Positions

Selected Publications

Academic Article

Year Title Altmetric
2020 Enhanced closed eye neutrophil degranulation in dry eye disease 2020
2020 Evaluation of cell harvesting techniques to optimize lipidomic analysis from human meibomian gland epithelial cells in cultureInternational Journal of Molecular Sciences.  21. 2020
2020 Dry Eye Disease Practice in Ghana: Diagnostic Perspectives, Treatment Modalities, and ChallengesOptometry and Vision Science.  97:137-144. 2020
2020 The closed eye harbors a unique microbiome in dry eye disease 2020
2019 Effect of the Bruder moist heat eye compress on contact lens discomfort in contact lens wearers: An open-label randomized clinical trialContact Lens and Anterior Eye.  42:625-632. 2019
2019 Tear Film and Meibomian Gland Characteristics in AdolescentsCornea.  38:1475-1482. 2019
2019 Efficacy of topical ophthalmic drugs in the treatment of dry eye disease: A systematic literature review 2019
2019 Safety and tolerability of lifitegrast ophthalmic solution 5.0%: Pooled analysis of five randomized controlled trials in dry eye diseaseEuropean Journal of Ophthalmology.  29:394-401. 2019
2019 Dry eye disease: Consideration for women's healthJournal of Women's Health.  28:502-514. 2019
2019 Untargeted lipidomic analysis of human tears: A new approach for quantification of O-acyl-omega hydroxy fatty acids 2019
2019 Erratum: Comprehensive shotgun lipidomics of human meibomian gland secretions using MS/MSall with successive switching between acquisition polarity modes (Journal of Lipid Research (2018) 59 (2223-2236) DOI: 10.1194/jlr.D088138)Journal of Lipid Research.  60:1640. 2019
2018 Comparison of Collection Methods for the Measure of Human Meibum and Tear Film-Derived Lipids Using Mass SpectrometryCurrent Eye Research.  43:1244-1252. 2018
2018 Leukocyte Distribution in the Open Eye Tears of Normal and Dry Eye SubjectsCurrent Eye Research.  43:1253-1259. 2018
2018 Short Tandem Repeat (STR) Profiles of Commonly Used Human Ocular Surface Cell LinesCurrent Eye Research.  43:1097-1101. 2018
2018 Relation Between Dietary Essential Fatty Acid Intake and Dry Eye Disease and Meibomian Gland Dysfunction in Postmenopausal WomenAmerican Journal of Ophthalmology.  189:29-40. 2018
2018 Ocular comfort assessment of lifitegrast ophthalmic solution 5.0% in OPUS-3, a phase III randomized controlled trialClinical Ophthalmology.  12:263-270. 2018
2018 Asingle vectored thermal pulsation treatment for meibomian gland dysfunction increases mean comfortable contact lens wearing time by approximately 4 hours per dayClinical Ophthalmology.  12:169-183. 2018
2018 Comprehensive shotgun lipidomics of human meibomian gland secretions using MS/MSall with successive switching between acquisition polarity modesJournal of Lipid Research.  59:2223-2236. 2018
2018 Erratum: Ocular comfort assessment of lifitegrast ophthalmic solution 5.0% in OPUS-3, a Phase III randomized controlled trial [Corrigendum].Clinical Ophthalmology.  12:913. 2018
2017 Neutrophil and T-cell homeostasis in the closed eyeInvestigative Ophthalmology and Visual Science.  58:6212-6220. 2017
2017 TFOS DEWS II Report Executive Summary 2017
2017 TFOS DEWS II Definition and Classification Report 2017
2017 TFOS DEWS II Introduction 2017
2017 Expression profiling of nonpolar lipids in meibum from patients with dry eye: A pilot studyInvestigative Ophthalmology and Visual Science.  58:2266-2274. 2017
2017 Lifitegrast for the Treatment of Dry Eye Disease: Results of a Phase III, Randomized, Double-Masked, Placebo-Controlled Trial (OPUS-3) 2017
2016 Compositional Analysis of Wax Esters in Human Meibomian Gland Secretions by Direct Infusion Electrospray Ionization Mass SpectrometryLipids.  51:1269-1287. 2016
2016 A randomized, double-masked, parallel-group, comparative study to evaluate the clinical efficacy and safety of 1% azithromycin–0.1% dexamethasone combination compared to 1% azithromycin alone, 0.1% dexamethasone alone, and vehicle in the treatment of subjects with blepharitisClinical Ophthalmology.  10:1495-1503. 2016
2016 Functional and morphologic changes of meibomian glands in an asymptomatic adult populationInvestigative Ophthalmology and Visual Science.  57:3996-4007. 2016
2016 Impact of dry eye disease on work productivity, and patients’ Satisfaction with Over-The-Counter dry eye treatmentsInvestigative Ophthalmology and Visual Science.  57:2975-2982. 2016
2016 Report of the Inaugural Meeting of the TFOS i2 = initiating innovation Series: Targeting the Unmet Need for Dry Eye Treatment 2016
