Positions

Selected Publications

Academic Article

Year Title Altmetric
2019 Safety and tolerability of lifitegrast ophthalmic solution 5.0%: Pooled analysis of five randomized controlled trials in dry eye diseaseEuropean Journal of Ophthalmology.  29:394-401. 2019
2019 Dry eye disease: Consideration for women's healthJournal of Women's Health.  28:502-514. 2019
2019 Untargeted lipidomic analysis of human tears: A new approach for quantification of O-acyl-omega hydroxy fatty acidsOcular Surface.  17:347-355. 2019
2019 Efficacy of topical ophthalmic drugs in the treatment of dry eye disease: A systematic literature reviewOcular Surface2019
2018 Comparison of Collection Methods for the Measure of Human Meibum and Tear Film-Derived Lipids Using Mass SpectrometryCurrent Eye Research.  43:1244-1252. 2018
2018 Leukocyte Distribution in the Open Eye Tears of Normal and Dry Eye SubjectsCurrent Eye Research.  43:1253-1259. 2018
2018 Short Tandem Repeat (STR) Profiles of Commonly Used Human Ocular Surface Cell LinesCurrent Eye Research.  43:1097-1101. 2018
2018 Relation Between Dietary Essential Fatty Acid Intake and Dry Eye Disease and Meibomian Gland Dysfunction in Postmenopausal WomenAmerican Journal of Ophthalmology.  189:29-40. 2018
2018 Ocular comfort assessment of lifitegrast ophthalmic solution 5.0% in OPUS-3, a phase III randomized controlled trialClinical Ophthalmology.  12:263-270. 2018
2018 Asingle vectored thermal pulsation treatment for meibomian gland dysfunction increases mean comfortable contact lens wearing time by approximately 4 hours per dayClinical Ophthalmology.  12:169-183. 2018
2018 Comprehensive shotgun lipidomics of human meibomian gland secretions using MS/MS all with successive switching between acquisition polarity modesJournal of Lipid Research.  59:2223-2236. 2018
2018 Erratum: Ocular comfort assessment of lifitegrast ophthalmic solution 5.0% in OPUS-3, a Phase III randomized controlled trial [Corrigendum].Clinical Ophthalmology.  12:913. 2018
2017 Neutrophil and T-cell homeostasis in the closed eyeInvestigative Ophthalmology & Visual Science.  58:6212-6220. 2017
2017 TFOS DEWS II Report Executive SummaryOcular Surface.  15:802-812. 2017
2017 TFOS DEWS II Definition and Classification ReportOcular Surface.  15:276-283. 2017
2017 TFOS DEWS II IntroductionOcular Surface.  15:269-275. 2017
2017 Expression profiling of nonpolar lipids in meibum from patients with dry eye: A pilot studyInvestigative Ophthalmology & Visual Science.  58:2266-2274. 2017
2017 Lifitegrast for the Treatment of Dry Eye Disease: Results of a Phase III, Randomized, Double-Masked, Placebo-Controlled Trial (OPUS-3)Ophthalmology: Journal of The American Academy of Ophthalmology.  124:53-60. 2017
2016 Compositional Analysis of Wax Esters in Human Meibomian Gland Secretions by Direct Infusion Electrospray Ionization Mass SpectrometryLipids.  51:1269-1287. 2016
2016 A randomized, double-masked, parallel-group, comparative study to evaluate the clinical efficacy and safety of 1% azithromycin–0.1% dexamethasone combination compared to 1% azithromycin alone, 0.1% dexamethasone alone, and vehicle in the treatment of subjects with blepharitisClinical Ophthalmology.  10:1495-1503. 2016
2016 Functional and morphologic changes of meibomian glands in an asymptomatic adult populationInvestigative Ophthalmology & Visual Science.  57:3996-4007. 2016
2016 Impact of dry eye disease on work productivity, and patients’ Satisfaction with Over-The-Counter dry eye treatmentsInvestigative Ophthalmology & Visual Science.  57:2975-2982. 2016
2016 Report of the Inaugural Meeting of the TFOS i2 = initiating innovation Series: Targeting the Unmet Need for Dry Eye TreatmentOcular Surface.  14:264-316. 2016
