Positions

Selected Publications

Academic Article

Year Title Altmetric
2019 Denervation-induced skeletal muscle fibrosis is mediated by CTGF/CCN2 independently of TGF-βCollagen and related research.  82:20-37. 2019
2019 Thrombospondin 1 and Its Diverse Roles as a Regulator of Extracellular Matrix in Fibrotic DiseaseJournal of Histochemistry and Cytochemistry.  67:683-699. 2019
2019 Multiscale simulation of the interaction of calreticulin-thrombospondin-1 complex with a model membrane microdomainJournal of Biomolecular Structure and Dynamics.  37:811-822. 2019
2018 Pericytes elicit resistance to vemurafenib and sorafenib therapy in thyroid carcinoma via the TSP-1/TGFB1 axisClinical Cancer Research.  24:6078-6097. 2018
2018 Thrombospondin-1 regulation of latent TGF-β activation: A therapeutic target for fibrotic diseaseCollagen and related research.  68-69:28-43. 2018
2018 The role of the endoplasmic reticulum protein calreticulin in mediating TGF-β-stimulated extracellular matrix production in fibrotic diseaseJournal of Cell Communication and Signaling.  12:289-299. 2018
2018 Thrombospondins: Purification of human platelet thrombospondin-1Methods in Cell Biology.  143:347-369. 2018
2016 Calreticulin Regulates Neointima Formation and Collagen Deposition following Carotid Artery LigationJournal of Vascular Research.  52:306-320. 2016
2016 Inhibition of transforming growth factor-β activation diminishes tumor progression and osteolytic bone disease in mouse models of multiple myelomaAmerican Journal of Pathology.  186:678-690. 2016
2015 High-magnitude and/or high-frequency mechanical strain promotes peripapillary scleral myofibroblast differentiationInvestigative Ophthalmology & Visual Science.  56:7821-7830. 2015
2015 The Thrombospondin1-TGF-β Pathway and GlaucomaJournal of Ocular Pharmacology and Therapeutics.  31:371-375. 2015
2014 Molecular insight into the effect of lipid bilayer environments on thrombospondin-1 and calreticulin interactionsBiochemistry.  53:6309-6322. 2014
2014 Hyperglycemic arterial disturbed flow niche as an in vitro model of atherosclerosisAnalytical Chemistry.  86:10948-10954. 2014
2014 Revisiting the matricellular conceptCollagen and related research.  37:1-14. 2014
2014 The role of matricellular proteins in glaucomaCollagen and related research.  37:174-182. 2014
2013 Calreticulin regulates transforming growth factor-β-stimulated extracellular matrix productionJournal of Biological Chemistry.  288:14584-14598. 2013
2013 CD36, but not G2A, modulates efferocytosis, infl ammation, and fibrosis following bleomycin-induced lung injuryJournal of Lipid Research.  54:1114-1123. 2013
2012 Thrombospondin-1 inhibits osteogenic differentiation of human mesenchymal stem cells through latent TGF-β activationBiochemical and Biophysical Research Communications.  422:488-493. 2012
2012 Thrombospondin1 in tissue repair and fibrosis: TGF-β-dependent and independent mechanismsCollagen and related research.  31:178-186. 2012
2012 Thrombospondins in physiology and disease: New tricks for old dogsCollagen and related research.  31:152-154. 2012
2012 Thrombospondin-1 in early flow-related remodeling of mesenteric arteries from young normotensive and spontaneously hypertensive ratsOpen Cardiovascular Medicine Journal.  6:50-59. 2012
2011 Thrombospondin-1 opens the paracellular pathway in pulmonary microvascular endothelia through EGFR/ErbB2 activationAJP - Lung Cellular and Molecular Physiology.  301:79-90. 2011
2011 Molecular and structural insight into the role of key residues of thrombospondin-1 and calreticulin in thrombospondin-1-calreticulin bindingBiochemistry.  50:566-573. 2011
2011 Blockade of TSP1-dependent TGF-β activity reduces renal injury and proteinuria in a murine model of diabetic nephropathyAmerican Journal of Pathology.  178:2573-2586. 2011
2011 TGF-β2 suppresses macrophage cytokine production and mucosal inflammatory responses in the developing intestineGastroenterology.  140:242-253. 2011
