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Thomas Atkinson
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patkinso@uab.edu
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Thomas Atkinson
Professor
Positions
Senior Scientist
,
Inflammation, Immunology and Immunotherapeutics
,
O'Neal Comprehensive Cancer Center
Assistant Professor (S)
,
Microbiology
,
Academic Joint Departments
1994 -
Associate Scientist (C)
,
Center for AIDS Research
,
School of Medicine
1997 -
Professor (P)
,
Pediatric - Allergy & Immunology
,
Pediatrics
1999 -
Senior Scientist (C)
,
Center for Clinical and Translational Science (CCTS)
,
General Clinical Research Center
2009 -
Professor (S)
,
Medicine - Immunology and Rheumatology
,
Department of Medicine
2010 -
Senior Scientist (C)
,
Comprehensive Arthritis, Musculoskeletal, Bone and Autoimmunity Center (CAMBAC)
,
School of Medicine
2015 -
Senior Scientist (C)
,
O'Neal Comprehensive Cancer Center
,
School of Medicine
2019 -
Publications
Research
Teaching
Background
Contact
Publications
Selected Publications
Academic Article
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Year
Title
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2020
Recurrent microdeletions at chromosome 2p11.2 are associated with thymic hypoplasia and features resembling DiGeorge syndrome
.
Journal of Allergy and Clinical Immunology
. 145:358-367.e2.
2020
2019
Hypomorphic caspase activation and recruitment domain 11 (CARD11) mutations associated with diverse immunologic phenotypes with or without atopic disease
.
Journal of Allergy and Clinical Immunology
. 143:1482-1495.
2019
2019
Allergic airway sensitization impairs antibacterial IgG antibody responses during bacterial respiratory tract infections
.
Journal of Allergy and Clinical Immunology
. 143:1183-1197.e7.
2019
2018
A previously unrecognized 22q13.2 microdeletion syndrome that encompasses TCF20 and TNFRSF13C
2018
2018
A rapid and simple chemical method for the preparation of Ag colloids for surface-enhanced Raman spectroscopy using the Ag mirror reaction
.
Vibrational Spectroscopy
. 98:1-7.
2018
2018
Analysis of the tonsillar microbiome in young adults with sore throat reveals a high relative abundance of Fusobacterium necrophorum with low diversity
.
PLoS ONE
. 13.
2018
2017
Mycoplasma pneumoniae from the respiratory tract and beyond
.
Clinical Microbiology Reviews
. 30:747-809.
2017
2017
Inter- and intra-strain variability of tandem repeats in Mycoplasma pneumoniae based on next-generation sequencing data
.
Future Microbiology
. 12:119-129.
2017
2017
Shaken or stirred?: Comparison of methods for dispersion of Mycoplasma pneumoniae aggregates for persistence in vivo
.
Journal of Microbiological Methods
. 132:56-62.
2017
2017
Ureaplasma infection-mediated release of matrix metalloproteinase-9 and PGP: A novel mechanism of preterm rupture of membranes and chorioamnionitis
.
Pediatric Research
. 81:75-79.
2017
2016
Killer cell immunoglobulin-like receptors are associated with common variable immune deficiency pathogenesis
.
Journal of Allergy and Clinical Immunology
. 138:1495-1498.
2016
2016
Dermatological clues to the diagnosis of atypical complete DiGeorge syndrome
.
Dermatology Online Journal
. 22.
2016
2016
The Extended Clinical Phenotype of 26 Patients with Chronic Mucocutaneous Candidiasis due to Gain-of-Function Mutations in STAT1
.
Journal of Clinical Immunology
. 36:73-84.
2016
2015
Disseminated Primary Herpes Simplex Virus Type 2 Infection in a 22-Year-Old male.
.
Open Forum Infectious Diseases
. 2:ofv092.
2015
2015
Comparative genome analysis of Mycoplasma pneumoniae
.
BMC Genomics
. 16.