2016 Analysis of tear inflammatory mediators: A comparison between the microarray and luminex methodsMolecular Vision.  22:177-188. 2016
2016 Association between serum levels of testosterone and estradiol with meibomian gland assessments in postmenopausal womenInvestigative Ophthalmology & Visual Science.  57:295-300. 2016
2016 Differential profiling of T-cell cytokines as measured by protein microarray across dry eye subgroupsCornea.  35:329-335. 2016
2016 Safety of lifitegrast ophthalmic solution 5.0% in patients with dry eye disease: A 1-year, multicenter, randomized, placebo-controlled studyCornea.  35:741-748. 2016
2015 Characterization of Wax Esters by Electrospray Ionization Tandem Mass Spectrometry: Double Bond Effect and Unusual Product IonsLipids.  50:821-836. 2015
2015 Characterization of Wax Esters by Electrospray Ionization Tandem Mass Spectrometry: Double Bond Effect and Unusual Product IonsLipids2015
2015 Clinical guidelines for management of dry eye associated with Sjögren diseaseOcular Surface.  13:118-132. 2015
2015 Agreement between automated and traditional measures of tear film breakupOptometry and Vision Science.  92:e257-e263. 2015
2015 Clinical Guidelines for Management of Dry Eye Associated with Sjögren DiseaseOcular Surface2015
2015 Dry eye diseaseOptometry and Vision Science.  92:922-924. 2015
2014 Correlations between commonly used objective signs and symptoms for the diagnosis of dry eye disease: Clinical implicationsActa Ophthalmologica Scandinavica.  92:161-166. 2014
2014 Erratum: Erratum to: Rethinking dry eye disease: A perspective on clinical implications (Ocul Surf (2014) 12:2S (S1-S32))Ocular Surface.  12:231. 2014
2014 Rethinking Dry Eye Disease: A Perspective on Clinical ImplicationsOcular Surface2014
2014 Rethinking dry eye disease: A perspective on clinical implicationsOcular Surface.  12. 2014
2013 The TFOS International Workshop on Contact Lens Discomfort: Executive summaryInvestigative Ophthalmology & Visual Science.  54. 2013
2013 The TFOS International Workshop on Contact Lens Discomfort: Report of the definition and classification subcommitteeInvestigative Ophthalmology & Visual Science.  54. 2013
2013 Quantitative profiling of major neutral lipid classes in human meibum by direct infusion electrospray ionization mass spectrometryInvestigative Ophthalmology & Visual Science.  54:5730-5753. 2013
2013 Tear film breakup and structure studied by simultaneous video recording of fluorescence and tear film lipid layer imagesInvestigative Ophthalmology & Visual Science.  54:4900-4909. 2013
2013 An algorithm for the management of allergic conjunctivitisAllergy and Asthma Proceedings.  35:408-420. 2013
2013 Dry Eye Disease and Microbial Keratitis: Is There a Connection?Ocular Surface2013
2013 Dry eye disease and microbial keratitis: Is there a connection?Ocular Surface.  11:75-92. 2013
2012 Improving awareness, identification, and management of meibomian gland dysfunctionOphthalmology: Journal of The American Academy of Ophthalmology.  119. 2012
2012 The use of fluorescent quenching in studying the contribution of evaporation to tear thinningInvestigative Ophthalmology & Visual Science.  53:5426-5432. 2012
2012 Tofacitinib (CP-690,550), a Janus kinase inhibitor for dry eye disease: Results from a phase 1/2 trialOphthalmology: Journal of The American Academy of Ophthalmology.  119:1328-1335. 2012
2012 iTRAQ quantitative proteomics in the analysis of tears in dry eye patientsInvestigative Ophthalmology & Visual Science.  53:5052-5059. 2012
2012 Development of the 4-3-2-1 meibum expressibility scaleClao Journal.  38:86-92. 2012
2012 Quantification of genes and gene transcripts for microbial perchlorate reduction in fixed-bed bioreactorsThe Journal of applied bacteriology.  112:579-592. 2012
