Positions

Overview

  • One of the most prominent features of M. tuberculosis is its unusual outer membrane that plays a crucial role in the intrinsic drug resistance and in survival of M. tuberculosis in vivo. This membrane is functionalized by intriguing proteins which provide essential functions such as nutrient uptake, have new structures and likely function by novel mechanisms. We discovered the first outer membrane channel protein in mycobacteria, obtained the first crystal structure of a mycobacterial outer membrane protein and demonstrated that mycobacteria indeed have two membranes. Our goal is to identify and characterize outer membrane proteins of M. tuberculosis. One of those proteins, CpnT, enables the secretion of the major exotoxin of M. tuberculosis, a NAD+ glycohydrolase which triggers necroptosis in infected macrophages. We use state-of-the art genetic, biochemical and biophysical approaches to achieve our aims.
  • Selected Publications

    Principal Investigator On

  • Heme and Hemoglobin Utilization by Mycobacterium Tuberculosis  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2019 - 2023
  • Siderophore-Dependent Inhibitors of Mycobacterium Tuberculosis  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2020 - 2022
  • The Necrosis-Inducing Toxin of Mycobacterium Tuberculosis  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2015 - 2021
  • Single-chain MspA for Nanopore Sequencing of DNA  awarded by National Human Genome Research Institute/NIH/DHHS 2019 - 2021
  • Self-Poisoning of Mycobacterium Tuberculosis by Inhibiting Siderophore Secretion  awarded by TRES CANTOS OPEN LAB FOUNDATION 2016 - 2020
  • Killing and Sensitizing Bacterial Pathogens to Conventional Antibiotics Using a Protein Complex From Human Milk  awarded by UNIVERSITY OF LUND, SWEDEN 2015 - 2018
  • Nanopore Sequencing of DNA with MspA  awarded by UNIVERSITY OF WASHINGTON 2013 - 2017
  • M. Tuberculosis Membrane Protein Pharmaceutical Targets  awarded by Florida State University 2009 - 2015
  • Copper Transport in Mycobacterium Tuberculosis  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2009 - 2015
  • Nanopore Sequencing of DNA with MspA  awarded by UNIVERSITY OF WASHINGTON 2009 - 2013
  • Characterization of a Mycobacterium Tuberculosis Porin with an Autotransporter-Like Toxin Activity  awarded by American Lung Association 2011 - 2012
  • The Interactions Network of the Outer Membrane Copper Efflux Channel Protein MctB of M. Tuberculosis  awarded by New York Community Trust 2009 - 2011
  • Teaching Activities

  • GBS760 - Prokar Gene and Mole Bio (Spring Term 2018) 2018
  • GBSC720 - Journal Club 2 (Fall Term 2017) 2017
  • UNIV398 - Undergraduate Research (Fall Term 2017) 2017
  • GBS760 - Prokar Gene and Mole Bio (Spring Term 2017) 2017
  • GBSC720 - Journal Club 2 (Spring Term 2017) 2017
  • UNIV398 - Undergraduate Research (Spring Term 2017) 2017
  • MIC712 - Phys and Path of Mycobacteria (Fall Term 2016) 2016
  • UNIV398 - Undergraduate Research (Fall Term 2016) 2016
  • GBS760 - Prokar Gene and Mole Bio (Spring Term 2016) 2016
  • MIC712 - Phys and Path of Mycobacteria (Spring Term 2016) 2016
  • MIC712 - Phys and Path of Mycobacteria (Fall Term 2015) 2015
  • GBS760 - Prokar Gene and Mole Bio (Spring Term 2015) 2015
  • MIC712 - Phys and Path of Mycobacteria (Spring Term 2015) 2015
  • MIC712 - Phys and Path of Mycobacteria (Fall Term 2014) 2014
  • MIC712 - Phys and Path of Mycobacteria (Spring Term 2014) 2014
  • MIC712 - Phys and Path of Mycobacteria (Fall Term 2013) 2013
  • GBS760 - Prokar Gene and Mole Bio (Spring Term 2013) 2013
  • MIC712 - Phys and Path of Mycobacteria (Spring Term 2013) 2013
  • GBS708 - Basic Genetics/Mole BIo (Fall Term 2012) 2012
  • MIC712 - Phys and Path of Mycobacteria (Fall Term 2012) 2012
  • GBS708 - CORE COURSE II: GENETICS/MOLECULAR BIOLOGY (Fall Term 2012) 2012
  • GBS760 - Prokar Gene and Mole Bio (Spring Term 2012) 2012
  • MIC712 - Phys and Path of Mycobacteria (Spring Term 2012) 2012
  • GBS708 - Basic Genetics/Mole BIo (Fall Term 2011) 2011
  • MIC712 - Phys and Path of Mycobacteria (Fall Term 2011) 2011
  • GBS708 - CORE COURSE II: GENETICS/MOLECULAR BIOLOGY (Fall Term 2011) 2011
  • MIC712 - Phys and Path of Mycobacteria (Spring Term 2011) 2011
  • GBS708 - Basic Genetics/Mole BIo (Fall Term 2010) 2010
  • GBS760 - Prokar Gene and Mole Bio (Fall Term 2010) 2010
  • MIC712 - Phys and Path of Mycobacteria (Fall Term 2010) 2010
  • GBS708 - CORE COURSE II: GENETICS/MOLECULAR BIOLOGY (Fall Term 2010) 2010
  • MIC712 - Phys and Path of Mycobacteria (Spring Term 2010) 2010
  • CMB720 - CMB II Genes (Fall Term 2009) 2009
  • MIC712 - Phys and Path of Mycobacteria (Fall Term 2009) 2009
  • MIC712 - Phys and Path of Mycobacteria (Spring Term 2009) 2009
  • CMB720 - CMB II Genes (Fall Term 2008) 2008
  • MIC712 - Phys and Path of Mycobacteria (Fall Term 2008) 2008
  • MIC712 - Phys and Path of Mycobacteria (Spring Term 2008) 2008
  • Education And Training

  • Doctor of Philosophy in Microbiology, Friedrich-Alexander University of Erlangen-Nuremberg 1993
  • Full Name

  • Michael Niederweis