Selected Publications

Academic Article

Year Title Altmetric
2018 The Lipase Activity of Phospholipase D2 is Responsible for Nigral Neurodegeneration in a Rat Model of Parkinson's DiseaseNeuroscience.  377:174-183. 2018
2017 Neurodegeneration: Keeping ATF4 on a tight leashFrontiers in Cellular Neuroscience.  11. 2017
2016 Up-regulation of activating transcription factor 4 induces severe loss of dopamine nigral neurons in a rat model of Parkinson's diseaseNeuroscience Letters.  627:36-41. 2016
2016 Neuronatin is a stress-responsive protein of rod photoreceptorsNeuroscience.  328:1-8. 2016
2016 Limited ATF4 Expression in Degenerating Retinas with Ongoing ER Stress Promotes Photoreceptor Survival in a Mouse Model of Autosomal Dominant Retinitis PigmentosaPLoS ONE.  11:e0154779. 2016
2015 Unfolded protein response is activated in aged retinasNeuroscience Letters.  609:30-35. 2015
2015 The loss of glucose-regulated protein 78 (GRP78) during normal aging or from siRNA knockdown augments human alpha-synuclein (α-syn) toxicity to rat nigral neuronsNeurobiology of Aging.  36:2213-2223. 2015
2014 The loss of glucose-regulated protein 78 (GRP78) during normal aging or from siRNA knockdown augments human alpha-synuclein (α-syn) toxicity to rat nigral neuronsNeurobiology of Aging2014
2014 Modulation of the rate of retinal degeneration in T17M RHO mice by reprogramming the unfolded protein response.Advances in Experimental Medicine and Biology.  801:455-462. 2014
2013 Salivary peptide tyrosine-tyrosine 3-36 modulates ingestive behavior without inducing taste aversionJournal of Neuroscience.  33:18368-18380. 2013
2013 Review: Retinal degeneration: Focus on the unfolded protein responseMolecular Vision.  19:1985-1998. 2013
2013 Improved Adeno-associated Viral Gene Transfer to Murine Glioma.Genetic Syndromes and Gene Therapy.  4. 2013
2013 The Molecular Chaperone GRP78/BiP as a Therapeutic Target for Neurodegenerative Disorders: A Mini Review.Genetic Syndromes and Gene Therapy.  4. 2013
2013 Caspase-7 ablation modulates UPR, reprograms TRAF2-JNK apoptosis and protects T17M rhodopsin mice from severe retinal degenerationCell Death and Disease.  4. 2013
2012 ER stress is involved in T17M rhodopsin-induced retinal degenerationInvestigative Ophthalmology & Visual Science.  53:3792-3800. 2012
2012 Functional rescue of P23H rhodopsin photoreceptors by gene deliveryAdvances in Experimental Medicine and Biology.  723:191-197. 2012
2012 Glucose regulated protein 78 diminishes α-synuclein neurotoxicity in a rat model of parkinson diseaseMolecular Therapy.  20:1327-1337. 2012
2011 Salivary PYY: A putative bypass to satietyPLoS ONE.  6. 2011
2010 In Vivo RNAi-Mediated α-Synuclein Silencing Induces Nigrostriatal Degeneration.Molecular Therapy.  18:1450-1457. 2010
2010 Restoration of visual function in P23H rhodopsin transgenic rats by gene delivery of BiP/Grp78Proceedings of the National Academy of Sciences.  107:5961-5966. 2010
2010 In vivo RNAi-mediated α-synuclein silencing induces nigrostriatal degenerationMolecular Therapy.  18:1450-1457. 2010
2010 α-synuclein expression in rat substantia nigra suppresses phospholipase D2 toxicity and nigral neurodegenerationMolecular Therapy.  18:1758-1768. 2010
2009 Nigrostriatal rAAV-mediated GDNF overexpression induces robust weight loss in a rat model of age-related obesityMolecular Therapy.  17:980-991. 2009
2009 Weight Loss in Obese Leptin-Resistant Rats Induced by Activation of CRH Neurons in the Paraventricular Nucleus of the Hypothalamus by Overexpression of Substantial Nigral-Injected rAAV5-GDNFCell Transplantation.  18:225-225. 2009
2008 The phosphorylation state of Ser-129 in human α-synuclein determines neurodegeneration in a rat model of Parkinson diseaseProceedings of the National Academy of Sciences.  105:763-768. 2008
