• Mythreye Karthikeyan (K. Mythreye) received her Bachelors in Science from Delhi University in the Biochemistry honors program and after completing her MS in Biochemistry, received her PhD from UNC Chapel hill in 2005. She received postdoctoral training at Duke University (Gerard Blobe mentor) prior to starting her independent lab at University of South Carolina in 2013.She received tenure and promotion in the Summer of 2019, following which she moved to University of Alabama at Birmingham as a tenured Associate Professor. She is also a Graduate Faculty, a Co-director of the TMS T32 and a Scientist Member of the Cancer Cell biology program at the O’Neal Comprehensive Cancer Center.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2021 A bioinformatic analysis of the inhibin-betaglycan-endoglin/CD105 network reveals prognostic value in multiple solid tumorsPLoS ONE.  16. 2021
    2021 TGFβ signaling networks in ovarian cancer progression and plasticityClinical and Experimental Metastasis.  38:139-161. 2021
    2021 Strength and duration of GIPC-dependent signaling networks as determinants in cancerNeoplasia.  23:181-188. 2021
    2020 Confinement-Driven Photophysics in Cages, Covalent-Organic Frameworks, Metal-Organic Frameworks, and DNAJournal of the American Chemical Society.  142:4769-4783. 2020
    2020 Context-dependent activation of SIRT3 is necessary for anchorage-independent survival and metastasis of ovarian cancer cellsOncogene.  39:1619-1633. 2020
    2019 GPx3 supports ovarian cancer progression by manipulating the extracellular redox environmentRedox Biology.  25. 2019
    2018 CDK8 selectively promotes the growth of colon cancer metastases in the liver by regulating gene expression of TIMP3 and matrix metalloproteinasesCancer Research.  78:6594-6606. 2018
    2018 TAK1 activation of alpha-TAT1 and microtubule hyperacetylation control AKT signaling and cell growthNature Communications.  9. 2018
    2018 Mediator kinase CDK8/CDK19 drives YAP1-dependent BMP4-induced EMT in cancerOncogene.  37:4792-4808. 2018
    2018 Inhibin is a novel paracrine factor for tumor angiogenesis and metastasisCancer Research.  78:2978-2989. 2018
    2018 Dually modified transmembrane proteoglycans in development and diseaseCytokine and Growth Factor Reviews.  39:124-136. 2018
    2017 Insights into the dichotomous regulation of SOD2 in cancerAntioxidants.  6. 2017
    2017 TGF-β triggers rapid fibrillogenesis via a novel TβRII-dependent fibronectin-trafficking mechanism 2017
    2017 Angiostatic actions of capsicodendrin through selective inhibition of VEGFR2-mediated AKT signaling and disregulated autophagyOncotarget.  8:12675-12685. 2017
    2016 Altering the proteoglycan state of transforming growth factor β type III receptor (TβRIII)/betaglycan modulates canonical Wnt/β-catenin signalingJournal of Biological Chemistry.  291:25716-25728. 2016
    2016 Activation of Mitofusin2 by Smad2-RIN1 Complex during Mitochondrial FusionMolecular Cell.  62:520-531. 2016
    2015 Endoglin regulation of Smad2 function mediates beclin1 expression and endothelial autophagyJournal of Biological Chemistry.  290:14884-14892. 2015
    2015 Epigenetic Regulation of GDF2 Suppresses Anoikis in Ovarian and Breast EpitheliaNeoplasia.  17:826-838. 2015
    2014 TGF-β regulates LARG and GEF-H1 during EMT to affect stiffening response to force and cell invasion 2014
    2014 Src-mediated post-translational regulation of endoglin stability and function is critical for angiogenesisJournal of Biological Chemistry.  289:25486-25496. 2014
    2013 Type III TGF-β receptor promotes FGF2-mediated neuronal differentiation in neuroblastomaJournal of Clinical Investigation.  123:4786-4798. 2013
    2013 The type III TGFβ receptor regulates filopodia formation via a Cdc42-mediated IRSp53-N-WASP interaction in epithelial cellsBiochemical Journal.  454:79-89. 2013
    2013 TβRIII/β-arrestin2 regulates integrin α5β1 trafficking, function, and localization in epithelial cellsOncogene.  32:1416-1427. 2013
    2012 Endoglin mediates fibronectin/α5β1 integrin and TGF-β pathway crosstalk in endothelial cells 2012
    2012 Endoglin inhibits ERK-induced c-Myc and cyclin D1 expression to impede endothelial cell proliferationBiochemical and Biophysical Research Communications.  424:620-623. 2012
    2011 Mechanical Stiffness grades metastatic potential in patient tumor cells and in cancer cell linesCancer Research.  71:5075-5080. 2011
    2011 The type III transforming growth factor-β receptor inhibits proliferation, migration, and adhesion in human myeloma cells 2011
    2009 Proteoglycan signaling co-receptors: Roles in cell adhesion, migration and invasionCellular Signalling.  21:1548-1558. 2009
    2009 The type III TGFβ receptor regulates directional migration: New tricks for an old dogCell Cycle.  8:3069-3070. 2009
    2009 The type III TGF-β receptor regulates epithelial and cancer cell migration through β-arrestin2-mediated activation of Cdc42 2009
    2009 TβRIII Restores Normal Cytoskeleton Mechanics In Ovarian Cancer CellsBiophysical Journal.  96:521a-521a. 2009
    2008 ApoA-I induced CD31 in bone marrow-derived vascular progenitor cells increases adhesion: Implications for vascular repair 2008
    2008 The microtubule-based motor Kar3 and plus end-binding protein Bim1 provide structural support for the anaphase spindle 2008
    2007 TGF-beta type I receptor 2007
    2006 Reactive oxygen species in vascular endothelial cell motility. Roles of NAD(P)H oxidase and Rac1Cardiovascular Research.  71:236-246. 2006
    2003 Differential kinetochore protein requirements for establishment versus propagation of centromere activity in Saccharomyces cerevisiae 2003
    A meta-analysis of the inhibin network reveals prognostic value in multiple solid tumors


    Year Title Altmetric
    2013 Emerging roles of TGF-β co-receptors in human disease.  59-89. 2013

    Research Overview

  • Lab is interested in understanding mechanisms of tumor progression and metastasis in gynecological cancers. Emphasis is on consequences of alterations in signaling due to various stress events.
    Major methodologies used include: Animal models of ovarian cancer metastasis, cell line and patient derived primary cellular strategies, transcriptomics ( RNA seq), kinome, proteomic approaches and therapeutic strategies ( antibody and small molecule)
  • Education And Training

  • Doctor of Philosophy, University of North Carolina at Chapel Hill 2005
  • Master of Science in Medical Biochemistry, Hamdard University 1998
  • Bachelor of Science or Mathematics in Medical Biochemistry, University of Delhi 1996
  • Full Name

  • Mythreye Karthikeyan