Positions

Overview

  • Dr. Gutiérrez is the Marie S. Ingalls Endowed Chair in Nephrology Leadership, Professor of Medicine and Epidemiology, Director of the Division of Nephrology, and Deputy Director of the Center for Clinical and Translational Science at the University of Alabama at Birmingham (UAB). Dr. Gutiérrez’s research is focused on understanding pathophysiological mechanisms underlying disorders of phosphorus metabolism in health and in individuals with kidney disease. He has a special interest in delineating environmental and/or behavioral factors that may modulate these associations, particularly those related to health disparities, poverty and nutrition. To this end, his group conducts epidemiologic and patient-oriented studies investigating the impact of disturbances in phosphorus metabolism on kidney and cardiovascular health. He also has interests in the association of biomarkers of kidney tubule function with clinical outcomes, and improving outcomes in individuals with acute kidney injury.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2022 Alpha globin gene copy number and hypertension risk among Black AmericansPLoS One.  17. 2022
    2022 Biomarkers of Kidney Tubule Disease and Risk of End-Stage Kidney Disease in Persons With Diabetes and CKDKidney International Reports.  7:1514-1523. 2022
    2022 Plasma Biomarkers as Risk Factors for Incident CKDKidney International Reports.  7:1493-1501. 2022
    2022 Associations of Plasma Biomarkers of Inflammation, Fibrosis, and Kidney Tubular Injury With Progression of Diabetic Kidney Disease: A Cohort StudyAmerican Journal of Kidney Diseases.  79:849-857.e1. 2022
    2022 Lung-kidney interactions and their role in chronic kidney disease-associated pulmonary diseasesAmerican Journal of Physiology: Lung Cellular and Molecular Physiology.  322:L625-L640. 2022
    2022 The Influence of Acute High Dose MitoQ on Urinary Kidney Injury Markers in Healthy AdultsThe FASEB Journal.  36. 2022
    2022 APOL1 Risk Variants Associated with Serum Albumin in a Population-Based Cohort StudyAmerican Journal of Nephrology.  53:182-190. 2022
    2022 Could Phosphate Provide a Second Chance for Statin Therapy in Kidney Failure?Clinical Journal of the American Society of Nephrology.  17:478-480. 2022
    2022 High dietary salt intake increases urinary NGAL excretion and creatinine clearance in healthy young adultsAmerican Journal of Physiology: Renal Physiology.  322:F392-F402. 2022
    2022 Fibroblast growth factor-23 and subclinical markers of cardiac dysfunction: The coronary artery risk development in young adults (CARDIA) studyAmerican Heart Journal.  245:10-18. 2022
    2022 Hyperphosphatemia increases inflammation to exacerbate anemia and skeletal muscle wasting independently of FGF23-FGFR4 signalingeLife.  11. 2022
    2022 Kidney Disease Prevalence in Transgender IndividualsClinical Journal of the American Society of Nephrology.  17:280-282. 2022
    2022 Alpha Globin Gene Copy Number Is Associated with Prevalent Chronic Kidney Disease and Incident End-Stage Kidney Disease among Black AmericansJournal of the American Society of Nephrology.  33:213-224. 2022
    2021 Characteristics and Outcomes of Survivors of Critical Illness and Acute Kidney Injury Followed in a Pilot Acute Kidney Injury ClinicKidney International Reports.  6:3070-3073. 2021
    2021 Recent Advances in the Role of Diet in Bone and Mineral Disorders in Chronic Kidney DiseaseCurrent Osteoporosis Reports.  19:574-579. 2021
    2021 Risk for recurrent cardiovascular disease events among patients with diabetes and chronic kidney diseaseCardiovascular Diabetology.  20. 2021
    2021 New creatinine- And cystatin C-based equations to estimate GFR without raceNew England Journal of Medicine.  385:1737-1749. 2021
    2021 Soluble klotho and incident hypertensionClinical Journal of the American Society of Nephrology.  16:1502-1511. 2021
    2021 Atherosclerotic Cardiovascular Disease Events in Adults With CKD Taking a Moderate- or High-Intensity Statin: The Chronic Renal Insufficiency Cohort (CRIC) Study 2021
    2021 Treatment of Iron Deficiency Anemia in CKD and End-Stage Kidney DiseaseKidney International Reports.  6:2261-2269. 2021
    2021 Fibroblast growth factor 23 and incident cardiovascular disease and mortality in middle-aged adultsJournal of the American Heart Association.  10. 2021
    2021 Metabolite biomarkers of ckd progression in childrenClinical Journal of the American Society of Nephrology.  16:1178-1189. 2021