2006 Molecular mechanism of the constitutive activation of the L250Q human melanocortin-4 receptor polymorphismPeptide research.  67:215-229. 2006
2004 Recombinant AAV viral vectors pseudotyped with viral capsids from serotypes 1, 2, and 5 display differential efficiency and cell tropism after delivery to different regions of the central nervous systemMolecular Therapy.  10:302-317. 2004
2004 Adeno-associated virus type 2 VP2 capsid protein is nonessential and can tolerate large peptide insertions at its N terminusJournal of Virology.  78:6595-6609. 2004
2004 Adaptation of baculovirus system for large-scale production of rAAV vector serotypesMolecular Therapy.  9:S161-S161. 2004
2004 Differential modulation of energy balance by leptin, ciliary neurotrophic factor, and leukemia inhibitory factor gene delivery: Microarray deoxyribonucleic acid-chip analysis of gene expressionEndocrinology.  145:2035-2045. 2004
2002 Evidence for endogenous agmatine in hypothalamo-neurohypophysial tract and its modulation on vasopressin release and Ca2+ channelsBrain Research.  932:25-36. 2002
2001 Localization of agmatine in vasopressin and oxytocin neurons of the rat hypothalamic paraventricular and supraoptic nucleiExperimental Neurology.  171:235-245. 2001
2000 Agmatine is an autocrine/paracrine inhibitor of pre-synaptic Ca plus plus channels and vasopressin release in vasopressinergic neurons of the hypothalamo-hypophyseal tractHypertension.  36:681-681. 2000
2000 Agmatine may be an autocrine/paracrine blocker of Ca channels in neurohypophysail vasopressinergic terminals via imidazoline receptors.Federation proceedings.  14:A62-A62. 2000
2000 Effect of 2-mercaptoacetate and 2-deoxy-D-glucose administration on the expression of NPY, AGRP, POMC, MCH and hypocretin/orexin in the rat hypothalamusNeuroReport.  11:117-121. 2000
1999 Some Current Approuches in Studying the Rat Hypothalamic Structures Influenced by Earthly Correlates of Micro- and MacrogravityUspekhi fiziologicheskikh nauk.  30:46-49. 1999
1998 Effect of inhibition of glucose and fat metabolism on galanin-R1 receptor mRNA levels in the rat hypothalamic paraventricular and supraoptic nucleiNeuroReport.  9:3565-3569. 1998
1998 Effects of antimetabolites to glucose and fatty acids on galanin-1 receptor mRNA levels in the hypothalamic paraventricular and supraoptic nucleiAnnals of the New York Academy of Sciences.  863:430-431. 1998
1998 Nitric oxide in paraventricular nuclei of rat hypothalamus under extreme conditionsBulletin of Experimental Biology and Medicine.  125:248-250. 1998
1997 Developmental expression of nitric oxide synthase in the rat diencephalon with special reference to the thalamic paratenial nucleusInternational Journal of Developmental Neuroscience.  15:931-938. 1997
1996 Reaction of the paraventricular nucleus of the hypothalamus and the dorsal nucleus of the vagus of rats to change in the gravitational environmentNeuroscience and Behavioral Physiology.  26:387-391. 1996
1991 Metabolism of testosterone in discrete regions of the brain of rat embryosNeuroscience and Behavioral Physiology.  21:259-263. 1991
1989 Response of single cell populations of the paraventricular hypothalamic nuclei to carbohydrate loading and starvation in ratsBulletin of Experimental Biology and Medicine.  108:1030-1032. 1989
1989 Aromatase activity in some areas of rat foetus brainNeuro Endocrinology Letters.  11:189-193. 1989
1989 The compensation of experimental diabetes in rats by means of the transplantation of embryonal pancreatic gland into the anterior chamber of the eyeDoklady Biological Sciences.  304:109-111. 1989

Education And Training

  • Doctor of Philosophy in Medical Basic Sciences, 1991
  • Full Name

  • Oleg Gorbatyuk