2012 Safety and efficacy of topical azithromycin ophthalmic solution 1.0% in the treatment of contact lens-related dry eyeClao Journal.  38:73-79. 2012
2012 Inter-examiner reliability in meibomian gland dysfunction assessment.Investigative Ophthalmology & Visual Science.  53:3120-3125. 2012
2011 Rasch analysis of the Ocular Surface Disease Index (OSDI)Investigative Ophthalmology & Visual Science.  52:8630-8635. 2011
2011 Examination of human meibum collection and extraction techniquesOptometry and Vision Science.  88:525-533. 2011
2011 Author response: On the presence of (O-acyl)-omega-hydroxy fatty acids and their esters in human meibomian gland secretionsInvestigative Ophthalmology & Visual Science.  52:1894-1895. 2011
2011 The international workshop on meibomian gland dysfunction: Executive summaryInvestigative Ophthalmology & Visual Science.  52:1922-1929. 2011
2011 The international workshop on meibomian gland dysfunction: IntroductionInvestigative Ophthalmology & Visual Science.  52:1917-1921. 2011
2011 The international workshop on meibomian gland dysfunction: Report of the clinical trials subcommitteeInvestigative Ophthalmology & Visual Science.  52:2065-2085. 2011
2011 The international workshop on meibomian gland dysfunction: Report of the subcommittee on management and treatment of meibomian gland dysfunctionInvestigative Ophthalmology & Visual Science.  52:2050-2064. 2011
2011 The international workshop on meibomian gland dysfunction: Report of the subcommittee on the epidemiology of, and associated risk factors for, MGDInvestigative Ophthalmology & Visual Science.  52:1994-2005. 2011
2011 High resolution microscopy of the lipid layer of the tear filmOcular Surface.  9:197-211. 2011
2010 An objective approach to dry eye disease severityInvestigative Ophthalmology & Visual Science.  51:6125-6130. 2010
2010 Re-on the presence and role of polar lipids in meibumInvestigative Ophthalmology & Visual Science.  51:6910-6911. 2010
2010 Shotgun lipidomic analysis of human meibomian gland secretions with electrospray ionization tandem mass spectrometryInvestigative Ophthalmology & Visual Science.  51:6220-6231. 2010
2010 Evaluation of extractants and precipitants in tear film proteomic analysesOptometry and Vision Science.  87:854-860. 2010
2010 Gas permeable and soft contact lens wear in childrenOptometry and Vision Science.  87:414-420. 2010
2009 Editorial: Collecting tear osmolarity measurements in the diagnosis of dry eyeExpert Review of Ophthalmology.  4:451-453. 2009
2009 The contribution of lipid layer movement to tear film thinning and breakupInvestigative Ophthalmology & Visual Science.  50:2747-2756. 2009
2009 Blepharitis in the United States 2009: A Survey-based Perspective on Prevalence and TreatmentOcular Surface.  7:S1-S14. 2009
2009 Blepharitis in the United States 2009: a survey-based perspective on prevalence and treatment.Ocular Surface.  7:S1-S14. 2009
2009 Blepharitis in the United States 2009: A survey-based perspective on prevalence and treatmentOcular Surface.  7:S1. 2009
2009 Epinastine 0.05% ophthalmic solution in contact lens-wearing subjects with a history of allergic conjunctivitisClao Journal.  35:26-31. 2009
2008 Contributions of evaporation and other mechanisms to tear film thinning and break-upOptometry and Vision Science.  85:623-630. 2008
2008 The changing times in dry eye researchOptometry and Vision Science.  85:613-614. 2008
2008 Investigation of the human tear film proteome using multiple proteomic approachesMolecular Vision.  14:456-470. 2008
2008 Current patterns in the use of diagnostic tests in dry eye evaluationCornea.  27:656-662. 2008
2007 Diabetic eye examination reportOptometry - Journal of the American Optometric Association.  78:588-595. 2007
