Positions

Overview

  • Dr. Solomon's clinical interest centers on the care of CF and non-CF bronchiectasis patients and the pursuit of continued inpatient medicine care of these patients in the acute care setting.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 Employment of an algorithm of care including chest physiotherapy results in reduced hospitalizations and stability of lung function in bronchiectasisBMC Pulmonary Medicine.  19. 2019
    2019 Proline-Glycine-Proline Peptides Are Critical in the Development of Smoke-Induced Emphysema.American Journal of Respiratory Cell and Molecular Biology2019
    2019 Colocolonic intussusception in an adult cystic fibrosis patientJournal of Cystic Fibrosis.  18:e11-e13. 2019
    2019 The economic burden of bronchiectasis - Known and unknown: A systematic reviewBMC Pulmonary Medicine.  19. 2019
    2019 Acquired cystic fibrosis transmembrane conductance regulator dysfunction and radiographic bronchiectasis in current and former smokers: A cross-sectional studyAnnals of the American Thoracic Society.  16:150-153. 2019
    2019 CFTR modulator theratyping: Current status, gaps and future directionsJournal of Cystic Fibrosis.  18:22-34. 2019
    2019 Effectiveness of ivacaftor in cystic fibrosis patients with non-G551D gating mutationsJournal of Cystic Fibrosis.  18:102-109. 2019
    2018 Muc5b overexpression causes mucociliary dysfunction and enhances lung fibrosis in miceNature Communications.  9. 2018
    2018 Standardized measurement of nasal membrane transepithelial potential difference (NPD)Journal of Visualized Experiments.  2018. 2018
    2018 Seeing cilia: Imaging modalities for ciliary motion and clinical connectionsAJP - Lung Cellular and Molecular Physiology.  314:L909-L921. 2018
    2018 MicroRNA-145 antagonism reverses TGF-b inhibition of F508del CFTR correction in airway EpitheliaAmerican Journal of Respiratory and Critical Care Medicine.  197:632-643. 2018
    2018 Implementation of a successful eradication protocol for Burkholderia Cepacia complex in cystic fibrosis patientsBMC Pulmonary Medicine.  18. 2018
    2018 Antisense oligonucleotide eluforsen improves CFTR function in F508del cystic fibrosisJournal of Cystic Fibrosis2018
    2017 A multiple reader scoring system for Nasal Potential Difference parametersJournal of Cystic Fibrosis.  16:573-578. 2017
    2017 Standardized Treatment of Pulmonary Exacerbations (STOP) study: Observations at the initiation of intravenous antibiotics for cystic fibrosis pulmonary exacerbationsJournal of Cystic Fibrosis.  16:592-599. 2017
    2017 Standardized Treatment of Pulmonary Exacerbations (STOP) study: Physician treatment practices and outcomes for individuals with cystic fibrosis with pulmonary ExacerbationsJournal of Cystic Fibrosis.  16:600-606. 2017
    2017 The therapeutic potential of CFTR modulators for COPD and other airway diseasesCurrent Opinion in Pharmacology.  34:132-139. 2017
    2017 Systematic Computational Identification of Variants That Activate Exonic and Intronic Cryptic Splice SitesAmerican Journal of Human Genetics.  100:751-765. 2017
    2017 Pharmacokinetics and safety of cavosonstat (N91115) in healthy and cystic fibrosis adults homozygous for F508DEL-CFTRJournal of Cystic Fibrosis.  16:371-379. 2017
