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Oleg Gorbatyuk
Research Associate Professor
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E-mail
oleggor@uab.edu
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Oleg Gorbatyuk
Research Associate Professor
Positions
Scientist (C)
,
Center for Clinical and Translational Science (CCTS)
,
General Clinical Research Center
Associate Scientist (C)
,
Neurodegeneration and Experimental Therapeutics (CNET)
,
Neurology
Associate Professor - Research (P)
,
Dept of Optometry & Vision Science
,
School of Optometry
Publications
Research
Background
Contact
Publications
Selected Publications
Academic Article
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Year
Title
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2019
Biodistribution of adeno-associated virus type 2 with mutations in the capsid that contribute to heparan sulfate proteoglycan binding
.
Virus Research
. 274.
2019
2018
The Lipase Activity of Phospholipase D2 is Responsible for Nigral Neurodegeneration in a Rat Model of Parkinson's Disease
.
Neuroscience
. 377:174-183.
2018
2017
Neurodegeneration: Keeping ATF4 on a tight leash
.
Frontiers in Cellular Neuroscience
. 11.
2017
2016
Up-regulation of activating transcription factor 4 induces severe loss of dopamine nigral neurons in a rat model of Parkinson's disease
.
Neuroscience Letters
. 627:36-41.
2016
2016
Neuronatin is a stress-responsive protein of rod photoreceptors
.
Neuroscience
. 328:1-8.
2016
2016
Limited ATF4 expression in degenerating retinas with ongoing ER stress promotes photoreceptor survival in a mouse model of autosomal dominant retinitis pigmentosa
.
PLoS One
. 11.
2016
2015
Unfolded protein response is activated in aged retinas
.
Neuroscience Letters
. 609:30-35.
2015
2015
The loss of glucose-regulated protein 78 (GRP78) during normal aging or from siRNA knockdown augments human alpha-synuclein (α-syn) toxicity to rat nigral neurons
.
Neurobiology of Aging
. 36:2213-2223.
2015
2014
Modulation of the rate of retinal degeneration in T17M RHO mice by reprogramming the unfolded protein response.
.
Advances in Experimental Medicine and Biology
. 801:455-462.
2014
2013
Salivary peptide tyrosine-tyrosine 3-36 modulates ingestive behavior without inducing taste aversion
2013
2013
Review: Retinal degeneration: Focus on the unfolded protein response
.
Molecular Vision
. 19:1985-1998.
2013
2013
Improved Adeno-associated Viral Gene Transfer to Murine Glioma.
.
Genetic Syndromes and Gene Therapy
. 4.
2013
2013
The Molecular Chaperone GRP78/BiP as a Therapeutic Target for Neurodegenerative Disorders: A Mini Review.
.
Genetic Syndromes and Gene Therapy
. 4.
2013
2013
Caspase-7 ablation modulates UPR, reprograms TRAF2-JNK apoptosis and protects T17M rhodopsin mice from severe retinal degeneration
.
Cell Death and Disease
. 4.
2013
2012
ER stress is involved in T17M rhodopsin-induced retinal degeneration
2012
2012
Functional rescue of P23H rhodopsin photoreceptors by gene delivery
.
Advances in Experimental Medicine and Biology
. 723:191-197.
2012
2012
Glucose regulated protein 78 diminishes α-synuclein neurotoxicity in a rat model of parkinson disease
.
Molecular Therapy
. 20:1327-1337.
2012
2011
Salivary PYY: A putative bypass to satiety
.
PLoS One
. 6.
2011
2010
In Vivo RNAi-Mediated α-Synuclein Silencing Induces Nigrostriatal Degeneration.
.
Molecular Therapy
. 18:1450-1457.
2010
2010
Restoration of visual function in P23H rhodopsin transgenic rats by gene delivery of BiP/Grp78
2010
2010
In vivo RNAi-mediated α-synuclein silencing induces nigrostriatal degeneration
.
Molecular Therapy
. 18:1450-1457.
2010
2010
α-synuclein expression in rat substantia nigra suppresses phospholipase D2 toxicity and nigral neurodegeneration
.
Molecular Therapy
. 18:1758-1768.
2010
2009
Nigrostriatal rAAV-mediated GDNF overexpression induces robust weight loss in a rat model of age-related obesity
.
Molecular Therapy
. 17:980-991.
2009
2009
Weight Loss in Obese Leptin-Resistant Rats Induced by Activation of CRH Neurons in the Paraventricular Nucleus of the Hypothalamus by Overexpression of Substantial Nigral-Injected rAAV5-GDNF
.
Cell Transplantation
. 18:225-225.
2009
2008
The phosphorylation state of Ser-129 in human α-synuclein determines neurodegeneration in a rat model of Parkinson disease
2008
2006
Molecular mechanism of the constitutive activation of the L250Q human melanocortin-4 receptor polymorphism
.
Chemical Biology and Drug Design
. 67:215-229.
