Thomas Atkinson

Thomas Atkinson
Professor

Senior Scientist (C), UWIRC Microbiome Center , School of Medicine
Senior Scientist (C), Comprehensive Arthritis, Musculoskeletal, Bone and Autoimmunity Center (CAMBAC) , School of Medicine
Senior Scientist (C), O'Neal Comprehensive Cancer Center , School of Medicine
Associate Scientist (C), Center for AIDS Research , School of Medicine
Senior Scientist, Inflammation, Immunology and Immunotherapeutics , O'Neal Comprehensive Cancer Center
Senior Scientist (C), Center for Clinical and Translational Science (CCTS) , General Clinical Research Center
Professor (S), Medicine - Immunology and Rheumatology , Department of Medicine
Professor (P), Pediatric - Allergy & Immunology , Pediatrics
Assistant Professor (S), Microbiology , Academic Joint Departments

Selected Publications

Academic Article

Year	Title	Altmetric
2021	Genetic Analysis of a Cohort of 275 Patients with Hyper-IgE Syndromes and/or Chronic Mucocutaneous Candidiasis. Journal of Clinical Immunology. 41:1804-1838. 2021
2021	Candidatus Mycoplasma haemohominis: Emerging Infection in New Caledonia. Clinical Infectious Diseases. 73:e1454-e1455. 2021
2021	Treatment of children with primary immunodeficiencies with a subcutaneous immunoglobulin 16.5% (cutaquig^®[octanorm]). Immunotherapy. 13:813-824. 2021
2021	Constrained chromatin accessibility in PU.1-mutated agammaglobulinemia patients. Journal of Experimental Medicine. 218. 2021
2021	Oncolytic HSV-1 G207 immunovirotherapy for pediatric high-grade gliomas. New England Journal of Medicine. 384:1613-1622. 2021
2021	Septic polyarthritis with Mycoplasma salivarium in a patient with common variable immunodeficiency: case report and review of the literature. 2021
2020	Mycoplasma genitalium Biofilms Contain Poly-GlcNAc and Contribute to Antibiotic Resistance. Frontiers in Microbiology. 11. 2020
2020	Molecular characterization of Mycoplasma pneumoniae isolates in the United States from 2012 to 2018. Journal of Clinical Microbiology. 58. 2020
2020	Evaluation of commercial molecular diagnostic methods for detection and determination of macrolide resistance in mycoplasma pneumoniae. Journal of Clinical Microbiology. 58. 2020
2020	Benefit of Anakinra in Treating Pediatric Secondary Hemophagocytic Lymphohistiocytosis. Arthritis and Rheumatology. 72:326-334. 2020
2020	Recurrent microdeletions at chromosome 2p11.2 are associated with thymic hypoplasia and features resembling DiGeorge syndrome. Journal of Allergy and Clinical Immunology. 145:358-367.e2. 2020
2019	A novel in situ multiplex immunofluorescence panel for the assessment of tumor immunopathology and response to virotherapy in pediatric glioblastoma reveals a role for checkpoint protein inhibition. OncoImmunology. 8. 2019
2019	A unique phenotype of T-cell acute lymphoblastic leukemia in a patient with GATA2 haploinsufficiency 2019
2019	Hypomorphic caspase activation and recruitment domain 11 (CARD11) mutations associated with diverse immunologic phenotypes with or without atopic disease. Journal of Allergy and Clinical Immunology. 143:1482-1495. 2019
2019	Allergic airway sensitization impairs antibacterial IgG antibody responses during bacterial respiratory tract infections. Journal of Allergy and Clinical Immunology. 143:1183-1197.e7. 2019
2019	Epidermodysplasia verruciformis in a young adult with activated PI3Kδ syndrome. JAAD Case Reports. 5:195-197. 2019
2019	Clinical efficiency, safety and tolerability of a new subcutaneous immunoglobin 16.5% (octanorm cutaquig^® in the treatment of patients with primary immunodefieciencies. Frontiers in Immunology. 10. 2019
2019	Differential susceptibility of Mycoplasma and Ureaplasma species to compound-enhanced copper toxicity. Frontiers in Microbiology. 10. 2019
2019	Macrolide-resistant mycoplasma pneumoniae in the United States as determined from a national surveillance program. Journal of Clinical Microbiology. 57. 2019
2019	Mycoplasma pneumoniae Carriage with De Novo Macrolide-Resistance and Breakthrough Pneumonia. Pediatrics. 144. 2019
2018	A previously unrecognized 22q13.2 microdeletion syndrome that encompasses TCF20 and TNFRSF13C 2018
