Positions

Overview

  • Ashish Pathak, Ph.D., is an advanced research scientist in the Chemistry Department at Southern Research (SR), where he joined in 2009. His main research interests are medicinal chemistry approaches in the area of infectious diseases (anti-bacterials and anti-virals) and cancer, carbohydrates and saponins as immune stimulants, and vaccine adjuvants.

    Pathak received his doctorate in chemistry from University of Lucknow in Lucknow, India, in 1993. Subsequently, he completed post-doctoral studies at Central Institute of Medicinal Aromatic Plants, Lucknow, National Institute of Health Sciences, Tokyo, and SR in various aspects of phytochemistry, carbohydrates, and medicinal chemistry. He was assistant professor of organic chemistry at Western Illinois University in Macomb, Illinois, for four years prior to rejoining SR in 2009.

    Pathak is also an adjunct faculty in the Chemistry Department at the University of Alabama at Birmingham (UAB) and member of UAB’s Comprehensive Cancer Center.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 Studies on Dibenzylamines as Inhibitors of Venezuelan Equine Encephalitis Virus.ACS Infectious Diseases2019
    2019 Synthesis of Aza-acyclic Nucleoside Libraries of Purine, Pyrimidine, and 1,2,4-TriazoleACS Combinatorial Science.  21:183-191. 2019
    2015 Benzimidazole analogs inhibit respiratory syncytial virus G protein functionAntiviral Research.  121:31-38. 2015
    2014 Unique functional and structural properties of the LRRK2 protein ATP-binding pocketJournal of Biological Chemistry.  289:32937-32951. 2014
    2014 Solution-phase parallel synthesis of acyclic nucleoside libraries of purine, pyrimidine, and triazole acetamidesACS Combinatorial Science.  16:485-493. 2014
    2013 6-Oxo and 6-thio purine analogs as antimycobacterial agentsBioorganic and Medicinal Chemistry.  21:1685-1695. 2013
    2011 A high-throughput screening assay for inhibitors of bacterial motility identifies a novel inhibitor of the Na + -driven flagellar motor and virulence gene expression in Vibrio choleraeAntimicrobial Agents and Chemotherapy.  55:4134-4143. 2011
    2010 Antioxidant and anti-inflammatory potential of Pterospermum acerifoliumInternational journal of pharmaceutical sciences review and research.  2:1-5. 2010
    2009 Synthesis of deoxygenated α(1 → 5)-linked arabinofuranose disaccharides as substrates and inhibitors of arabinosyltransferases of Mycobacterium tuberculosisBioorganic and Medicinal Chemistry.  17:872-881. 2009
    2007 Evaluation of CNS activities of aerial parts of Jasminum multiflorum Andr.Asian Journal of Chemistry.  19:4452-4458. 2007
    2007 Disaccharide analogs as probes for glycosyltransferases in Mycobacterium tuberculosisBioorganic and Medicinal Chemistry.  15:5629-5650. 2007
    2007 Synthesis of symmetrical C- and pseudo-symmetrical O-linked disaccharide analogs for arabinosyltransferase inhibitory activity in Mycobacterium tuberculosisBioorganic and Medicinal Chemistry Letters.  17:4527-4530. 2007
    2007 Evaluation of anthelmintic activity of leaves of Callistemon citrinus curtisAsian Journal of Chemistry.  19:2839-2842. 2007
    2006 Novel conjugate of moxifloxacin and carboxymethylated glucan with enhanced activity against Mycobacterium tuberculosisAntimicrobial Agents and Chemotherapy.  50:1982-1988. 2006
    2005 Erratum: Degradation of Quillaja saponaria Molina saponins: Loss of the protective effects of a herpes simplex virus 1 subunit vaccine (International Immunopharmacology (2002) 2:12 (1703-1711) DOI: 10.1016/S1567-5769(02)00192-3)International Immunopharmacology.  5:1658. 2005
    2004 Synthesis of mannopyranose disaccharides as photoaffinity probes for mannosyltransferases in Mycobacterium tuberculosisCarbohydrate Research.  339:683-691. 2004
    2002 Synthesis of an arabinofuranosyl disaccharide photoaffinity probe for arabinosyltransferase activity in Mycobacterium tuberculosisBioorganic and Medicinal Chemistry Letters.  12:2749-2752. 2002
    2002 Studies on n-octyl-5-(α-D-arabinofuranosyl)-β-D-galactofuranosides for mycobacterial glycosyltransferase activityBioorganic and Medicinal Chemistry.  10:923-928. 2002
    2002 Degradation of Quillaja saponaria Molina saponins: Loss of the protective effects of a herpes simplex virus 1 subunit vaccineInternational Immunopharmacology.  2:1703-1711. 2002
    2001 Altered immunomodulating and toxicological properties of degraded Quillaja saponaria Molina saponinsInternational Immunopharmacology.  1:813-818. 2001
    2001 Studies on (β,1→5) and (β,1→6) linked octyl Galf disaccharides as substrates for mycobacterial galactosyltransferase activityBioorganic and Medicinal Chemistry.  9:3129-3143. 2001
    2001 Studies on α(1→5) linked octyl arabinofuranosyl disaccharides for mycobacterial arabinosyl transferase activityBioorganic and Medicinal Chemistry.  9:3145-3151. 2001
    2000 Synthesis of disaccharides related to the mycobacterial arabinogalactanCarbohydrate Letters.  4:117-122. 2000
    1999 Studies on β-D-Gal(f)-(1→4)-α-L-Rha(p) octyl analogues as substrates for mycobacterial galactosyl transferase activityBioorganic and Medicinal Chemistry.  7:2407-2413. 1999
    1997 Stereoselective epoxidation of acyclic allylic ethers using ketone-Oxone® systemChemistry Letters.  1015-1016. 1997
    1995 Chemistry and biological activities of the genera TinosporaInternational Journal of Pharmacognosy.  33:277-287. 1995

    Research Overview

  • Keywords - Drug Design and Medicinal Chemistry in Infectious diseases, Carbohydrates, saponin adjuvants and drug delivery
  • Education And Training

  • Doctor of Philosophy in Organic Chemistry, 1993
  • Full Name

  • Ashish Pathak