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Ping Zhang
Professor
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E-mail
pingz@uab.edu
Phone
205-996-9803
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Co-investigator Network
Ping Zhang
Professor
Positions
Senior Scientist (C)
,
UAB Immunology Institute
,
School of Medicine
Senior Scientist (C)
,
UWIRC Microbiome Center
,
School of Medicine
Scientist (C)
,
Comprehensive Arthritis, Musculoskeletal, Bone and Autoimmunity Center (CAMBAC)
,
School of Medicine
Senior Scientist (C)
,
Center for Clinical and Translational Science (CCTS)
,
General Clinical Research Center
Senior Scientist (C)
,
Neurodegeneration and Experimental Therapeutics (CNET)
,
Neurology
Scientist (C)
,
Global Center for Craniofacial, Oral and Dental Disorders (GC-CODED)
,
School of Dentistry
Professor (P)
,
Pediatric Dentistry
,
School of Dentistry
Director/ Pediatric Dental Research
,
Pediatric Dentistry
,
School of Dentistry
Senior Scientist (C)
,
Civitan International Research Center
,
Academic Joint Departments
Publications
Research
Teaching
Background
Contact
Publications
Selected Publications
Academic Article
Filter
Year
Title
Altmetric
2022
Evaluation of C-shaped canals in maxillary molars in a Chinese population using CBCT
.
BMC Medical Imaging
. 22.
2022
2022
Structure-Activity Relationship Study of Momordica Saponin II Derivatives as Vaccine Adjuvants
.
Journal of Medicinal Chemistry
. 65:14589-14598.
2022
2022
Role of chromatin modulator Dpy30 in osteoclast differentiation and function
.
Bone
. 159.
2022
2022
Periodontal Infection Aggravates C1q-Mediated Microglial Activation and Synapse Pruning in Alzheimer’s Mice
.
Frontiers in Immunology
. 13.
2022
2022
Transcriptome analysis of differentially expressed genes involved in the inflammageing status of gingiva in aged mice
.
Oral Diseases
.
2022
2021
Age-related expansion and increased osteoclastogenic potential of myeloid-derived suppressor cells
.
Molecular Immunology
. 137:187-200.
2021
2020
Impact of C28 Oligosaccharide on Adjuvant Activity of QS-7 Analogues
.
Journal of Organic Chemistry
. 85:15837-15848.
2020
2020
Frontline Science: Characterization and regulation of osteoclast precursors following chronic Porphyromonas gingivalis infection
.
Journal of Leukocyte Biology
. 108:1037-1050.
2020
2020
Enhanced dual function of osteoclast precursors following calvarial Porphyromonas gingivalis infection
.
Journal of Periodontal Research
. 55:410-425.
2020
2020
Structural Effect on Adjuvanticity of Saponins
.
Journal of Medicinal Chemistry
. 63:3290-3297.
2020
2020
Pulp–dentin tissue healing response: A discussion of current biomedical approaches
.
Journal of Clinical Medicine
. 9.
2020
2019
Vaccine Adjuvants Derivatized from Momordica Saponins i and II
.
Journal of Medicinal Chemistry
. 62:9976-9982.
2019
2019
Specific RANK Cytoplasmic Motifs Drive Osteoclastogenesis
.
Journal of Bone and Mineral Research
. 34:1938-1951.
2019
2019
Synthesis and Evaluation of QS-7-Based Vaccine Adjuvants
.
ACS Infectious Diseases
. 5:974-981.
2019
2019
Synthesis and Evaluation of a QS-17/18-Based Vaccine Adjuvant
.
Journal of Medicinal Chemistry
. 62:1669-1676.
2019
2018
Phosphatidylinositol 3-Kinase/Akt signal pathway resists the apoptosis and inflammation in human extravillous trophoblasts induced by Porphyromonas gingivalis
.
Molecular Immunology
. 104:100-107.
2018
2018
Periodontal infection with Porphyromonas gingivalis induces preterm birth and lower birth weight in rats
.
Molecular Oral Microbiology
. 33:312-321.
2018
2017
Phenotype and function of myeloidderived suppressor cells induced by Porphyromonas gingivalis infection
.
Infection and Immunity
. 85.