2006
2004
Recombinant AAV viral vectors pseudotyped with viral capsids from serotypes 1, 2, and 5 display differential efficiency and cell tropism after delivery to different regions of the central nervous system
.
Molecular Therapy
. 10:302-317.
2004
2004
Adeno-associated virus type 2 VP2 capsid protein is nonessential and can tolerate large peptide insertions at its N terminus
.
Journal of Virology
. 78:6595-6609.
2004
2004
Adaptation of baculovirus system for large-scale production of rAAV vector serotypes
.
Molecular Therapy
. 9:S161-S161.
2004
2004
Differential modulation of energy balance by leptin, ciliary neurotrophic factor, and leukemia inhibitory factor gene delivery: Microarray deoxyribonucleic acid-chip analysis of gene expression
2004
2002
Evidence for endogenous agmatine in hypothalamo-neurohypophysial tract and its modulation on vasopressin release and Ca
2+
channels
.
Brain Research
. 932:25-36.
2002
2001
Localization of agmatine in vasopressin and oxytocin neurons of the rat hypothalamic paraventricular and supraoptic nuclei
.
Experimental Neurology
. 171:235-245.
2001
2000
Agmatine is an autocrine/paracrine inhibitor of pre-synaptic Ca plus plus channels and vasopressin release in vasopressinergic neurons of the hypothalamo-hypophyseal tract
.
Hypertension
. 36:681-681.
2000
2000
Agmatine may be an autocrine/paracrine blocker of Ca channels in neurohypophysail vasopressinergic terminals via imidazoline receptors.
2000
2000
Effect of 2-mercaptoacetate and 2-deoxy-D-glucose administration on the expression of NPY, AGRP, POMC, MCH and hypocretin/orexin in the rat hypothalamus
.
NeuroReport
. 11:117-121.
2000
1999
Some Current Approuches in Studying the Rat Hypothalamic Structures Influenced by Earthly Correlates of Micro- and Macrogravity
.
Uspekhi fiziologicheskikh nauk
. 30:46-49.
1999
1998
Effect of inhibition of glucose and fat metabolism on galanin-R1 receptor mRNA levels in the rat hypothalamic paraventricular and supraoptic nuclei
.
NeuroReport
. 9:3565-3569.
1998
1998
Effects of antimetabolites to glucose and fatty acids on galanin-1 receptor mRNA levels in the hypothalamic paraventricular and supraoptic nuclei
.
Annals of the New York Academy of Sciences
. 863:430-431.
1998
1998
Nitric oxide in paraventricular nuclei of rat hypothalamus under extreme conditions
.
Bulletin of Experimental Biology and Medicine
. 125:248-250.
1998
1997
Developmental expression of nitric oxide synthase in the rat diencephalon with special reference to the thalamic paratenial nucleus
.
International Journal of Developmental Neuroscience
. 15:931-938.
1997
1996
Reaction of the paraventricular nucleus of the hypothalamus and the dorsal nucleus of the vagus of rats to change in the gravitational environment
.
Neuroscience and Behavioral Physiology
. 26:387-391.
1996
1992
STRUCTURAL AND NEUROCHEMICAL FEATURES OF BRAIN SEX-DEPENDENT NEURONS GRAFTED INTO THE ANTERIOR EYE CHAMBER
.
Annals of the Russian academy of medical sciences
. 12-16.
1992
1991
Metabolism of testosterone in discrete regions of the brain of rat embryos
.
Neuroscience and Behavioral Physiology
. 21:259-263.
1991
1991
SEXUAL DIMORPHISM IN RESPONDING TO SALT LOADING AND WATER-DEPRIVATION OF THE RAT HYPOTHALAMIC LARGE CELL PARAVENTRICULAR NUCLEI
.
Arkhiv patologii
. 53:13-15.
1991
1989
Response of single cell populations of the paraventricular hypothalamic nuclei to carbohydrate loading and starvation in rats
.
Bulletin of Experimental Biology and Medicine
. 108:1030-1032.
1989
1989
Aromatase activity in some areas of rat foetus brain
.
Neuro endocrinology letters
. 11:189-193.
1989
1989
The compensation of experimental diabetes in rats by means of the transplantation of embryonal pancreatic gland into the anterior chamber of the eye
.
Doklady Biological Sciences
. 304:109-111.
1989
Research
Principal Investigator On
Unfolded Protein Response (UPR) Perk Signaling in Parkinson's Disease Progression
awarded by
Fox (Michael J.) Foundation for Parkinson's Research
Investigator On
Development and Validation of a Tree Shrew Model of Diabetic Retinopathy
awarded by
National Eye Institute/NIH/DHHS
The Mechanism of Vesicant-Induced Ocular injury
awarded by
National Eye Institute/NIH/DHHS
Background
Education And Training
Doctor of Philosophy in Medical Basic Sciences,
1991
Contact
Full Name
Oleg
Gorbatyuk