2010 Human cytomegalovirus induces TGF-β1 activation in renal tubular epithelial cells after epithelial-to- mesenchymal transitionPLoS Pathogens.  6. 2010
2010 Modulation of mammary cancer cell migration by 15-deoxy-Δ 12,14-prostaglandin J2: Implications for anti-metastatic therapyBiochemical Journal.  430:69-78. 2010
2010 Thy-1-integrin αvβ5 interactions inhibit lung fibroblast contraction-induced latent transforming growth factor-β1 activation and myofibroblast differentiationJournal of Biological Chemistry.  285:22382-22393. 2010
2010 Stainless steel ions stimulate increased thrombospondin-1-dependent tgf-beta activation by vascular smooth muscle cells: Implications for in-stent restenosisJournal of Vascular Research.  47:309-322. 2010
2010 Structural insight into the role of thrombospondin-1 binding to calreticulin in calreticulin-induced focal adhesion disassemblyBiochemistry.  49:3685-3694. 2010
2010 Glucose downregulation of PKG-I protein mediates increased thrombospondin1-dependent TGF-β activity in vascular smooth muscle cellsAmerican Journal of Physiology - Cell Physiology.  298. 2010
2010 Intracellular calreticulin regulates multiple steps in fibrillar collagen expression, trafficking, and processing into the extracellular matrixJournal of Biological Chemistry.  285:7067-7078. 2010
2010 Calreticulin: Non-endoplasmic reticulum functions in physiology and diseaseFederation proceedings.  24:665-683. 2010
2010 The calreticulin-binding sequence of thrombospondin 1 regulates collagen expression and organization during tissue remodelingAmerican Journal of Pathology.  177:1710-1724. 2010
2009 β1 integrin cytoplasmic variants differentially regulate expression of the antiangiogenic extracellular matrix protein thrombospondin 1Cancer Research.  69:5374-5382. 2009
2009 Epidermal growth factor-like repeats of thrombospondins activate phospholipase Cγ and increase epithelial cell migration through indirect epidermal growth factor receptor activationJournal of Biological Chemistry.  284:6389-6402. 2009
2009 Latent transforming growth factor-β-binding protein-4 regulates transforming growth factor-β1 bioavailability for activation by fibrogenic lung fibroblasts in response to bleomycinAmerican Journal of Pathology.  174:21-33. 2009
2009 The counteradhesive proteins, thrombospondin 1 and SPARC/osteonectin, open the tyrosine phosphorylation-responsive paracellular pathway in pulmonary vascular endotheliaMicrovascular Research.  77:13-20. 2009
2008 Thrombospondin 1 binding to calreticulin-LRP1 signals resistance to anoikisFederation proceedings.  22:3968-3979. 2008
2008 LDL receptor-related protein 1: Unique tissue-specific functions revealed by selective gene knockout studiesPhysiological Reviews.  88:887-918. 2008
2008 Transforming growth factor-β signaling mediates hypoxia-induced pulmonary arterial remodeling and inhibition of alveolar development in newborn mouse lungAJP - Lung Cellular and Molecular Physiology.  295. 2008
2008 Role of matrix metalloproteinase-2 in newborn mouse lungs under hypoxic conditionsPediatric Research.  63:26-32. 2008
2008 The small heat shock-related protein, HSP20, is a cAMP-dependent protein kinase substrate that is involved in airway smooth muscle relaxationAJP - Lung Cellular and Molecular Physiology.  294. 2008
2007 Deoxymyoglobin is a nitrite reductase that generates nitric oxide and regulates mitochondrial respirationCirculation Research.  100:654-661. 2007
2007 A thrombospondin-1 antagonist of transforming growth factor-β activation blocks cardiomyopathy in rats with diabetes and elevated angiotensin IIAmerican Journal of Pathology.  171:777-789. 2007
2007 Endothelin-1 Mediates Hypoxia-Induced Increases in Vascular Collagen in the Newborn Mouse LungPediatric Research.  61:559-564. 2007
2006 Thy-1, via its GPI anchor, modulates Src family kinase and focal adhesion kinase phosphorylation and subcellular localization, and fibroblast migration, in response to thrombospondin-1/hep IExperimental Cell Research.  312:3752-3767. 2006