2017
2016
Synthesis and Evaluation of QS-21-Based Immunoadjuvants with a Terminal-Functionalized Side Chain Incorporated in the West Wing Trisaccharide
.
Journal of Organic Chemistry
. 81:9560-9566.
2016
2016
Effects of 1,25-dihydroxyvitamin D
3
on macrophage cytokine secretion stimulated by Porphyromonas gingivalis
.
Japanese Journal of Infectious Diseases
. 69:482-487.
2016
2015
IL-1R/TLR2 through MyD88 divergently modulates osteoclastogenesis through regulation of nuclear factor of activated T cells c1 (NFATc1) and B lymphocyte-induced maturation protein-1 (Blimp1)
.
Journal of Biological Chemistry
. 290:30163-30174.
2015
2015
Comparison of immunological and microbiological characteristics in children and the elderly with or without dental caries
.
European Journal of Oral Sciences
. 123:80-87.
2015
2015
Extensive description and comparison of human supra-gingival microbiome in root caries and health
.
PLoS One
. 10.
2015
2013
Role of mTOR downstream effector signaling molecules in Francisella tularensis internalization by murine macrophages
.
PLoS One
. 8.
2013
2013
Synthesis of QS-21-based immunoadjuvants
.
Journal of Organic Chemistry
. 78:11525-11534.
2013
2012
Molecular basis of requirement of receptor activator of nuclear factor κB signaling for interleukin 1-mediated osteoclastogenesis
.
Journal of Biological Chemistry
. 287:15728-15738.
2012
2011
Contribution of a Streptococcus mutans antigen expressed by a Salmonella vector vaccine in dendritic cell activation
.
Infection and Immunity
. 79:3792-3800.
2011
2011
TLR2-dependent modulation of osteoclastogenesis by Porphyromonas gingivalis through differential induction of NFATc1 and NF-κB
.
Journal of Biological Chemistry
. 286:24159-24169.
2011
2011
VDR deficiency affects alveolar bone and cementum apposition in mice
.
Archives of Oral Biology
. 56:672-677.
2011
2011
Alum interaction with dendritic cell membrane lipids is essential for its adjuvanticity
.
Nature Medicine
. 17:479-487.
2011
2009
Normalisation of calcium status reverses the phenotype in dentin, but not in enamel of VDR-deficient mice
.
Archives of Oral Biology
. 54:1105-1110.
2009
2009
Molecular mechanism of the bifunctional role of lipopolysaccharide in osteoclastogenesis
.
Journal of Biological Chemistry
. 284:12512-12523.
2009
2009
Different enamel and dentin mineralization observed in VDR deficient mouse model
.
Archives of Oral Biology
. 54:299-305.
2009
2009
Glycogen synthase kinase-3β (GSK3β) inhibition suppresses the inflammatory response to Francisella infection and protects against tularemia in mice
.
Molecular Immunology
. 46:677-687.
2009
2008
TLR4-mediated activation of dendritic cells by the heat shock protein DnaK from Francisella tularensis
.
Journal of Leukocyte Biology
. 84:1434-1446.
2008
2008
Sec translocase and sortase A are colocalised in a locus in the cytoplasmic membrane of Streptococcus mutans
.
Archives of Oral Biology
. 53:150-154.
2008
2008
Eosinophil-derived neurotoxin acts as an alarmin to activate the TLR2-MyD88 signal pathway in dendritic cells and enhances Th2 immune responses
.
Journal of Experimental Medicine
. 205:79-90.
2008
2007
Role of CD80 and CD86 in host immune responses to the recombinant hemagglutinin domain of Porphyromonas gingivalis gingipain and in the adjuvanticity of cholera toxin B and monophosphoryl lipid A
.
Vaccine
. 25:6201-6210.
2007
2006
Immunogenicity of Salmonella vector vaccines expressing SBR of Streptococcus mutans under the control of a T7-nirB (dual) promoter system
.
Vaccine
. 24:5003-5015.
2006
2006
Toll-like receptor 2 is required for inflammatory responses to Francisella tularensis LVS
.
Infection and Immunity
. 74:2809-2816.
2006
2005
Effectiveness of the B subunit of cholera toxin in potentiating immune responses to the recombinant hemagglutinin/adhesin domain of the gingipain Kgp from Porphyromonas gingivalis
.
