics
. 28:32-38.
1995
1995
Autosomal recessive retinitis pigmentosa caused by mutations in the α subunit of rod cGMP phosphodiesterase
.
Nature Genetics
. 11:468-471.
1995
1995
Clyde Edgar Keeler (1900–1994)
.
Experimental Eye Research
. 60:3-4.
1995
1995
Lysosomal chitobiase (CTB) and the G-protein γ
5
subunit (GNG5) genes co-localize to human chromosome 1p22
.
Cytogenetic and Genome Research
. 71:44-46.
1995
1994
Sequence of rho Small GTP-Binding Protein cDNAs From Human Retina and Identification of Novel 5′ End Cloning Artifacts
.
Experimental Eye Research
. 59:235-237.
1994
1994
A yac contig of approximately 3 mb from human chromosome 5q31 → q33
.
Genomics
. 19:470-477.
1994
1994
Human retinal guanylate cyclase (GUC2D) maps to chromosome 17p13.1
.
Genomics
. 22:478-481.
1994
1993
In vivo biosynthesis of cholesterol in the rat retina
.
FEBS Letters
. 335:234-238.
1993
1993
PCR analysis of DNA from 70-year-old sections of rodless retina demonstrates identity with the mouse rd defect
1993
1993
Irish setter dogs affected with rod/cone dysplasia contain a nonsense mutation in the rod cGMP phosphodiesterase β-subunit gene
1993
1992
Primary structure of frog rhodopsin
.
FEBS Letters
. 313:103-108.
1992
1992
INVITRO ISOPRENYLATION AND MEMBRANE ASSOCIATION OF MOUSE ROD PHOTORECEPTOR CGMP PHOSPHODIESTERASE ALPHA-SUBUNIT AND BETA-SUBUNIT EXPRESSED IN BACTERIA
.
Journal of Biological Chemistry
. 267:8458-8463.
1992
1992
Primary structure and chromosomal localization of human and mouse rod photoreceptor cGMP-gated cation channel
.
Journal of Biological Chemistry
. 267:6257-6262.
1992
1992
Chromosome mapping of the rod photoreceptor cGMP phosphodiesterase β-subunit gene in mouse and human: Tight linkage to the Huntington disease region (4p16.3)
.
Genomics
. 12:750-754.
1992
1992
In vitro isoprenylation and membrane association of mouse rod photoreceptor cGMP phosphodiesterase α and β subunits expressed in bacteria
.
Journal of Biological Chemistry
. 267:8458-8463.
1992
1992
Novel morphological changes in rat retina induced by intravitreal injection of lovastatin
.
Experimental Eye Research
. 54:149-152.
1992
1992
Syntenic assignments of visual transduction genes in cattle
.
Genomics
. 14:699-706.
1992
1991
Identification of a nonsense mutation in the rod photoreceptor cGMP phosphodiesterase β-subunit gene of the rd mouse
1991
1991
Complete cDNA sequences of mouse rod photoreceptor cGMP phosphodiesterase α- and β-subunits, and identification of β′-, a putative β-subunit isozyme produced by alternative splicing of the β-subunit gene
.
FEBS Letters
. 278:107-114.
1991
1991
HSV antigens and HSV DNA in avascular and vascularized lesions of human herpes simplex keratitis
.
Current Eye Research
. 10:63-68.
1991
1991
The molecular genetics of retinal photoreceptor proteins involved in cGMP metabolism.
.
Progress in clinical and biological research
. 362:33-66.
1991
1990
Mouse opsin. Gene structure and molecular basis of multiple transcripts
.
Journal of Biological Chemistry
. 265:20563-20569.
1990
1990
Molecular characterization of human and bovine rod photoreceptor cGMP phosphodiesterase α-subunit and chromosomal localization of the human gene
.
Genomics
. 6:272-283.
1990
1987
A new family of the poly-deoxyadenylated class of Drosophila transposable elements identified by a representative member at the dunce locus
1987
1987
An interchromosomal gene conversion of the Drosophila dunce locus identified with restriction site polymorphisms: A potential involvement of transposable elements in gene conversion
1987
1985
In vitro synthesis of rat brain hexokinase
1985
Research
Principal Investigator On
Adult Eye Care in the Black Belt of Alabama Counties of Lowndes, Autauga, Montgomery, Bullock, and Elmore
awarded by
MID-SOUTH RESOURCE CONSERVATION AND DEVELOPMENT COUNCIL
Analysis of Retina Rod Photoreceptor GARP and cGMP-Gated Cation Channel
awarded by
National Eye Institute/NIH/DHHS
Analysis of Retina Rod Photoreceptor GARP and cGMP-Gated Channel
awarded by
National Eye Institute/NIH/DHHS
Analysis of Retina Rod Photoreceptor GARP and cGMP-Gated Channel
awarded by
NIH - National Institutes of Health/DHHS
Characterization of DHDDS RP59 Knockin Models of Retinitis Pigmentosa
awarded by
National Eye Institute/NIH/DHHS
Development and Characterization of Mouse Models of RP59 DHDDS Deficiency
awarded by
National Eye Institute/NIH/DHHS
Development of a Novel Drug-Based Molecular Therapy for A Class of Hereditary Retinal Degeneration
awarded by
EyeSight Foundation of Alabama ^
Noninvasive Visualization and Analysis of Organ Systems Using OCT and Digital Fundus Photography
awarded by
National Center for Research Resources/NIH/DHHS
Private Grant
awarded by
PTC THERAPEUTICS, INC.