    2021 Chronobiology of Natriuretic Peptides and Blood Pressure in Lean and Obese IndividualsJournal of the American College of Cardiology.  77:2291-2303. 2021
    2021 UAB-UCSD o'brien center for acute kidney injury researchAmerican Journal of Physiology: Renal Physiology.  320:F870-F882. 2021
    2021 Examining the relationship between nutrition, quality of life, and depression in hemodialysis patientsQuality of Life Research.  30:759-768. 2021
    2021 FGF23 and Cause-Specific Mortality in Community-Living Individuals—The Health, Aging, and Body Composition StudyJournal of the American Geriatrics Society.  69:711-717. 2021
    2021 Kidneys also speak SpanishNefrología (English Edition).  41:224-226. 2021
    2021 Association of multiple plasma biomarker concentrations with progression of prevalent diabetic kidney disease: Findings from the Chronic Renal Insufficiency Cohort (CRIC) studyJournal of the American Society of Nephrology.  32:115-126. 2021
    2021 Red blood cell exosome hemoglobin content increases after cardiopulmonary bypass and mediates acute kidney injury in an animal modelJournal of Thoracic and Cardiovascular Surgery2021
    2021 State-of-the-Art Management of Hyperphosphatemia in Patients With CKD: An NKF-KDOQI Controversies PerspectiveAmerican Journal of Kidney Diseases.  77:132-141. 2021
    2020 Association of Educational Attainment With Incidence of CKD in Young AdultsKidney International Reports.  5:2256-2263. 2020
    2020 Fibroblast growth factor 23 and cognitive impairment: The health, aging, and body composition studyPLoS One.  15. 2020
    2020 Race, ancestry, and Vitamin D metabolism: The multi-ethnic study of atherosclerosisJournal of Clinical Endocrinology and Metabolism.  105. 2020
    2020 Racial Differences in the Associations Between Food Insecurity and Fibroblast Growth Factor 23 in the Coronary Artery Risk Development in Young Adults StudyJournal of Renal Nutrition.  30:509-517. 2020
    2020 Incorporating kidney disease measures into cardiovascular risk prediction: Development and validation in 9 million adults from 72 datasetsEClinicalMedicine.  27. 2020
    2020 Association of FGF23 with Incident Sepsis in Community-Dwelling Adults: A Cohort Study. 2020
    2020 Effect of ferric citrate versus ferrous sulfate on iron and phosphate parameters in patients with iron deficiency and ckd: A randomized trialClinical Journal of the American Society of Nephrology.  15:1251-1258. 2020
    2020 Fibroblast growth factor 23 and the last mileClinical Journal of the American Society of Nephrology.  15:1355-1357. 2020
    2020 Efficacy of burosumab in a case of tumor-induced osteomalaciaRevue du Rhumatisme.  87:300-302. 2020
    2020 Fibroblast Growth Factor 23 and Blood Pressure in Older Adults: The Health, Aging, and Body Composition StudyHypertension.  76:236-243. 2020
    2020 Chronic Kidney Disease Awareness and Longitudinal Health Outcomes: Results from the REasons for Geographic and Racial Differences in Stroke StudyAmerican Journal of Nephrology.  51:463-472. 2020
    2020 Effects of phosphorus and calcium to phosphorus consumption ratio on mineral metabolism and cardiometabolic healthJournal of Nutritional Biochemistry.  80. 2020
    2020 Incidence and Implications of Atrial Fibrillation/Flutter in Hypertension: Insights from the SPRINT TrialHypertension.  75:1483-1490. 2020
    2020 Ambulatory blood pressure phenotypes in adults taking antihypertensive medication With and Without CKDClinical Journal of the American Society of Nephrology.  15:501-510. 2020
    2020 APOL1 Nephropathy Risk Alleles and Mortality in African American Adults: A Cohort StudyAmerican Journal of Kidney Diseases.  75:54-60. 2020
    2020 Burosumab in tumor-induced osteomalacia: A case report 2020
    2019 Apol1 nephropathy risk alleles and risk of sepsis in blacksClinical Journal of the American Society of Nephrology.  14:1733-1740. 2019
    2019 Race, Natriuretic Peptides, and High-Carbohydrate Challenge: A Clinical TrialCirculation Research.  125:957-968. 2019
    2019 Association of 25-hydroxyvitamin D with incident coronary heart disease in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) studyAmerican Heart Journal.  217:140-147. 2019
    2019 Race-based demographic, anthropometric and clinical correlates of N-terminal-pro B-type natriuretic peptideInternational Journal of Cardiology.  286:145-151. 2019
    2019 Plasma 25-Hydroxyvitamin D and the Longitudinal Risk of Sepsis in the REGARDS CohortClinical Infectious Diseases.  68:1926-1931. 2019