2018	A rapid and simple chemical method for the preparation of Ag colloids for surface-enhanced Raman spectroscopy using the Ag mirror reaction. Vibrational Spectroscopy. 98:1-7. 2018
2018	Analysis of the tonsillar microbiome in young adults with sore throat reveals a high relative abundance of Fusobacterium necrophorum with low diversity. PLoS ONE. 13. 2018
2017	Mycoplasma pneumoniae from the respiratory tract and beyond. Clinical Microbiology Reviews. 30:747-809. 2017
2017	Inter- and intra-strain variability of tandem repeats in Mycoplasma pneumoniae based on next-generation sequencing data. Future Microbiology. 12:119-129. 2017
2017	Shaken or stirred?: Comparison of methods for dispersion of Mycoplasma pneumoniae aggregates for persistence in vivo. Journal of Microbiological Methods. 132:56-62. 2017
2017	Ureaplasma infection-mediated release of matrix metalloproteinase-9 and PGP: A novel mechanism of preterm rupture of membranes and chorioamnionitis. Pediatric Research. 81:75-79. 2017
2016	Killer cell immunoglobulin-like receptors are associated with common variable immune deficiency pathogenesis. Journal of Allergy and Clinical Immunology. 138:1495-1498. 2016
2016	Dermatological clues to the diagnosis of atypical complete DiGeorge syndrome. Dermatology Online Journal. 22. 2016
2016	The Extended Clinical Phenotype of 26 Patients with Chronic Mucocutaneous Candidiasis due to Gain-of-Function Mutations in STAT1. Journal of Clinical Immunology. 36:73-84. 2016
2015	Disseminated Primary Herpes Simplex Virus Type 2 Infection in a 22-Year-Old male.. Open Forum Infectious Diseases. 2:ofv092. 2015
2015	Comparative genome analysis of Mycoplasma pneumoniae. BMC Genomics. 16. 2015
2015	Macrolide-resistant Mycoplasma pneumoniae, United States. Emerging Infectious Diseases. 21:1470-1472. 2015
2015	Specificity and strain-typing capabilities of nanorod array-surface enhanced raman spectroscopy for Mycoplasma pneumoniae detection. PLoS ONE. 10. 2015
2015	Fusobacterium-Positive and Streptococcal-Positive Pharyngitis. Annals of Internal Medicine. 162:877-878. 2015
2015	Sore Throat: Avoid Overcomplicating the Uncomplicated. Annals of Internal Medicine. 162:878. 2015
2015	The clinical presentation of Fusobacterium-positive and streptococcal-positive pharyngitis in a university health clinic: A cross-sectional study. Annals of Internal Medicine. 162:241-247. 2015
2014	Genetic Defects in Cytolysis in Macrophage Activation Syndrome. Current Rheumatology Reports. 16. 2014
2014	Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiency. Nature Immunology. 15:88-97. 2014
2014	Hypogammaglobulinemia after cardiopulmonary bypass in infants. Journal of Thoracic and Cardiovascular Surgery. 147. 2014
2014	Mycoplasma pneumoniae infections in childhood 2014
2014	Somatic reversion in dedicator of cytokinesis 8 immunodeficiency modulates disease phenotype. Journal of Allergy and Clinical Immunology. 133:1667-1675. 2014
2014	Suppression of antimicrobial peptide expression by Ureaplasma species. Infection and Immunity. 82:1657-1665. 2014
2013	Is asthma an infectious disease? New evidence. Current Allergy and Asthma Reports. 13:702-709. 2013
2013	High doses of infliximab in the management of juvenile idiopathic arthritis. Journal of Rheumatology. 40:1749-1755. 2013
2013	Genotype-Phenotype Correlations Emerging from the Identification of Missense Mutations in MBTPS2. Human Mutation. 34:587-594. 2013
2013	Clinical presentation and laboratory findings of Mycoplasma pneumoniae respiratory infections in children. Current Pediatric Reviews. 9:268-272. 2013
2013	Mycoplasma pneumoniae: Does it have a role in asthma pathogenesis?. Current Pediatric Reviews. 9:289-295. 2013
2013	Thematic Issue on Mycoplasma pneumoniae. Current Pediatric Reviews. 9:267. 2013
2012	Human immunodeficiency-causing mutation defines CD16 in spontaneous NK cell cytotoxicity. Journal of Clinical Investigation. 122:3769-3780. 2012
2012	Immune deficiency and autoimmunity. Current Opinion in Rheumatology. 24:515-521. 2012
2012	Feasibility of exercising adults with asthma: a randomized pilot study 2012
