Positions

Overview

  • Mythreye Karthikeyan (K. Mythreye) received her Bachelors in Science from Delhi University in the Biochemistry honors program and after completing her MS in Biochemistry, received her PhD from UNC Chapel hill in 2005. She received postdoctoral training at Duke University prior to starting her independent lab at University of South Carolina in 2013.She received tenure and promotion in the Summer of 2019, following which she moved to University of Alabama at Birmingham as a tenured Associate Professor. She is a Graduate Faculty, Co-director of the TMS T32 and a Scientist Member of the Cancer Cell biology program at the O’Neal Comprehensive Cancer Center.

    • Selected Publications

    Academic Article

    Year Title Altmetric
    2022 Hypoxia-induced inhibin promotes tumor growth and vascular permeability in ovarian cancers.  Communications Biology.  5. 2022
    2022 βIV-spectrin as a stalk cell-intrinsic regulator of VEGF signaling.  Nature Communications.  13. 2022
    2022 Emerging perspectives on growth factor metabolic relationships in the ovarian cancer ascites environment.  Seminars in Cancer Biology.  86:709-719. 2022
    2022 PVT1 is a stress-responsive lncRNA that drives ovarian cancer metastasis and chemoresistance.  Life Science Alliance.  5. 2022
    2022 EPDR1 is a noncanonical effector of insulin-mediated angiogenesis regulated by an endothelial-specific TGF-β receptor complex.  Journal of Biological Chemistry.  298. 2022
    2022 Reciprocal SOX2 regulation by SMAD1-SMAD3 is critical for anoikis resistance and metastasis in cancer.  Cell Reports.  40. 2022
    2022 HuR-dependent SOD2 protein synthesis is an early adaptation to anchorage-independence.  Redox Biology.  53. 2022
    2022 Optimization of Extracellular Flux Assay to Measure Respiration of Anchorage-independent Tumor Cell Spheroids.  Bio-protocol.  12. 2022
    2022 Reciprocal epigenetic Sox2 regulation by SMAD1-SMAD3 is critical for anoikis resistance and metastasis in cancer 2022
    2022 Regulation of mitochondrial fission by GIPC-mediated Drp1 retrograde transport.  Molecular Biology of the Cell.  33. 2022
    2021 Hypoxia Regulated Inhibin Promotes Tumor Growth and Vascular Permeability By ACVRL1 and CD105 Dependent VE-Cadherin Internalization 2021
    2021 A bioinformatic analysis of the inhibin-betaglycan-endoglin/CD105 network reveals prognostic value in multiple solid tumors.  PLoS One.  16. 2021
    2021 TGFβ signaling networks in ovarian cancer progression and plasticity.  Clinical and Experimental Metastasis.  38:139-161. 2021
    2021 Strength and duration of GIPC-dependent signaling networks as determinants in cancer.  Neoplasia.  23:181-188. 2021
    2020 A meta-analysis of the inhibin network reveals prognostic value in multiple solid tumors 2020
    2020 Confinement-Driven Photophysics in Cages, Covalent-Organic Frameworks, Metal-Organic Frameworks, and DNA.  Journal of the American Chemical Society.  142:4769-4783. 2020
    2020 Context-dependent activation of SIRT3 is necessary for anchorage-independent survival and metastasis of ovarian cancer cells.  Oncogene.  39:1619-1633. 2020
    2019 GPx3 supports ovarian cancer progression by manipulating the extracellular redox environment.  Redox Biology.  25. 2019
    2018 CDK8 selectively promotes the growth of colon cancer metastases in the liver by regulating gene expression of TIMP3 and matrix metalloproteinases.  Cancer Research.  78:6594-6606. 2018
    2018 TAK1 activation of alpha-TAT1 and microtubule hyperacetylation control AKT signaling and cell growth.  Nature Communications.  9. 2018
    2018 Mediator kinase CDK8/CDK19 drives YAP1-dependent BMP4-induced EMT in cancer.  Oncogene.  37:4792-4808. 2018
    2018 Inhibin is a novel paracrine factor for tumor angiogenesis and metastasis.  Cancer Research.  78:2978-2989. 2018
    2018 Dually modified transmembrane proteoglycans in development and disease.  Cytokine and Growth Factor Reviews.  39:124-136. 2018
    2017 Insights into the dichotomous regulation of SOD2 in cancer.  Antioxidants.  6. 2017
    2017 TGF-β triggers rapid fibrillogenesis via a novel TβRII-dependent fibronectin-trafficking mechanism.  Molecular Biology of the Cell.  28:1195-1207. 2017