    2019 Association of Urine Albumin Excretion With Incident Heart Failure Hospitalization in Community-Dwelling AdultsJACC: Heart Failure.  7:394-401. 2019
    2019 Brief Report: Kidney Dysfunction Does Not Contribute Significantly to Antiretroviral Therapy Modification in Treatment-Naive PLWH Receiving Initial ARTJournal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association.  81:E6-E9. 2019
    2019 Dietary Patterns and Incident Heart Failure in U.S. Adults Without Known Coronary DiseaseJournal of the American College of Cardiology.  73:2036-2045. 2019
    2019 Risks of anticoagulation in patients with chronic kidney disease and atrial fibrillation: More than just bleeding?Research and Practice in Thrombosis and Haemostasis.  3:147-148. 2019
    2019 Relationship of Estimated GFR and Albuminuria to Concurrent Laboratory Abnormalities: An Individual Participant Data Meta-analysis in a Global ConsortiumAmerican Journal of Kidney Diseases.  73:206-217. 2019
    2019 A PheWAS study of a large observational epidemiological cohort of African Americans from the REGARDS studyBMC Medical Genomics.  12. 2019
    2019 APOL1 kidney risk variants and cardiovascular disease: An individual participant data meta-analysisJournal of the American Society of Nephrology.  30:2027-2036. 2019
    2019 Adiposity and risk of decline in glomerular filtration rate: Meta-analysis of individual participant data in a global consortiumBMJ.  364. 2019
    2019 Racial differences in the association of NT-proBNP with risk of incident heart failure in REGARDSJCI insight.  4. 2019
    2018 Adherence to Mediterranean-style diet and risk of sepsis in the REasons for Geographic and Racial Differences in Stroke (REGARDS) cohortThe British Journal of Nutrition: an international journal of nutritional science.  120:1415-1421. 2018
    2018 The Role of Vitamin D in CKD Stages 3 to 4: Report of a Scientific Workshop Sponsored by the National Kidney FoundationAmerican Journal of Kidney Diseases.  72:834-845. 2018
    2018 Serum albumin concentration and risk of end-stage renal disease: The REGARDS studyNephrology Dialysis Transplantation.  33:1770-1777. 2018
    2018 Serum Calcitriol Concentrations and Kidney Function Decline, Heart Failure, and Mortality in Elderly Community-Living Adults: The Health, Aging, and Body Composition StudyAmerican Journal of Kidney Diseases.  72:419-428. 2018
    2018 Urinary Biomarkers of Kidney Tubular Damage and Risk of Cardiovascular Disease and Mortality in EldersAmerican Journal of Kidney Diseases.  72:205-213. 2018
    2018 FGF23 (fibroblast growth factor-23) and incident hypertension in young and middle-aged adults: The CARDIA studyHypertension.  72:70-76. 2018
    2018 Association of serum albumin levels with kidney function decline and incident chronic kidney disease in eldersNephrology Dialysis Transplantation.  33:986-992. 2018
    2018 Dietary Oxidative Balance Scores and Biomarkers of Inflammation among Individuals with and without Chronic Kidney DiseaseNephron Extra.  8:11-23. 2018
    2018 Fibroblast Growth Factor 23: A Biomarker of Kidney Function DeclineAmerican Journal of Nephrology.  47:242-250. 2018
    2018 Association of fibroblast growth factor 23 with risk of incident coronary heart disease in community-living adultsJAMA Cardiology.  3:318-325. 2018
    2018 APOL1 nephropathy risk variants do not associate with subclinical atherosclerosis or left ventricular mass in middle-aged black adultsKidney International.  93:727-732. 2018
    2018 Effect of calcitriol on serum hepcidin in individuals with chronic kidney disease: A randomized controlled trialBMC Nephrology.  19. 2018
    2018 Racial differences in plasma levels of n-Terminal pro-b-Type natriuretic peptide and outcomes the reasons for geographic and racial differences in stroke (regards) studyJAMA Cardiology.  3:11-17. 2018
    2018 The Association between Residence in a Food Desert Census Tract and Adherence to Dietary Patterns in the REGARDS Cohort.Food and Public Health.  8:79-85. 2018
    2017 Association between APOL1 genotypes and risk of cardiovascular disease in MESA (Multi-Ethnic Study of Atherosclerosis)Journal of the American Heart Association.  6. 2017
    2017 KDOQI US Commentary on the 2017 KDIGO Clinical Practice Guideline Update for the Diagnosis, Evaluation, Prevention, and Treatment of Chronic Kidney Disease–Mineral and Bone Disorder (CKD-MBD)American Journal of Kidney Diseases.  70:737-751. 2017
    2017 APOL1 genetic variants are not associated with longitudinal blood pressure in young black adultsKidney International.  92:964-971. 2017
