Positions

Selected Publications

Academic Article

Year Title Altmetric
2017 Tracing the dynamics of gene transcripts after organismal deathOpen Biology.  7. 2017
2015 Interruption of electrical conductivity of titanium dental implants suggests a path towards elimination of corrosionPLoS ONE.  10. 2015
2014 A revised design for microarray experiments to account for experimental noise and uncertainty of probe responsePLoS ONE.  9. 2014
2013 Physico-chemical foundations underpinning microarray and next-generation sequencing experimentsNucleic Acids Research.  41:2779-2796. 2013
2011 High-throughput methods for analysis of the human oral microbiomePeriodontology 2000.  55:70-86. 2011
2010 Beyond Affymetrix arrays: expanding the set of known hybridization isotherms and observing pre-wash signal intensities.Nucleic Acids Research.  38. 2010
2007 Revision of the nonequilibrium thermal dissociation and stringent washing approaches for identification of mixed nucleic acid targets by microarraysNucleic Acids Research.  35. 2007
2006 Tests of rRNA hybridization to microarrays suggest that hybridization characteristics of oligonucleotide probes for species discrimination cannot be predictedNucleic Acids Research.  34. 2006
2005 DNA microarray detection of nitrifying bacterial 16S rRNA in wastewater treatment plant samplesWater Research.  39:3229-3238. 2005
1999 Spatial and temporal assessment of diazotroph assemblage composition in vegetated salt marsh sediments using denaturing gradient gel electrophoresis analysisMicrobial Ecology.  38:157-167. 1999
1990 A Numerical Taxonomic Study of Pelagic and Benthic Surface-layer Bacteria in Seasonally-cold Coastal WatersSystematic and Applied Microbiology.  13:77-85. 1990

Chapter

Year Title Altmetric
2012 Artificial Neural Network Modeling of Phytoplankton Blooms and its Application to Sampling Sites within the Same Estuary.  161-172. 2012

Research Overview

  • I am interested in basic and interdisciplinary research in molecular biology, microbial ecology, and bioinformatics.

    My research studies depend on high throughput devices such as DNA microarrays and next-generation sequencing instruments. To improve their accuracy and precision, my team developed calibrated DNA microarrays (Gene Meters) and we are currently trying to calibrate next-generation instruments in the same way. Output from these instruments can then be used to model biological systems and understand how they work.

    Research has a way of dragging you down different paths from where you started -- whether you like it or not. One path I traveled was fixing the “noise” problem in DNA microarray output. My team produced a large body of research on the physicochemistry of DNA microarrays and with this newfound knowledge, developed a way to quantify genes and transcripts in biological samples. Another path was human oral microbiome research in patients with periodontitis and caries. Our focus was finding a way to return an unhealthy microbiome to a healthy one. A third path was investigating how vertebrates respond to stress in terms of their genetic regulatory networks. Microorganisms exploit stressful situations in vertebrates and therefore understanding how vertebrates respond to stress will shed light on how microbial populations interact with them in both health and disease. Lastly, a fortuitous outcome of my travels is the discovery that I have a talent for C++ programming, statistics (e.g., Machine Learning) and scientific writing. I use these tools to investigate challenging problems and provide solutions.
  • Full Name

  • Peter Noble