2006 Function-blocking antithrombospondin-1 monoclonal antibodiesJournal of Thrombosis and Haemostasis.  4:459-468. 2006
2006 Thrombospondin 1 mediates angiotensin II induction of TGF-β activation by cardiac and renal cells under both high and low glucose conditionsBiochemical and Biophysical Research Communications.  339:633-641. 2006
2005 Glutathione restores collagen degradation in TGF-β-treated fibroblasts by blocking plasminogen activator inhibitor-1 expression and activating plasminogenAJP - Lung Cellular and Molecular Physiology.  289. 2005
2005 Cell-surface calreticulin initiates clearance of viable or apoptotic cells through trans-activation of LRP on the phagocyteCell.  123:321-334. 2005
2005 Endothelin-A receptor blockade prevents and partially reverses neonatal hypoxic pulmonary vascular remodelingPediatric Research.  57:631-636. 2005
2005 Transducible heat shock protein 20 (HSP20) phosphopeptide alters cytoskeletal dynamicsFederation proceedings.  19:261-263. 2005
2004 Thrombospondin induces RhoA inactivation through FAK-dependent signaling to stimulate focal adhesion disassemblyJournal of Biological Chemistry.  279:48983-48992. 2004
2004 The tryptophan-rich motifs of the thrombospondin type 1 repeats bind VLAL motifs in the latent transforming growth factor-β complexJournal of Biological Chemistry.  279:47633-47642. 2004
2004 Molecular interactions that confer latency to transforming growth factor-βJournal of Biological Chemistry.  279:38032-38039. 2004
2004 Glucose up-regulates thrombospondin 1 gene transcription and transforming growth factor-β activity through antagonism of cGMP-dependent protein kinase repression via upstream stimulatory factor 2Journal of Biological Chemistry.  279:34311-34322. 2004
2004 Elevated expression of TGF-β1 in head and neck cancer-associated fibroblastsMolecular Carcinogenesis.  40:116-121. 2004
2004 The N-terminus of thrombospondin: The domain stands apartThe International journal of biochemistry.  36:1090-1101. 2004
2004 Thrombospondin-1-induced focal adhesion disassembly in fibroblasts requires Thy-1 surface expression, lipid raft integrity, and Src activationJournal of Biological Chemistry.  279:23510-23516. 2004
2004 Thy-1 regulates fibroblast focal adhesions, cytoskeletal organization and migration through modulation of p190 RhoGAP and Rho GTPase activityExperimental Cell Research.  295:488-496. 2004
2004 Intercellular Adhesion Molecule-1 (ICAM-1) Regulates Endothelial Cell Motility through a Nitric Oxide-dependent PathwayJournal of Biological Chemistry.  279:19230-19238. 2004
2004 Regulation of endothelial cell function by FAK and Pyk2Frontiers in Bioscience.  9:1254-1266. 2004
2004 Thrombospondin-1 is a major activator of TGF-β in fibrotic renal disease in the rat in vivoKidney International.  65:459-468. 2004
2004 Thy-1 expression regulates the ability of rat lung fibroblasts to activate transforming growth factor-β in response to fibrogenic stimuliAmerican Journal of Pathology.  165:659-669. 2004
2003 Expression of constitutively active cGMP-dependent protein kinase prevents glucose stimulation of thrombospondin 1 expression and TGF-β activityDiabetes.  52:2144-2150. 2003
2003 Thrombospondin signaling through the calreticulin/LDL receptor-related protein co-complex stimulates random and directed cell migrationJournal of Cell Science.  116:2917-2927. 2003
2003 Amino acids induce indicators of response to injury in glomerular mesangial cellsAJP - Renal Physiology.  285. 2003
2003 Low density lipoprotein receptor-related protein is a calreticulin coreceptor that signals focal adhesion disassemblyJournal of Cell Biology.  161:1179-1189. 2003
2003 Cellular response to hypoxia involves signaling via Smad proteinsBlood.  101:2253-2260. 2003
2002 The anti-adhesive activity of thrombospondin is mediated by the N-terminal domain of cell surface calreticulinJournal of Biological Chemistry.  277:37219-37228. 2002
