Positions

Overview

  • Dr. Bullard received his undergraduate degree in zoology from Iowa State University and his Ph.D. in genetics from Case Western Reserve University. During his postdoctoral studies in the Department of Human and Molecular Genetics at Baylor College of Medicine in Houston, he initiated research investigating the role of leukocyte/endothelial cell adhesion molecules in inflammatory processes. He joined the Department of Genetics at UAB in 1996.
  • Research Overview

  • Dr. Bullard’s research interests are centered on defining the mechanisms that regulate inflammation. For these investigations, we have focused our studies on defining the roles of leukocyte/endothelial cell adhesion molecules in mediating inflammatory responses. These proteins, along with chemoattractant/activating molecules, mediate the process by which leukocytes exit the vasculature into tissue in response to an inflammatory stimulus. Many different adhesion molecules have been described, including the selectins, integrins, and members of the immunoglobulin superfamily of adhesion receptors. Recent evidence from our lab and others suggest that these molecules play both pro- and anti-inflammatory roles, and we are using a genetic approach in mice to further define these functions. For our studies, we have developed many different lines of adhesion molecule mutant mice using gene-targeting methodologies. Mice with single or multiple mutations are currently being analyzed in models of rheumatoid arthritis, lupus erythematosus, vasculitis, and inflammatory bowel disease to determine their specific roles in the pathogenesis of these diseases. Our lab has also characterized a novel model for psoriasis and psoriatic arthritis that develops in Beta-2 integrin mutant mice backcrossed onto the PL/J strain background. We are now trying to map and clone the genes that control the development of both the skin disease and the arthritis in this model system.
  • Investigator On

  • Summer Undergraduate Research Experiences in Genomic Medicine (SURE-GM)  awarded by National Human Genome Research Institute/NIH/DHHS 2018 - 2023
  • Effects of ITGAM Genetic Variation on Mac-1 Mediated Functions of B Cells  awarded by DOD - Department of Defense 2018 - 2021
  • Virus-Induced Cell Fate Decisions in Anti-Viral Immunity  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2014 - 2020
  • Virus-Induced Cell Fate Decisions in Anti-Viral Immunity - Project 2 - Regulation of Anti-Viral CD8+ T Cell Responses Via Adhesion Molecules  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2014 - 2020
  • Impact of SLE-Associated ITGAM Variants on Dendritic Cell Function  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2016 - 2019
  • Glycan Control of Stem Cell-Associated Pathways in Pancreatic Cancer  awarded by National Cancer Institute/NIH/DHHS 2015 - 2017
  • Glycosylation-Dependent Control of TNFR1 Signaling in Macrophage Survival  awarded by American Heart Association (Southeast Affiliate) 2014 - 2016
  • Training Program in Cardiovascular Pathophysiology  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2014 - 2015
  • The Regulation of T Cell Exhaustion by Adhesion Molecules  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2012 - 2015
  • UAB-UCSD O'Brien Core Center for Acute Kidney Injury Research  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2008 - 2014
  • Teaching Activities

  • GRD741 - UAB PREP Scholar Workshop I (Summer Term 2019) 2019
  • GGSC250 - Sp Tp Genetics/Genomics Sci (Spring Term 2019) 2019
  • GGSC380 - UG Research-Genetics/Genomics (Spring Term 2019) 2019
  • GRD300 - Intro to Health Professions (Spring Term 2019) 2019
  • GRD741 - UAB PREP Scholar Workshop I (Spring Term 2019) 2019
  • GGSC350 - Sp Tp Genetics/Genomics Sci (Fall Term 2018) 2018
  • GRD740 - UAB Prep Scholar Workshop (Fall Term 2018) 2018
  • GRD790 - Research/Lab Rotation (Fall Term 2018) 2018
  • GGSC493 - Hon Res Sem-Genetics/Genomics (Summer Term 2018) 2018
  • GRD790 - Research/Lab Rotation (Summer Term 2018) 2018
  • GGSC390 - Hon Research-Genetics/Genomics (Spring Term 2018) 2018
  • GRD741 - UAB PREP Scholar Workshop I (Spring Term 2018) 2018
  • GGSC390 - Hon Research-Genetics/Genomics (Fall Term 2017) 2017
  • GRD790 - Research/Lab Rotation (Summer Term 2017) 2017
  • GBSC711 - Advanced Genetics Study (Spring Term 2017) 2017
  • GRD741 - UAB PREP Scholar Workshop I (Spring Term 2017) 2017
  • GRD790 - Research/Lab Rotation (Summer Term 2016) 2016
  • GBSC711 - Advanced Genetics Study (Fall Term 2014) 2014
  • HON342 - Seminar: Medicine (Fall Term 2014) 2014
  • GBS724 - Principles of Genetics (Fall Term 2011) 2011
  • MGE798 - Doc Lev Non-Dissertation Res (Fall Term 2010) 2010
  • MGE799 - Doc Lev Dissertation Res (Fall Term 2010) 2010
  • MGE798 - Doc Lev Non-Dissertation Res (Summer Term 2010) 2010
  • MGE799 - Doc Lev Dissertation Res (Summer Term 2010) 2010
  • MGE709 - Human Genetics (Spring Term 2010) 2010
  • MGE798 - Doc Lev Non-Dissertation Res (Spring Term 2010) 2010
  • MGE799 - Doc Lev Dissertation Res (Spring Term 2010) 2010
  • MGE798 - Doc Lev Non-Dissertation Res (Fall Term 2009) 2009
  • MGE799 - Doc Lev Dissertation Res (Fall Term 2009) 2009
  • MGE798 - Doc Lev Non-Dissertation Res (Summer Term 2009) 2009
  • MGE799 - Doc Lev Dissertation Res (Summer Term 2009) 2009
  • MGE798 - Doc Lev Non-Dissertation Res (Spring Term 2009) 2009
  • MGE799 - Doc Lev Dissertation Res (Spring Term 2009) 2009
  • Education And Training

  • Doctor of Philosophy in Genetics, Case Western Reserve University 1992
  • Full Name

  • Daniel Bullard