    2017 Urinary Markers of Fibrosis and Risk of Cardiovascular Events and Death in Kidney Transplant Recipients: The FAVORIT TrialAmerican Journal of Transplantation.  17:2640-2649. 2017
    2017 Global cardiovascular and renal outcomes of reduced GFRJournal of the American Society of Nephrology.  28:2167-2179. 2017
    2017 Sickle cell trait and the risk of ESRD in blacksJournal of the American Society of Nephrology.  28:2180-2187. 2017
    2017 Association between soluble klotho and change in kidney function: The health aging and body composition studyJournal of the American Society of Nephrology.  28:1859-1866. 2017
    2017 Oxidative Balance Score and the Risk of End-Stage Renal Disease and Cardiovascular DiseaseAmerican Journal of Nephrology.  45:338-345. 2017
    2017 BP control and long-term risk of ESRD and mortalityJournal of the American Society of Nephrology.  28:671-677. 2017
    2017 Albuminuria, kidney function, and sudden cardiac death: Findings from The Reasons for Geographic and Racial Differences in Stroke (REGARDS) studyHeart Rhythm.  14:65-71. 2017
    2017 Association of urinary uromodulin with kidney function decline and mortality: The health ABC studyClinical Nephrology.  87:278-286. 2017
    2016 Response by Gutiérrez et al to letter regarding article, "Hemoglobin concentration and risk of incident stroke in community-living adults"Stroke.  47:e260. 2016
    2016 Vitamin D, Fibroblast growth factor 23 and incident cognitive impairment: Findings from the REGARDS studyPLoS One.  11. 2016
    2016 Associations of 25-hydroxyvitamin D with markers of inflammation, insulin resistance and obesity in black and white community-dwelling adultsJournal of Clinical and Translational Endocrinology.  5:21-25. 2016
    2016 Associations of blood pressure, sunlight, and Vitamin D in community-dwelling adultsJournal of Hypertension.  34:1704-1710. 2016
    2016 Hemoglobin Concentration and Risk of Incident Stroke in Community-Living AdultsStroke.  47:2017-2024. 2016
    2016 Disorders of Iron Metabolism and Anemia in Chronic Kidney DiseaseSeminars in Nephrology.  36:252-261. 2016
    2016 Admixture mapping of serum vitamin D and parathyroid hormone concentrations in the African American-Diabetes Heart StudyBone.  87:71-77. 2016
    2016 Fibroblast growth factor 23 and heart failure: The plot thickensNephrology Dialysis Transplantation.  31:688-690. 2016
    2016 Genetic african ancestry and markers of mineral metabolism in CKDClinical Journal of the American Society of Nephrology.  11:653-662. 2016
    2016 APOL1 nephropathy risk variants are associated with altered high-density lipoprotein profiles in African AmericansNephrology Dialysis Transplantation.  31:602-608. 2016
    2016 The role of cystatin-C in the confirmation of reduced glomerular filtration rate among the oldest oldArchives of Medical Science.  12:55-67. 2016
    2016 Connecting the dots on fibroblast growth factor 23 and left ventricular hypertrophyNephrology Dialysis Transplantation.  31:1031-1033. 2016
    2016 Association of reduced eGFR and albuminuria with serious fall injuries among older adultsClinical Journal of the American Society of Nephrology.  11:1236-1243. 2016
    2016 Vitamin D deficiency and incident stroke risk in community-living black and white adultsInternational Journal of Stroke.  11:93-102. 2016
    2016 Waist Circumference, Body Mass Index, and ESRD in the REGARDS (Reasons for Geographic and Racial Differences in Stroke) StudyAmerican Journal of Kidney Diseases.  67:62-69. 2016
    2015 Oxidative Balance Score and Chronic Kidney DiseaseAmerican Journal of Nephrology.  42:320-327. 2015
    2015 Impact of phosphorus-based food additives on bone and mineral metabolismJournal of Clinical Endocrinology and Metabolism.  100:4264-4271. 2015
    2015 Validation of an albuminuria self-assessment tool in the Multi-Ethnic Study of Atherosclerosis (MESA)Ethnicity and Disease.  25:427-434. 2015
    2015 Estimated glomerular filtration rate and albuminuria for prediction of cardiovascular outcomes: A collaborative meta-analysis of individual participant dataLancet Diabetes and Endocrinology.  3:514-525. 2015
    2015 Diet patterns and risk of sepsis in community-dwelling adults: A cohort studyBMC Infectious Diseases.  15. 2015
    2015 Bone mineral content as a driver of energy expenditure in prepubertal and early pubertal boysJournal of Pediatrics.  166:1397-1403. 2015
    2015 Obesity, metabolic health, and the risk of end-stage renal diseaseKidney International.  87:1216-1222. 2015