2002 Thrombospondin stimulates focal adhesion disassembly through Gi- and phosphoinositide 3-kinase-dependent ERK activationJournal of Biological Chemistry.  277:20453-20460. 2002
2002 Nitric oxide and cGMP-dependent protein kinase regulation of glucose-mediated thrombospondin 1-dependent transforming growth factor-β activation in mesangial cellsJournal of Biological Chemistry.  277:9880-9888. 2002
2001 Actions of the soy phytoestrogen genistein in models of human chronic disease: potential involvement of transforming growth factor beta.Biochemical Society Transactions.  29:216-222. 2001
2001 Tamoxifen and estrogen effects on TGF-β formation: Role of thrombospondin-1, αvβ3, and integrin-associated proteinBiochemical and Biophysical Research Communications.  284:11-14. 2001
2001 The de-adhesive activity of matricellular proteins: Is intermediate cell adhesion an adaptive state?Journal of Clinical Investigation.  107:785-790. 2001
2000 Thrombospondin mediates focal adhesion disassembly through interactions with cell surface calreticulinJournal of Biological Chemistry.  275:36358-36368. 2000
2000 Restructuring of focal adhesion plaques by PI 3-kinase: Regulation by PtdIns (3,4,5)-P3 binding to α-actininJournal of Cell Biology.  150:627-641. 2000
2000 Cell signaling by reactive nitrogen and oxygen species in atherosclerosisFree Radical Biology and Medicine.  28:1780-1794. 2000
2000 Activation of latent TGF-β by thrombospondin-1: Mechanisms and physiologyCytokine and Growth Factor Reviews.  11:59-69. 2000
2000 A CD36 synthetic peptide inhibits bleomycin-induced pulmonary inflammation and connective tissue synthesis in the ratAmerican Journal of Respiratory Cell and Molecular Biology.  23:204-212. 2000
2000 Glucose stimulation of transforming growth factor-β bioactivity in mesangial cells is mediated by thrombospondin-1American Journal of Pathology.  157:1353-1363. 2000
1999 Retinoic acid alters the mechanism of attachment of malignant astrocytoma and neuroblastoma cells to thrombospondin-1Experimental Cell Research.  249:86-101. 1999
1999 The activation sequence of thrombospondin-1 interacts with the latency- associated peptide to regulate activation of latent transforming growth factor-βJournal of Biological Chemistry.  274:13586-13593. 1999
1999 Activation of rat alveolar macrophage-derived latent transforming growth factor β-1 by plasmin requires interaction with thrombospondin-1 and its cell surface receptor, CD36American Journal of Pathology.  155:841-851. 1999
1999 Thrombospondin peptides are potent inhibitors of mesangial and glomerular endothelial cell proliferation in vitro and in vivoKidney International.  55:2236-2249. 1999
1999 Thrombospondin-1 induces tyrosine phosphorylation of adherens junction proteins and regulates an endothelial paracellular pathwayCell regulation.  10:1537-1551. 1999
1998 Signaling of de-adhesion in cellular regulation and motilityMicroscopy Research and Technique.  43:420-432. 1998
1998 Thrombospondin-1 is a major activator of TGF-β1 in vivoCell.  93:1159-1170. 1998
1998 EGF receptor regulation of cell motility: EGF induces disassembly of focal adhesions independently of the motility-associated PLCγ signaling pathwayJournal of Cell Science.  111:615-624. 1998
1998 Cyclic GMP-dependent protein kinase inhibits osteopontin and thrombospondin production in rat aortic smooth muscle cellsCirculation Research.  82:139-146. 1998
1998 Thrombospondin signaling of focal adhesion disassembly requires activation of phosphoinositide 3-kinaseJournal of Biological Chemistry.  273:1755-1763. 1998
1997 EGF decreases fraction of FAC (focal adhesion complex) positive NR6 mouse febroblastsFederation proceedings.  11. 1997
1996 In vitro AL-ahyloid formation is associated with low TGF-B activityFederation proceedings.  10. 1996
1996 Cyclic GMP-dependent protein kinase is required for thrombospondin and tenascin mediated focal adhesion disassemblyJournal of Cell Science.  109:2499-2508. 1996