2015
2015
Macrolide-resistant Mycoplasma pneumoniae, United States
.
Emerging Infectious Diseases
. 21:1470-1472.
2015
2015
Specificity and strain-typing capabilities of nanorod array-surface enhanced raman spectroscopy for Mycoplasma pneumoniae detection
.
PLoS ONE
. 10.
2015
2015
Fusobacterium-Positive and Streptococcal-Positive Pharyngitis
.
Annals of Internal Medicine
. 162:877-878.
2015
2015
Sore Throat: Avoid Overcomplicating the Uncomplicated
.
Annals of Internal Medicine
. 162:878.
2015
2015
The clinical presentation of Fusobacterium-positive and streptococcal-positive pharyngitis in a university health clinic: A cross-sectional study
.
Annals of Internal Medicine
. 162:241-247.
2015
2014
Genetic Defects in Cytolysis in Macrophage Activation Syndrome
.
Current Rheumatology Reports
. 16.
2014
2014
Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiency
.
Nature Immunology
. 15:88-97.
2014
2014
Hypogammaglobulinemia after cardiopulmonary bypass in infants
.
Journal of Thoracic and Cardiovascular Surgery
. 147.
2014
2014
Mycoplasma pneumoniae infections in childhood
2014
2014
Somatic reversion in dedicator of cytokinesis 8 immunodeficiency modulates disease phenotype
.
Journal of Allergy and Clinical Immunology
. 133:1667-1675.
2014
2014
Suppression of antimicrobial peptide expression by Ureaplasma species
.
Infection and Immunity
. 82:1657-1665.
2014
2013
Is asthma an infectious disease? New evidence
.
Current Allergy and Asthma Reports
. 13:702-709.
2013
2013
High doses of infliximab in the management of juvenile idiopathic arthritis
.
Journal of Rheumatology
. 40:1749-1755.
2013
2013
Genotype-Phenotype Correlations Emerging from the Identification of Missense Mutations in MBTPS2
.
Human Mutation
. 34:587-594.
2013
2013
Clinical presentation and laboratory findings of Mycoplasma pneumoniae respiratory infections in children
.
Current Pediatric Reviews
. 9:268-272.
2013
2013
Mycoplasma pneumoniae: Does it have a role in asthma pathogenesis?
.
Current Pediatric Reviews
. 9:289-295.
2013
2013
Thematic Issue on Mycoplasma pneumoniae
.
Current Pediatric Reviews
. 9:267.
2013
2012
Human immunodeficiency-causing mutation defines CD16 in spontaneous NK cell cytotoxicity
.
Journal of Clinical Investigation
. 122:3769-3780.
2012
2012
Immune deficiency and autoimmunity
.
Current Opinion in Rheumatology
. 24:515-521.
2012
2012
Feasibility of exercising adults with asthma: a randomized pilot study
2012
2011
Stevens-Johnson syndrome in a boy with macrolide-resistant Mycoplasma pneumoniae pneumonia
.
Pediatrics
. 127.
2011
2010
Critical role of macrophages and their activation via MyD88-NFκB signaling in lung innate immunity to Mycoplasma pneumoniae
.
PLoS ONE
. 5.
2010
2009
Rituximab Therapy for Severe Refractory Chronic Henoch-Schönlein Purpura
.
Journal of Pediatrics
. 155:136-139.
2009
2009
The role of Mycoplasma in upper respiratory infections
.
Current Infectious Disease Reports
. 11:198-206.
2009
2009
Deficient immune response to Mycoplasma pneumoniae in childhood asthma
.
Allergy and Asthma Proceedings
. 30:158-165.
2009
2009
Emerging macrolide resistance in mycoplasma pneumoniae in children: Detection and characterization of resistant isolates
2009
2008
New insights into the pathogenesis and detection of Mycoplasma pneumoniae infections
.
Future Microbiology
. 3:635-648.
2008
2008
Epidemiology, clinical manifestations, pathogenesis and laboratory detection of Mycoplasma pneumoniae infections
.