    2015 APOL1 G1 genotype modifies the association between HDLC and kidney function in African AmericansBMC Genomics.  16. 2015
    2015 Response to Letter Regarding Article, "fibroblast Growth Factor 23 and Risk of Incident Stroke in Community-Living Adults"Stroke.  46:e124. 2015
    2015 Contrasting cholesterol management guidelines for adults with CKDJournal of the American Society of Nephrology.  26:1173-1180. 2015
    2015 Cystatin C and long term risk of community-acquired sepsis: A population-based cohort study Epidemiology and Health OutcomesBMC Nephrology.  16. 2015
    2015 Fibroblast growth factor-21, body composition, and insulin resistance in pre-pubertal and early pubertal males and femalesClinical Endocrinology.  82:550-556. 2015
    2015 Associations of fibroblast growth factor-23 with markers of inflammation, insulin resistance and obesity in adultsPLoS One.  10. 2015
    2015 Fibroblast growth factor 23 and risk of incident stroke in community-living adultsStroke.  46:322-328. 2015
    2015 Validation study of medicare claims to identify older US adults with CKD using the reasons for geographic and racial differences in stroke (REGARDS) studyAmerican Journal of Kidney Diseases.  65:249-258. 2015
    2015 Circulating levels of fibroblast growth factor-21 increase with age independently of body composition indices among healthy individualsJournal of Clinical and Translational Endocrinology.  2:77-82. 2015
    2015 Contextual poverty, nutrition, and chronic kidney disease 2015
    2015 Prehospitalization risk factors for acute kidney injury during hospitalization for serious infections in the REGARDS cohortNephron Extra.  5:87-99. 2015
    2014 Reply to MF McCartyAmerican Journal of Clinical Nutrition.  99:966-967. 2014
    2014 High dietary phosphorus intake is associated with all-cause mortality: Results from NHANES III1-3American Journal of Clinical Nutrition.  99:320-327. 2014
    2014 Contribution of Food Additives to Sodium and Phosphorus Content of Diets Rich in Processed FoodsJournal of Renal Nutrition.  24. 2014
    2014 Dietary patterns and risk of death and progression to ESRD in individuals with CKD: A cohort studyAmerican Journal of Kidney Diseases.  64:204-213. 2014
    2014 Incident ESRD and treatment-resistant hypertension: The reasons for geographic and racial differences in stroke (REGARDS) studyAmerican Journal of Kidney Diseases.  63:781-788. 2014
    2014 Low income, community poverty and risk of end stage renal diseaseBMC Nephrology.  15. 2014
    2014 N-terminal pro-B-type natriuretic peptide and stroke risk: The reasons for geographic and racial differences in stroke cohortStroke.  45:1646-1650. 2014
    2014 Nondisease-specific problems and all-cause mortality among older adults with CKD: The REGARDS studyClinical Journal of the American Society of Nephrology.  9:1737-1745. 2014
    2014 The association between race and income on riskof mortality in patients with moderate chronic kidney diseaseBMC Nephrology.  15. 2014
    2013 Metabolic subtypes and risk of mortality in normal weight, overweight, and obese individuals with CKDClinical Journal of the American Society of Nephrology.  8:2064-2071. 2013
    2013 Dietary patterns are associated with incident stroke and contribute to excess risk of stroke in black americansStroke.  44:3305-3311. 2013
    2013 Prevalence of apparent treatment-resistant hypertension among individuals with CKDClinical Journal of the American Society of Nephrology.  8:1583-1590. 2013
    2013 Fibroblast growth factor 23, vitamin d, and health disparities among african americans with chronic kidney diseaseSeminars in Nephrology.  33:448-456. 2013
    2013 Association between urinary albumin excretion and coronary heart disease in black vs white adultsJAMA: Journal of the American Medical Association.  310:706-713. 2013
    2013 Cardiovascular risk factors in CKD associate with both ESRD and mortalityJournal of the American Society of Nephrology.  24:1159-1165. 2013
    2013 Effects of dietary phosphate restriction and phosphate binders on FGF23 levels in CKDClinical Journal of the American Society of Nephrology.  8:1009-1018. 2013
    2013 α-Klotho and kidney function decline: An important step forward in understanding the link between mineral metabolism and kidney disease progressionAmerican Journal of Kidney Diseases.  61:855-857. 2013
    2013 Fibroblast Growth Factor 23, Klotho, and Disordered Mineral Metabolism in Chronic Kidney Disease: Unraveling the Intricate Tapestry of Events and Implications for TherapyJournal of Renal Nutrition.  23:250-254. 2013