1996 A role for gelsolin in actuating epidermal growth factor receptor- mediated cell motilityJournal of Cell Biology.  134:689-698. 1996
1996 Mitogenesis, cell migration, and loss of focal adhesions induced by tenascin-C interacting with its cell surface receptor, annexin IICell regulation.  7:883-892. 1996
1995 Anti-adhesive Proteins of the Extracellular Matrix: Thrombospondin, Tenascin, and SPARCTrends in Glycoscience and Glycotechnology.  7:89-100. 1995
1995 Heparin-binding vitronectin up-regulates latent TGF-β production by bovine aortic endothelial cellsJournal of Cell Science.  108:1553-1561. 1995
1995 Pathogenesis of glomerulosclerosis in light chain deposition disease: Role for transforming growth factor-βAmerican Journal of Pathology.  147:375-385. 1995
1995 Regulation of transforming growth factor-β activation by discrete sequences of thrombospondin 1Journal of Biological Chemistry.  270:7304-7310. 1995
1995 SPARC mediates focal adhesion disassembly in endothelial cells through a follistatin‐like region and the Ca2+‐binding EF‐handJournal of Cellular Biochemistry.  57:341-350. 1995
1994 The type 1 repeats of thrombospondin 1 activate latent transforming growth factor-βJournal of Biological Chemistry.  269:26783-26788. 1994
1994 Thrombospondin binds and activates the small and large forms of latent transforming growth factor-β in a chemically defined systemJournal of Biological Chemistry.  269:26775-26782. 1994
1994 Identification and Possible Localization of cGMP-Dependent Protein Kinase in Bovine Aortic Endothelial CellsBiochemical and Biophysical Research Communications.  201:531-537. 1994
1993 Erratum: (Journal of Cell Biology (August 1993) 122:4 (923-932))Journal of Cell Biology.  122:1149. 1993
1993 Heparin-binding peptides from thrombospondins 1 and 2 contain focal adhesion-labilizing activityJournal of Biological Chemistry.  268:26784-26789. 1993
1993 Thrombospondin causes activation of latent transforming growth factor-β secreted by endothelial cells by a novel mechanismJournal of Cell Biology.  122:923-932. 1993
1992 Erratum: (The Journal of Cell Biology, Murphy-Ullrich et al., Vol. 115, No. 4, 1127-1136)Journal of Cell Biology.  116:833. 1992
1992 Regulation of cell substrate adhesion: Effects of small galactosaminoglycan-containing proteoglycansJournal of Cell Biology.  118:1523-1531. 1992
1992 Transforming growth factor-β complexes with thrombospondinCell regulation.  3:181-188. 1992
1992 Urokinase binding to laminin‐nidogen: Structural requirements and interactions with heparinEuropean Journal of Biochemistry.  207:937-942. 1992
1991 Focal adhesion integrity is downregulated by the alternatively spliced domain of human tenascin [published erratum appears in J Cell Biol 1992 Feb;116(3):833]Journal of Cell Biology.  115:1127-1136. 1991
1991 A different approach to determining platelet thrombospondin receptorsJournal of Laboratory and Clinical Medicine.  118:418-420. 1991
1991 Focal adhesion integrity is downregulated by the alternatively spliced domain of human tenascinJournal of Cell Biology.  115:1127-1136. 1991
1989 Thrombospondin modulates focal adhesions in endothelial cellsJournal of Cell Biology.  109:1309-1319. 1989
1988 Altered metabolism of thrombospondin by Chinese hamster ovary cells defective in glycosaminoglycan synthesisJournal of Biological Chemistry.  263:6400-6406. 1988
1987 Interactions of thrombospondin with endothelial cells: receptor- mediated binding and degradationJournal of Cell Biology.  105:1603-1611. 1987
1987 Interactions of thrombospondin with cells in culture: rapid degradation of both soluble and matrix thrombospondin.Seminars in Thrombosis and Hemostasis.  13:343-351. 1987
1987 Interactions of thrombospondin with endothelial cells: receptor-mediated binding and degradation.Journal of Cell Biology.  105:1603-1611. 1987
1986 Serologic and pathologic studies of mice immunized with homologous fibronectinAmerican Journal of Pathology.  125:182-190. 1986