2011	Stevens-Johnson syndrome in a boy with macrolide-resistant Mycoplasma pneumoniae pneumonia. Pediatrics. 127. 2011
2010	Critical role of macrophages and their activation via MyD88-NFκB signaling in lung innate immunity to Mycoplasma pneumoniae. PLoS ONE. 5. 2010
2009	Rituximab Therapy for Severe Refractory Chronic Henoch-Schönlein Purpura. Journal of Pediatrics. 155:136-139. 2009
2009	The role of Mycoplasma in upper respiratory infections. Current Infectious Disease Reports. 11:198-206. 2009
2009	Deficient immune response to Mycoplasma pneumoniae in childhood asthma. Allergy and Asthma Proceedings. 30:158-165. 2009
2009	Emerging macrolide resistance in mycoplasma pneumoniae in children: Detection and characterization of resistant isolates 2009
2008	New insights into the pathogenesis and detection of Mycoplasma pneumoniae infections. Future Microbiology. 3:635-648. 2008
2008	Epidemiology, clinical manifestations, pathogenesis and laboratory detection of Mycoplasma pneumoniae infections. FEMS Microbiology Reviews. 32:956-973. 2008
2008	Inhibition of message for FcεRI α chain blocks mast cell IL-4 production induced by co-culture with Mycoplasma pneumoniae. Microbial Pathogenesis. 44:286-292. 2008
2008	Mycoplasma pneumoniae induces airway epithelial cell expression of MUC5AC in asthma. European Respiratory Journal. 31:43-46. 2008
2007	Pulmonary aneurysms and intracardiac thrombi due to Behçet's disease in an African-American adolescent with oculocutaneous albinism. Clinical Rheumatology. 26:1537-1539. 2007
2007	Dominant inhibition of Fas ligand-mediated apoptosis due to a heterozygous mutation associated with autoimmune lymphoproliferative syndrome (ALPS) Type Ib. BMC Medical Genetics. 8. 2007
2007	Activation-induced changes in alternate splice acceptor site usage. Biochemical and Biophysical Research Communications. 358:590-595. 2007
2005	Induction of a late asthmatic response associated with airway inflammation in mice 2005
2005	A role for the Mycoplasma pneumoniae adhesin P1 in interleukin (IL)-4 synthesis and release from rodent mast cells. Microbial Pathogenesis. 39:149-158. 2005
2005	Oral and nasal sensitization promote distinct immune responses and lung reactivity in a mouse model of peanut allergy. American Journal of Pathology. 167:1621-1630. 2005
2004	Aerobic Exercise Attenuates Airway Inflammatory Responses in a Mouse Model of Atopic Asthma. Journal of Immunology. 172:4520-4526. 2004
2003	Splice variant in TCRζ links T cell receptor signaling to a G-protein-related signaling pathway. Biochemical and Biophysical Research Communications. 310:761-766. 2003
2002	Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency. Nature. 419:395-399. 2002
2002	Identification of an alternatively spliced isoform of the fyn tyrosine kinase. Biochemical and Biophysical Research Communications. 298:501-504. 2002
2002	Mycoplasma pneumoniae - Induced activation and cytokine production in rodent mast cells. Journal of Allergy and Clinical Immunology. 109:470-476. 2002
2002	Primary immunodeficiency studies at University of Alabama at Birmingham: Continuing the search for genetic causes. Immunologic Research. 26:1-5. 2002
2001	An immune defect causing dominant chronic mucocutaneous candidiasis and thyroid disease maps to chromosome 2p in a single family. American Journal of Human Genetics. 69:791-803. 2001
2001	Cd5 (OKT1) augments CD3-mediated intracellular signaling events in human T lymphocytes. Inflammation. 25:215-221. 2001
2001	TcR-α/β⁺ CD4^-CD8^- T cells in humans with the autoimmune lymphoproliferative syndrome express a novel CD45 isoform that is analogous to murine B220 and represents a marker of altered O-glycan biosynthesis. Clinical Immunology. 100:314-324. 2001
2000	High prevalence of complement component C6 deficiency among African- Americans in the South-eastern USA. Clinical and Experimental Immunology. 119:305-310. 2000
2000	Early expression of Iε, CD23 (FcεRII), IL-4Rα, and IgE in the human fetus. Journal of Allergy and Clinical Immunology. 106:911-917. 2000