2016 Analysis of tear inflammatory mediators: A comparison between the microarray and luminex methodsMolecular Vision.  22:177-188. 2016
2016 Association between serum levels of testosterone and estradiol with meibomian gland assessments in postmenopausal womenInvestigative Ophthalmology and Visual Science.  57:295-300. 2016
2016 Differential profiling of T-cell cytokines as measured by protein microarray across dry eye subgroupsCornea.  35:329-335. 2016
2016 Safety of lifitegrast ophthalmic solution 5.0% in patients with dry eye disease: A 1-year, multicenter, randomized, placebo-controlled studyCornea.  35:741-748. 2016
2015 Characterization of Wax Esters by Electrospray Ionization Tandem Mass Spectrometry: Double Bond Effect and Unusual Product IonsLipids.  50:821-836. 2015
2015 Clinical guidelines for management of dry eye associated with Sjögren disease 2015
2015 Agreement between automated and traditional measures of tear film breakupOptometry and Vision Science.  92:e257-e263. 2015
2015 Dry eye diseaseOptometry and Vision Science.  92:922-924. 2015
2014 Correlations between commonly used objective signs and symptoms for the diagnosis of dry eye disease: Clinical implications 2014
2014 Erratum: Erratum to: Rethinking dry eye disease: A perspective on clinical implications (Ocul Surf (2014) 12:2S (S1-S32)) 2014
2014 Rethinking dry eye disease: A perspective on clinical implications 2014
2013 The TFOS International Workshop on Contact Lens Discomfort: Executive summaryInvestigative Ophthalmology and Visual Science.  54. 2013
2013 The TFOS International Workshop on Contact Lens Discomfort: Report of the definition and classification subcommitteeInvestigative Ophthalmology and Visual Science.  54. 2013
2013 Quantitative profiling of major neutral lipid classes in human meibum by direct infusion electrospray ionization mass spectrometryInvestigative Ophthalmology and Visual Science.  54:5730-5753. 2013
2013 Tear film breakup and structure studied by simultaneous video recording of fluorescence and tear film lipid layer imagesInvestigative Ophthalmology and Visual Science.  54:4900-4909. 2013
2013 An algorithm for the management of allergic conjunctivitisAllergy and Asthma Proceedings.  35:408-420. 2013
2013 Dry eye disease and microbial keratitis: Is there a connection? 2013
2012 Improving awareness, identification, and management of meibomian gland dysfunction 2012
2012 The use of fluorescent quenching in studying the contribution of evaporation to tear thinningInvestigative Ophthalmology and Visual Science.  53:5426-5432. 2012
2012 Tofacitinib (CP-690,550), a Janus kinase inhibitor for dry eye disease: Results from a phase 1/2 trial 2012
2012 iTRAQ quantitative proteomics in the analysis of tears in dry eye patientsInvestigative Ophthalmology and Visual Science.  53:5052-5059. 2012
2012 Development of the 4-3-2-1 meibum expressibility scale 2012
2012 Quantification of genes and gene transcripts for microbial perchlorate reduction in fixed-bed bioreactors 2012
2012 Safety and efficacy of topical azithromycin ophthalmic solution 1.0% in the treatment of contact lens-related dry eye 2012
2012 Inter-examiner reliability in meibomian gland dysfunction assessment.Investigative Ophthalmology and Visual Science.  53:3120-3125. 2012
2011 Rasch analysis of the Ocular Surface Disease Index (OSDI)Investigative Ophthalmology and Visual Science.  52:8630-8635. 2011
2011 Examination of human meibum collection and extraction techniquesOptometry and Vision Science.  88:525-533. 2011
2011 Author response: On the presence of (O-acyl)-omega-hydroxy fatty acids and their esters in human meibomian gland secretionsInvestigative Ophthalmology and Visual Science.  52:1894-1895. 2011
2011 The international workshop on meibomian gland dysfunction: Executive summaryInvestigative Ophthalmology and Visual Science.  52:1922-1929. 2011
2011 The international workshop on meibomian gland dysfunction: IntroductionInvestigative Ophthalmology and Visual Science.  52:1917-1921. 2011
2011 The international workshop on meibomian gland dysfunction: Report of the clinical trials subcommitteeInvestigative Ophthalmology and Visual Science.  52:2065-2085. 2011
2011 The international workshop on meibomian gland dysfunction: Report of the subcommittee on management and treatment of meibomian gland dysfunctionInvestigative Ophthalmology and Visual Science.  52:2050-2064. 2011
2011 The international workshop on meibomian gland dysfunction: Report of the subcommittee on the epidemiology of, and associated risk factors for, MGDInvestigative Ophthalmology and Visual Science.  52:1994-2005. 2011