1985 Localization of thrombospondin in clots formed in situBlood.  66:1098-1104. 1985
1984 Detection of autoantibodies and glomerular injury in rabbits immunized with denatured human fibronectin monomerAmerican Journal of Pathology.  117:1-11. 1984
1984 Immune-mediated injury to basement membranes in mice immunized with murine lamininClinical immunology and immunopathology.  31:33-43. 1984
1984 Localization of thrombospondin in clots formed in situFederation proceedings.  43. 1984
1983 The effect of the dimeric and multimeric forms of fibronectin on the adhesion and growth of primary glomerular cellsExperimental Cell Research.  145:265-276. 1983
1982 Glomerular and vascular injury in mice following immunization with heterologous and autologous fibronectinVirchows Archiv B Cell Pathology Including Molecular Pathology.  39:305-321. 1982
1981 Morphologic and immunofluorescence studies of the effect of fibroblast growth factor on the culture of guinea pig glomerular cell strainsAmerican Journal of Pathology.  103:129-136. 1981
1981 Studies on the localization of the glycoprotein GP-2 within the renal glomerulus in vivo and in cultured kidney cell strains in vitroJournal of Histochemistry and Cytochemistry.  29:1237-1242. 1981
1981 The effect of fetal calf serum on the biology of cultured primary glomerular cellsJournal of Pathology.  4:117-128. 1981
1981 The growth of primary glomerular cells as a confluent monolayer in a chemically defined serum-free medium. Specific requirements for prostaglandins and extracellular matrix moleculesAmerican Journal of Pathology.  104:181-188. 1981
1980 Growth and maintenance of glomerular cells under defined conditionsAmerican Journal of Pathology.  101:195-203. 1980

Research Overview

  • extracellular matrix in disease; thrombospondin control of latent TGF-beta activation, calreticulin regulation of ECM and fibrosis
  • Principal Investigator On

  • Mechanobiological Activation Of Latent TGF-beta In Intrinsic Repair Of Musculoskeletal Tissues  awarded by Boston University 2019 - 2022
  • 2018 Biennial Conference of the American Society for Matrix Biology, Extracellular Matrix Microenvironments in Disease, Aging, and Regeneration  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2018 - 2019
  • The Thrombospondin1-TGF-Beta Axis in Multiple Myeloma  awarded by National Cancer Institute/NIH/DHHS 2014 - 2019
  • The Endoplasmic Reticulum Stress Protein Calreticulin in Diabetic Chronic Kidney Disease  awarded by DOD - ARMY MEDICAL RESEARCH ACQUISITION ACTIVITY 2014 - 2017
  • 2016 American Society for Matrix Biology Biennial Meeting, The ECM Microenvironment, a Regulatory Force in Aging and Disease  awarded by National Institute on Aging/NIH/DHHS 2016 - 2017
  • Thrombospondin1-TGF-Beta Axis in Multiple Myeloma  awarded by American Society of Hematology 2014 - 2015
  • Calreticulin in Diabetic Vascular Disease  awarded by American Heart Association 2012 - 2013
  • Thrombospondin1 Antagonists and Diabetic Nephropathy  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2007 - 2013
  • Blockade of TSP1 Depedent TGF-beta Activation for Diabetic Complications  awarded by Juvenile Diabetes Research Foundation International 2009 - 2012
  • Thrombospondin 1 TGFbeta Activation and in Stent Restenosis  awarded by American Heart Association (Southeast Affiliate) 2009 - 2012
  • Thrombospondin-1 Opens Endothelial Paracellular Pathway Via EGFR/ErB2 Activation  awarded by UNIVERSITY OF MARYLAND (BALTIMORE) 2007 - 2011
  • UAB Recessive PKD Research and Translational Core Center - Core D  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2005 - 2010
  • Education And Training

  • Doctor of Philosophy in Pathology Residency Program, University of Wisconsin System : Madison 1983
  • Bachelor's Degree in Medical Staff Services Technology / Technician, Marquette University 1976
  • University of Wisconsin Medicine, Postdoctoral Fellowship 1986
  • Full Name

  • Joanne Murphy-Ullrich