2007 Identification of fatty acids and fatty acid amides in human meibomian gland secretionsInvestigative Ophthalmology & Visual Science.  48:34-39. 2007
2007 The contact lens and tear film laboratory, The Ohio State University College of OptometryOcular Surface.  5:259-261. 2007
2006 The global sex disparity in blindness and visual impairmentOptometry and Vision Science.  83:700-701. 2006
2006 Interferometric imaging of the full thickness of the precorneal tear filmJournal of the Optical Society of America A.  23:2097-2104. 2006
2006 Patient-reported symptoms in dry dye diseaseOcular Surface.  4:137-145. 2006
2005 The frequency of dilated diabetic eye examinations by optometrists in the state of OhioOptometry and Vision Science.  82:959-963. 2005
2005 Double-masked, placebo-controlled safety and efficacy trial of diguafosol tetrasodium (INS365) ophthalmic solution for the treatment of dry eye (vol 23, pg 784, 2004)Cornea.  24:637-637. 2005
2005 Self-reported dry eye disease across refractive modalitiesInvestigative Ophthalmology & Visual Science.  46:1911-1914. 2005
2005 An assessment of grading scales for meibography imagesCornea.  24:382-388. 2005
2005 Assessment of meibomian lipids in postmenopausal women using electrospray ionization mass spectrometryInvestigative Ophthalmology & Visual Science.  46. 2005
2005 Human tear film breakup studied by a new imaging interferometer: Preliminary observationsInvestigative Ophthalmology & Visual Science.  46. 2005
2005 Identification and analysis of polar and non-polar lipids from meibomian gland secretions using electrospray ionization mass spectrometryInvestigative Ophthalmology & Visual Science.  46. 2005
2004 Double-masked, placebo-controlled safety and efficacy trial of diquafosol tetrasodium (INS365) ophthalmic solution for the treatment of dry-eyeCornea.  23:784-792. 2004
2004 Patients' perspectives on noncompliance with Diabetic Retinopathy Standard of Care GuidelinesOptometry - Journal of the American Optometric Association.  75:709-716. 2004
2004 The lack of association between signs and symptoms in patients with dry eye diseaseCornea.  23:762-770. 2004
2004 An assessment of self-reported disease classification in epidemiological studies of dry eyeInvestigative Ophthalmology & Visual Science.  45:3453-3457. 2004
2004 The Reliability and Validity of McMonnies Dry Eye IndexCornea.  23:365-371. 2004
2004 Assessment of the reliability of self-reported dry eye in contact lens wearers: The contact lens dry eye questionnaire (CLDEQ) short-formInvestigative Ophthalmology & Visual Science.  45:U142-U142. 2004
2004 The Repeatability of Clinical Measurements of Dry EyeCornea.  23:272-285. 2004
2004 Diquafosol tetrasodium: A novel dry eye therapyExpert Opinion on Investigational Drugs.  13:47-54. 2004
2004 Diquafosol tetrasodium: a novel dry eye therapyExpert Opinion on Investigational Drugs.  13:47-54. 2004
2003 The relation between tear film tests in patients with dry eye diseaseOphthalmic and Physiological Optics.  23:553-560. 2003
2003 Adherence to diabetic standard of care guidelinesInvestigative Ophthalmology & Visual Science.  44:U113-U113. 2003
2003 Double masked, placebo-controlled safety and efficacy trial of diquafosol tetrasodium (INS365) ophthalmic solution for the treatment of dry eyeInvestigative Ophthalmology & Visual Science.  44:U312-U312. 2003
2003 Dry eye in postmenopausal women enrolled in the observational study cohort of the Women's Health InitiativeInvestigative Ophthalmology & Visual Science.  44:U429-U429. 2003
2003 Is inferior tear film thinner than superior tear film?Investigative Ophthalmology & Visual Science.  44:U431-U431. 2003