FEMS Microbiology Reviews
. 32:956-973.
2008
2008
Inhibition of message for FcεRI α chain blocks mast cell IL-4 production induced by co-culture with Mycoplasma pneumoniae
.
Microbial Pathogenesis
. 44:286-292.
2008
2007
Pulmonary aneurysms and intracardiac thrombi due to Behçet's disease in an African-American adolescent with oculocutaneous albinism
.
Clinical Rheumatology
. 26:1537-1539.
2007
2007
Dominant inhibition of Fas ligand-mediated apoptosis due to a heterozygous mutation associated with autoimmune lymphoproliferative syndrome (ALPS) Type Ib
.
BMC Medical Genetics
. 8.
2007
2007
Activation-induced changes in alternate splice acceptor site usage
.
Biochemical and Biophysical Research Communications
. 358:590-595.
2007
2005
Induction of a late asthmatic response associated with airway inflammation in mice
2005
2005
A role for the Mycoplasma pneumoniae adhesin P1 in interleukin (IL)-4 synthesis and release from rodent mast cells
.
Microbial Pathogenesis
. 39:149-158.
2005
2005
Oral and nasal sensitization promote distinct immune responses and lung reactivity in a mouse model of peanut allergy
.
American Journal of Pathology
. 167:1621-1630.
2005
2004
Aerobic Exercise Attenuates Airway Inflammatory Responses in a Mouse Model of Atopic Asthma
.
Journal of Immunology
. 172:4520-4526.
2004
2003
Splice variant in TCRζ links T cell receptor signaling to a G-protein-related signaling pathway
.
Biochemical and Biophysical Research Communications
. 310:761-766.
2003
2002
Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency
.
Nature
. 419:395-399.
2002
2002
Mycoplasma pneumoniae-induced activation and cytokine production in rodent mast cells.
.
Journal of Allergy and Clinical Immunology
. 109:470-476.
2002
2002
Identification of an alternatively spliced isoform of the fyn tyrosine kinase
.
Biochemical and Biophysical Research Communications
. 298:501-504.
2002
2002
Primary immunodeficiency studies at University of Alabama at Birmingham: Continuing the search for genetic causes
.
Immunologic Research
. 26:1-5.
2002
2001
An immune defect causing dominant chronic mucocutaneous candidiasis and thyroid disease maps to chromosome 2p in a single family
.
American Journal of Human Genetics
. 69:791-803.
2001
2001
Cd5 (OKT1) augments CD3-mediated intracellular signaling events in human T lymphocytes
.
Inflammation
. 25:215-221.
2001
2001
TcR-α/β
+
CD4
-
CD8
-
T cells in humans with the autoimmune lymphoproliferative syndrome express a novel CD45 isoform that is analogous to murine B220 and represents a marker of altered O-glycan biosynthesis
.
Clinical Immunology
. 100:314-324.
2001
2000
High prevalence of complement component C6 deficiency among African- Americans in the South-eastern USA
.
Clinical and Experimental Immunology
. 119:305-310.
2000
2000
Early expression of Iε, CD23 (FcεRII), IL-4Rα, and IgE in the human fetus
.
Journal of Allergy and Clinical Immunology
. 106:911-917.
2000
1999
Defects of T-cell effector function and post-thymic maturation in X- linked hyper-IgM syndrome
.
Journal of Clinical Investigation
. 103:1151-1158.
1999
1999
Genetic linkage of hyper-IgE syndrome to chromosome 4
.
American Journal of Human Genetics
. 65:735-744.
1999
1998
A novel type II complement C2 deficiency allele in an African-American family
.
Journal of Immunology
. 161:578-584.
1998
1998
CD50 (ICAM-3) costimulates CD3 activated human T lymphocytes
.
The FASEB Journal
. 12.
1998
1998
Molecular defects leading to human complement component C6 deficiency in an African-American family
.
Clinical and Experimental Immunology
. 111:91-96.