    2017 Angiostatic actions of capsicodendrin through selective inhibition of VEGFR2-mediated AKT signaling and disregulated autophagy.  Oncotarget.  8:12675-12685. 2017
    2016 Altering the proteoglycan state of transforming growth factor β type III receptor (TβRIII)/betaglycan modulates canonical Wnt/β-catenin signaling.  Journal of Biological Chemistry.  291:25716-25728. 2016
    2016 Activation of Mitofusin2 by Smad2-RIN1 Complex during Mitochondrial Fusion.  Molecular Cell.  62:520-531. 2016
    2015 Endoglin regulation of Smad2 function mediates beclin1 expression and endothelial autophagy.  Journal of Biological Chemistry.  290:14884-14892. 2015
    2015 Epigenetic Regulation of GDF2 Suppresses Anoikis in Ovarian and Breast Epithelia.  Neoplasia.  17:826-838. 2015
    2014 TGF-β regulates LARG and GEF-H1 during EMT to affect stiffening response to force and cell invasion.  Molecular Biology of the Cell.  25:3528-3540. 2014
    2014 Src-mediated post-translational regulation of endoglin stability and function is critical for angiogenesis.  Journal of Biological Chemistry.  289:25486-25496. 2014
    2013 Type III TGF-β receptor promotes FGF2-mediated neuronal differentiation in neuroblastoma.  Journal of Clinical Investigation.  123:4786-4798. 2013
    2013 The type III TGFβ receptor regulates filopodia formation via a Cdc42-mediated IRSp53-N-WASP interaction in epithelial cells.  Biochemical Journal.  454:79-89. 2013
    2013 TβRIII/β-arrestin2 regulates integrin α5β1 trafficking, function, and localization in epithelial cells.  Oncogene.  32:1416-1427. 2013
    2012 Endoglin mediates fibronectin/α5β1 integrin and TGF-β pathway crosstalk in endothelial cells 2012
    2012 Endoglin inhibits ERK-induced c-Myc and cyclin D1 expression to impede endothelial cell proliferation.  Biochemical and Biophysical Research Communications.  424:620-623. 2012
    2011 Mechanical Stiffness grades metastatic potential in patient tumor cells and in cancer cell lines.  Cancer Research.  71:5075-5080. 2011
    2011 The type III transforming growth factor-β receptor inhibits proliferation, migration, and adhesion in human myeloma cells.  Molecular Biology of the Cell.  22:1463-1472. 2011
    2009 Proteoglycan signaling co-receptors: Roles in cell adhesion, migration and invasion.  Cellular Signalling.  21:1548-1558. 2009
    2009 The type III TGFβ receptor regulates directional migration: New tricks for an old dog.  Cell Cycle.  8:3069-3070. 2009
    2009 The type III TGF-β receptor regulates epithelial and cancer cell migration through β-arrestin2-mediated activation of Cdc42 2009
    2009 TβRIII Restores Normal Cytoskeleton Mechanics In Ovarian Cancer Cells.  Biophysical Journal.  96:521a. 2009
    2008 ApoA-I induced CD31 in bone marrow-derived vascular progenitor cells increases adhesion: Implications for vascular repair 2008
    2008 The microtubule-based motor Kar3 and plus end-binding protein Bim1 provide structural support for the anaphase spindle 2008
    2007 TGF-beta type I receptor.  The AFCS-nature molecule pages.  2007
    2006 Reactive oxygen species in vascular endothelial cell motility. Roles of NAD(P)H oxidase and Rac1.  Cardioscience.  71:236-246. 2006
    2003 Differential kinetochore protein requirements for establishment versus propagation of centromere activity in Saccharomyces cerevisiae 2003

    Chapter

    Year Title Altmetric
    2013 Emerging roles of TGF-β co-receptors in human disease.  59-89. 2013

    Research Overview

  • Lab is interested in understanding mechanisms of tumor progression and metastasis in gynecological cancers. Emphasis is on consequences of alterations in signaling due to various cellular stressors.
    Major methodologies used include: Animal models of ovarian cancer metastasis, cell line and patient derived primary cellular strategies, transcriptomics, kinome, proteomic approaches and therapeutic strategies ( antibody and small molecule)

    • Principal Investigator On

    Investigator On

    Education And Training

  • Doctor of Philosophy, University of North Carolina at Chapel Hill 2005
  • Master of Science in Medical Biochemistry, Hamdard University 1998
  • Bachelor of Science or Mathematics in Medical Biochemistry, University of Delhi 1996

    • Full Name

  • Mythreye Karthikeyan