    2017 Assessment of ciliary phenotype in primary ciliary dyskinesia by micro-optical coherence tomography.JCI insight.  2:e91702. 2017
    2017 Flexible, high-resolution micro-optical coherence tomography endobronchial probe toward in vivo imaging of ciliaOptics Letters.  42:867-870. 2017
    2017 Therapeutic benefit observed with the CFTR potentiator, ivacaftor, in a CF patient homozygous for the W1282X CFTR nonsense mutationJournal of Cystic Fibrosis.  16:24-29. 2017
    2016 Airway progenitor clone formation is enhanced by Y-27632-dependent changes in the transcriptomeAmerican Journal of Respiratory Cell and Molecular Biology.  55:323-336. 2016
    2016 Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal CellsCell Stem Cell.  19:217-231. 2016
    2016 In vivo imaging of airway cilia and mucus clearance with micro-optical coherence tomographyBiomedical Optics Express.  7:2494-2505. 2016
    2016 Pilot evaluation of ivacaftor for chronic bronchitisLancet Respiratory Medicine.  4:e32-e33. 2016
    2016 Combination therapy with cystic fibrosis transmembrane conductance regulator modulators augment the airway functional microanatomyAJP - Lung Cellular and Molecular Physiology.  310:L928-L939. 2016
    2016 Neutrophil fates in bronchiectasis and alpha-1 antitrypsin deficiencyAnnals of the American Thoracic Society.  13:S123-S129. 2016
    2016 Therapeutic approaches to acquired cystic fibrosis transmembrane conductance regulator dysfunction in Chronic bronchitisAnnals of the American Thoracic Society.  13:S169-S176. 2016
    2016 Acquired Cystic Fibrosis Transmembrane Conductance Regulator Dysfunction in Chronic Bronchitis and Other Diseases of Mucus ClearanceClinics in Chest Medicine.  37:147-158. 2016
    2015 Breakthrough therapies: Cystic fibrosis (CF) potentiators and correctorsPediatric Pulmonology.  50:S3-S13. 2015
    2015 Improved clinical and radiographic outcomes after treatment with ivacaftor in a young adult with cystic fibrosis with the P67L CFTR mutationChest.  147:e79-e82. 2015
    2015 Pharmacokinetics and tolerability of oral sildenafil in adults with cystic fibrosis lung diseaseJournal of Cystic Fibrosis.  14:228-236. 2015
    2013 IP-10 Is a Potential Biomarker of Cystic Fibrosis Acute Pulmonary ExacerbationsPLoS ONE.  8. 2013
    2013 Effects of azithromycin in Pseudomonas aeruginosa burn wound infectionJournal of Surgical Research.  183:767-776. 2013
    2013 Mycobacterium abscessus Induces a Limited Pattern of Neutrophil Activation That Promotes Pathogen SurvivalPLoS ONE.  8. 2013
    2013 Reduced sodium transport with nasal administration of the prostasin inhibitor camostat in subjects with cystic fibrosisChest.  144:200-207. 2013
    2010 An international randomized multicenter comparison of nasal potential difference techniquesChest.  138:919-928. 2010
    2008 Potential role of high-mobility group box 1 in cystic fibrosis airway diseaseAmerican Journal of Respiratory and Critical Care Medicine.  178:822-831. 2008
    2006 Airborne mold and endotoxin concentrations in New Orleans, Louisiana, after flooding, October through November 2005Environmental Health Perspectives.  114:1381-1386. 2006

