Positions

Overview

  • Moon H. Nahm, Professor of Department of Medicine, with secondary appointment in Microbiology, obtained both his BA degree (in 1970) and MD degree (in 1974) from Washington University in St. Louis MO. In 1980, he completed both Internal Medicine and Laboratory Medicine residency training in Pathology Department, as well as completing post-doctoral research training in Microbiology Department at Washington University in St. Louis MO. He was a faculty member at Washington University in St. Louis and University of Rochester before he joined UAB. He was the director of the Clinical Immunology Laboratory for UAB hospitals.
  • Selected Publications

    Chapter

    Year Title Altmetric
    2003 Immunity to Extracellular Bacteria:.  1263-1284. 2003

    Research Overview

  • Pneumococcus is a major human pathogen causing pneumonia and is responsible for a large number of deaths worldwide among young children and old adults. Its virulence is mostly due to its carbohydrate capsule, which encases the pneumococci and shields them from the host immune system. Antibodies to the capsule can kill pneumococci and protect us from infections. Because our body can make these antibodies if the capsule is injected into us, the capsule is useful as a vaccine against pneumococcal infections. Pneumococci can express almost 100 types of capsule, but actual vaccines contain 10-23 common capsule types (serotypes). Following the widespread use of these vaccines however, serotypes absent from the vaccine have become more common, and vaccines have become less effective overall. To understand how pneumococci can evade vaccines, and to improve these vaccines, my laboratory studies diversity and immunity to the pneumococcus capsule. Our studies of capsule diversity have led us to discover many new and important capsule types. Our discovery of serotype 6C showed how pneumococci can evade pneumococcal vaccines and has provided knowledge essential to vaccine design. Our discovery of 11E showed that innate immunity can recognize capsule and induce changes in capsule-making genes as pneumococci adapt to live in different body niches. It also showed that innate immunity can recognize variable pathogen structures and how pneumococci adapt to different niches of the body. We are now investigating how completely the capsule encases a bacterium. If the capsule leaves some areas of the pneumococcal surface exposed, then the molecules in the exposed areas can be useful as new vaccines. To do this, we are currently studying bacterial capsules and their synthesis with new super-resolution microscopy, which can visualize down to molecular dimensions. Our studies of immunity to the capsule showed that some vaccines can elicit non-functional antibodies. Thus, vaccine development can be simplified if antibodies can be tested directly for their function. We have developed a practical way to measure antibody function by inventing MOPA (Multiplexed OpsonoPhagocytic Assay). MOPA has become essential in improving pneumococcal vaccines and has simplified vaccine manufacture and evaluation. MOPA is now facilitating production of low cost pneumococcal vaccines available for the entire world. Our laboratory has been serving as a reference laboratory to the World Health Organization in this field.
  • Principal Investigator On

  • Group B Streptococcus Serologic Assay Standardization  awarded by ST. GEORGE'S UNIVERSITY OF LONDON 2016 - 2022
  • Private Grant  awarded by MERCK SHARP & DOHME CORP 2019 - 2021
  • Private Grant  awarded by MERCK SHARP & DOHME CORP 2019 - 2021
  • Private Grant  awarded by MERCK SHARP & DOHME CORP 2019 - 2021
  • Private Grant  awarded by MERCK SHARP & DOHME CORP 2019 - 2021
  • Serological Assays to Predict Shigella Vaccine Efficacy  awarded by University of Maryland, Baltimore County 2016 - 2021
  • Integrating Microbial Glycan Arrays with Genomic Sequences to Study Host Microbe Interactions  awarded by Emory University 2019 - 2020
  • Private Grant  awarded by Jackson Laboratory 2016 - 2020
  • Acquired Deficiency of Innate Immunity (Ficolin-2) Among Elderly Adults  awarded by National Institute on Aging/NIH/DHHS 2015 - 2020
  • Private Grant  awarded by GLAXOSMITHKLINE BIOLOGICALS SA 2018 - 2019
  • Private Grant  awarded by GLAXOSMITHKLINE BIOLOGICALS SA 2018 - 2019
  • Private Grant  awarded by GLAXOSMITHKLINE BIOLOGICALS SA 2018 - 2019
  • RPRC Respiratory Pathogens Research Center  awarded by University of Rochester 2012 - 2018
  • Establishment of Functional Assays for Evaluation of Diarrheal Vaccines  awarded by PATH VACCINE SOLUTIONS 2012 - 2018
  • Private Grant  awarded by MERCK SHARP & DOHME CORP 2016 - 2018
  • Pneumoccoccal Colonization  awarded by University of Rochester 2015 - 2018
  • Private Grant  awarded by GlaxoSmithKline 2015 - 2017
  • Private Grant  awarded by MERCK SHARP & DOHME CORP 2015 - 2016
  • Serologic Analysis of VTEU Study 11-0034  awarded by University of Rochester 2015
  • A Multiplex Label-Free Chip for Pneumococcus Serology  awarded by University of Rochester 2013 - 2015
  • Private Grant  awarded by MERCK & COMPANY, INC. ^ 2014 - 2015
  • Transferring MOPA4 to the National Institute for the Control of Pharmaceutical and Biological Products of China  awarded by PATH VACCINE SOLUTIONS 2012 - 2014
  • The Role of wcjE Disruption in Pneumococcal Serotype 11A Humoral Escape  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2011 - 2014
  • International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) Group  awarded by JOHNS HOPKINS SCHOOL OF MEDICINE 2012 - 2013
  • Pneumococcal Capsule and Host Innate Immunity  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2012 - 2013
  • Bacterial Respiratory Pathogens Reference Laboratory Support  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2003 - 2012
  • Impact of a New Group 6 Serotype on Pneumococcal Vaccines  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2007 - 2012
  • 2012 International Meeting on Opsonophagocytosis Assy (OPA) Standardization  awarded by PATH VACCINE SOLUTIONS 2011 - 2012
  • Pneumococcal Conjugate Vaccines and Old Adults  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2006 - 2011
  • Education And Training

  • Doctor of Medicine, Washington University/St. Louis 1974
  • Full Name

  • Moon Nahm