2002 Association of clinical diagnostic tests and dry eye surveys: The NEI-VFQ-25 and the OSDI©Advances in Experimental Medicine and Biology.  506 B:1177-1181. 2002
2002 Patient-reported versus doctor-diagnosed dry eye: The assessment of symptomsAdvances in Experimental Medicine and Biology.  506 B:1189-1193. 2002
2002 The repeatability of diagnostic tests and surveys in dry eyeAdvances in Experimental Medicine and Biology.  506 B:1171-1175. 2002
2002 Performance and repeatability of the NEI-VFQ-25 in patients with dry eyeCornea.  21:578-583. 2002
2002 The performance of the contact lens dry eye questionnaire as a screening survey for contact lens-related dry eyeCornea.  21:469-475. 2002
2002 In vivo measurement of the thickness of human corneal endothelium and Descemet's membrane using interferometryInvestigative Ophthalmology & Visual Science.  43:U27-U27. 2002
2002 Is there an association between signs and symptoms in patients with dry eye?Investigative Ophthalmology & Visual Science.  43:U1117-U1117. 2002
2002 Corneal staining in hydrogel lens wearersOptometry and Vision Science.  79:20-30. 2002
2002 Evaluation of tear film interference patterns and measures of tear break-up timeOptometry and Vision Science.  79:363-369. 2002
2002 Results of a dry eye questionnaire from optometric practices in North AmericaAdvances in Experimental Medicine and Biology.  506 B:1009-1016. 2002
2001 Characterization of ocular surface symptoms from optometric practices in North AmericaCornea.  20:610-618. 2001
2001 The contact lens and myopia progression (CLAMP) study: Design and baseline dataOptometry and Vision Science.  78:223-233. 2001
2000 Assessment of ocular symptoms in patient-reported dry eye versus doctor-diagnosed dry eyeOptometry and Vision Science.  77:181. 2000
2000 Dry eye diagnostic tests and surveys: performance and associationOptometry and Vision Science.  77:20. 2000
2000 Evaluation of the touch scientific lactoferrin microassay system: repeatability of tear lactoferrin measurementsOptometry and Vision Science.  77:121. 2000
2000 Frequency of dry eye diagnostic test procedures used in various modes of ophthalmic practiceCornea.  19:477-482. 2000
2000 Further evidence that the thickness of the normal human tear film is about 3 mu m.Investigative Ophthalmology & Visual Science.  41:S65-S65. 2000
2000 Responses of contact lens wearers to a dry eye surveyOptometry and Vision Science.  77:40-46. 2000
2000 The thickness of the human precorneal tear film: Evidence from reflection spectraInvestigative Ophthalmology & Visual Science.  41:3348-3359. 2000
1999 Is the thickness of the tear film about 40 mu m or about 3 mu m?Investigative Ophthalmology & Visual Science.  40:S544-S544. 1999
1999 Repeatability of the NEI-VFQ in patients with dry eye syndromeInvestigative Ophthalmology & Visual Science.  40:S910-S910. 1999
1999 Repeatability and validity of astigmatism measurementsJournal of Refractive Surgery.  15:23-31. 1999
1999 Symptoms of ocular irritation in patients diagnosed with dry eyeOptometry and Vision Science.  76:838-844. 1999
1997 Repeatability of astigmatism measurementsInvestigative Ophthalmology & Visual Science.  38:3965-3965. 1997

Education And Training

  • Doctor of Philosophy in Vision Science / Physiological Optics, The Ohio State University 2001
  • Master of Public Health in Epidemiology, The Ohio State University 2000
  • Master of Sciences or Mathematics in Vision Science / Physiological Optics, The Ohio State University 1998
  • Doctor of Optometry, University of California 1995
  • Bachelor of Science or Mathematics in Vision Science / Physiological Optics, University of California 1993
  • Bachelor of Arts in Biology, University of California 1991
  • Full Name

  • Kelly Nichols