UAB Core Grant for Vision Research - Molecular & Cellular Analysis Core
awarded by
National Eye Institute/NIH/DHHS
UAB Vision Science Research Center
awarded by
National Eye Institute/NIH/DHHS
UAB Vision Science Research Center - Admin-Core
awarded by
National Eye Institute/NIH/DHHS
UAB Vision Science Research Center - Biostatistical Analysis Core
awarded by
National Eye Institute/NIH/DHHS
UAB Vision Science Research Center - Mole/Cell Core
awarded by
National Eye Institute/NIH/DHHS
UAB Vision Science Research Center - Mole/Cell Core
awarded by
National Eye Institute/NIH/DHHS
Vision Science Research Center
awarded by
National Eye Institute/NIH/DHHS
Vision Science Research Center P30 Core Grant - Administrative Core
awarded by
National Eye Institute/NIH/DHHS
Vision Science Research Center P30 Core Grant - Molecular & Cellular Analysis
awarded by
National Eye Institute/NIH/DHHS
Investigator On
Functional Imaging of Retinal Photoreceptors
awarded by
National Eye Institute/NIH/DHHS
Training Program in the Neurobiology of Cognition and Cognitive Disorders
awarded by
National Institute of Neurological Disorders and Stroke/NIH/DHHS
UAB Core Grant for Vision Research
awarded by
National Eye Institute/NIH/DHHS
UAB Vision Science Research Center
awarded by
National Eye Institute/NIH/DHHS
UAB Vision Science Research Center
awarded by
National Eye Institute/NIH/DHHS
Teaching
Teaching Activities
OBHS111 - Fundamentals of Dent and Opt I (Fall Term 2008)
OBHS111 - Fundamentals of Dent and Opt I (Fall Term 2009)
OBHS111 - Fundamentals of Dent and Opt I (Fall Term 2010)
OBHS111 - Fundamentals of Dent and Opt I (Fall Term 2011)
OPVS111 - Basic Science/Clinical Opt I (Fall Term 2009)
VIS702 - Techniques in Vision Science (Fall Term 2019)
VIS702 - Techniques in Vision Science (Fall Term 2021)
VIS702 - Techniques in Vision Science (Fall Term 2022)
VIS745 - Biology/Patholgy Posterior Seg (Spring Term 2013)
VIS745 - Biology/Patholgy Posterior Seg (Spring Term 2014)
VIS745 - Biology/Patholgy Posterior Seg (Spring Term 2015)
VIS745 - Biology/Patholgy Posterior Seg (Spring Term 2016)
VIS745 - Biology/Patholgy Posterior Seg (Spring Term 2017)
VIS745 - Biology/Patholgy Posterior Seg (Spring Term 2018)
VIS745 - Biology/Patholgy Posterior Seg (Spring Term 2019)
VIS745 - Ocular Anat: Physio/Biochem II (Fall Term 2007)
VIS745 - Ocular Anat: Physio/Biochem II (Fall Term 2008)
VIS745 - Ocular Anat: Physio/Biochem II (Fall Term 2009)
VIS745 - Ocular Anat: Physio/Biochem II (Fall Term 2010)
VIS745 - Ocular Anat: Physio/Biochem II (Spring Term 2012)
VS113 - Biochemistry of the Eye (Fall Term 2012)
VS113 - Biochemistry of the Eye (Fall Term 2013)
VS113 - Biochemistry of the Eye (Fall Term 2014)
VS113 - Biochemistry of the Eye (Fall Term 2015)
VS113 - Biochemistry of the Eye (Fall Term 2018)
VS113 - Biochemistry of the Eye (Fall Term 2019)
VS113 - Biochemistry of the Eye (Fall Term 2020)
VS113 - Biochemistry of the Eye (Fall Term 2021)
VS113 - Biochemistry of the Eye (Fall Term 2022)
VS121 - Biochemistry of the Eye (Fall Term 2011)
Background
Education And Training
Doctor of Philosophy in Biochemistry,
Michigan State University
1989
Contact
Full Name
Steven
Pittler