2011 High resolution microscopy of the lipid layer of the tear film 2011
2010 An objective approach to dry eye disease severityInvestigative Ophthalmology and Visual Science.  51:6125-6130. 2010
2010 Re-on the presence and role of polar lipids in meibumInvestigative Ophthalmology and Visual Science.  51:6910-6911. 2010
2010 Shotgun lipidomic analysis of human meibomian gland secretions with electrospray ionization tandem mass spectrometryInvestigative Ophthalmology and Visual Science.  51:6220-6231. 2010
2010 Evaluation of extractants and precipitants in tear film proteomic analysesOptometry and Vision Science.  87:854-860. 2010
2010 Gas permeable and soft contact lens wear in childrenOptometry and Vision Science.  87:414-420. 2010
2009 Editorial: Collecting tear osmolarity measurements in the diagnosis of dry eyeExpert Review of Ophthalmology.  4:451-453. 2009
2009 The contribution of lipid layer movement to tear film thinning and breakupInvestigative Ophthalmology and Visual Science.  50:2747-2756. 2009
2009 Blepharitis in the United States 2009: A Survey-based Perspective on Prevalence and Treatment 2009
2009 Blepharitis in the United States 2009: a survey-based perspective on prevalence and treatment. 2009
2009 Blepharitis in the United States 2009: A survey-based perspective on prevalence and treatment 2009
2009 Epinastine 0.05% ophthalmic solution in contact lens-wearing subjects with a history of allergic conjunctivitis 2009
2008 Contributions of evaporation and other mechanisms to tear film thinning and break-upOptometry and Vision Science.  85:623-630. 2008
2008 The changing times in dry eye researchOptometry and Vision Science.  85:613-614. 2008
2008 Investigation of the human tear film proteome using multiple proteomic approachesMolecular Vision.  14:456-470. 2008
2008 Current patterns in the use of diagnostic tests in dry eye evaluationCornea.  27:656-662. 2008
2007 Diabetic eye examination report 2007
2007 Identification of fatty acids and fatty acid amides in human meibomian gland secretionsInvestigative Ophthalmology and Visual Science.  48:34-39. 2007
2007 The contact lens and tear film laboratory, The Ohio State University College of Optometry 2007
2006 The global sex disparity in blindness and visual impairmentOptometry and Vision Science.  83:700-701. 2006
2006 Interferometric imaging of the full thickness of the precorneal tear film 2006
2006 Patient-reported symptoms in dry dye disease 2006
2005 The frequency of dilated diabetic eye examinations by optometrists in the state of OhioOptometry and Vision Science.  82:959-963. 2005
2005 Double-masked, placebo-controlled safety and efficacy trial of diguafosol tetrasodium (INS365) ophthalmic solution for the treatment of dry eye (vol 23, pg 784, 2004)Cornea.  24:637-637. 2005
2005 Self-reported dry eye disease across refractive modalitiesInvestigative Ophthalmology and Visual Science.  46:1911-1914. 2005
2005 An assessment of grading scales for meibography imagesCornea.  24:382-388. 2005
2005 Assessment of meibomian lipids in postmenopausal women using electrospray ionization mass spectrometryInvestigative Ophthalmology and Visual Science.  46. 2005
2005 Human tear film breakup studied by a new imaging interferometer: Preliminary observationsInvestigative Ophthalmology and Visual Science.  46. 2005
2005 Identification and analysis of polar and non-polar lipids from meibomian gland secretions using electrospray ionization mass spectrometryInvestigative Ophthalmology and Visual Science.  46. 2005
2004 Double-masked, placebo-controlled safety and efficacy trial of diquafosol tetrasodium (INS365) ophthalmic solution for the treatment of dry-eyeCornea.  23:784-792. 2004
2004 Patients' perspectives on noncompliance with Diabetic Retinopathy Standard of Care Guidelines 2004
2004 The lack of association between signs and symptoms in patients with dry eye diseaseCornea.  23:762-770. 2004
2004 An assessment of self-reported disease classification in epidemiological studies of dry eyeInvestigative Ophthalmology and Visual Science.  45:3453-3457. 2004
2004 The Reliability and Validity of McMonnies Dry Eye IndexCornea.  23:365-371. 2004
2004 Assessment of the reliability of self-reported dry eye in contact lens wearers: The contact lens dry eye questionnaire (CLDEQ) short-formInvestigative Ophthalmology and Visual Science.  45:U142-U142. 2004
2004 The Repeatability of Clinical Measurements of Dry EyeCornea.  23:272-285. 2004
2004 Diquafosol tetrasodium: A novel dry eye therapyExpert Opinion on Investigational Drugs.  13:47-54. 2004
2004 Diquafosol tetrasodium: a novel dry eye therapyExpert Opinion on Investigational Drugs.  13:47-54. 2004