    2013 Geographic variation in CKD prevalence and ESRD incidence in the united states: Results from the reasons for geographic and racial differences in stroke (REGARDS) studyAmerican Journal of Kidney Diseases.  61:395-403. 2013
    2013 Healthy behaviors, risk factor control and awareness of chronic kidney diseaseAmerican Journal of Nephrology.  37:135-143. 2013
    2013 Sodium- and Phosphorus-Based Food Additives: Persistent but Surmountable Hurdles in the Management of Nutrition in Chronic Kidney Disease 2013
    2013 Associations of Dietary Phosphorus Intake, Urinary Phosphate Excretion, and Fibroblast Growth Factor 23 With Vascular Stiffness in Chronic Kidney DiseaseJournal of Renal Nutrition.  23:12-20. 2013
    2013 Chronic Kidney Disease in African Americans: Past, Present, and Future: IntroductionSeminars in Nephrology.  33:407-408. 2013
    2013 Fibroblast growth factor 23, high-sensitivity cardiac troponin, and left ventricular hypertrophy in CKDAmerican Journal of Kidney Diseases.  61:67-73. 2013
    2013 Risk for recurrent coronary heart disease and all-cause mortality among individuals with chronic kidney disease compared with diabetes mellitus, metabolic syndrome, and cigarette smokersAmerican Heart Journal.  166. 2013
    2013 The connection between dietary phosphorus, cardiovascular disease, and mortality: Where we stand and what we need to knowAdvances in Nutrition.  4:723-729. 2013
    2012 Racial differences in albuminuria, kidney function, and risk of strokeNeurology.  79:1686-1692. 2012
    2012 Statement of concern about a commercial assay used to measure soluble hemojuvelin in humansAmerican Journal of Nephrology.  36:332-333. 2012
    2012 Associations of Socioeconomic Status and Processed Food Intake With Serum Phosphorus Concentration in Community-Living Adults: The Multi-Ethnic Study of Atherosclerosis (MESA)Journal of Renal Nutrition.  22:480-489. 2012
    2012 High-dose cholecalciferol reduces parathyroid hormone in patients with early chronic kidney disease: A pilot, randomized, double-blind, placebo-controlled trialAmerican Journal of Clinical Nutrition.  96:672-679. 2012
    2012 Prevalence and prognosis of unrecognized myocardial infarctions in chronic kidney diseaseNephrology Dialysis Transplantation.  27:3482-3488. 2012
    2012 Blood pressure indexes and end-stage renal disease risk in adults with chronic kidney diseaseAmerican Journal of Hypertension.  25:789-796. 2012
    2012 Tubular markers are associated with decline in kidney function in proteinuric type 2 diabetic patientsDiabetes Research and Clinical Practice.  97:71-76. 2012
    2012 Earlier onset and greater severity of disordered mineral metabolism in diabetic patients with chronic kidney diseaseDiabetes Care.  35:994-1001. 2012
    2012 (1-34) parathyroid hormone infusion acutely lowers fibroblast growth factor 23 concentrations in adult volunteersClinical Journal of the American Society of Nephrology.  7:139-145. 2012
    2011 Age-specific associations of reduced estimated glomerular filtration rate with concurrent chronic kidney disease complicationsClinical Journal of the American Society of Nephrology.  6:2822-2828. 2011
    2011 Fibroblast growth factor 23, cardiovascular disease risk factors, and phosphorus intake in the health professionals follow-up studyClinical Journal of the American Society of Nephrology.  6:2871-2878. 2011
    2011 Recent insights into racial differences in bone and mineral metabolismCurrent Opinion in Endocrinology, Diabetes and Obesity.  18:347-351. 2011
    2011 FGF23 induces left ventricular hypertrophyJournal of Clinical Investigation.  121:4393-4408. 2011
    2011 Vitamin D Deficiency, Inflammation, and Albuminuria in Chronic Kidney Disease: Complex InteractionsJournal of Renal Nutrition.  21:295-302. 2011
    2011 Fibroblast growth factor 23 and risks of mortality and end-stage renal disease in patients with chronic kidney diseaseJAMA: Journal of the American Medical Association.  305:2432-2439. 2011
    2011 Racial differences in the relationship between vitamin D, bone mineral density, and parathyroid hormone in the National Health and Nutrition Examination SurveyOsteoporosis International.  22:1745-1753. 2011
    2011 Increased serum phosphate and adverse clinical outcomes: Unraveling mechanisms of diseaseCurrent Opinion in Nephrology and Hypertension.  20:224-228. 2011