Vaccine
. 23:4734-4744.
2005
2005
Role of mitogen-activated protein kinases and NF-κB in the regulation of proinflammatory and anti-inflammatory cytokines by Porphyromonas gingivalis hemagglutinin B
.
Infection and Immunity
. 73:3990-3998.
2005
2004
[Preliminary study on gene related to acid tolerance of Streptococcus mutans].
.
Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology
. 39:382-385.
2004
2004
Role of B7 Costimulatory Molecules in Immune Responses and T-Helper Cell Differentiation in Response to Recombinant HagB from Porphyromonas gingivalis
.
Infection and Immunity
. 72:637-644.
2004
2004
Effect of a separated instrument on bacterial penetration of obturated root canals
.
Journal of Endodontics
. 30:177-179.
2004
2004
Effectiveness of sodium hypochlorite in preventing inoculation of periapical tissues with contaminated patency files
.
Journal of Endodontics
. 30:92-94.
2004
2004
pH required to kill Enterococcus faecalis in vitro
.
Journal of Endodontics
. 30:218-219.
2004
2003
Effectiveness of the quillaja saponin semi-synthetic analog GPI-0100 in potentiating mucosal and systemic responses to recombinant HagB from Porphyromonas gingivalis
.
Vaccine
. 21:4459-4471.
2003
2002
Enhanced immunogenicity of a genetic chimeric protein consisting of two virulence antigens of Streptococcus mutans and protection against infection
.
Infection and Immunity
. 70:6779-6787.
2002
2002
Hydrolysis of epithelial junctional proteins by Porphyromonas gingivalis gingipains
.
Infection and Immunity
. 70:2512-2518.
2002
2001
Effect of attenuated Salmonella enterica serovar Typhimurium expressing a Streptococcus mutans antigen on secondary responses to the cloned protein
.
Infection and Immunity
. 69:6604-6611.
2001
1999
Immunolabeling of the major cell surface protein antigen of Streptococcus sobrinus with monoclonal antibody.
.
Chinese Journal of Dental Research
. 2:23-26.
1999
1999
[Immunization against dental caries: current strategies].
.
Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology
. 34:69-72.
1999
1999
Effects of monoclonal antibody on colonization of Streptococcus sobrinus and development of dental caries in rats.
.
Chinese Journal of Dental Research
. 2:12-15.
1999
Research
Principal Investigator On
Molecular Mechanisms of the Innate Regulation of Osteoclastogenesis
awarded by
National Institute of Dental and Craniofacial Research/NIH/DHHS
Role of Osteoclast Precursors in Periodontal Bone Loss
awarded by
National Institute of Dental and Craniofacial Research/NIH/DHHS
UAB Core Center for Basic Skeletal Research - P&F3
awarded by
National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
Investigator On
Development of Structurally Defined QS-17/18-Based Vaccine Adjuvants
awarded by
National Institute of Allergy and Infectious Diseases/NIH/DHHS
Development of Structurally Defined Synthetic Vaccine Adjuvants
awarded by
National Institute of General Medical Sciences/NIH/DHHS
Genetically Engineered Oral Vaccines and Caries Immunity
awarded by
National Institute of Dental and Craniofacial Research/NIH/DHHS
UAB Core Center for Basic Skeletal Research
awarded by
National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
Teaching
Teaching Activities
OB620 - Oral Microbio and Immunology (Spring Term 2020)
PG507 - Fundamentals of Research (Fall Term 2022)
PG508 - Adv Topics in Pediatric Dent (Fall Term 2021)
PG508 - Adv Topics in Pediatric Dent (Fall Term 2022)
PG569 - Oral Microbiology & Immunology (Spring Term 2020)
PG569 - Oral Microbiology & Immunology (Spring Term 2022)
Background
Education And Training
University of Alabama at Birmingham Microbiology, Postdoctoral Research
University of Alabama at Birmingham Pediatric Dentistry, Residency
Doctor of Philosophy in Oral Biology and Oral and Maxillofacial Pathology,
Hubei University of Medicine
1997
Doctor of Dental Science in Dentistry,
Hubei University of Medicine
1992
Contact
Full Name
Ping
Zhang