Selected Publications

Academic Article

Year Title Altmetric
2019 Biodistribution of adeno-associated virus type 2 with mutations in the capsid that contribute to heparan sulfate proteoglycan bindingVirus Research.  274. 2019
2018 The Lipase Activity of Phospholipase D2 is Responsible for Nigral Neurodegeneration in a Rat Model of Parkinson's DiseaseNeuroscience.  377:174-183. 2018
2017 Neurodegeneration: Keeping ATF4 on a tight leashFrontiers in Cellular Neuroscience.  11. 2017
2016 Up-regulation of activating transcription factor 4 induces severe loss of dopamine nigral neurons in a rat model of Parkinson's diseaseNeuroscience Letters.  627:36-41. 2016
2016 Neuronatin is a stress-responsive protein of rod photoreceptorsNeuroscience.  328:1-8. 2016
2016 Limited ATF4 expression in degenerating retinas with ongoing ER stress promotes photoreceptor survival in a mouse model of autosomal dominant retinitis pigmentosaPLoS One.  11. 2016
2015 Unfolded protein response is activated in aged retinasNeuroscience Letters.  609:30-35. 2015
2015 The loss of glucose-regulated protein 78 (GRP78) during normal aging or from siRNA knockdown augments human alpha-synuclein (α-syn) toxicity to rat nigral neuronsNeurobiology of Aging.  36:2213-2223. 2015
2014 Modulation of the rate of retinal degeneration in T17M RHO mice by reprogramming the unfolded protein response.Advances in Experimental Medicine and Biology.  801:455-462. 2014
2013 Salivary peptide tyrosine-tyrosine 3-36 modulates ingestive behavior without inducing taste aversion 2013
2013 Review: Retinal degeneration: Focus on the unfolded protein responseMolecular Vision.  19:1985-1998. 2013
2013 Improved Adeno-associated Viral Gene Transfer to Murine Glioma.Genetic Syndromes and Gene Therapy.  4. 2013
2013 The Molecular Chaperone GRP78/BiP as a Therapeutic Target for Neurodegenerative Disorders: A Mini Review.Genetic Syndromes and Gene Therapy.  4. 2013
2013 Caspase-7 ablation modulates UPR, reprograms TRAF2-JNK apoptosis and protects T17M rhodopsin mice from severe retinal degenerationCell Death and Disease.  4. 2013
2012 ER stress is involved in T17M rhodopsin-induced retinal degeneration 2012
2012 Functional rescue of P23H rhodopsin photoreceptors by gene deliveryAdvances in Experimental Medicine and Biology.  723:191-197. 2012
2012 Glucose regulated protein 78 diminishes α-synuclein neurotoxicity in a rat model of parkinson diseaseMolecular Therapy.  20:1327-1337. 2012
2011 Salivary PYY: A putative bypass to satietyPLoS One.  6. 2011
2010 In Vivo RNAi-Mediated α-Synuclein Silencing Induces Nigrostriatal Degeneration.Molecular Therapy.  18:1450-1457. 2010
2010 Restoration of visual function in P23H rhodopsin transgenic rats by gene delivery of BiP/Grp78 2010
2010 In vivo RNAi-mediated α-synuclein silencing induces nigrostriatal degenerationMolecular Therapy.  18:1450-1457. 2010
2010 α-synuclein expression in rat substantia nigra suppresses phospholipase D2 toxicity and nigral neurodegenerationMolecular Therapy.  18:1758-1768. 2010
2009 Nigrostriatal rAAV-mediated GDNF overexpression induces robust weight loss in a rat model of age-related obesityMolecular Therapy.  17:980-991. 2009
2009 Weight Loss in Obese Leptin-Resistant Rats Induced by Activation of CRH Neurons in the Paraventricular Nucleus of the Hypothalamus by Overexpression of Substantial Nigral-Injected rAAV5-GDNFCell Transplantation.  18:225-225. 2009
2008 The phosphorylation state of Ser-129 in human α-synuclein determines neurodegeneration in a rat model of Parkinson disease 2008