2000	Measurement of phosphatidylinositol (PI) hydrolysis in activated T lymphocytes.. Methods in Molecular Biology. 134:211-219. 2000
1999	Defects of T-cell effector function and post-thymic maturation in X- linked hyper-IgM syndrome. Journal of Clinical Investigation. 103:1151-1158. 1999
1999	Genetic linkage of hyper-IgE syndrome to chromosome 4. American Journal of Human Genetics. 65:735-744. 1999
1999	ICAM-3 (CD50) cross-linking augments signaling in CD3-activated peripheral human T lymphocytes. Journal of Leukocyte Biology. 65:867-874. 1999
1998	A novel type II complement C2 deficiency allele in an African-American family. Journal of Immunology. 161:578-584. 1998
1998	CD50 (ICAM-3) costimulates CD3 activated human T lymphocytes. The FASEB Journal. 12. 1998
1998	Evidence for an alternatively-spliced isoform of Fyn in hematopoietic cells. The FASEB Journal. 12. 1998
1998	Molecular defects leading to human complement component C6 deficiency in an African-American family. Clinical and Experimental Immunology. 111:91-96. 1998
1998	Leukocyte transfusion-associated granulocyte responses in a patient with x-linked hyper-IgM syndrome. Journal of Clinical Immunology. 18:430-439. 1998
1998	Susceptibility locus for IgA deficiency and common variable immunodeficiency in the HLA-DR3, -B8, -A1 haplotypes. Molecular Medicine. 4:72-86. 1998
1997	Alpha 1-antitrypsin deficiency in a child with X-linked lymphoproliferative disease.. Archives of Pathology and Laboratory Medicine. 121:996-999. 1997
1997	Chronic granulomatous disease in two children with recurrent infections: Family studies using dihydrorhodamine-based flow cytometry. Journal of Pediatrics. 130:488-491. 1997
1996	Cross-linking of cd5 synergizes with anti-cds induced phosphatidylinositol hydrolysis in t lymphocytes. The FASEB Journal. 10. 1996
1996	Ligands for plc-y isozymes in human b and t lymphocytes: evidence for functional differences between PLC-γ1 and PLC-γ2. The FASEB Journal. 10. 1996
1996	Translocation of phospholipase C-γ2 induced by in vitro activation of protein Tyrosine kinase activity in mast cell lysates. Cellular Signalling. 8:461-465. 1996
1996	Granulocyte response to cellular infusions in a severely neutropenic patient with dysgammaglobulinemia. Journal of Investigative Medicine. 44. 1996
1995	Phosphatidylinositol hydrolysis in freshly isolated human T lymphocytes. Journal of Immunological Methods. 186:71-77. 1995
1993	Orthovanadate induces translocation of phospholipase C-γ1 and -γ2 in permeabilized mast cells. Journal of Immunology. 151:1448-1455. 1993
1992	Anaphylaxis. Medical Clinics of North America. 76:841-855. 1992
1992	Evidence for GTP-binding protein involvement in the tyrosine phosphorylation of the T cell receptor ζ chain. Journal of Biological Chemistry. 267:14527-14530. 1992
1992	Phospholipase C-γ1 is translocated to the membrane of rat basophilic leukemia cells in response to aggregation of IgE receptors. Journal of Immunology. 148:2194-2200. 1992
1988	Histamine release from human basophils by synthetic block co-polymers composed of polyoxyethylene and polyoxypropylene and synergy with immunologic and non-immunologic stimuli. Journal of Immunology. 141:1307-1310. 1988
1988	In vitro release of histmaine from murine mast cells by block co-polymers composed of polyoxyethylene and polyoxypropylene. Journal of Immunology. 141:1302-1306. 1988
1988	Ion transport mediated by copolymers composed of polyoxyethylene and polyoxypropylene. American Journal of Physiology. 254. 1988
1988	Ion transport mediated by copolymers composed of polyoxyethylene and polyoxypropylene.. American Journal of Physiology. 254:C20-C26. 1988
1985	Induction of suppressor cells by reverse block copolymers. The FASEB Journal. 44. 1985
1984	Direct quantitation of antibody production in cell populations using an enzyme-linked immunosorbant assay. The FASEB Journal. 43. 1984

Book

Year	Title	Altmetric
2018	The microbiome in rheumatic diseases and infection 2018

Chapter

Year	Title	Altmetric
2018	Immunodeficiency and autoimmunity. 45-54. 2018
2018	Mollicutes: Mycoplasma pneumoniae. 103-111. 2018
2005	Immune responses to mycoplasma. 1451-1464. 2005