2003 The relation between tear film tests in patients with dry eye diseaseOphthalmic and Physiological Optics.  23:553-560. 2003
2003 Adherence to diabetic standard of care guidelinesInvestigative Ophthalmology and Visual Science.  44:U113-U113. 2003
2003 Double masked, placebo-controlled safety and efficacy trial of diquafosol tetrasodium (INS365) ophthalmic solution for the treatment of dry eyeInvestigative Ophthalmology and Visual Science.  44:U312-U312. 2003
2003 Dry eye in postmenopausal women enrolled in the observational study cohort of the Women's Health InitiativeInvestigative Ophthalmology and Visual Science.  44:U429-U429. 2003
2003 Is inferior tear film thinner than superior tear film?Investigative Ophthalmology and Visual Science.  44:U431-U431. 2003
2002 Performance and repeatability of the NEI-VFQ-25 in patients with dry eyeCornea.  21:578-583. 2002
2002 The performance of the contact lens dry eye questionnaire as a screening survey for contact lens-related dry eyeCornea.  21:469-475. 2002
2002 In vivo measurement of the thickness of human corneal endothelium and Descemet's membrane using interferometryInvestigative Ophthalmology and Visual Science.  43:U27-U27. 2002
2002 Is there an association between signs and symptoms in patients with dry eye?Investigative Ophthalmology and Visual Science.  43:U1117-U1117. 2002
2002 Association of clinical diagnostic tests and dry eye surveys: The NEI-VFQ-25 and the OSDI©Advances in Experimental Medicine and Biology.  506 B:1177-1181. 2002
2002 Corneal staining in hydrogel lens wearersOptometry and Vision Science.  79:20-30. 2002
2002 Evaluation of tear film interference patterns and measures of tear break-up timeOptometry and Vision Science.  79:363-369. 2002
2002 Patient-reported versus doctor-diagnosed dry eye: The assessment of symptomsAdvances in Experimental Medicine and Biology.  506 B:1189-1193. 2002
2002 Results of a dry eye questionnaire from optometric practices in North AmericaAdvances in Experimental Medicine and Biology.  506 B:1009-1016. 2002
2002 The repeatability of diagnostic tests and surveys in dry eyeAdvances in Experimental Medicine and Biology.  506 B:1171-1175. 2002
2001 Characterization of ocular surface symptoms from optometric practices in North AmericaCornea.  20:610-618. 2001
2001 The contact lens and myopia progression (CLAMP) study: Design and baseline dataOptometry and Vision Science.  78:223-233. 2001
2000 Frequency of dry eye diagnostic test procedures used in various modes of ophthalmic practiceCornea.  19:477-482. 2000
2000 Further evidence that the thickness of the normal human tear film is about 3 mu m.Investigative Ophthalmology and Visual Science.  41:S65-S65. 2000
2000 Assessment of ocular symptoms in patient-reported dry eye versus doctor-diagnosed dry eyeOptometry and Vision Science.  77:181. 2000
2000 Dry eye diagnostic tests and surveys: performance and associationOptometry and Vision Science.  77:20. 2000
2000 Evaluation of the touch scientific lactoferrin microassay system: repeatability of tear lactoferrin measurementsOptometry and Vision Science.  77:121. 2000
2000 Responses of contact lens wearers to a dry eye surveyOptometry and Vision Science.  77:40-46. 2000
2000 The thickness of the human precorneal tear film: Evidence from reflection spectraInvestigative Ophthalmology and Visual Science.  41:3348-3359. 2000
1999 Is the thickness of the tear film about 40 mu m or about 3 mu m?Investigative Ophthalmology and Visual Science.  40:S544-S544. 1999
1999 Repeatability of the NEI-VFQ in patients with dry eye syndromeInvestigative Ophthalmology and Visual Science.  40:S910-S910. 1999
1999 Repeatability and validity of astigmatism measurementsJournal of Refractive Surgery.  15:23-31. 1999
1999 Symptoms of ocular irritation in patients diagnosed with dry eyeOptometry and Vision Science.  76:838-844. 1999
1997 Repeatability of astigmatism measurementsInvestigative Ophthalmology and Visual Science.  38:3965-3965. 1997

Education And Training

  • Doctor of Philosophy in Vision Science / Physiological Optics, The Ohio State University 2001
  • Master of Public Health in Epidemiology, The Ohio State University 2000
  • Master of Sciences or Mathematics in Vision Science / Physiological Optics, The Ohio State University 1998
  • Doctor of Optometry, University of California 1995
  • Bachelor of Science or Mathematics in Vision Science / Physiological Optics, University of California 1993
  • Bachelor of Arts in Biology, University of California 1991
  • Full Name

  • Kelly Nichols