    Research Overview

  • Dr. Solomon's research goal is the pursuit of translational sciences and an academic medical career focusing on the use of in vivo and in vitro ion transport, inflammatory, and rheological research techniques to explore mechanisms of disease and opportunities for novel treatments in CF, non-CF bronchiectasis patients and the pursuit of continued inpatient medicine care of these patients in the acute care setting.
  • Principal Investigator On

  • Functional Categorization of Ciliary Motion in PCD  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2019 - 2023
  • A Prospective Study to Evaluate Biological and Clinical Effects of Significantly Corrected CFTR Function (the PROMISE Study) (PROMISE-OB-18)  awarded by Cystic Fibrosis Foundation 2018 - 2023
  • Rare Mutations in Cystic Fibrosis: Overcoming Barriers to Personalized Medicine  awarded by Emory University 2018 - 2023
  • Rare CFTR Mutation Cell Collection Protocol (RARE)  awarded by SEATTLE CHILDREN'S HOSPITAL 2016 - 2021
  • Prospective Evaluation of a Standardized Approach to Diagnosis (PREDICT) and Treatment (PATIENCE) of Nontuberculous Mycobacteria Disease in Cystic Fibrosis  awarded by SEATTLE CHILDREN'S HOSPITAL 2018 - 2021
  • Private Grant  awarded by ASTRAZENECA AB 2018 - 2020
  • Private Grant  awarded by INSMED PHARMACEUTICALS, INC. 2018 - 2020
  • Private Grant  awarded by VERTEX PHARMACEUTICALS, INC. 2018 - 2020
  • Cystic Fibrosis Learning Network: A CF C3N Model of the Future: Proposal for Piloting a Learning Health System  awarded by CINCINNATI CHILDREN'S HOSPITAL 2017 - 2019
  • Implementation Of The Depression And Anxiety Guidelines Award For A Mental Health Coordinator  awarded by Cystic Fibrosis Foundation 2017 - 2019
  • Standardized Treatment of Pulmonary Exacerbations II  awarded by SEATTLE CHILDREN'S HOSPITAL 2016 - 2019
  • UAB Cystic Fibrosis Therapeutic Development Network Center for CFTR Detection  awarded by Cystic Fibrosis Foundation 2016 - 2019
  • Award for a Physical Therapist  awarded by Cystic Fibrosis Foundation 2017 - 2019
  • Private Grant  awarded by ELECTROMED, INC. 2017 - 2019
  • Private Grant  awarded by VERTEX PHARMACEUTICALS, INC. 2018 - 2019
  • UAB Cystic Fibrosis Center For Care Teaching And Research (Adult)  awarded by Cystic Fibrosis Foundation 2017 - 2019
  • Private Grant  awarded by VERTEX PHARMACEUTICALS, INC. 2018 - 2019
  • Private Grant  awarded by PARION SCIENCES, INC. 2016 - 2018
  • Proof of Principal Evaluation of IV Gallium Nitrate (Ganite) in Patients with Cystic Fibrosis  awarded by SEATTLE CHILDREN'S HOSPITAL 2013 - 2018
  • Private Grant  awarded by VERTEX PHARMACEUTICALS, INC. 2017 - 2018
  • Rare Cell Collection Protocol for CF Patients with Rare CFTR Mutations (RACE)  awarded by CYSTIC FIBROSIS FOUNDATION THERAPEUTICS., INC 2016 - 2017
  • Private Grant  awarded by NIVALIS THERAPEUTICS, INC. - NEW 2016 - 2017
  • Private Grant  awarded by PROQR THERAPEUTICS 2015 - 2016
  • Pilot Observational Study to Determine Feasibility of a Standardized Treatment of Pulmonary Exacerbations in Patients with Cystic Fibrosis  awarded by SEATTLE CHILDREN'S RESEARCH INSTITUTE 2013 - 2016
  • Private Grant  awarded by VERTEX PHARMACEUTICALS, INC. 2015 - 2016
  • Private Grant  awarded by VERTEX PHARMACEUTICALS, INC. 2015 - 2016
  • Private Grant  awarded by NIVALIS THERAPEUTICS, INC. - NEW 2015
  • Private Grant  awarded by NIVALIS THERAPEUTICS, INC. - NEW 2014 - 2015
  • Private Grant  awarded by N30 PHARMACEUTICALS, LLC 2013 - 2014
  • Investigator On

