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Mythreye Karthikeyan
Associate Professor
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E-mail
mythreye@uab.edu
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Mythreye Karthikeyan
Associate Professor
Positions
Scientist
,
Cancer Cell Biology
,
O'Neal Comprehensive Cancer Center
Scientist (C)
,
O'Neal Comprehensive Cancer Center
,
School of Medicine
2019 -
Associate Professor (P)
,
Molecular & Cellular Pathology
,
Joint Pathology
2019 -
Publications
Research
Background
Contact
Publications
Selected Publications
Academic Article
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Year
Title
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2021
Strength and duration of GIPC-dependent signaling networks as determinants in cancer
.
Neoplasia
. 23:181-188.
2021
2020
Context-dependent activation of SIRT3 is necessary for anchorage-independent survival and metastasis of ovarian cancer cells
.
Oncogene
. 39:1619-1633.
2020
2019
GPx3 supports ovarian cancer progression by manipulating the extracellular redox environment
.
Redox Biology
. 25.
2019
2018
CDK8 selectively promotes the growth of colon cancer metastases in the liver by regulating gene expression of TIMP3 and matrix metalloproteinases
.
Cancer Research
. 78:6594-6606.
2018
2018
TAK1 activation of alpha-TAT1 and microtubule hyperacetylation control AKT signaling and cell growth
.
Nature Communications
. 9.
2018
2018
Mediator kinase CDK8/CDK19 drives YAP1-dependent BMP4-induced EMT in cancer
.
Oncogene
. 37:4792-4808.
2018
2018
Inhibin is a novel paracrine factor for tumor angiogenesis and metastasis
.
Cancer Research
. 78:2978-2989.
2018
2018
Dually modified transmembrane proteoglycans in development and disease
.
Cytokine and Growth Factor Reviews
. 39:124-136.
2018
2017
Insights into the dichotomous regulation of SOD2 in cancer
.
Antioxidants
. 6.
2017
2017
TGF-β triggers rapid fibrillogenesis via a novel TβRII-dependent fibronectin-trafficking mechanism
2017
2017
Angiostatic actions of capsicodendrin through selective inhibition of VEGFR2-mediated AKT signaling and disregulated autophagy
.
Oncotarget
. 8:12675-12685.
2017
2016
Altering the proteoglycan state of transforming growth factor β type III receptor (TβRIII)/betaglycan modulates canonical Wnt/β-catenin signaling
.
Journal of Biological Chemistry
. 291:25716-25728.
2016
2016
Activation of Mitofusin2 by Smad2-RIN1 Complex during Mitochondrial Fusion
.
Molecular Cell
. 62:520-531.
2016
2015
Endoglin regulation of Smad2 function mediates beclin1 expression and endothelial autophagy
.
Journal of Biological Chemistry
. 290:14884-14892.
2015
2015
Epigenetic Regulation of GDF2 Suppresses Anoikis in Ovarian and Breast Epithelia
.
Neoplasia
. 17:826-838.
2015
2014
Src-mediated post-translational regulation of endoglin stability and function is critical for angiogenesis
.
Journal of Biological Chemistry
. 289:25486-25496.
2014
2014
TGF-β regulates LARG and GEF-H1 during EMT to affect stiffening response to force and cell invasion
2014
2013
Type III TGF-β receptor promotes FGF2-mediated neuronal differentiation in neuroblastoma
.
Journal of Clinical Investigation
. 123:4786-4798.
2013
2013
The type III TGFβ receptor regulates filopodia formation via a Cdc42-mediated IRSp53-N-WASP interaction in epithelial cells
.
Biochemical Journal
. 454:79-89.
2013
2013
TβRIII/β-arrestin2 regulates integrin α5β1 trafficking, function, and localization in epithelial cells
.
Oncogene
. 32:1416-1427.
2013
2012
Endoglin mediates fibronectin/α5β1 integrin and TGF-β pathway crosstalk in endothelial cells
2012
2012
Endoglin inhibits ERK-induced c-Myc and cyclin D1 expression to impede endothelial cell proliferation
.
Biochemical and Biophysical Research Communications
. 424:620-623.
2012
2011
Mechanical Stiffness grades metastatic potential in patient tumor cells and in cancer cell lines
.
Cancer Research
. 71:5075-5080.
2011
2011
The type III transforming growth factor-β receptor inhibits proliferation, migration, and adhesion in human myeloma cells
2011
2009
Proteoglycan signaling co-receptors: Roles in cell adhesion, migration and invasion
.
Cellular Signalling
. 21:1548-1558.
2009
2009
The type III TGFβ receptor regulates directional migration: New tricks for an old dog
.
Cell Cycle
. 8:3069-3070.
2009
2009
The type III TGF-β receptor regulates epithelial and cancer cell migration through β-arrestin2-mediated activation of Cdc42
2009
2009
TβRIII Restores Normal Cytoskeleton Mechanics In Ovarian Cancer Cells
.
Biophysical Journal
. 96:521a-521a.
2009
2008
ApoA-I induced CD31 in bone marrow-derived vascular progenitor cells increases adhesion: Implications for vascular repair
2008
2008
The microtubule-based motor Kar3 and plus end-binding protein Bim1 provide structural support for the anaphase spindle
2008
2006
Reactive oxygen species in vascular endothelial cell motility. Roles of NAD(P)H oxidase and Rac1
.
Cardiovascular Research
. 71:236-246.
2006
2003
Differential kinetochore protein requirements for establishment versus propagation of centromere activity in Saccharomyces cerevisiae
2003
A meta-analysis of the inhibin network reveals prognostic value in multiple solid tumors
TGF-beta type I receptor
Chapter
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Year
Title
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2013
Emerging roles of TGF-β co-receptors in human disease
. 59-89.
2013
Research
Principal Investigator On
SOX2 Inhibitor PIP 664
awarded by
KYOTO UNIVERSITY
2020 - 2025
Regulation of Mitochondrial Redox Homeostasis and Signaling in Metastatic Ovarian Cancer
awarded by
Pennsylvania State University
2020 - 2025
Inhibin Function in Tumor Angiogenesis
awarded by
National Cancer Institute/NIH/DHHS
2020 - 2023
Analysis of Biomarkers in Granulosa Cell Tumors
awarded by
Duke University
2020 - 2023
Role of Sox2 in Stress Adaptations to Ovarian Cancer Anchorage Independence
awarded by
Pennsylvania State University
2019 - 2021
Background
Education And Training
Doctor of Philosophy,
University of North Carolina at Chapel Hill
2005
Master of Science in Medical Biochemistry,
Hamdard University
1998
Bachelor of Science or Mathematics in Medical Biochemistry,
University of Delhi
1996
Contact
Full Name
Mythreye
Karthikeyan