2006 Molecular mechanism of the constitutive activation of the L250Q human melanocortin-4 receptor polymorphismChemical Biology and Drug Design.  67:215-229. 2006
2004 Recombinant AAV viral vectors pseudotyped with viral capsids from serotypes 1, 2, and 5 display differential efficiency and cell tropism after delivery to different regions of the central nervous systemMolecular Therapy.  10:302-317. 2004
2004 Adeno-associated virus type 2 VP2 capsid protein is nonessential and can tolerate large peptide insertions at its N terminusJournal of Virology.  78:6595-6609. 2004
2004 Adaptation of baculovirus system for large-scale production of rAAV vector serotypesMolecular Therapy.  9:S161-S161. 2004
2004 Differential modulation of energy balance by leptin, ciliary neurotrophic factor, and leukemia inhibitory factor gene delivery: Microarray deoxyribonucleic acid-chip analysis of gene expression 2004
2002 Evidence for endogenous agmatine in hypothalamo-neurohypophysial tract and its modulation on vasopressin release and Ca2+ channelsBrain Research.  932:25-36. 2002
2001 Localization of agmatine in vasopressin and oxytocin neurons of the rat hypothalamic paraventricular and supraoptic nucleiExperimental Neurology.  171:235-245. 2001
2000 Agmatine is an autocrine/paracrine inhibitor of pre-synaptic Ca plus plus channels and vasopressin release in vasopressinergic neurons of the hypothalamo-hypophyseal tractHypertension.  36:681-681. 2000
2000 Agmatine may be an autocrine/paracrine blocker of Ca channels in neurohypophysail vasopressinergic terminals via imidazoline receptors. 2000
2000 Effect of 2-mercaptoacetate and 2-deoxy-D-glucose administration on the expression of NPY, AGRP, POMC, MCH and hypocretin/orexin in the rat hypothalamusNeuroReport.  11:117-121. 2000
1999 Some Current Approuches in Studying the Rat Hypothalamic Structures Influenced by Earthly Correlates of Micro- and MacrogravityUspekhi fiziologicheskikh nauk.  30:46-49. 1999
1998 Effect of inhibition of glucose and fat metabolism on galanin-R1 receptor mRNA levels in the rat hypothalamic paraventricular and supraoptic nucleiNeuroReport.  9:3565-3569. 1998
1998 Effects of antimetabolites to glucose and fatty acids on galanin-1 receptor mRNA levels in the hypothalamic paraventricular and supraoptic nucleiAnnals of the New York Academy of Sciences.  863:430-431. 1998
1998 Nitric oxide in paraventricular nuclei of rat hypothalamus under extreme conditionsBulletin of Experimental Biology and Medicine.  125:248-250. 1998
1997 Developmental expression of nitric oxide synthase in the rat diencephalon with special reference to the thalamic paratenial nucleusInternational Journal of Developmental Neuroscience.  15:931-938. 1997
1996 Reaction of the paraventricular nucleus of the hypothalamus and the dorsal nucleus of the vagus of rats to change in the gravitational environmentNeuroscience and Behavioral Physiology.  26:387-391. 1996
1991 Metabolism of testosterone in discrete regions of the brain of rat embryosNeuroscience and Behavioral Physiology.  21:259-263. 1991
1989 Response of single cell populations of the paraventricular hypothalamic nuclei to carbohydrate loading and starvation in ratsBulletin of Experimental Biology and Medicine.  108:1030-1032. 1989
1989 Aromatase activity in some areas of rat foetus brainNeuro endocrinology letters.  11:189-193. 1989
1989 The compensation of experimental diabetes in rats by means of the transplantation of embryonal pancreatic gland into the anterior chamber of the eyeDoklady Biological Sciences.  304:109-111. 1989

Education And Training

  • Doctor of Philosophy in Medical Basic Sciences, 1991
  • Full Name

  • Oleg Gorbatyuk