    2011 Diuretics, calciuria and secondary hyperparathyroidism in the Chronic Renal Insufficiency CohortNephrology Dialysis Transplantation.  26:1258-1265. 2011
    2011 Impact of Poverty on Serum Phosphate Concentrations in the Third National Health and Nutrition Examination SurveyJournal of Renal Nutrition.  21:140-148. 2011
    2011 Pilot study of dietary phosphorus restriction and phosphorus binders to target fibroblast growth factor 23 in patients with chronic kidney diseaseNephrology Dialysis Transplantation.  26:584-591. 2011
    2011 Fibroblast growth factor 23 is elevated before parathyroid hormone and phosphate in chronic kidney diseaseKidney International.  79:1370-1378. 2011
    2011 Hepcidin and disordered mineral metabolism in chronic kidney diseaseClinical Nephrology.  76:90-98. 2011
    2010 Racial differences in postprandial mineral ion handling in health and in chronic kidney diseaseNephrology Dialysis Transplantation.  25:3970-3977. 2010
    2010 Low socioeconomic status associates with higher serum phosphate irrespective of raceJournal of the American Society of Nephrology.  21:1953-1960. 2010
    2010 Fibroblast growth factor 23 and disordered vitamin D metabolism in chronic kidney disease: Updating the "trade-off" hypothesisClinical Journal of the American Society of Nephrology.  5:1710-1716. 2010
    2010 Dietary phosphorus restriction in advanced chronic kidney disease: Merits, challenges, and emerging strategiesSeminars in Dialysis.  23:401-406. 2010
    2010 Vitamin D deficiency and anemia in early chronic kidney diseaseKidney International.  77:715-720. 2010
    2010 Response to Targeting hyperphosphatemia: Truth or dareKidney International.  77:257. 2010
    2010 The authors replyKidney International.  77:743-744. 2010
    2010 The authors replyKidney International.  77:930. 2010
    2009 A blueprint for randomized trials targeting phosphorus metabolism in chronic kidney diseaseKidney International.  76:705-716. 2009
    2009 Fibroblast growth factor 23 and left ventricular hypertrophy in chronic kidney diseaseCirculation.  119:2545-2552. 2009
    2009 Plasma gelsolin and circulating actin correlate with hemodialysis mortalityJournal of the American Society of Nephrology.  20:1140-1148. 2009
    2009 Phosphorus binders and survival on hemodialysisJournal of the American Society of Nephrology.  20:388-396. 2009
    2008 Fibroblast growth factor 23 and mortality among patients undergoing hemodialysisNew England Journal of Medicine.  359:584-592. 2008
    2008 N-terminal pro-B-type natriuretic peptide (NT-proBNP) concentrations in hemodialysis patients: Prognostic value of baseline and follow-up measurementsClinical Chemistry (Washington, DC): international journal of molecular diagnostics and laboratory medicine.  54:1339-1348. 2008
    2008 Impact of activated vitamin D and race on survival among hemodialysis patientsJournal of the American Society of Nephrology.  19:1379-1388. 2008
    2008 Postprandial mineral metabolism and secondary hyperparathyroidism in early CKDJournal of the American Society of Nephrology.  19:615-623. 2008
    2008 Prevalence and severity of disordered mineral metabolism in Blacks with chronic kidney diseaseKidney International.  73:956-962. 2008
    2007 Vitamin D levels and early mortality among incident hemodialysis patientsKidney International.  72:1004-1013. 2007
    2007 Emphysematous pyelonephritisKidney International.  71:462-465. 2007
    2007 Refractory hyponatremiaKidney International.  71:79-82. 2007
    2006 Post-transplant hypophosphatemia: Tertiary 'Hyper-Phosphatoninism'?Kidney International.  70:1486-1494. 2006
    2005 Fibroblast growth factor-23 mitigates hyperphosphatemia but accentuates calcitriol deficiency in chronic kidney diseaseJournal of the American Society of Nephrology.  16:2205-2215. 2005
    1999 CACP, encoding a secreted proteoglycan, is mutated in camptodactyly- arthropathy-coxa vara-pericarditis syndromeNature Genetics.  23:319-322. 1999

    Chapter

    Year Title Altmetric
    2017 Impact of socioeconomic factors on phosphorus balance.  213-220. 2017
    2016 Vitamin D and racial differences in chronic kidney disease.  131-145. 2016
    2013 Disorders of Phosphorus Homeostasis: Emerging Targets for Slowing Progression of Chronic Kidney Disease.  249-255. 2013

    Research Overview

  • Chronic kidney disease
    Acute Kidney Injury
    Mineral metabolism
    nutrition
    disparities
  • Principal Investigator On

  • Beyond the Glomerulus: Novel Clinical Markers of Kidney Health and Prognosis  awarded by TUFTS MEDICAL CENTER, INC.