  • Translational Program in CFTR-Related Airway Diseases  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2017 - 2023
  • UAB CF Research and Translation Core Center  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2018 - 2023
  • UAB CF Research and Translation Core Center - Core A  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2018 - 2023
  • UAB CF Research and Translation Core Center - Core C  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2018 - 2023
  • Private Grant  awarded by TRANSLATE BIO, INC 2019 - 2021
  • Novel Therapeutic Approaches for Treatment of CF Patients with W1282X Premature Termination Codon Mutations  awarded by EMILY'S ENTOURAGE 2019 - 2020
  • Characterizing CFTR Modulated Changes in Sweat Chloride & Clinical Outcomes  awarded by SEATTLE CHILDREN'S RESEARCH INSTITUTE 2017 - 2020
  • A Two-Part Multicenter Prospective Longitudinal Study of CFTR-Dependent Disease Profiling in Cystic Fibrosis (PROSPECT) ("Clinical Study")  awarded by SEATTLE CHILDREN'S HOSPITAL 2014 - 2020
  • Private Grant  awarded by VERTEX PHARMACEUTICALS, INC. 2016 - 2020
  • UAB Cystic Fibrosis Translational Development Center  awarded by Cystic Fibrosis Foundation 2017 - 2019
  • Private Grant  awarded by PROTEOSTASIS THERAPEUTICS, INC. 2017 - 2019
  • Private Grant  awarded by VERTEX PHARMACEUTICALS, INC. 2017 - 2019
  • Award for a Physical Therapist  awarded by Cystic Fibrosis Foundation 2017 - 2019
  • Implementation of Direct-to-Patient Telemedicine Healthcare Initiatives  awarded by UNIVERSITY OF ALABAMA HEALTH SERVICES FOUNDATION 2017 - 2019
  • Private Grant  awarded by VERTEX PHARMACEUTICALS, INC. 2017 - 2019
  • Private Grant  awarded by PROTEOSTASIS THERAPEUTICS, INC. 2018 - 2019
  • Private Grant  awarded by VERTEX PHARMACEUTICALS, INC. 2016 - 2019
  • Research Development Program  awarded by Cystic Fibrosis Foundation 2015 - 2019
  • Training and Equipment for the MBW sub-study of the PROSPECT Study.  awarded by Cystic Fibrosis Foundation 2014 - 2019
  • A Two-Part Multicenter Prospective Longitudinal Study of CFTR-Dependent Disease Profiling in Cystic Fibrosis (PROSPECT)  awarded by Cystic Fibrosis Foundation 2014 - 2018
  • Private Grant  awarded by VERTEX PHARMACEUTICALS, INC. 2016 - 2018
  • Private Grant  awarded by VERTEX PHARMACEUTICALS, INC. 2017 - 2018
  • Private Grant  awarded by ASTRAZENECA AB 2017 - 2018
  • Private Grant  awarded by CELTAXSYS, INC. 2016 - 2018
  • UAB CF Research and Translation Core Center  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2015 - 2018
  • UAB CF Research and Translation Core Center - Core C: Clinical & Translational Core  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2015 - 2018
  • Private Grant  awarded by VERTEX PHARMACEUTICALS, INC. 2015 - 2018
  • An Open Label N of 1 Study to Evaluate the Safety and Efficacy of Long-Term Treatment with Ivacaftor in Combination with ALTALUREN (PTCD124) In Subjects with Nonsense Mutation Cystic Fibrosis  awarded by University of Pennsylvania 2016 - 2017
  • Private Grant  awarded by VERTEX PHARMACEUTICALS, INC. 2016 - 2017
  • Private Grant  awarded by PTC THERAPEUTICS, INC. 2015 - 2017
  • Private Grant  awarded by Bayer HealthCare 2014 - 2017
  • Private Grant  awarded by PROGENRA, INC. 2016 - 2017
  • UAB Cystic Fibrosis Center for Care, Teaching, and Research (Adult)  awarded by Cystic Fibrosis Foundation 2011 - 2017
  • Private Grant  awarded by PTC THERAPEUTICS, INC. 2014 - 2017
  • Private Grant  awarded by Gilead Sciences 2017
  • Private Grant  awarded by PTC THERAPEUTICS, INC. 2016 - 2017
  • Private Grant  awarded by Bayer AG 2014 - 2017
  • UAB Therapeutic Development Network Center  awarded by Cystic Fibrosis Foundation 2015 - 2016
  • Private Grant  awarded by PTC THERAPEUTICS, INC. 2014 - 2016
  • Private Grant  awarded by VERTEX PHARMACEUTICALS, INC. 2014 - 2016
  • Private Grant  awarded by NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH, INC. 2014 - 2016
  • Private Grant  awarded by VERTEX PHARMACEUTICALS, INC. 2014 - 2016
  • Therapeutic Development Center - UAB Center for CFTR Detection  awarded by Cystic Fibrosis Foundation 2013 - 2015
  • UAB Research Development Program Component II - Overall Program  awarded by Cystic Fibrosis Foundation 2015
  • Nasal Epithelial Cells as an Outcome Tool for Individualized CFTR Therapies  awarded by Cystic Fibrosis Foundation 2014 - 2015
  • Translational Therapeutic Development Center  awarded by Cystic Fibrosis Foundation 2013 - 2014
  • Private Grant  awarded by VERTEX PHARMACEUTICALS, INC. 2010 - 2014
  • Private Grant  awarded by VERTEX PHARMACEUTICALS, INC. 2013 - 2014
  • Private Grant  awarded by VERTEX PHARMACEUTICALS, INC. 2012 - 2014
  • Private Grant  awarded by N30 PHARMACEUTICALS, LLC 2013
  • Education And Training

  • Doctor of Medicine, University of Alabama at Birmingham 2007
  • UAB Hospital, Residency 2010
  • University of Colorado Health Sciences Center, Postdoctoral Fellowship 2013
  • Full Name

  • George Solomon