Positions

Selected Publications

Academic Article

Year Title Altmetric
2021 A bioinformatic analysis of the inhibin-betaglycan-endoglin/CD105 network reveals prognostic value in multiple solid tumors.  PLoS ONE.  16. 2021
2021 TGFβ signaling networks in ovarian cancer progression and plasticity.  Clinical and Experimental Metastasis.  38:139-161. 2021
2021 Strength and duration of GIPC-dependent signaling networks as determinants in cancer.  Neoplasia.  23:181-188. 2021
2020 Context-dependent activation of SIRT3 is necessary for anchorage-independent survival and metastasis of ovarian cancer cells.  Oncogene.  39:1619-1633. 2020
2019 GPx3 supports ovarian cancer progression by manipulating the extracellular redox environment.  Redox Biology.  25. 2019
2018 CDK8 selectively promotes the growth of colon cancer metastases in the liver by regulating gene expression of TIMP3 and matrix metalloproteinases.  Cancer Research.  78:6594-6606. 2018
2018 TAK1 activation of alpha-TAT1 and microtubule hyperacetylation control AKT signaling and cell growth.  Nature Communications.  9. 2018
2018 Mediator kinase CDK8/CDK19 drives YAP1-dependent BMP4-induced EMT in cancer.  Oncogene.  37:4792-4808. 2018
2018 Inhibin is a novel paracrine factor for tumor angiogenesis and metastasis.  Cancer Research.  78:2978-2989. 2018
2018 Dually modified transmembrane proteoglycans in development and disease.  Cytokine and Growth Factor Reviews.  39:124-136. 2018
2017 Insights into the dichotomous regulation of SOD2 in cancer.  Antioxidants.  6. 2017
2017 TGF-β triggers rapid fibrillogenesis via a novel TβRII-dependent fibronectin-trafficking mechanism 2017
2017 Angiostatic actions of capsicodendrin through selective inhibition of VEGFR2-mediated AKT signaling and disregulated autophagy.  Oncotarget.  8:12675-12685. 2017
2016 Altering the proteoglycan state of transforming growth factor β type III receptor (TβRIII)/betaglycan modulates canonical Wnt/β-catenin signaling.  Journal of Biological Chemistry.  291:25716-25728. 2016
2016 Activation of Mitofusin2 by Smad2-RIN1 Complex during Mitochondrial Fusion.  Molecular Cell.  62:520-531. 2016
2015 Endoglin regulation of Smad2 function mediates beclin1 expression and endothelial autophagy.  Journal of Biological Chemistry.  290:14884-14892. 2015
2015 Epigenetic Regulation of GDF2 Suppresses Anoikis in Ovarian and Breast Epithelia.  Neoplasia.  17:826-838. 2015
2014 Src-mediated post-translational regulation of endoglin stability and function is critical for angiogenesis.  Journal of Biological Chemistry.  289:25486-25496. 2014
2014 TGF-β regulates LARG and GEF-H1 during EMT to affect stiffening response to force and cell invasion 2014
2013 Type III TGF-β receptor promotes FGF2-mediated neuronal differentiation in neuroblastoma.  Journal of Clinical Investigation.  123:4786-4798. 2013
2013 The type III TGFβ receptor regulates filopodia formation via a Cdc42-mediated IRSp53-N-WASP interaction in epithelial cells.  Biochemical Journal.  454:79-89. 2013
2013 TβRIII/β-arrestin2 regulates integrin α5β1 trafficking, function, and localization in epithelial cells.  Oncogene.  32:1416-1427. 2013
2012 Endoglin mediates fibronectin/α5β1 integrin and TGF-β pathway crosstalk in endothelial cells 2012
2012 Endoglin inhibits ERK-induced c-Myc and cyclin D1 expression to impede endothelial cell proliferation.  Biochemical and Biophysical Research Communications.  424:620-623. 2012
2011 Mechanical Stiffness grades metastatic potential in patient tumor cells and in cancer cell lines.  Cancer Research.  71:5075-5080. 2011
2011 The type III transforming growth factor-β receptor inhibits proliferation, migration, and adhesion in human myeloma cells 2011
2009 Proteoglycan signaling co-receptors: Roles in cell adhesion, migration and invasion.  Cellular Signalling.  21:1548-1558. 2009
2009 The type III TGFβ receptor regulates directional migration: New tricks for an old dog.  Cell Cycle.  8:3069-3070. 2009
2009 The type III TGF-β receptor regulates epithelial and cancer cell migration through β-arrestin2-mediated activation of Cdc42 2009
2009 TβRIII Restores Normal Cytoskeleton Mechanics In Ovarian Cancer Cells.  Biophysical Journal.  96:521a-521a. 2009
2008 ApoA-I induced CD31 in bone marrow-derived vascular progenitor cells increases adhesion: Implications for vascular repair 2008
2008 The microtubule-based motor Kar3 and plus end-binding protein Bim1 provide structural support for the anaphase spindle 2008
2006 Reactive oxygen species in vascular endothelial cell motility. Roles of NAD(P)H oxidase and Rac1.  Cardiovascular Research.  71:236-246. 2006
2003 Differential kinetochore protein requirements for establishment versus propagation of centromere activity in Saccharomyces cerevisiae 2003
A meta-analysis of the inhibin network reveals prognostic value in multiple solid tumors
TGF-beta type I receptor

Chapter

Year Title Altmetric
2013 Emerging roles of TGF-β co-receptors in human disease.  59-89. 2013

Education And Training

  • Doctor of Philosophy, University of North Carolina at Chapel Hill 2005
  • Master of Science in Medical Biochemistry, Hamdard University 1998
  • Bachelor of Science or Mathematics in Medical Biochemistry, University of Delhi 1996

    • Full Name

  • Mythreye Karthikeyan