  • Deep South Center to Reduce Disparities in Chronic Diseases - Investigator Development Core  awarded by NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES/NIH/DHHS
  • Impact of Disordered Mineral Metabolism on Stroke and Cognitive Impairment  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS
  • Impact of Lowering Phosphate Additive Intake on Mineral Metabolism and Cardiovascular Health in Community-Living Adults  awarded by American Heart Association
  • Interdisciplinary Training in Kidney-Related Research  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Kidney Tubule Dysfunction and Future Risk of Acute Kidney Injury  awarded by University of California, San Diego
  • Mentored Patient-Oriented Research in Disparities in Cardiovascular and Kidney Disease  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Phosphate and FGF23: Dietary and Molecular Mediators of Health Disparities in Cardiovascular and Kidney Diseases (Impact of Lowering Phosphate Additive Intake on Mineral Metabolism and Cardiovascular Health in Community-Living Adults)”.  awarded by Northwestern University
  • Phosphorus-Based Food Additives, Mineral Metabolism and Cardiovascular Health  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Private Grant  awarded by Genzyme Corporation
  • Private Grant  awarded by KERYX BIOPHARMACEUTICALS, INC. - NEW
  • Private Grant  awarded by GlaxoSmithKline
  • Racial Differences in Phosphorus Metabolism in Health and in Kidney Disease  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • The Southeastern Acute Kidney Injury (SEAK) Alliance for the COPE-AKI Consortium  awarded by VANDERBILT UNIVERSITY MEDICAL CENTER ^
  • UAB-UCSD O'Brien Center for Acute Kidney Injury Research - Enhancing the capacity to examine the impact of acute kidney injury on disparities in chronic kidney disease outcomes in the Southeastern US  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • UAB-UCSD O'Brien Center for Acute Kidney Injury Research - Kidney Tubular Injury and Dysfunction and Racial Disparities in Incident Hypertension and Kidney Function Decline  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Investigator On

  • 3/3 Morehouse School of Medicine/Tuskegee University/University of Alabama Cancer Center Partnership  awarded by National Cancer Institute/NIH/DHHS
  • Atrial Natriuretic Peptide and Regulation of Cardiometabolic Health: A Genotype-Guided Human Physiological Study  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Center for Clinical and Translational Science (3 Linked Awards UL1, KL2, TL1)  awarded by National Center for Advancing Translational Sciences/NIH/DHHS
  • Continuation of the Coordinating Center for the Chronic Renal Insufficiency Cohort (CRIC) Study  awarded by University of Pennsylvania
  • Deep South Center to Reduce Disparities in Chronic Diseases  awarded by NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES/NIH/DHHS
  • Deep South Center to Reduce Disparities in Chronic Diseases - Administrative Core  awarded by NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES/NIH/DHHS
  • Elucidating Genetic and Environmental Second Hits in Racial and Ethnic Minorities with APOL1 High-Risk Genotypes  awarded by ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
  • Endovascular vs. Surgical Arteriovenous Fistula Outcomes  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • FGF23: A Novel Biomarker in ALS and More  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS
  • Integrating Genomic Risk Assessment for Chronic Disease Management in a Diverse Population  awarded by National Human Genome Research Institute/NIH/DHHS
  • Interdisciplinary Training In Kidney-Related Research  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Kidney Undergraduate Research Experience (KURE)  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Natriuretic Peptide-Renin-Angiotensin-Aldosterone System Rhythm Axis and Nocturnal Blood Pressure  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Novel Regulators of Fibroblast Growth Factor 23 in Chronic Kidney Disease: Iron Deficiency and Hypoxia  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • PRedOctoral Phd and MD Research Training In TEams (PROmoTE)  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • PRedoctoral Interdisciplinary Training in Renal Physiology and MEdIcIne (PRIME)  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Private Grant  awarded by AMGEN, INC.^
  • Private Grant  awarded by AMGEN, INC.^
  • Private Grant  awarded by AMGEN, INC.^
  • Private Grant  awarded by AMGEN, INC.^
  • Race, Natriuretic Peptides and Physiological Perturbations  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Racial Differences in the Natriuretic Peptide Response to Exercise and Beta-blockers  awarded by American Heart Association
  • Targeting the Interactions Between Disordered Iron Homeostasis and Mineral Metabolism in Chronic Kidney Disease to Improve Cardiovascular Outcomes  awarded by American Heart Association
  • The Effects of Neprilysin Inhibition on Cardiometabolic Health in Black Individuals  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Timing of Sodium Intake and Nocturnal Sodium Excretion and Blood Pressure in Obese African Americans  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • UAB Precision Nutrition Clinical Center  awarded by National Institute of Child Health and Human Development/NIH/DHHS
  • UAB-Tuskegee Faculty Institutional Recruitment for Sustainable Transformation Partnership (UAB-TU FIRST Partnership) - Faculty Development Core  awarded by National Cancer Institute/NIH/DHHS
  • UAB-UCSD O'Brien Center for Acute Kidney Injury Research  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • UAB-UCSD O'Brien Center for Acute Kidney Injury Research - Admin Core  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • UAB/Tuskegee Faculty Institutional Recruitment for Sustainable Transformation (UAB/TU FIRST) Partnership (NIH U54)  awarded by National Cancer Institute/NIH/DHHS
  • UAB/UCSD O'Brien Core Center for Acute Kidney Injury Research  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • UAB/UCSD O'Brien Core Center for Acute Kidney Injury Research - Administrative Core  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • University of Alabama at Birmingham Strategically Focused Hypertension Research Center  awarded by American Heart Association
  • University of Alabama at Birmingham Strategically Focused Hypertension Research Center - Mechanisms of Nocturnal Hypertension and Non-Dipping Blood Pressure - Project 2  awarded by American Heart Association
  • Education And Training

  • Massachusetts General Hospital, Internship
  • Massachusetts General Hospital, Residency
  • Brigham & Women's Hospital, Postdoctoral Fellowship
  • Doctor of Medicine in Nephrology Residency Program, University of Toledo 2002
  • Full Name

  • Orlando Gutierrez