1998
1998
Leukocyte transfusion-associated granulocyte responses in a patient with x-linked hyper-IgM syndrome
.
Journal of Clinical Immunology
. 18:430-439.
1998
1998
Susceptibility locus for IgA deficiency and common variable immunodeficiency in the HLA-DR3, -B8, -A1 haplotypes
.
Molecular Medicine
. 4:72-86.
1998
1997
Alpha 1-antitrypsin deficiency in a child with X-linked lymphoproliferative disease.
.
Archives of Pathology and Laboratory Medicine
. 121:996-999.
1997
1997
Chronic granulomatous disease in two children with recurrent infections: Family studies using dihydrorhodamine-based flow cytometry
.
Journal of Pediatrics
. 130:488-491.
1997
1996
Cross-linking of cd5 synergizes with anti-cds induced phosphatidylinositol hydrolysis in t lymphocytes
.
The FASEB Journal
. 10.
1996
1996
Ligands for plc-y isozymes in human b and t lymphocytes: evidence for functional differences between PLC-γ1 and PLC-γ2
.
The FASEB Journal
. 10.
1996
1996
Translocation of phospholipase C-γ2 induced by in vitro activation of protein Tyrosine kinase activity in mast cell lysates
.
Cellular Signalling
. 8:461-465.
1996
1996
Granulocyte response to cellular infusions in a severely neutropenic patient with dysgammaglobulinemia
.
Journal of Investigative Medicine
. 44.
1996
1995
Phosphatidylinositol hydrolysis in freshly isolated human T lymphocytes
.
Journal of Immunological Methods
. 186:71-77.
1995
1988
Histamine release from human basophils by synthetic block co-polymers composed of polyoxyethylene and polyoxypropylene and synergy with immunologic and non-immunologic stimuli
.
Journal of Immunology
. 141:1307-1310.
1988
1988
In vitro release of histmaine from murine mast cells by block co-polymers composed of polyoxyethylene and polyoxypropylene
.
Journal of Immunology
. 141:1302-1306.
1988
1988
Ion transport mediated by copolymers composed of polyoxyethylene and polyoxypropylene
.
American Journal of Physiology
. 254.
1988
1988
Ion transport mediated by copolymers composed of polyoxyethylene and polyoxypropylene.
.
American Journal of Physiology
. 254:C20-C26.
1988
1985
Induction of suppressor cells by reverse block copolymers
.
The FASEB Journal
. 44.
1985
1984
Direct quantitation of antibody production in cell populations using an enzyme-linked immunosorbant assay
.
The FASEB Journal
. 43.
1984
Chapter
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Year
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2005
Immune responses to mycoplasma
. 1451-1464.
2005
Research
Principal Investigator On
Private Grant
awarded by
BAXALTA US INC.
2018 - 2023
Unique- ADP-ribosylating and Vacuolating Properties of Mycoplasma Pneumoniae CARDS Toxin Trigger Airway Inflammation and Disease Progression
awarded by
UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER (SAN ANTONIO)
2019 - 2021
Newborn Screening SCID Consultant Grant
awarded by
ALABAMA DEPARTMENT OF PUBLIC HEALTH
2019 - 2020
Newborn Screening SCID Consultant Grant
awarded by
ALABAMA DEPARTMENT OF PUBLIC HEALTH
2018 - 2019
Newborn Screening SCID Consultant Grant
awarded by
ALABAMA DEPARTMENT OF PUBLIC HEALTH
2017 - 2018
Private Grant
awarded by
OCTAPHARMA - NEW
2015 - 2018
Newborn Screening SCID Consultant Grant
awarded by
ALABAMA DEPARTMENT OF PUBLIC HEALTH
2016 - 2017
Nanotechnology-Based Detection of Mycoplasma Pneumoniae
awarded by
University of Georgia
2012 - 2014
Safety and Efficacy of Hizentra in Patients Less than 5 Years of Age
awarded by
CHARLOTTE-MECKLENBURG HOSPITAL AUTHORITY - DBA ATRIUM HEALTH
2013 - 2014
Virulence Mechanisms in Ureaplasma Infection
awarded by
KAUL PEDIATRIC RESEARCH INSTITUTE
2012 - 2013
Emerging Macrolide Resistance in Mycoplasma Pneumoniae
awarded by
National Institute of Allergy and Infectious Diseases/NIH/DHHS
2009 - 2012
Investigator On
Private Grant
awarded by
BIOTEST PHARMACEUTICALS CORPORATION
2016 - 2018
Teaching
Teaching Activities
52-421 - PEDIATRIC ALLERGY (Fall Term 2019)
2019
28-306 - IMMUNOLOGY (Fall Term 2018)
2018
52-421 - PEDIATRIC ALLERGY (Fall Term 2018)
2018
28-306 - IMMUNOLOGY (Spring Term 2018)
2018
52-421 - PEDIATRIC ALLERGY (Spring Term 2018)
2018
28-306 - IMMUNOLOGY (Spring Term 2017)
2017
52-421 - PEDIATRIC ALLERGY (Spring Term 2017)
2017
52-421 - PEDIATRIC ALLERGY (Spring Term 2017)
2017
28-306 - IMMUNOLOGY (Fall Term 2016)
2016
52-421 - PEDIATRIC ALLERGY (Fall Term 2016)
2016
52-421 - PEDIATRIC ALLERGY (Fall Term 2014)
2014
52-421 - PEDIATRIC ALLERGY (Fall Term 2013)
2013
52-421 - PEDIATRIC ALLERGY (Fall Term 2012)
2012
52-421 - PEDIATRIC ALLERGY (Fall Term 2012)
2012
28-306 - IMMUNOLOGY (Spring Term 2012)
2012
28-306 - IMMUNOLOGY (Spring Term 2012)
2012
28-306 - IMMUNOLOGY (Spring Term 2012)
2012
28-306 - IMMUNOLOGY (Spring Term 2012)
2012
OBHS121 - Fundamentals of Dent and Opt 2 (Fall Term 2011)
2011
52-421 - PEDIATRIC ALLERGY (Fall Term 2011)
2011
52-421 - PEDIATRIC ALLERGY (Fall Term 2011)
2011
MIC778 - Primary Immune Deficiencies (Spring Term 2011)
2011
52-421 - PEDIATRIC ALLERGY (Spring Term 2010)
2010
52-421 - PEDIATRIC ALLERGY (Spring Term 2010)
2010
52-421 - PEDIATRIC ALLERGY (Spring Term 2010)
2010
OBHS121 - Fundamentals of Dent and Opt 2 (Fall Term 2009)
2009
28-306 - IMMUNOLOGY (Fall Term 2009)
2009
52-421 - PEDIATRIC ALLERGY (Fall Term 2009)
2009
52-421 - PEDIATRIC ALLERGY (Fall Term 2009)
2009
MIC778 - Primary Immune Deficiencies (Fall Term 2008)
2008
52-421 - PEDIATRIC ALLERGY (Fall Term 2008)
2008
52-421 - PEDIATRIC ALLERGY (Spring Term 2008)
2008
52-421 - PEDIATRIC ALLERGY (Fall Term 2007)
2007
52-421 - PEDIATRIC ALLERGY (Fall Term 2007)
2007
52-421 - PEDIATRIC ALLERGY (Spring Term 2007)
2007
52-421 - PEDIATRIC ALLERGY (Spring Term 2007)
2007
Background
Education And Training
Doctor of Medicine,
Emory University
1987
Doctor of Philosophy in Pathology / Experimental Pathology,
Emory University
1986
UAB Hospital, Internship
1988
Georgetown University Hospital, Residency
1990
UAB Hospital, Residency
1989
National Institute of Health, Postdoctoral Fellowship
1992
Contact
Full Name
Thomas
Atkinson